請用此 Handle URI 來引用此文件:
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/28550
完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 梁庚辰(Keng-Chen Liang) | |
dc.contributor.author | Ke-Hsin Chen | en |
dc.contributor.author | 陳可欣 | zh_TW |
dc.date.accessioned | 2021-06-13T00:11:51Z | - |
dc.date.available | 2008-07-30 | |
dc.date.copyright | 2007-07-30 | |
dc.date.issued | 2007 | |
dc.date.submitted | 2007-07-29 | |
dc.identifier.citation | 陳秀貞(2000)。「終紋床核在逃避反應之學習與記憶的角色」。臺北:國立臺灣大學心理學研究所。
陳韋凡(2005)。「α氯醛醣麻醉劑量對功能性磁振照影相關參數之影響」。臺北:國立臺灣大學動物學研究所。 趙樹堂(2006)。「周邊腎上腺素對清醒與麻醉狀態下恐懼條件學習之調節作用」。臺北:國立臺灣大學心理學研究所。 楊芳齊(2007)。「恐懼記憶形成的神經機制:海馬、前額葉皮質與依核的互動」。臺北:國立臺灣大學心理學研究所。 Abe, K., Nakata, A., Mizutani, A., & Saito, H. (1994). Facilitatory but nonessential role of the muscarinic cholinergic system in the generation of long-term potentiation of population spikes in the dentate gyrus in vivo. Neuropharmacology, 33(7), 847-852. Allegrini, P. R., & Wiessner, C. (2003). Three-dimensional MRI of cerebral projections in rat brain in vivo after intracortical injection of MnCl2. NMR in Biomedicine, 16, 252-256. Ambrogi Lorenzini, C. G., Baldi, E., Bucherelli, C., Sacchetti, B., & Tassoni, G. (1997). Role of ventral hippocampus in acquisition, consolidation and retrieval of rat's passive avoidance response memory trace. Brain Research, 768(1-2), 242-248. Aoki, I., Lin Wu, Y. J., Silva, A. C., Lynch, R. M., & Koretsky, A. P. (2004). In vivo detection of neuroarchitecture in the rodent brain using manganese-enhanced MRI. NeuroImage, 22, 1046-1059. Aoki, I., Naruse, S., & Tanaka, C. (2004). Manganese-enhanced magnetic resonance imaging (MEMRI) of brain activity and applications to early detection of brain ischemia. NMR in Biomedicine, 17, 569-580. Aoki, I., Tanaka, C., Takegami, T., Ebisu, T., Umeda, M., Fukunaga, M., et al. (2002). Dynamic activity-induced manganese-dependent contrast magnetic resonance imaging (DAIM MRI). Magnetic Resonance in Medicine, 48, 927-933. Aschner, M., & Aschner, J. L. (1991). Manganese neurotoxicity: cellular effects and blood-brain barrier transport. Neuroscience & Biobehavioral Reviews, 15, 333-340. Baker, K. B., & Kim, J. J. (2004). Amygdalar lateralization in fear conditioning: evidence for greater involvement of the right amygdala. Behavioral Neuroscience, 118(1), 15-23. Bliss, T. V. P., & Lomo, T. (1973). Long-lasting potentiation of synaptic transmission in the dentate area of the anesthetized rabbit following stimulation of the perforant path. Journal of Physiology, 232, 357-374. Calne, D. B., Chu, N.-S., Huang, C.-C., & Olanow, W. (1994). Manganism and idiopathic parkinsonism: similarities and differences. Neurology, 44, 1583-1586. Chang, C. H., Liang, K. C., & Yen, C. T. (2005). Inhibitory avoidance learning altered ensemble activity of amygdaloid neurons in rats. European Journal of Neuroscience, 21, 210-218. Chang, S. D., Wang, C. Y., Chien, P. F., & Liang, K. C. (2005). Formation of context-shock association in classical fear conditioning: a role of the dorsal hippocampus. Poster session presented at the Society for Neuroscience 35th Annual Meeting, Washington, DC, USA. Chen, W., Tenney, J., Kulkarni, P., & King, J. A. (2007). Imaging