請用此 Handle URI 來引用此文件:
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/27924
完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 陳振陽 | |
dc.contributor.author | Shih-Lung Hsu | en |
dc.contributor.author | 徐世隆 | zh_TW |
dc.date.accessioned | 2021-06-12T18:28:12Z | - |
dc.date.available | 2012-08-13 | |
dc.date.copyright | 2007-08-13 | |
dc.date.issued | 2007 | |
dc.date.submitted | 2007-08-07 | |
dc.identifier.citation | Acharya S., Wilson T., Gradia S., Kane, M., Guerrette S., Marsischky G.,Kolodner R., and Fishel R. (1996) hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6. Proc Natl Acad Sci USA. 93, 13629–13634
Auer G.,and Ried T. (1997), Advanced-stage cervical carcinomas are defined by a recurrent pattern of chromosomal aberrations revealing high genetic instability and a consistent gain of chromosome. Genes Chromosomes Can 19, 233–240. Baer R, Bankier A.T., Biggin M.D., Deininger P.L., Farrell P J, Gibson T. J., Hatfull G., Hudson G..S., Satchwell S.C., Seguin C., Tuffnell P.S. ,and Barrell B.G.. (1984). DNA sequence and expression of the B95-8 Epstein-Barr virus genome. Nature 310, 207-211. Bellows S., M. Howell, Pearson C., Hazlewood S.A., and Hardwick J.M. (2002)Epstein–Barr virus BALF1 is a BCL-2-like antagonist of the herpesvirus antiapoptotic BCL-2 proteins, J Virol 76, 2469–2479. Burkitt D.A. (1958). A sarcoma involving the jaws in African children. Brit J Surg 45, 218-223. Burkitt D.A. (1962). A children’s cancer dependent upon climatic factors. Nature 194, 232-234 Cabras G., Decaussin G., Zeng Y., Djennaoui D., Melouli H., Broully P., Bouguermouh A.M., and Ooka T. (2005) Epstein-Barr virus encoded BALF1 gene is transcribed in Burkitt's lymphoma cell lines and in nasopharyngeal carcinoma's biopsies.J Clin Virol 34, 26-34. Chang Y., Cesarman E., Pessin M.S., Lee F., Culpepper J., Knowles D.M., and Moore P.S.(1994) Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science 266,1865-1869. Chien Y.C., Chen J.Y., Liu M.Y., Yang H.I., Hsu M.M., Chen C.J., and Yang CS. (2001). Serologic markers of Epstein-Barr virus infection and nasopharyngeal carcinoma in Taiwanese men. N Engl J Med 345, 1877-1882. Cleary M.L., Smith S.D., and Sklar J. (1986) Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation.Cell 47, 19–28. Crum C.P., Ikenberg H., Richart R.M., and Gissman L. (1984)Human papillomavirus type 16 and early cervical neoplasia. N Engl J Med 310, 880–883. Cuconati A., and White E. (2002) Viral homologs of BCL-2: role of apoptosis in the regulation of virus infection. Genes Dev 16, 2465-2478. Dambaugh T., Beisel C., Hummel M., King W., Fennewald S., Cheung A., Heller M., Raab-Traub N.,and Kieff E. (1980) Epstein-Barr virus (B95-8) DNA VII: molecular cloning and detailed mapping. Proc Natl Acad Sci USA 77, 2999-3003. de Wind N., Dekker M., Claij N., Jansen L., van Klink Y., Radman M.,Riggins G., van der Valk M., van’t Wout K., and te riele H. (1999) HNPCC-like cancer predisposition in mice through simultaneous loss of Msh3 and Msh6 mismatch-repair protein functions. Nat Genet 23, 359–362. Dolyniuk M., Pritchett R., and Kieff E.