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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 江俊斌 | |
dc.contributor.author | Tung-Chieh Tsai | en |
dc.contributor.author | 蔡東潔 | zh_TW |
dc.date.accessioned | 2021-06-13T00:09:45Z | - |
dc.date.available | 2007-08-08 | |
dc.date.copyright | 2007-08-08 | |
dc.date.issued | 2007 | |
dc.date.submitted | 2007-07-28 | |
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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/28488 | - |
dc.description.abstract | 背景:過去之研究顯示表現於SiSo細胞之受器結合癌抗原(RCAS1)之過度表現和腫瘤的大小、淋巴結的轉移、臨床或病理的分期、和病人的預後等有統計上有意義的相關。
方法:本研究利用免疫組織化學染色的方法,探討RCAS1於84例口腔鱗狀細胞癌(OSCC),106例口腔上皮變異(OED;32例輕度,44例中度,30例重度上皮變異),和20例正常口腔黏膜(NOM)之表現。 結果:我們發現RCAS1平均標記指數,從正常口腔黏膜之12 ± 5%,至輕度口腔上皮變異之31 ± 13%,中度口腔上皮變異之44 ± 17%,及重度口腔上皮變異之56 ± 18%,至口腔鱗狀細胞之68 ± 20%,有隨著惡性程度的增加而呈現統計學上有意義增加的情形(P < 0.001)。統計分析的結果也顯示,較大的口腔鱗狀細胞癌(P = 0.001)、有局部淋巴結轉移者(P < 0.001)與有較高的臨床分期者(P < 0.001),其RCAS1平均標記指數通常呈統計學上有意義之增高。經過Cox regression model之多變數分析發現,有局部淋巴結轉移(P = 0.0073)及RCAS1 LI ≧ 60%(P = 0.048)為預測不利預後之獨立變相,Kaplan-Meier 曲線分析發現,當口腔鱗狀細胞癌之RCAS1 LI ≧ 60%比其RCAS1 LI < 60%之患者,通常有較差之累積存活率(log-rank test, P = 0.0113)。 結論:我們的結果顯示,RCAS1之表現在口腔癌前病變時期,也就是說口腔上皮變異時期,即有明顯之增加。RCAS1之表現和口腔鱗狀細胞癌患者的腫瘤大小、淋巴結轉移以及臨床分期呈現統計學上有意義之正相關。因此口腔鱗狀細胞的RCAS1之標記指數,可預測台灣口腔鱗狀細胞的進展及預後。 | zh_TW |
dc.description.abstract | BACKGROUND: Overexpression of receptor-binding cancer antigen expressed on SiSo cells (RCAS1) has been found to be significantly associated with the tumor size, lymph node metastasis, clinical or pathological stage, and prognosis of a variety of human cancers.
METHODS: This study examined the expression of RCAS1 in 84 specimens of oral squamous cell carcinoma (OSCC), 106 specimens of oral epithelial dysplasia (OED, 32 mild, 44 moderate, and 30 severe OED cases), and 20 specimens of normal oral mucosa (NOM) by immunohistochemistry. RESULTS: We found that the mean RCAS1 labeling indices (LIs) increased significantly from NOM (12 ± 5%) through mild OED (31 ± 13%), moderate OED (44 ± 17%), and severe OED (56 ± 18%) to OSCC samples (68 ± 20%, P < 0.001). A significant correlation was found between the higher mean RCAS1 and OSCCs with larger tumor size (P = 0.001), positive lymph node metastasis (P < 0.001), or more advanced clinical stages (P < 0.001). Positive lymph node metastasis (P = 0.0073) and RCAS1 LI ≧ 60% (P = 0.048) were identified as independent unfavorable prognosis factor by multivariate analyses with Cox regression model. Kaplan-Meier curve showed that OSCC patients with a RCAS1 LI ≧ 60% had a significantly poorer cumulative survival than those with a RCAS1 LI < 60% (log-rank test, P = 0.0113). CONCLUSIONS: We conclude that the expression of RCAS1 is an early event in oral carcinogenesis. The RCAS1 LI in OSCC samples can predict the progression of OSCCs and the survival of OSCC patients. | en |
dc.description.provenance | Made available in DSpace on 2021-06-13T00:09:45Z (GMT). No. of bitstreams: 1 ntu-96-R94422008-1.pdf: 729148 bytes, checksum: 26f37577384dae32a4f8d4b9376fa03b (MD5) Previous issue date: 2007 | en |
dc.description.tableofcontents | 中文摘要 10