unconditioned fear response with manganese-enhanced MRI (MEMRI). NeuroImage, in press. Cheng, D. T., Knight, D. C., Smith, C. N., Stein, E. A., & Helmstetter, F. J. (2003). Functional MRI of human amygdala activity during Pavlovian fear conditioning: stimulus processing versus response expression. Behavioral Neuroscience, 117, 3-10. Chuang, K. H., & Koretsky, A. (2006). Improved neuronal track tracing using manganese enhanced magnetic resonance imaging with fast T1 mapping. Magnetic Resonance in Medicine, 55, 604-611. Coleman-Mesches, K., & McGaugh, J. L. (1995). Differential effects of pretraining inactivation of the right or left amygdala on retention of inhibitory avoidance training. Behavioral Neuroscience, 109(4), 642-647. Cross, D. J., Minoshima, S., Anzai, Y., Flexman, J. A., Keogh, B. P., Kim, Y., et al. (2004). Statistical mapping of functional olfactory connections of the rat brain in vivo. NeuroImage, 23, 1326-1335. Davis, M. (1992). The role of the amygdala in fear and anxiety. Annual Review of Neuroscience, 15, 353-375. Drapeau, P., & Nachshen, D. A. (1984). Manganese fluxes and manganese-dependent neurotransmitter release in presynaptic nerve endings isolated from rat brain. The Journal of Physiology, 348, 493-510. Duong, T. Q., Silva, A. C., Lee, S. P., & Kim, S. G. (2000). Functional MRI of calcium-dependent synaptic activity: cross correlation with CBF and BOLD measurements. Magnetic Resonance in Medicine, 43, 383-392. Eichenbaum, H. (1997). Declarative memory: insights from cognitive neurobiology. Annual Review of Psychology, 48, 547-572. Erikson, K. M., & Aschner, M. (2003). Manganese neurotoxicity and glutamate-GABA interaction Neurochemistry International, 43, 475-480. Gonzales, C., & Chesselet, M.-F. (1990). Amygdalonigral pathway: An anterograde study in the rat with phaseolus vulgaris leucoagglutinin (PHA-L). The Journal of Comparative Neurology, 297, 182-200. Hebb, D. O. (1949). The Organization of Behavior: A Neuropsychological Theory. New York: John Wiley and Sons. Ito, M. (1989). Long-term depression. Annual Review of Neuroscience, 12, 85-102. Jasanoff, A. (2005). Functional MRI using molecular imaging agents. TRENDS in Neuroscience, 28(3), 120-126. Kong, Q., Sun, S., Liu, C., Huang, J., & Xu, H. (2005). Brain functional localization of kindling cats: manganese ion enhanced T1-weighted MRI study [Electronic Version]. The Internet Journal of Neurology, retrieved from http://www.ispub.com/ostia/index.php?xmlPrinter=true&xmlFilePath=journals/ijn/vol4n2/mri.xml. Kou, Y. T., Herlihy, A. H., So, P. W., & Bell, J. D. (2006). Manganese-enhanced magnetic resonance imaging (MEMRI) without compromise of the blood-brain barrier detects hypothalamic neuronal activity in vivo. NMR in Biomedicine, 19, 1028-1034. Kwong, K. K., Belliveau, J. W., Chesler, D. A., Goldberg, I. E., Weisskoff, R. M., Poncelet, B. P., et al. (1992). Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation. PNAS, 89, 5675-5679. LaBar, K. S., Gatenby, J. C., Gore, J. C., LeDoux, J. E., & Phelps, E. A. (1998). Human amygdala activation during conditioned fear acquisition and extinction: a mixed-trial fMRI study. Neuron, 20, 937-945. Lee, E. H. Y., Lin, W. R., Chen, H. Y., Shiu, W. H., & Liang, K. C. (1992). Fluoxetine and 8-OH-DPAT in the lateral septum enhances and impairs retention of an inhibitory avoidance response in rats. Physiology and Behavior, 51(4), 681-688. Lee, H. J., Youn, J. M., O, M. J., Gallagher, M., & Holland, P. C. (2006). Role of substantia nigra-amygdala connections in surprise-induced enhancement of attention. The Journal of Neuroscience, 26(22), 6077-6081. Lee, J. H., Silva, A. C., Merkle, H., & Koretsky, A. P. (2005). Manganese-enhanced magnetic resonance imaging of mouse brain after systemic administration of MnCl2: dose-dependent and temporal evolution of T1 contrast. Magnetic Resonance in Medicine, 53, 640-648. Leergaard, T. B., Bjaalie, J. G., Devor, A., Wald, L. L., & Dale, A. M. (2003). In vivo tracing of major rat brain pathways using manganese-enhanced magnetic resonance imaging and three-dimensional digital atlasing. NeuroImage, 20, 1591-1600. Liang, K. C., & McGaugh, J. L. (1983). Lesions of the stria terminalis attenuate the enhancing effect of post-training epinephrine on retention of an inhibitory avoidance response. Behavioural Brain Research, 9, 49-58. Liang, K. C., McGaugh, J. L., & Yao, H.-Y. (1990). Involvement of amygdala pathways in the influence of post-training intra-amygdala norepinephrine and peripheral epinephrine on memory storage. Brain Research, 508, 225-233. Liang, K. C., Chen, H.-C., & Chen, D.-Y. (2001). Posttraining infusion of norepinephrine and corticotropin releasing factor into the bed nucleus of the stria terminalis enhanced retention in an inhibitory avoidance task. Chinese Journal of Physiology, 44(1), 33-43. Lin, C. P., Tseng, W.-Y. I., Cheng, H.-C., & Chen, J. H. (2001). Validation of diffusion tensor magnetic resonance axonal fiber imaging with registered manganese-enhanced optic tracts. NeuroImage, 14, 1035-1047. Lin, C. P., Wedeen, V. J., Chen, J. H., Yao, C., & Tseng, W.-Y. I. (2003). Validation of diffusion spectrum magnetic resonance imaging with manganese-enhanced rat optic tracts and ex vivo phantoms. NeuroImage, 19, 482-495. Lin, Y. J., & Koretsky, A. P. (1997). Manganese ion enhances T1-weighted MRI during brain activation: an approach to direct imaging of brain function. Magnetic Resonance in Medicine, 38, 378-388. Liu, C. H., D'Arceuil, H. E., & de Crespigny, A. J. (2004). Direct CSF injection of MnCl2 for dynamic manganese-enhanced MRI. Magnetic Resonance in Medicine, 51, 978-987. Lorenzini, C. A., Baldi, E., Bucherelli, C., Sacchetti, B., & Tassoni, G. (1996). Role of dorsal hippocampus in acquisition, consolidation and retrieval of rat's passive avoidance response: a tetrodotoxin functional inactivation study. Brain Research, 730(1-2), 32-39. McDonald, A. J. (1991). Organization of amygdaloid projections to the prefrontal cortex and associated striatum in the rat. Neuroscience, 44(1), 1-14. McDonald, A. J., Mascagni, F., & Gou, L. (1996). Projections of the medial and lateral prefrontal cortices to the amygdala: a phaseolus vulgaris leucoagglutinin study in the rat. Neuroscience, 71(1), 55-75. McGaugh, J. L. (2004). The amygdala modulates the consolidation of memories of emotionally arousing experiences. Annual Review of Neuroscience, 27, 1-28. Morita, H., Ogino, T., Seo, Y., Fujiki, N., Tanaka, K., Takamata, A., et al. (2002). Detection of hypothalamic activation by manganese ion contrasted T1-weighted magnetic resonance imaging in rats. Neuroscience Letters, 326, 101-104. Moser, E. I., & Moser, M.