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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 李世光(Chih-Kung Lee) | |
| dc.contributor.author | Chun-Kuang Chen | en |
| dc.contributor.author | 陳俊光 | zh_TW |
| dc.date.accessioned | 2021-06-12T18:12:02Z | - |
| dc.date.available | 2012-11-15 | |
| dc.date.copyright | 2007-11-15 | |
| dc.date.issued | 2007 | |
| dc.date.submitted | 2007-10-08 | |
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/27611 | - |
| dc.description.abstract | 石英微質量天平在液相中應用時，面臨到Q值大幅下降以致影響振盪頻率穩定度，以及電容效應導致相位零點的振盪條件消失，所以本論文乃針對此兩大難題提出相位補償式的石英振盪電路以茲解決。
本研究從石英的基本特性分析切入，並從現有的理論模型得知，其理論所依據的參考頻率為串聯諧振頻率，然一般振盪電路其回授振盪乃是操作在相位零點的諧振頻率，而當石英在高阻尼的流體環境時，此兩頻率的差異也就越大，因此一般振盪電路所量測到的頻率與理論值也就存在更大的誤差，容易造成在生物質量分析上的誤判，所以本論文提出以負電容的方式以消除石英的並聯電容值，使其振盪頻率能夠準確地操作在串聯諧振頻率，使石英微質量天平在生物的量測應用中得到更精準地分析。 本論文從各種振盪電路的分析研究中，提出創新式的橋式振盪電路，使其振盪電路能夠具有額外的環路Q值增益，並且維持石英端的電壓恆定，使其整體振盪頻率的穩定度提升。 新的相位補償式振盪電路，除了可以修正在液相中振盪相位所產生的頻率誤差, 更可透過控制得知石英在液相中所受到的電容值之變化與阻尼狀況，因此本論文所開發的相位補償式石英微質量天平，可量測的參數除了頻率之外，還有電容值與阻尼值可提供生物應用時的分析，因此具有同時解析分子質量與液相阻尼之功能，故對於生物研究可以進一步了解其構形變化與力學特性。 | zh_TW |
| dc.description.abstract | The application of Quartz Crystal Microbalance (QCM) in the liquid phase condition usually subjected to two major problems. The first one is the extra damping in liquid phase that causes the mechanical quality factor drop to a level that may induce unstable oscillation frequency. The second one is the self oscillation zero phase condition will be lost due to the shunt capacitance effect. In this study, a novel phase compensated quartz crystal oscillation circuit is proposed and will try to resolve these problems.
According to the traditional theoretical analysis, the prediction of frequency change is done by using the series resonance frequency as a reference. However, the general oscillation circuit is designed and operated at the actual resonance frequency condition. The difference between the two above-mentioned frequencies became even larger in the high damping liquid environment, and will lead to errors on bio-medical samples measurement. To hold self oscillation operated on the series resonance frequency accurately, a negative capacitance compensation circuit is proposed to cancel out the shut capacitance of the quartz crystal. It was shown that the simple self oscillation circuit will lead to accurate series resonant frequency oscillation no matter it is in liquid phase or not. The experimental result of the impedance analysis shows that the method is successful and work well to stabilize the oscillation and eliminate the measurement errors in liquid phase. A new bridge oscillation circuit to enhance the circuit loop quality factor and to sustain the constant voltage cross the quartz was also developed in this study. It also helps to further stabilize the oscillation in liquid phase. The new compensated oscillation circuit not only fix the phase error in the liquid phase, but also can be used to get the capacitance and damping values by using a control loop design. With all these developmnets, not only the bio-mass loading but also the damping coefficient can be measured on the circuit simultaneously. With the improved stability and precision on the new QCM system, it will be shown that protein conformation changes and bio-mechanisms can then be examined. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-12T18:12:02Z (GMT). No. of bitstreams: 1 ntu-96-D91543011-1.pdf: 1425738 bytes, checksum: 4e9ba8b9f9fe2b74eba3bf440e4316e3 (MD5) Previous issue date: 2007 | en |