Abstract 11 Introduction 12 Background 14 Purposes of this study 16 Literature review Part 1: Introduction of oral squamous cell carcinoma 17 (i) Epidemiology in the world 17 (ii) Epidemiology in Taiwan 17 (iii) Etiology 18 (iv) Clinical presentation 20 (v) Histologic features 21 (vi) Grading of oral squamous cell carcinoma 22 (vii) Our previous studies on oral cancers 22 Part 2: Molecular prognostic factors of oral squamous cell carcinoma 27 (i) Oncogenes 27 (ii) Tumor suppressor genes 28 (iii) Ploidy 29 (iv) Cell proliferation markers 30 (v) Intercellular adhesion molecules 30 (vi) Human papillomavirus 31 Part 3: Receptor binding cancer antigen expressed on SiSo cells (RCAS1) 33 (i) Structure of RCAS1 protein and gene location 33 (ii) Function of RCAS1 34 (iii) Regulation of RCAS1 expression 35 (iv) RCAS1 expression in human normal, hyperplastic, and dysplastic epithelial cells 36 (v) RCAS1 expression in serum or pleural effusion 38 (vi) RCAS1 expression and tumor or lymphovascular invasion 39 (vii) RCAS1 expression and tumor cell differentiation 40 (viii)RCAS1 expression and tumor size 41 (ix) RCAS1 expression and lymph node metastasis 41 (x) RCAS1 expression and clinical or pathologic stage 42 (xi) RCAS1 expression and patients’ survival or prognosis 43 (xii) RCAS1 expression in OSCCs 44 Materials and Methods Part 1: Patients and specimens 46 Part 2: Immunohistochemical staining 47 Part 3: Statistical analysis 48 Results Part 1: The mean RCAS1 LIs for NOM, OED, and OSCC samples 50 Part 2: Correlation between RCAS1 LIs in OSCCs and clinicopathological parameters of OSCC patients 50 Part 3: Correlation between RCAS1 LIs in OSCCs and oral habits of OSCC patients 51 Part 4: Correlation between RCAS1 LIs in OSCCs and survival of OSCC patients 51 Discussion 52 Conclusions 56 References 57 Tables 72 Figures 76 Tables Table1. The mean RCAS1 labeling indices (LIs) in normal oral mucosa (NOM), oral epithelial dysplasia (OED), and oral squamous cell carcinoma (OSCC) samples 72 Table 2. Correlation between the RCAS1 labeling indices (LIs) in OSCC samples and clinicopathological parameters of OSCC patients 73 Table 3. Correlation between the RCAS1 labeling indices (LIs) in OSCC samples and oral habits of OSCC patients 74 Table 4. Univariate and multivariate survival analyses of RCAS1 LI and clinicopathological parameters in patients with OSCC by Cox proportional hazard regression model 75 Figures Figure 1. Immunohistochemical staining for RCAS1 78 Figure 2. Kaplan-Meier curve showing relation between the lymph node metastasis and survival of OSCC patients . 79 Figure 3. Kaplan-Meier curve showing relation between the clinical stage and survival of OSCC patients . 80 Figure 4. Kaplan-Meier curve showing relation between the RCAS1 labeling indices (LIs) in OSCC samples and survival of OSCC patients . 81 | |
dc.language.iso | en | |
dc.title | 表現於SiSo細胞之受器結合癌抗原(RCAS1)於口腔癌前病變及口腔癌之表現 | zh_TW |
dc.title | Expression of receptor-binding cancer antigen expressed on SiSo cells (RCAS1) in oral precancers and cancers | en |
dc.type | Thesis | |
dc.date.schoolyear | 95-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 關學婉,張龍昌 | |
dc.subject.keyword | 表現於SiSo細胞之受器結合癌抗原(RCAS1),口腔癌,口腔癌前病變, | zh_TW |
dc.subject.keyword | RCAS1,oral cancer,oral dysplasia,prognosis, | en |
dc.relation.page | 77 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2007-07-30 | |
dc.contributor.author-college | 醫學院 | zh_TW |
dc.contributor.author-dept | 臨床牙醫學研究所 | zh_TW |
顯示於系所單位: | 臨床牙醫學研究所 |
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