( 1976) Proteins of Epstein-Barr virus. I. Analysis of the polypeptides of purified enveloped Epstein-Barr virus. J Virol 17,935-949. Duensing S.,and Munger K. (2003) Human papillomavirus type 16 E7 oncoprotein can induce abnormal centrosome duplicationthrough a mechanism independent of inactivation of retinoblastoma protein family members. J Virol 77, 12331–12335. Epstein M.A., Achong B.G.,and Barr Y.M. (1964a) Virus particles in cultured lymphoblasts from Burkitt's lymphoma. Lancet 1, 702-703. Epstein M.A., and Barr Y.M. (1964b) Cultivation in vitro of human lymphoblasts from Burkitt’s malignant lymphoma. Lancet 1, 252-253. Forgues M., Difilippantonio M.J., Linke S., Ried P., Nagashima T. K., Feden J. , Valerie K., Fukasawa K., and Wang X.W. (2003), Involvement of Crm1 in hepatitis B virus X protein-induced aberrant centriole replication and abnormal mitotic spindles, Mol Cell Biol 23 ,5282–5292. Friedberg E.C. (2001)How nucleotide excision repair protects against cancer. Nat Rev Cancer. 1,22-33. Gaspar M., and Shenk T.(2006) Human cytomegalovirus inhibits a DNA damage response by mislocalizing checkpoint proteins. Proc Natl Acad Sci U S A 103, 2821-2826. Glaser P, Ogino T, Zimmerman J.J., and Rapp F. (1973) Thymidine kinase activity in Burkitt lymphoblastoid somatic cell hybrids after induction of the EB virus. Proc Soc Exp Biol Med 142, 1059-1062. Given D., Yee D., Griem K., and Kieff E.(1979) DNA of Epstein-Barr virus. V. Direct repeats of the ends of Epstein-Barr virus DNA. J Virol 30, 852-862. Hammerschmidt W., and Sugden B. (1988) Identification and characterization of oriLyt, a lytic origin of DNA replication of Epstein-Barr virus. Cell 55,427-433. Hardwick J.M. (1997) Virus-induced apoptosis, Adv Pharmacol 41,295–336. Harfe B. D. , and Jinks-Robertson S. (2000) DNA mismatch repair and genetic instability. Annu Rev Genet 34, 359–399. Heselmeyer K., Macville M., Schrock E., Blegen H., Hellstrom A.C., Shah K., Kieff E. ,and Rickinson A. (2001) Epstein–Barr virus and its replication. 4th ed. in Fields Virology. Vol.2 , 2511-2573. Lippincott Williams and Wilkins, Philadelphia. Henderson S., Huen D., Rowe M., Dawson C., Johnson G. ,and Rickinson A. (1993) Epstein–Barr virus-coded BHRF1 protein, a viral homolog of Bcl-2, protects human B-cells from programmed cell-death. Proc Natl Acad Sci USA 90, 8479–8483. Henle G., and Henle W. (1966) Immunofluorescence in cells derived from Burkitt's lymphoma. J Bacteriol 91, 1248-1256. Henle G., and Henle W. (1976) Epstein-Barr virus-specific IgA serum antibodies as an outstanding feature of nasopharyngeal carcinoma. Int J Cancer 17, 1-7. Henle G., Henle W., and Diehl V. (1968) Relation of Burkitt's tumor-associated herpes-type virus to infectious mononucleosis. Proc Natl Acad Sci USA 59, 94-101. Hou Y., Gao F., Wang Q., Zhao J., Flagg T., Zhang Y.,and Deng X.(2007). Bcl2 impedes DNA mismatch repair by directly regulating the hMSH2-hMSH6 heterodimeric complex.J Biol Chem 282, 9279-9287. Jin Z., May W.S., Gao F., Flagg T., and Deng X. (2006) Bcl2 suppresses DNA repair by enhancing c-Myc transcriptional activity.J Biol Chem 281, 14446-14456. Kaklamanis L., Savage A., Mortensen N., Tsiotos P., Doussis-Anagnostopoulou I., Biddolph S., Whitehouse R., Harris A., and Gatter K. (1996) Early expression of bcl-2 protein in the adenoma-carcinoma sequence of colorectal neoplasia. J Pathol 179, 10–14. Kawanishi M. (1997) Epstein– Barr virus BHRF1 protein protects intestine 407 epithelial cells from apoptosis induced by tumor necrosis factor alpha and anti-Fas antibody. J Virol 71, 3319– 3322. Kazanji M., Dussart P., Duprez R., Tortevoye P., Pouliquen J.F., Vandekerkhove J., Couppie P., Morvan J., Talarmin A., and Gessain A.