-B. (1999). Is learning blocked by saturation of synaptic weights in the hippocampus? Neuroscience and Biobehavioral Reviews, 23, 661-672. Murayama, Y., Weber, B., Saleem, K. S., Augath, M., & Logothetis, N. K. (2006). Tracing neural circuits in vivo with Mn-enhanced MRI. Magnetic Resonance Imaging, 24(4), 349-358. Nairismagi, J., Pitkanen, A., Narkilahti, S., Huttunen, J., Kauppinen, R. A., & Grohn, O. H. J. (2006). Manganese-enhanced magnetic resonance imaging of mossy fiber plasticity in vivo. NeuroImage, 30, 130-135. Narita, K., Kawasaki, F., & Kita, H. (1990). Mn and Mg influxes through Ca channel of motor nerve terminals are prevented by verapamil in frogs. Brain Research, 510, 289-295. O'Keffe, J., & Speakman, A. (1987). Single unit activity in the rat hippocampus during a spatial memory task. Experimental Brain Research, 68, 1-27. Oner, G., & Senturk, U. K. (1995). Reversibility of manganese-induced learning defect in rats. Food and Chemical Toxicology, 33(7), 559-563. Pare, D. (2003). Role of the basolateral amygdala in memory consolidation. Progress in Neurobiology, 70, 409-420. Parent, M. B., & Baxter, M. K. (2004). Septohippocampal acetylcholine: involved in but not necessary for learning and memory? Learning and Memory, 11, 9-11. Pastalkova, E., Serrano, P., Pinkhasova, D., Wallace, E., Fenton, A. A., & Sacktor, T. C. (2006). Storage of spatial information by the maintenance mechanism of LTP. Science, 313, 1141-1144. Pautler, R. G. (2004). In vivo, trans-synaptic tract-tracing utilizing manganese-enhanced magnetic resonance imaging (MEMRI). NMR in Biomedicine, 17, 595-601. Pautler, R. G., & Koretsky, A. P. (2002). Tracing odor-induced activation in the olfactory bulbs of mice using manganese-enhanced magnetic resonance imaging. NeuroImage, 16, 441-448. Pautler, R. G., Mongeau, R., & Jacobs, R. E. (2003). In vivo trans-synaptic tract tracing from the murine striatum and amygdala utilizing manganese enhanced MRI (MEMRI). Magnetic Resonance in Medicine, 50, 33-39. Pautler, R. G., Silva, A. C., & Koretsky, A. P. (1998). In vivo neuronal tract tracing using manganese-enhanced magnetic resonance imaging. Magnetic Resonance in Medicine, 40, 740-748. Pelletier, J. G., Likhtik, E., Filali, M., & Pare, D. (2005). Lasting increases in basolateral amygdala activity after emotional arousal: Implications for facilitated consolidation of emotional memories. Learning & Memory, 12, 96-102. Pixinos, G., & Watson, C. (1998). The rat brain in stereotaxic coordinates (4th ed.). San Diego, CA: Academic Press. Roels, H., Meiers, G., Delos, M., Ortega, I., Lauwerys, R., Buchet, J. P., et al. (1997). Influence of the route of administration and the chemical form (MnCl2, MnO2) on the absorption and cerebral distribution of manganese in rats. Archives of Toxicology, 71, 223-230. Roozendaal, B., de Quervain, D. J.