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http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/28660完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 林文澧(Win-Li Lin) | |
| dc.contributor.author | Sun-Yi Young | en |
| dc.contributor.author | 楊善義 | zh_TW |
| dc.date.accessioned | 2021-06-13T00:16:07Z | - |
| dc.date.available | 2008-03-01 | |
| dc.date.copyright | 2007-07-31 | |
| dc.date.issued | 2007 | |
| dc.date.submitted | 2007-07-27 | |
| dc.identifier.citation | [1] B. F. Krantz JC, 'Sound waves are tried as cancer treatment,' Arch Phys Ther, vol. 20, p. 370, 1939.
[2] W. C. Dewey, D. E. Thrall, and E. L. Gillette, 'Hyperthermia and radiation--a selective thermal effect on chronically hypoxic tumor cells in vivo,' Int J Radiat Oncol Biol Phys, vol. 2, pp. 99-103, Jan-Feb 1977. [3] E. S. Ebbini, 'Multiple-Focus Ultrasound Phased-Array Pattern Synthesis - Optimal Driving-Signal Distributions for Hyperthermia,' Ieee Transactions on Ultrasonics Ferroelectrics and Frequency Control, vol. 36, pp. 540-548, Sep 1989. [4] J. E. Kennedy, 'High-intensity focused ultrasound in the treatment of solid tumours,' Nat Rev Cancer, vol. 5, pp. 321-7, Apr 2005. [5] C. Chaussy, S. Thuroff, X. Rebillard, and A. Gelet, 'Technology insight: High-intensity focused ultrasound for urologic cancers,' Nat Clin Pract Urol, vol. 2, pp. 191-8, Apr 2005. [6] J. Hindley, W. M. Gedroyc, L. Regan, E. Stewart, C. Tempany, K. Hynyen, N. McDannold, Y. Inbar, Y. Itzchak, J. Rabinovici, H. S. Kim, J. F. Geschwind, G. Hesley, B. Gostout, T. Ehrenstein, S. Hengst, M. Sklair-Levy, A. Shushan, and F. Jolesz, 'MRI guidance of focused ultrasound therapy of uterine fibroids: early results,' AJR Am J Roentgenol, vol. 183, pp. 1713-9, Dec 2004. [7] C. W. Song, H. J. Park, C. K. Lee, and R. Griffin, 'Implications of increased tumor blood flow and oxygenation caused by mild temperature hyperthermia in tumor treatment,' Int J Hyperthermia, vol. 21, pp. 761-7, Dec 2005. [8] C. M. Tempany, E. A. Stewart, N. McDannold, B. J. Quade, F. A. Jolesz, and K. Hynynen, 'MR imaging-guided focused ultrasound surgery of uterine leiomyomas: a feasibility study,' Radiology, vol. 226, pp. 897-905, Mar 2003. [9] R. Illing and M. Emberton, 'Sonablate-500: transrectal high-intensity focused ultrasound for the treatment of prostate cancer,' Expert Rev Med Devices, vol. 3, pp. 717-29, Nov 2006. [10] J. W. Jenne, R. Rastert, G. Rademaker, G. Divkovic, J. Debus, and P. E. Huber, '[MRI-guided surgery with high intensity focused ultrasound],' Z Med Phys, vol. 13, pp. 193-7, 2003. [11] H. Chen, X. Li, M. Wan, and S. Wang, 'High-speed observation of cavitation bubble cloud structures in the focal region of a 1.2 MHz high-intensity focused ultrasound transducer,' Ultrason Sonochem, vol. 14, pp. 291-7, Mar 2007. [12] M. N. Patil and A. B. Pandit, 'Cavitation - A novel technique for making stable nano-suspensions,' Ultrason Sonochem, Jan 3 2007. [13] W. C. Dewey, L. E. Hopwood, S. A. Sapareto, and L. E. Gerweck, 'Cellular responses to combinations of hyperthermia and radiation,' Radiology, vol. 123, pp. 463-74, May 1977. [14] K. Hynynen, C. A. Damianou, V. Colucci, E. Unger, H. H. Cline, and