( 2005) Serological and molecular evidence that human herpesvirus 8 is endemic among Amerindians in French Guiana. J Infect Dis 192,1525-1529. Kikuta H., Taguchi Y., Tomizawa K., Kojima K., Kawamura N., Ishizaka A., Sakiyama Y., Matsumoto S., Imai S., and Kinoshita T. (1988) Epstein-Barr virus genome-positive T lymphocytes in a boy with chronic active EBV infection associated with Kawasaki-like disease. Nature 333,455-7. Kunkel T.A., and Erie D.A.(2005) DNA mismatch repair. Annu Rev Biochem 74, 681-710. Kuo M., Shiah S., Wang C.., and Chuang S. (1999) Suppression of apoptosis by Bcl-2 to enhance benzene metabolites-induced oxidative DNA damage and mutagenesis: A possible mechanism of carcinogenesis. Mol Pharmacol 55, 894–901. Lawley P.D., and Thatcher C.J. (1970) Methylation of deoxyribonucleic acid in cultured mammalian cells by N-methyl-N'-nitro-N-nitrosoguanidine. The influence of cellular thiol concentrations on the extent of methylation and the 6-oxygen atom of guanine as site of methylation. Biochem J 116,693-707. Leung S.Y., Yuen S.T., Chung L.P., Chu K.M., Wong M.P., Branicki F.J., and Ho J.C.(1999) Microsatellite instability, Epstein-Barr virus, mutation of type II transforming growth factor beta receptor and BAX in gastric carcinomas in Hong Kong Chinese. Br J Cancer 79, 582-588. Li L.Y., Shih H.M., Liu M.Y., and Chen J.Y. (2001) The cellular protein. PRA1 modulates the anti-apoptotic activity of Epstein-Barr. Virus BHRF1, a homologue of Bcl-2, through direct interaction. J Biol Chem 276, 27354–27362. Li L. Y., Liu M. Y., Shih H.M., Tsai C. H., and Chen J.Y. (2006) Human cellular protein VRK2 interacts specifically with Epstein-Barr virus BHRF1, a homologue of Bcl-2, and enhances cell survival. J Gen Virol 87, 2869-2878. Linette G. P., Hess J. L., Sentman C. L., and Korsmeyer S. J. (1995) Peripheral T-cell lymphoma in lckpr-bcl-2 transgenic mice. Blood 86, 1255–1260. Liu M.T., Chen Y.R., Chen S.C., Hu C.Y., Lin C.S., Chang Y.T., Wang W.B., and Chen J.Y. (2004) Epstein-Barr virus latent membrane protein 1 induces .micronucleus formation, represses DNA repair and enhances sensitivity to DNA-damaging agents in human epithelial cells. Oncogene 23, 2531-9. Liu M.Y., Shih Y.Y., Chou S.P., Sheen T.S., Chen C.L., Yang C.S.,and Chen J.Y. (2000) Expression of the Epstein-Barr virus BHRF1 gene, a homologue of Bcl-2, in nasopharyngeal carcinoma tissue. J Med Virol 61, 241-250. Liu Y., Naumovski L., and Hanawalt P. (1997) Nucleotide excision repair capacity is attenuated in human promyelocytic HL60 cells that overexpress BCL2. Cancer Res. 57, 1650–1653. Luka J, Kallin B ,and Klein G. (1979) Induction of the Epstein-Barr virus (EBV) cycle in latently infected cells by n-butyrate. Virology 94, 228-231. Marshall W.L., Yim C., Gustafson E., Graf T., Sage D.R., Hanify K., Williams L., Fingeroth J., and Finberg R.W. (1999) Epstein–Barr virus encodes a novel homolog of the bcl-2 oncogene that inhibits apoptosis and associates with Bax and Bak J. Virol. 