-F., Ferry, B., Setlow, B., & McGaugh, J. L. (2001). Basolateral amygdala-nucleus accumbens interactions in mediating glucocorticoid enhancement of memory consolidation. The Journal of Neuroscience, 21(7), 2518-2525. Saleem, K. S., Pauls, J. M., Prause, B. A., Hashikawa, T., & Logothetis, N. K. (2002). Magnetic resonance imaging of neuronal connections in the macaque monkey. Neuron, 34, 685-700. Setlow, B., Roozendaal, B., & McGaugh, J. L. (2000). Involvement of a basolateral amygdala complex-nucleus accumbens pathway in glucocorticoid-induced modulation of memory consolidation. European Journal of Neuroscience, 12(1), 367-375. Silva, A. C., & Koretsky, A. P. (2002). Laminar specificity of functional MRI onset times during somatosensory stimulation of rat. PNAS, 99(23), 15182-15187. Silva, A. C., Lee, J. H., Aoki, I., & Koretsky, A. P. (2004). Manganese-enhanced magnetic resonance imaging (MEMRI): methodological and practical considerations. NMR in Biomedicine, 17, 532-543. Sloot, W. N., & Gramsbergen, J.-B. P. (1994). Axonal transport of manganese and its relevance to selective neurotoxicity in the rat basal ganglia. Brain Research, 657, 124-132. Takeda, A. (2003). Manganese action in brain function. Brain Research Reviews, 41, 79-87. Takeda, A., Ishiwatari, S., & Okada, S. (1998). In vivo stimulation-induced release of manganese in rat amygdala. Brain Research, 811, 147-151. Takeda, A., Kodama, Y., Ishiwatari, S., & Okada, S. (1998). Manganese transport in the neural circuit of rat CNS. Brain Research Bulletin, 45(2), 149-152. Takeda, A., Sotogaku, N., & Oku, N. (2002). Manganese Influences the levels of neurotransmitters in synapses in rat brain. Neuroscience, 114(3), 669-674. Taubenfeld, S. M., Wiig, K. A., Bear, M. F., & Alberini, C. M. (1999). A molecular correlate of memory and amnesia in the hippocampus. Nature Neuroscience, 2, 309-310. Thierry, A.-M., Gioanni, Y., Degenetais, E., & Glowinski, J. (2000). Hippocampo-prefrontal cortex pathway: anatomical and electrophysiological characteristics. Hippocampus, 10(4), 411-419. Thuen, M., Singstad, T. E., Pedersen, T. B., Haraldseth, O., Berry, M., Sandvig, A., et al. (2005). Manganese-enhanced MRI of the optic visual pathway and optic nerve injury in adult rats. Journal of Magnetic Resonance Imaging, 22, 492-500. Tindemans, I., Verhoye, M., Balthazart, J., & Van der Linden, A. (2003). In vivo dynamic ME-MRI reveals differential functional responses of RA- and area X-projecting neurons in the HVC of canaries exposed to conspecific song. European Journal of Neuroscience, 18, 3352-3360. Van der Linden, A., Verhoye, M., Van Meir, V., Tindemans, I., Eens, M., Absil, P., et al. (2002). In vivo manganese-enhanced magnetic resonance imaging reveals connections and functional properties of the songbird vocal control system. Neuroscience, 112, 467-474. Watanabe, T., Frahm, J., & Michaelis, T. (2004). Functional mapping of neural pathways in rodent brain in vivo using manganese-enhanced three-dimensional magnetic resonance imaging. NMR in Biomedicine, 17, 554-568. Watanabe, T., Radulovic, J., Boretius, S., Frahm, J., & Michaelis, T. (2006). Mapping