F. A. Jolesz, 'MR monitoring of focused ultrasonic surgery of renal cortex: experimental and simulation studies,' J Magn Reson Imaging, vol. 5, pp. 259-66, May-Jun 1995. [15] H. E. Cline, J. F. Schenck, K. Hynynen, R. D. Watkins, S. P. Souza, and F. A. Jolesz, 'MR-guided focused ultrasound surgery,' J Comput Assist Tomogr, vol. 16, pp. 956-65, Nov-Dec 1992. [16] K. R. Gorny, N. J. Hangiandreou, G. K. Hesley, B. S. Gostout, K. P. McGee, and J. P. Felmlee, 'MR guided focused ultrasound: technical acceptance measures for a clinical system,' Phys Med Biol, vol. 51, pp. 3155-73, Jun 21 2006. [17] Y. S. Tung, H. L. Liu, C. C. Wu, K. C. Ju, W. S. Chen, and W. L. Lin, 'Contrast-agent-enhanced ultrasound thermal ablation,' Ultrasound Med Biol, vol. 32, pp. 1103-10, Jul 2006. [18] K. Takegami, Y. Kaneko, T. Watanabe, T. Maruyama, Y. Matsumoto, and H. Nagawa, 'Polyacrylamide gel containing egg white as new model for irradiation experiments using focused ultrasound,' Ultrasound Med Biol, vol. 30, pp. 1419-22, Oct 2004. [19] E. L. Madsen, F. Dong, G. R. Frank, B. S. Garra, K. A. Wear, T. Wilson, J. A. Zagzebski, H. L. Miller, K. K. Shung, S. H. Wang, E. J. Feleppa, T. Liu, W. D. O'Brien, Jr., K. A. Topp, N. T. Sanghvi, A. V. Zaitsev, T. J. Hall, J. B. Fowlkes, O. D. Kripfgans, and J. G. Miller, 'Interlaboratory comparison of ultrasonic backscatter, attenuation, and speed measurements,' J Ultrasound Med, vol. 18, pp. 615-31, Sep 1999. [20] H. Y. C. Yazhu, 'Temperature Distribution Estimation of Self-Focusing Large Sphere Aperture Transducer,' Beijing Biomedical Engineering, vol. 19, pp. 212-216, 2000. [21] T. Yu, S. Xiong, T. J. Mason, and Z. Wang, 'The use of a micro-bubble agent to enhance rabbit liver destruction using high intensity focused ultrasound,' Ultrason Sonochem, vol. 13, pp. 143-9, Feb 2006. [22] R. L. Clarke and G. R. ter Haar, 'Temperature rise recorded during lesion formation by high-intensity focused ultrasound,' Ultrasound Med Biol, vol. 23, pp. 299-306, 1997. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/28660 | - |
| dc.description.abstract | 超音波熱手術治療為一種非侵入式手術，利用機械波的震動與聚焦造成組織溫度的升高以達成腫瘤燒灼的目標；而在燒灼過程中需要溫度的監控來告訴操作人員或是醫師，且近年來，不僅許多論文探討以磁振造影引導超音波熱治療的方式觀測異常組織位置與燒灼治療時溫度變化，並且國外已經有許多研究證實影像引導式超音波熱手術治療用於子宮肌瘤，或是良性及惡性乳房腫瘤為有效的治療方法。
有鑑於此，本研究主要為開發一台與磁振造影相容的超音波熱手術系統。利用伺服馬達帶動油壓缸的方式推動移動平台，並使用Visual Basic軟體整合了二維移動平台控制機構，超音波功率放大器，CCD影像擷取，與熱手術治療規劃的使用者介面以達成軟硬體之間的整合。初步利用CCD影像觀測透明仿體的方式，暫時模擬醫學影像(磁振造影)看透物體的能力，當作此系統影像引導工具來做仿體燒灼加熱實驗。此系統經過測試運轉後，目前成功的達成二維移動的控制，移動誤差小於0.5mm；並完成了初步的仿體燒灼實驗，證實此系統能夠正確達成規劃多點加熱的動作。 | zh_TW |
| dc.description.abstract | High intensity focused ultrasound is a noninvasive method of tissue ablation that can be guided and monitored with magnetic resonance imaging (MRI). Magnetic resonance-guided focused ultrasound surgery (MRgFUS) has been shown clinically effective in treatment of uterine fibroids and it is being evaluated as a method of thermal ablation for other benign and malignant tumors. In this study, we develop a MRI- compatible focused ultrasound thermal surgery system with image guidance. We use hydraulic position devices driven by a computer-controlled servo motor to move the transducer holder, and