73, 5181– 5185. Marsischky G., Filosi N., Kane M., and Kolodner R. (1996) Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repair. Genes Dev 10, 407–420. McDonnell T.J., Deane N., Platt F.M., Nunez G., Jaeger U., McKearn J.P., and Korsmeyer S.J. (1989)bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation. Cell 57, 79-88. Middeldorp JM, Brink AA, van den Brule AJ and Meijer CJ. (2003) Pathogenic roles for Epstein-Barr virus (EBV) gene products in EBV-associated proliferative disorders. Crit Rev Oncol Hematol 45, 1-36. Mutirangura A., Tanunyutthawongese C., Pornthanakasem W., Kerekhanjanarong V., Sriuranpong V., Yenrudi S., Supiyaphun P., and Voravud N.(1997) Genomic alterations in nasopharyngeal carcinoma: loss of heterozygosity and Epstein-Barr virus infection.Br J Cancer 76,770-776. Pathmanathan R., Prasad U., Sadler R., Flynn K., and Raab-Traub N. (1995). Clonal proliferations of cells infected with Epstein-Barr virus in preinvasive lesions related to nasopharyngeal carcinoma. New Engl J Med 333, 693-698. Pickard A., Chen C.J., Diehl S.R., Liu M.Y., Cheng Y.J., Hsu W.L., Sun B., Hsu M.M., Chen I.H., Chen J.Y., Yang C.S., Mittl B.L., Chou S.P., Ruggles D.D., Goldstein A.M., and Hildesheim A. (2004). Epstein-Barr virus seroreactivity among unaffected individuals within high-risk nasopharyngeal carcinoma families in Taiwan. Int J Cancer 111, 117-123. Rickinson A., Kieff E. ,and Cohen J. (1989) Expression of Epstein-Barr virus transformation-association genes in tissue of patients with EBV lymphoproliferative disease. N Engl J Med 321, 1080-1085. Saintigny Y., Dumay, A., Lambert S., and Lopez B. (2001) A novel role for the Bcl-2 protein family: specific suppression of the RAD51 recombination pathway. EMBO J 20, 2596–2607. Sancar A., Lindsey-Boltz L.A., Unsal-Kacmaz K., and Linn S. (2004)Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu Rev Biochem 73,39-85. Sarid R., Sato T., Bohenzky R.A., Russo J.J., and Chang Y. (1997). Kaposi's sarcoma-associated herpesvirus encodes a functional bcl-2 homologue. Nat Med 3293-3298. Sixbey J.W., Vesterinen E.H., Nedrud J.G., Raab-Traub N., Walton L.A., and Pagano J.S. (1983) Replication of Epstein-Barr virus in human epithelial cells infected in vitro. Nature 306, 480-483. Skare J., and Strominger J.L. (1980) Cloning and mapping of BamHI endonuclease fragments of DNA from the transforming B95-8 strain of Epstein-Barr virus. Proc Natl Acad Sci USA 77, 3860-3864. Snowden T., Acharya S., Butz C., Berardini M., and Fishel R. (2004) hMSH4-hMSH5 recognizes Holliday Junctions and forms a meiosis-specific sliding clamp that embraces homologous chromosomes. Mol Cell 15,437-451. Srivenugopal K.S.,and Ali-Osman F. (2002) The DNA repair protein, O(6)-methylguanine-DNA methyltransferase is a proteolytic target for the E6 human papillomavirus oncoprotein. Oncogene 21, 5940–5945. Svetlova M., Nikiforov A., Solovjeva L., Pleskach N., Tomilin N., and Hanawalt P.C. (1999)Reduced extractability of the XPA DNA repair protein in ultraviolet light-irradiated mammalian cells. FEBS Lett 463, 49-52. Takada K., and Ono Y. (1989) Synchronous and sequential activation of latently infected Epstein-Barr virus genomes.J Virol 63,445-449. Tarodi B., Subramanian T., and Chinnadurai G. (1994) Epstein –Barr virus BHRF1 protein protects against cell death induced by DNA-damaging agents and heterologous viral infection, Virology 201 ,404– 407. Tovey M.G., Lenoir G., and Begon-Lours J. (1978). Activation of latent Epstein-Barr virus by antibody to human IgM. Nature 276, 270-272. Tsai W.S., Chang M.H., Chen J.Y., Lee C.Y., and Liu Y.G.