of the habenulo-interpeduncular pathway in living mice using manganese-enhanced 3D MRI. Magnetic Resonance Imaging, 24(3), 209-215. Watanabe, T., Radulovic, J., Spiess, J., Natt, O., Boretius, S., Frahm, J., et al. (2004). In vivo 3D MRI staining of the mouse hippocampal system using intracerebral injection of MnCl2. NeuroImage, 22, 860-867. Whitlock, J. R., Heynen, A. J., Shuler, M. G., & Bear, M. F. (2006). Learning induces long-term potentiation in the hippocampus. Science, 313, 1093-1097. Williams, L. M., Phillips, M. L., Brammer, M. J., Skerrett, D., Lagopoulos, J., Rennie, C., et al. (2001). Arousal dissociates amygdala and hippocampus fear responses: evidence from simultaneous fMRI and skin conductance recording. NeuroImage, 14, 1070-1079. Xue, R., van Zijl, P. C. M., Crain, B. J., Solaiyappan, M., & Mori, S. (1999). In vivo three-dimensional reconstruction of rat brain axonal projections by diffusion tensor imaging. Magnetic Resonance in Medicine, 42, 1123-1127. Yu, X., Wadghiri, Y. Z., Sanes, D. H., & Turnbull, D. H. (2005). In vivo auditory brain mapping in mice with Mn-enhanced MRI. Nature Neuroscience, 8(7), 961-968. Zola-Morgan, S. (1995). Localization of brain function: the legacy of Franz Joseph Gall (1758-1828). Annual Review of Neuroscience, 18, 359-383. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/28550 | - |
dc.description.abstract | 錳離子在核磁共振顯影中可增強T1權重影像信號,加上其生化特質與鈣離子相似,並且可由鈣離子管道進入神經細胞。由於神經系統沒有代謝錳離子之機制,因此錳離子會順著軸突運輸傳送至軸突末端釋放,再被下一個有活動的細胞吸收。基於上述特質,錳離子可作為顯影劑、神經徑路追蹤劑、以及神經活動標記,通稱為「錳增強核磁共振顯影」。相較於功能性核磁共振顯影,錳增強核磁共振顯影的信號提升率較高,且提供一個能直接追蹤神經活動之方法。本研究企圖將錳增強核磁共振顯影應用於學習與記憶議題上,先於大白鼠顱內注射錳離子,並讓大白鼠在清醒狀態下執行學習作業。假設大白鼠經過學習事件後,神經活動產生改變,其錳離子的吸收與傳送速度會不同於沒有經歷學習經驗的動物,神經活動的差異會顯現於T1權重影像上錳離子的分布範圍與信號強度。實驗一以黑質為測試區域,目的在於找出適合顱內注射的容積,結果發現當錳離子濃度為60 mM時,容積採用63 nl可達到最好效果。實驗二於聚乙烯塑膠管內填入12種濃度之錳離子作為假體插入大白鼠腦中,當錳離子濃度介於50至1000 μM時在T1權重影像中具有信號增強效果。實驗三將錳離子注入杏仁核與海馬,接著讓大白鼠在清醒狀態下進行抑制型逃避學習作業。電擊組的大白鼠在訓練階段接受五次足部電擊(1 mA, 1 s),控制組則否。隔日所取得的影像結果顯示注射於海馬的錳離子會透過穹窿傳至側膈核與韁核,而在杏仁核之錳離子會傳送到終紋床核與黑質。分析各腦區之影像強度,只有終紋床核之亮度在電擊組會顯著低於無電擊組。實驗四中將終紋切斷再於杏仁核注射錳離子,確認累積於杏仁核之錳離子是透過終紋傳至終紋床核。本研究證實錳離子的確可作為神經活動標記,並應用於學習與記憶之動物模型上。未來在影像解析度與分析方法上仍須改進,以增加錳增強核磁共振顯影之可用性。 | zh_TW |
dc.description.abstract | Manganese (Mn2+) is used as a contrast agent because it enhances the signal of T1-weighted images in magnetic resonance imaging (MRI). It shares with calcium (Ca2+) certain biochemical properties, and could be taken up by excitable neurons through the calcium channel. No metabolic mechanism washes out Mn2+ accumulated within a neuron, it thus can be transported along the axons, released at the terminal, and taken up by the postsynaptic neuron during excitation. These properties allow Mn2+ to trace fiber track and code the neuronal activity history in the so-called “manganese-enhanced magnetic resonance imaging (MEMRI)”. The present study was aimed to test the hypothesis that the learning-related neuronal activity alters the absorption and transportation rate of Mn2+ in comparison with those without learning, and the difference could be detected by T1-weighted images of MRMRI. The first experiment used the substantia nigra as a testing