integrate the automatic position devices, ultrasound power amplifier, CCD image capture into a graphical user interface. At this stage, we use two CCD cameras to capture the transparent gel phantom as an image guided tool for this system in order to simulate the future MR image system which will be employed for animal experiments and patient treatments. This system was evaluated and operated. It can do two-dimensional motion control, and the localization error is smaller than 0.5mm. Through the user interface, we can move the transducer to ablate the target region under the CCD images. The preliminary gel phantom ablation experiment demonstrated that the system can achieve reach the desired treatment plan satisfactorily. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-13T00:16:07Z (GMT). No. of bitstreams: 1 ntu-96-R94548044-1.pdf: 9477826 bytes, checksum: 7b8ba0397499aa08ac7d52bde168ebd2 (MD5) Previous issue date: 2007 | en |
| dc.description.tableofcontents | 口試委員審定書.................................................. I
致謝................................................ II 摘要.............................................. . III Abstract.......................................... . IV 目錄............................................... . V 圖目錄............................................... VI 表目錄................................................VII 第一章 緒論 1 1-1 超音波熱治療簡介 1 1-2 超音波熱治療之現階段發展與應用 3 1-3 超音波熱手術系統概觀 4 1-4 研究動機與目的 8 第二章 超音波與生物物質相互作用的基本原理 9 2-1 機械效應 9 2-2 熱效應 9 2-3 空蝕化現象 10 2-4 溫度與熱劑量分析 11 第三章 磁振相容性加熱系統平台開發與製作 12 3-1 熱治療系統架構說明 12 3-2 防磁材料選擇與測試 13 3-3 機構致動元件說明 15 3-4 系統介面整合與動作說明 17 3-4-1 伺服馬達控制 18 3-4-2 CCD影像擷取及燒灼規劃介面 19 3-4-3 超音波功率放大器介面 22 第四章 實驗設備與材料方法 23 4-1 實驗設備 23 4-1-1 強聚焦型超音波換能器與其匹配電路 23 4-1-2 四頻道功率放大器 26 4-1-3 診斷式超音波影像系統 27 4-1-4 溫度測量儀器 28 4-2 實驗材料準備 29 4-2-1 仿體成分及製作 29 4-2-2 衰減係數之測量 29 4-3 MRI與離體(EX VIVO)豬里肌肉燒灼實驗方法 31 4-4 自動化平台多點燒灼實驗方法 34 第五章 系統測試與實驗結果 36 5-1 手動MRI平台離體豬肉燒灼測試 36 5-2 油壓平台移動誤差測試 39 5-3 平台防磁性測試 40 5-4 仿體連續式加熱結果 43 第六章 討論 45 6-1 機構開發及系統介面整合 45 6-2 防磁平台測試 46 6-3 加熱燒灼實驗 47 第七章 未來工作 50 參考文獻 51 | |
| dc.language.iso | zh-TW | |
| dc.subject | 組織燒灼 | zh_TW |
| dc.subject | 磁振造影引導式聚焦超音波 | zh_TW |
| dc.subject | 熱手術 | zh_TW |
| dc.subject | Magnetic resonance guided focus ultrasound surgery (MRgFUS) | en |
| dc.subject | Thermal surgery | en |
| dc.subject | Tissue ablation | en |
| dc.title | 磁振造影相容之高強度聚焦型超音波熱手術系統開發 | zh_TW |
| dc.title | Development of MRI Compatible High-intensity Focused Ultrasound Thermal Surgery System | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 95-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.coadvisor | 陳永耀(Yung-Yaw Chen) | |
| dc.contributor.oralexamcommittee | 王士豪(Shyh-Hau Wang),陳文翔(Wen-Shiang Chen),劉浩澧(Hao-Li Liu) | |
| dc.subject.keyword | 磁振造影引導式聚焦超音波,熱手術,組織燒灼, | zh_TW |
| dc.subject.keyword | Magnetic resonance guided focus ultrasound surgery (MRgFUS),Thermal surgery,Tissue ablation, | en |
| dc.relation.page | 52 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2007-07-27 | |
| dc.contributor.author-college | 工學院 | zh_TW |
| dc.contributor.author-dept | 醫學工程學研究所 | zh_TW |
| 顯示於系所單位： | 醫學工程學研究所 | |
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