(1989) Seroepidemiological study of Epstein-Barr virus infection in children in Taipei. Chinese J Microbiol Immunol 30, 81-86 Tsujimoto Y., Finger L.R., Yunis J., Nowell P.C., and Croce C.M. (1984) Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation .Science 226,1097-1099. Umar A., Koi M., Risinger J.I., Glaab W.E., Tindall K.R., Kolodner R.D., Boland C.R., Barrett J.C., and Kunkel T.A. (1997) Correction of hypermutability, N-methyl-N'-nitro-N-nitrosoguanidine resistance, and defective DNA mismatch repair by introducing chromosome 2 into human tumor cells with mutations in MSH2 and MSH6.Cancer Res 57, 3949-3955. Wang Y.,and Qin J. (2003). MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation. Proc Natl Acad Sci USA 100, 15387–15392. Wilkinson D.E., and Weller S.K. (2006) Herpes simplex virus type I disrupts the ATR-dependent DNA-damage response during lytic infection. J Cell Sci 119, 2695-2703. Youn C.K., Cho H.J., Kim S.H., Kim H.B., Kim M.H., Chang I.Y., Lee J.S., Chung M.H., Hahm K.S., and You H.J. (2005)Bcl-2 expression suppresses mismatch repair activity through inhibition of E2F transcriptional activity. Nat Cell Biol 7, 137-147. Zeng Y., Zhang L.G., Wu Y.C., Huang Y.S., Huang N.Q., Li J.Y., Wang Y.B., Jiang M.K., Fang Z. and Meng N.N. (1985) Prospective studies on nasopharyngeal carcinoma in Epstein-Barr virus Iga/VCA antibody-positive persons in Wuzhou City, China. Int J Cancer. 36545–36547. zur Hausen H., Schulte-Holthausen H., Klein G., Henle W., Henle G., Clifford P., and Santesson L. (1970) EBV DNA in biopsies of Burkitt tumours and anaplastic carcinomas of the nasopharynx. Nature 228, 1056-1058. zur Hausen H., O’Neill F.J., Freese U.K., and Hecker E. (1978) Persisting oncogenic herpesvirus induced by the tumour promotor TPA. Nature 272, 373-375. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/27924 | - |
dc.description.abstract | 許多疱疹病毒和癌症的發生有密切關聯性,例如EB 病毒與淋巴瘤、鼻咽癌、胃癌等多種癌症有關,另卡波西氏肉瘤疱疹病毒(KSHV)會造成卡波西氏肉瘤的發生。
癌症發生之時往往會伴隨著大量的基因體不安定性。本實驗室先前發現某些EB病毒蛋白質表現會造成基因體不安定的情形,而在KSHV也已經被證實其潛伏期蛋白表現也會造成基因體的不穩定性。依據以上結果而讓我們對於這兩個人類致癌性疱疹病毒在溶解期所表現的其他蛋白質是否會造成基因體不安定性有著高度的興趣,這是一個過去從未被探討過的領域。 我們實驗室經初步的實驗觀察EB病毒所轉譯出的Bcl2同源分子BHRF1有可能會促進基因體的不安定性,因而選擇在疱疹病毒中EB病毒及KSHV在溶解期所轉譯出的Bcl-2同源分子(EBV的BHRF1,BALF1以及KSHV的KsBcl2)進行基因體不安定性的研究,透過和宿主細胞的交互作用來了解其造成基因體不安定性的可能原因。在本實驗中,我們先行構築了可以表現Bcl2及其同源分子的表現質體,將其轉染至H1299細胞,並證實此組蛋白質表現質體可以在H1299細胞中大量表現。Bcl2及其同源分子可以增加細胞對於DNA損傷藥物的耐受力。進ㄧ步利用宿主細胞再活化實驗,針對核苷酸修復系統也發現H1299細胞表現Bcl2及其同源分子時會降低細胞對於紫外線造成的DNA缺損的修復力。也針對錯誤配對修復系統進行研究。利用ELISA的方法在僅轉染Bcl2及其同源分子表現質體以及在轉染之後暴露在DNA損傷的藥物的情形下,發現會降低錯誤配對辨識的能力。並且利用西方墨點法監測H1299細胞在轉染Bcl2以及病毒同源分子之後暴露在DNA損傷藥物的環境下,發現Bcl2,BHRF1表現會使得參與錯誤配對系統的hMsh2以及hMsh6的蛋白質表現有下降的情形推測因此而促使其錯誤配對修復辨識能力下降:基於以上結果我們認為EB病毒的病毒蛋白BHRF1以及卡波西氏肉瘤疱疹病毒的KsBcl2均會抑制DNA修復機制,進而導致基因體的穩定性遭受破壞,可能進而促進細胞的癌化。 | zh_TW |
dc.description.abstract | Several herpesviruses are associated with cancer formation. Two human oncogenic herpesviruses, namely Epstein-Barr virus (EBV) and Kaposi’s Sarcoma Associated Herpesvirus (KSHV), have been linked to a number of malignancies including lymphomas, nasopharyngeal carcinoma, gastric carcinoma, and Kaposi’s sarcoma.