site for stereotaxic micro-infusion and showed that the optimal dose is 63 nl of 60 mM MnCl2. The second experiment used polyethylene catheters filled with different concentration of manganese inserted into the rat brain as phantom. The signal intensity of those in T1-weighted images was recorded as the concentration varied between 50 to 1000 μM. In the third experiment, male Sprague-Dawley rats received stereotaxic micro-infusion of Mn2+ (60 mM, 63 nl) into the amygdala and hippocampus. After recovery from the anesthesia, the shocked group was subjected to a step-through inhibitory avoidance task with 5 footshocks (1 mA, 1 s). In contrast, the control group was exposed to the same task apparatus but received no footshocks. On the next day, the T1-weighted images were acquired on the Bruker BioSpect 3 T MRI system. The results showed that the manganese infused into hippocampus was transported to the lateral septal nuclei through fornix, and that in amygdala was to bed nucleus of stria terminalis (BNST) and substantia nigra. Only the signal intensity of BNST in the shocked group was significantly lower than the control. After cutting the stria terminalis, manganese was infused into the amygdala in the fourth experiment. The result showed the manganese accumulated in amygdala was transported to BNST through stria ternimalis. The present study proved that Mn2+ could be used as neuronal activity marker in an animal model of learning and memory. However, for this method to be better applied in the future, spatial resolution of images and the analyzing method remain to be improved. | en |
dc.description.provenance | Made available in DSpace on 2021-06-13T00:11:51Z (GMT). No. of bitstreams: 1 ntu-96-R93227112-1.pdf: 3480207 bytes, checksum: d80419abb8e1fc3223cb6d7f731c8ed8 (MD5) Previous issue date: 2007 | en |
dc.description.tableofcontents | 中文摘要 i
英文摘要 ii 第一章 緒言 1 第一節 核磁共振顯影原理 2 第二節 功能性核磁共振顯影 5 第三節 錳增強核磁共振顯影 7 第四節 學習與記憶 12 第五節 本論文之研究議題與策略 16 第二章 實驗材料與方法 18 第三章 實驗與結果 31 實驗一:錳離子顱內注射容積測試 31 實驗二:錳離子濃度假體測試 33 實驗三:以錳離子追蹤涉入抑制型逃避學習作業之功能聯結 38 實驗四:切斷終紋對終紋床核亮度之影響 56 第四章 討論 62 第一節 研究與測量方法之考量 62 第二節 顱內注射錳離子產生影像信號增強之區域 65 第三節 抑制型逃避學習作業對影像強度產生之影響 69 第四節 未來研究方法改進與應用 76 第五節 結語 81 參考文獻 83 附錄 92 | |
dc.language.iso | zh-TW | |
dc.title | 使用錳增強核磁共振顯影探討與學習有關之功能性神經聯結 | zh_TW |
dc.title | Manganese-Enhanced Magnetic Resonance Imaging (MEMRI) Reveals Functional Connectivity Associated with Learning | en |
dc.type | Thesis | |
dc.date.schoolyear | 95-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 徐嘉宏(Chia-Hung Hsu),賴文崧(Wen-Sung Lai),林慶波(Chin-Po Lin),陳志宏(Jyh-Horng Chen) | |
dc.subject.keyword | 杏仁核,海馬,終紋床核,側膈核,神經活動標記,抑制型逃避學習作業, | zh_TW |
dc.subject.keyword | amygdala,hippocampus,bed nucleus of stria terminalis,lateral septal nuclei,neuronal activity history marker,inhibitory avoidance task, | en |
dc.relation.page | 94 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2007-07-29 | |
dc.contributor.author-college | 理學院 | zh_TW |
dc.contributor.author-dept | 心理學研究所 | zh_TW |
顯示於系所單位: | 心理學系 |
文件中的檔案:
檔案 | 大小 | 格式 | |
---|---|---|---|
ntu-96-1.pdf 目前未授權公開取用 | 3.4 MB | Adobe PDF |
系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。