請用此 Handle URI 來引用此文件：
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/28427完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 林文澧(Win-Li Lin) | |
| dc.contributor.author | Sung-Yi Lin | en |
| dc.contributor.author | 林松誼 | zh_TW |
| dc.date.accessioned | 2021-06-13T00:07:58Z | - |
| dc.date.available | 2007-07-31 | |
| dc.date.copyright | 2007-07-31 | |
| dc.date.issued | 2007 | |
| dc.date.submitted | 2007-07-27 | |
| dc.identifier.citation | [1] D. R. Daum, N. B. Smith, R. King, and K. Hynynen, 'In vivo demonstration of noninvasive thermal surgery of the liver and kidney using an ultrasonic phased array,' Ultrasound Med Biol, vol. 25, pp. 1087-98, Sep 1999.
[2] V. J. Robertson and K. G. Baker, 'A review of therapeutic ultrasound: effectiveness studies,' Phys Ther, vol. 81, pp. 1339-50, Jul 2001. [3] M. Fatemi and J. F. Greenleaf, 'Ultrasound-stimulated vibro-acoustic spectrography,' Science, vol. 280, pp. 82-5, Apr 3 1998. [4] P. Z. He, R. M. Xia, S. M. Duan, W. D. Shou, and D. C. Qian, 'The affection on the tissue lesions of difference frequency in dual-frequency high-intensity focused ultrasound (HIFU),' Ultrason Sonochem, vol. 13, pp. 339-44, May 2006. [5] M. Fatemi and J. F. Greenleaf, 'Vibro-acoustography: An imaging modality based on ultrasound-stimulated acoustic emission,' Proc Natl Acad Sci U S A, vol. 96, pp. 6603-8, Jun 8 1999. [6] M. Fatemi and J. F. Greenleaf, 'Probing the dynamics of tissue at low frequencies with the radiation force of ultrasound,' Phys Med Biol, vol. 45, pp. 1449-64, Jun 2000. [7] S. Calle, J. P. Remenieras, O. Bou Matar, and F. Patat, 'Presence of nonlinear interference effects as a source of low frequency excitation force in vibro-acoustography,' Ultrasonics, vol. 40, pp. 873-8, May 2002. [8] H. Tang, C. C. Wang, D. Blankschtein, and R. Langer, 'An investigation of the role of cavitation in low-frequency ultrasound-mediated transdermal drug transport,' Pharm Res, vol. 19, pp. 1160-9, Aug 2002. [9] A. Vogel, W. Hentschel, J. Holzfuss, and W. Lauterborn, 'Cavitation bubble dynamics and acoustic transient generation in ocular surgery with pulsed neodymium: YAG lasers,' Ophthalmology, vol. 93, pp. 1259-69, Oct 1986. [10] 'Ultrasound. Nonthermal issues: cavitation--its nature, detection and measurement,' Ultrasound Med Biol, vol. 24 Suppl 1, pp. S11-21, 1998. [11] L. Chen, I. Rivens, G. ter Haar, S. Riddler, C. R. Hill, and J. P. Bensted, 'Histological changes in rat liver tumours treated with high-intensity focused ultrasound,' Ultrasound Med Biol, vol. 19, pp. 67-74, 1993. [12] K. Hynynen, 'The threshold for thermally significant cavitation in dog's thigh muscle in vivo,' Ultrasound Med Biol, vol. 17, pp. 157-69, 1991. [13] H. H. Pennes, 'Analysis of tissue and arterial blood temperatures in the resting human forearm. 1948,' J Appl Physiol, vol. 85, pp. 5-34, Jul 1998. [14] S. A. Sapareto and W. C. Dewey, 'Thermal dose determination in cancer therapy,' Int J Radiat Oncol Biol Phys, vol. 10, pp. 787-800, Jun 1984. [15] R. R. D. Halliday, J. Walker, 'Beats,' in Fundamentals of Physics, Fifith Edition, 1997, pp. 437-438. [16] J. D. F. Richard L. Burden, Numerical analysis 8th ed ed., 2005. [17] K. Takegami, Y. Kaneko, T. Watanabe, T. Maruyama, Y. Matsumoto, and H. Nagawa, 'Polyacrylamide gel containing egg white as new model for irradiation experiments using focused ultrasound,' Ultrasound Med Biol, vol. 30, pp. 1419-22, Oct 2004. [18] Salas, 'Volume by parallel cross sections; discs and washers,' in Calculus, 8th ed, 1999, pp. 326-335. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/28427 | - |
| dc.description.abstract | 有研究顯示，兩頻率相近之雙頻超音波換能器可能增大高能超音波燒灼的區域。在本研究中，使用了雷利積分式來模擬雙頻超音波線性聲場，在雙頻聲場中，兩頻率相近會產生隨時間改變的拍音效應，為求分析此種時變聲場，我們必須建立在時域上的分析方法。拍音會隨時間變化，聲場強度亦隨之以拍音的頻率變化，亦為一週期函數，故我們可以求得在一週期內聲場強度之平均值，來模擬溫度場與熱劑量的分佈。我們採用了0.5MHz切半之半球形超音波換能器，以雙頻驅動來做進一步的探討（直徑/曲率半徑：10cm/10cm）。
在模擬的部分裡，雙頻兩元素同軸環形之超音波換能器的聲場分佈會有朝軸向延伸的情形發生，對於HIFU治療時要盡量避免燒灼到正常組織來說，是較不利的，另一種切半球形之超音波換能器之聲場強度則有朝橫向延伸的情形，形成一截面為橢圓形之焦斑，在線性的探討上，模擬的結果顯示雙頻超音波換能器所能產生的焦斑體積與單頻所產生的體積並無明顯差異。 另外在此研究中進行了初步的實驗探討，結果證實雙頻超音波換能器會形成截面為橢圓形之焦斑，然而在體積的定量上有其難度故不予計算，所使用的電功率為25W + 25W。 | zh_TW |
| dc.description.abstract | The dual-frequency high-intensity focused ultrasound was shown to have the potential ability to increase the size of HIFU lesions. In this study, we proposed a Rayleigh integral method to predict the linear pressure field of the dual-frequency driven transducers that dual frequencies were slightly different. Because two slightly different frequencies generate time-varying beats, time-domain analysis should be employed. With time-varying beats, acoustic intensity also changes with time at the beat frequency. That time-varying intensity is a periodic function with a short period（1 / beat frequency）, and we can apply time-average intensity to study temperature and thermal lesions. The dual-frequency ultrasound was generated by a 0.5MHz（diameter and radius of curvature：10 cm）confocal transducer, which was cut from a bowl-shape piezo-electrical element into two half-hemispherical elements.