The hallmark of tumor cells is genomic instability. Our previous finding provides an insight about the role of EBV viral proteins in DNA repair suppression to promote genomic instability. Studies carried out in other laboratories also demonstrated that infection of KSHV increased genomic instability. Based on these findings, we are interested in identifying EBV and KSHV encoded viral proteins that can lead to genomic instability. EBV and KSHV carry Bcl2 homologues and whether these homologues supress DNA repair activity has not been elucidated yet. Preliminary data in our laboratory indicate BHRF1 may promote genomic instability. By this finding, we have been interested in illustrating how viral Bcl2 homologues cause genomic instability. We chose BHRF1, BALF1 (Bcl2 homologues of EBV), and KsBcl2 (Bcl2 homologue of KSHV) to further study their activity in promotion of genomic instability. First, we constructed Bcl2 and viral Bcl2 homologues expression plasmids and checked their expressions in H1299 cell. Bcl2 and Viral Bcl2 homologues expressed in H1299 cell correctly by recombinant plasmids constructed. Bcl2 and viral Bcl2 expressions in H1299 prevent cell death by MNNG treatment. We monitored nucleotide excision repair efficiency by host cell reactivation assay. Results showed that viral Bcl2 homologues over-expressed in H1299 cell attenuated the capacity of UV-induced DNA repair. In the other repair process, we focused on mismatch repair (MMR). Using ELISA assay to investigate MutSα activity. We revealed that Bcl2 and viral Bcl2 homologues (BHRF1 and BALF1 in EBV, KsBcL2 in KSHV) potently suppressed MMR in association with decreased MutS alpha activity through the down-regulation of Msh2 and Msh6 expression in protein level. Based on these results, viral Bcl2 homologues may potentially contribute to the induction of genetic instability and subsequent carcinogenesis. | en |
dc.description.provenance | Made available in DSpace on 2021-06-12T18:28:12Z (GMT). No. of bitstreams: 1 ntu-96-R94445122-1.pdf: 843209 bytes, checksum: d1e20ea646fead5cfd56ae5812f7987f (MD5) Previous issue date: 2007 | en |
dc.description.tableofcontents | 中文摘要-----------------------------------------------1
英文摘要-----------------------------------------------2 背景介紹-----------------------------------------------4 目的---------------------------------------------------13 材料與方法---------------------------------------------14 實驗結果-----------------------------------------------24 討論---------------------------------------------------29 圖表---------------------------------------------------33 附錄---------------------------------------------------39 參考文獻-----------------------------------------------41 | |
dc.language.iso | zh-TW | |
dc.title | 疱疹病毒Bcl2同源分子壓制核苷酸剪切修復能力以及干擾錯誤配對辨識程序 | zh_TW |
dc.title | Gamma-Herpesviral Bcl-2 Homologues Suppress Nucleotide Excision Repair And Disrupt MutSα Activity | en |
dc.type | Thesis | |
dc.date.schoolyear | 95-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 許翠瑛,林素芳 | |
dc.subject.keyword | 疱,疹病毒,修復, | zh_TW |
dc.subject.keyword | Bcl2,BHRF1,EBV,KSHV,MMR, | en |
dc.relation.page | 49 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2007-08-07 | |
dc.contributor.author-college | 醫學院 | zh_TW |
dc.contributor.author-dept | 微生物學研究所 | zh_TW |
顯示於系所單位: | 微生物學科所 |
文件中的檔案:
檔案 | 大小 | 格式 | |
---|---|---|---|
ntu-96-1.pdf 目前未授權公開取用 | 823.45 kB | Adobe PDF |
系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。