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http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/28091完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 林中天(Chung-Tein Lin) | |
| dc.contributor.author | Shih-Hung Yang | en |
| dc.contributor.author | 楊世鴻 | zh_TW |
| dc.date.accessioned | 2021-06-13T00:00:57Z | - |
| dc.date.available | 2007-08-01 | |
| dc.date.copyright | 2007-08-01 | |
| dc.date.issued | 2007 | |
| dc.date.submitted | 2007-07-30 | |
| dc.identifier.citation | 參考文獻
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/28091 | - |
| dc.description.abstract | 乾眼症定義為因水樣淚液不足或成分不正確所引起的慢性角膜結膜的炎症
反應，同時也是伴侶動物常見的眼睛疾病，是影響動物生活品質與視力的原因之 一。局部點眼的環孢靈被認為是治療的首選，它被認為同時有減緩眼球表面的炎症反應與刺激淚液分泌等作用而達到治療的改善。本研究是以1999年10月至2007年2月間於台大動物醫院眼科門診就診的犬隻為族群所作的回溯性研究，以薛墨氏淚液測試為測量方式，主要的目的是可以獲得乾眼症在本教學醫院的發生概況，年齡，嚴重程度與不同品種間發病的臨床症狀來加以探討以及對健康的犬隻，探討影響淚液分泌量的因素。研究結果發現，對正常犬隻而言，淚液的分泌量會隨著年齡降低，性別與體重則不影響。另總共有224例乾眼症犬，其中201例為不明原因乾眼症，其中以Shih-tzu，American cocker spanial與Maltese犬占大多數，其中Maltese犬多發生早期的乾眼症，而Shihtzu犬則多很快進展為慢性乾眼症，同時此兩犬種角膜潰瘍的發生情形也較普遍。對於環孢靈的治療在本研究族群中約有70%不明原因乾眼症的患犬在6-8周的治療後有良好的治療反應。動物眼科疾病常是與品種相關的，而台灣地區乾眼症犬種的發生情況，也與文獻上提到的不盡相同，因此藉由回溯性調查可提供未來乾眼症發病與治療的參考。 | zh_TW |
| dc.description.abstract | Abstract
Keratoconjunctivitis sicca (KCS, xerophthalmia) can be defined as a progressive inflammatory condition of the cornea and conjunctiva caused by lack of tears and deficiency of the precorneal tear film is commonly encountered in small animal practice. The topical cyclosporin is thought to be a gold standard treatment of KCS through both lacrimomimetic and anti-inflammatory effect. The aim of this study was to investigate the tear production in dogs with KCS, normal lacrimal function and efficacy of cyclosporin treatment in Taiwan. Data were obtained from the database of the Ophthalmology Section of the National Taiwan University Veterinary Hospital. Totally 344 dogs (26 breeds) were included in the study. In the group of dogs with normal lacrimal function (n=119), the value of Schirmer tear test (STT) was ranged from 15mm/min to 28mm/min and the mean STT1 value decreased with age. There was no significant difference in STT1 value in the aspects of patient’s weight, gender and side of eyes. In dogs with KCS (STT<15mm/min, n=201), there were represented in 22 breeds and American cocker spaniel, Shih-tzu and Maltese were the leading affected breeds. Mixed breed, Chihuahua and Shih-tzu showed significant variations in the onset age of KCS. There was a significantly higher incidence of ulcerative keratitis in KCS affected Shih-tzu and Maltese. 70% of KCS dogs treated with topical 1% cyclosporine solution showed a good response to the treatment. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-13T00:00:57Z (GMT). No. of bitstreams: 1 ntu-96-R93629032-1.pdf: 789512 bytes, checksum: fd64765b69a4c0b2b1dd628ca32df606 (MD5) Previous issue date: 2007 | en |
| dc.description.tableofcontents | 目錄 …………………………………………………………………………………….…….I
圖表目錄 ………………………………………………………………………………….…II 英文摘要 ……………………………………………………………………………………III 中文摘要 …………………………………………………………………………………....IV 第一章 序言 ………………………………………………………………………………...1 第二章 文獻回顧 …………………………………………………………………………...3 第一節 淚液的分泌與正常生理 ………………………………………………………...3 第二節 淚液量測的方法 ………………………………………………………………...4 第三節 乾眼症的致病機轉 ……………………………………………………………...8 第四節 引起乾眼症的病因與機制 ……………………………………………………...9 第五節 乾眼症治療的簡介 ……………………………………………………………...16 第六節 環孢靈Cyclosporin ………………………………………………………………18 第三章 材料與方法 ……………………………………………………………………….26 第一節 研究對象 ……………………………………………………………………….26 第二節 Schirmer tear test檢測方法 ……………………………………………………26 第三節 Cyclosporn與乾眼症的治療 ……………………………………………………………………...28 第四節 研究設計……………………………………………………………………28 第五節 統計與分析 ………………………………………………………………….…28 第四章 結果 ……………………………………………………………………………….32 第一節 病例分布 ……………………………………………………………………….32 第二節 性別，體重與年齡對正常犬STT-1數值的影響 …………………………….32 第三節 乾眼症的發生原因 …………………………………………………………….34 第四節 原因不明性乾眼症病例之分析 ……………………………………………….34 第五節 評估cyclosporin的治療反應 ………………………………………………....36 第五章 討論 ……………………………………………………………………………....46 第一節 Schirmer tear test的量測條件的選擇 ……………………………………….. 46 第二節 影響淚液分泌的因素 ……………………………………………………….…49 第三節 乾眼症的發生與原因 …………………………………………………….……51 第四節 原因不明性乾眼症臨床症狀與犬種間差異 ………………………….………51 第五節 Cyclosporin的治療成效與犬種間差異 …………………………….…………54 第六章 結論……………………………………………………………………….…………58 參考文獻 ………………………………………………………………………….………..59 | |
| dc.language.iso | zh-TW | |
| dc.title | 正常犬與乾眼症犬淚液量之回溯性調查 | zh_TW |
| dc.title | Tear produciton in dogs with keratoconjunctivitis sicca and normal lacrimal function | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 95-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 葉力森(Lih-Seng Yeh),黃慧璧(Hui-Pi Huang) | |
| dc.subject.keyword | 乾眼症,淚膜,薛墨式淚液測試,環孢靈, | zh_TW |
| dc.subject.keyword | Keratoconjunctivitis sicca,Schirmer tear test,precorneal tear film,cyclosporin, | en |
| dc.relation.page | 69 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2007-07-31 | |
| dc.contributor.author-college | 生物資源暨農學院 | zh_TW |
| dc.contributor.author-dept | 獸醫學研究所 | zh_TW |
| 顯示於系所單位： | 獸醫學系 | |
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