In the simulation part, the intensity of dual-element annular confocal ultrasound transducer has some extension in the axial direction. This feature is a shortcoming in HIFU therapy. The other one, dual-element spherical ultrasound transducer driven by dual-frequency, has some extension in the transverse direction. An ellipse shape lesion was formed at the focal plane and it is more suitable for HIFU therapy. So we chose the latter one to do some experiments. The volume of the lesion didn’t show a significant difference in this linear study. Some preliminary experiments demonstrated the formation of the ellipse shape lesion by the dual-frequency sonication. However, there is no precisely quantitive method of the lesion in the porcine muscle, the lesion volume was not calculated. The power of both sonication（dual & single）is 25 walt in each element and 50 walt in total. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-13T00:07:58Z (GMT). No. of bitstreams: 1 ntu-96-R94548042-1.pdf: 6706202 bytes, checksum: 39047025e753980327c91f77cfd29d83 (MD5) Previous issue date: 2007 | en |
| dc.description.tableofcontents | 誌謝 I
中文摘要 II 英文摘要 III 第一章 緒論 1 1.1 高能超音波治療 1 1.2 雙頻高能聚焦超音波換能器 3 1.3 研究動機 4 第二章 超音波熱治療之理論分析 5 2.1 雷利-薩瑪菲爾德繞射積分式 5 2.2 溫度場與熱劑量理論分析 7 2.3 拍音（BEATS） 10 第三章 模擬方法與結果 12 3.1 超音波聲場模擬 12 3.2 拍頻之產生 13 3.3 文獻探討－雙陣元環形共焦超音波換能器 14 3.4 雙陣元球面超音波換能器 17 3.5 拍頻頻率對聲場之影響 20 3.6 振幅調變（AMPLITUDE MODULATION AM） 22 3.7 小結 24 3.8 熱劑量與溫升 25 3.9 0.5 MHZ雙陣元球面超音波換能器 26 第四章 實驗方法與材料 29 4.1 雙陣元球面超音波換能器： 29 4.2 實驗系統架設： 31 4.3 仿體製作 32 4.4 離體豬肉的使用 33 4.5 實驗定量步驟與方法： 34 第五章 實驗結果與討論 36 5.1 仿體實驗結果 36 5.2 焦斑長度與形狀的比較 37 5.3 離體豬里肌肉實驗結果 39 5.4 討論 43 第六章 未來展望 44 參考文獻 45 | |
| dc.language.iso | zh-TW | |
| dc.subject | 雷利積分式 | zh_TW |
| dc.subject | 雙頻超音波換能器 | zh_TW |
| dc.subject | 拍音 | zh_TW |
| dc.subject | Rayleigh integral | en |
| dc.subject | Beats | en |
| dc.subject | Dual-frequency transducer | en |
| dc.title | 雙頻高強度聚焦超音波熱治療之探討 | zh_TW |
| dc.title | Investigation of Dual-frequency High-intensity Focused Ultrasound in Thermal Therapy | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 95-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.coadvisor | 陳永耀(Yung-Yaw Chen) | |
| dc.contributor.oralexamcommittee | 王士豪(Shyh-Hau Wang),陳文翔(Wen-Shiang Chen),劉浩澧(Hao-Li Liu) | |
| dc.subject.keyword | 拍音,雙頻超音波換能器,雷利積分式, | zh_TW |
| dc.subject.keyword | Beats,Dual-frequency transducer,Rayleigh integral, | en |
| dc.relation.page | 46 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2007-07-30 | |
| dc.contributor.author-college | 工學院 | zh_TW |
| dc.contributor.author-dept | 醫學工程學研究所 | zh_TW |
| 顯示於系所單位： | 醫學工程學研究所 | |
文件中的檔案：
| 檔案 | 大小 | 格式 | |
|---|---|---|---|
| ntu-96-1.pdf 未授權公開取用 | 6.55 MB | Adobe PDF |
系統中的文件，除了特別指名其著作權條款之外，均受到著作權保護，並且保留所有的權利。