| dc.description.tableofcontents | 誌謝 i
中文摘要 iv 英文摘要 v 目錄 vii 圖目錄 xi 表目錄 xiv 第1章 緒論 1 1.1 動機與目標 1 1.2 石英晶體微天平基本運作原理 2 1.3 發展歷史 3 1.4 聲波元件作為生物感測之分析 5 1.5 常見生物檢測方式比較 6 1.6 石英產業與QCM生物檢測 8 1.7 應用領域 9 第2章 石英特性與QCM理論模型 10 2.1 石英特性 10 2.1.1 切面與振盪模式 10 2.1.2 等效電路 13 2.1.3 特徵頻率 14 2.1.4 溫度特性 18 2.2 理論模型 20 2.2.1 基本力學模型 20 2.2.2 等效電路Butterworth-Van Dyke (BVD circuit)模型 22 2.2.3 修正型BVD模型 24 2.2.4 傳輸線模型 25 2.3 其它影響特性 28 2.3.1 靈敏度 28 2.3.2 表面粗糙度 29 2.3.3 電容效應 30 2.3.4 表面應力，作用電壓等效應 31 第3章 量測方式 33 3.1 基本量測方式 33 3.1.1 脈波激發 33 3.1.2 網路分析儀或是阻抗分析儀 33 3.1.3 振盪電路 35 3.1.4 基本量測方式比較 36 3.2 特殊量測方式 37 3.2.1 阻尼量測QCM-Damping 37 3.2.2 電化學EQCM 39 第4章 液相量測探討 41 4.1 頻率變化誤差 41 4.2 穩定度Q值問題 44 4.3 振盪能力問題 46 第5章 振盪電路設計 49 5.1 基本振盪電路設計條件 50 5.1.1 巴克豪森振盪條件(Barkhausen Criterion) 50 5.1.2 串聯振盪與並聯振盪 50 5.1.3 電路增益與Q值 52 5.2 基本石英振盪電路分析 53 5.2.1 Miller Circuit 53 5.2.2 Colpitts Circuit 54 5.2.3 Pierce Circuit 56 5.3 QCM振盪電路要件 57 5.4 常見QCM振盪電路 58 5.4.1 Level oscillator 58 5.4.2 Emitter coupled oscillator 59 5.4.3 Operation amplifier oscillator 60 5.4.4 PLL based oscillator 61 5.4.5 Active-Bridge Oscillator 62 5.5 提升QCM振盪電路品質之方法 63 5.5.1 Q值提升 64 5.5.2 消除石英並聯電容 67 第6章 新型相位補償與高Q值石英振盪電路 71 6.1 負導抗轉換器消除石英並聯電容 71 6.1.1 負導抗轉換基本型態 71 6.1.2 進階型負導抗轉換器 73 6.1.3 負導抗實作與特性量測分析 77 6.2 補償控制設計 82 6.3 進階型OP-Amp 橋式振盪電路 84 6.3.1 新創橋式穩壓振盪電路特性 84 6.3.2 穩壓振盪電路特性實量測測 86 第7章 整體量測系統設計 93 7.1 晶片設計 93 7.2 機構設計 94 7.3 整體電路設計與軟體控制 96 第8章 結論與未來展望 99 8.1 結論 99 8.2 未來展望 99 參考文獻(Reference) 100 | |
| dc.language.iso | zh-TW | |
| dc.subject | 構形變化 | zh_TW |
| dc.subject | 振盪電路 | zh_TW |
| dc.subject | 負導抗 | zh_TW |
| dc.subject | Q值 | zh_TW |
| dc.subject | 微質量天平 | zh_TW |
| dc.subject | 石英 | zh_TW |
| dc.subject | Conformation Change | en |
| dc.subject | Quartz | en |
| dc.subject | Quality Factor | en |
| dc.subject | Negative Immittance | en |
| dc.subject | Oscillator Circuit | en |
| dc.subject | Mirco Balance | en |
| dc.title | 同時解析分子質量與液相阻尼之相位補償式石英微質量天平 | zh_TW |
| dc.title | Phase compensated Quartz Crystal Microbalance for Simultaneous Measurement of Bio-mass loading and liquid damping | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 96-1 | |
| dc.description.degree | 博士 | |
| dc.contributor.oralexamcommittee | 林世明(Shi-Ming Lin),楊鎣(Pauline Y. Lau),張培仁(Pei-Zen Chang),吳光鐘(Kuang-Chong Wu),林啟萬(Chii-Wann Lin),呂學士(Shey-Shi Lu) | |
| dc.subject.keyword | 石英,微質量天平,Q值,負導抗,振盪電路,構形變化, | zh_TW |
| dc.subject.keyword | Quartz,Mirco Balance,Quality Factor,Negative Immittance,Oscillator Circuit,Conformation Change, | en |
| dc.relation.page | 112 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2007-10-08 | |
| dc.contributor.author-college | 工學院 | zh_TW |
| dc.contributor.author-dept | 應用力學研究所 | zh_TW |
| 顯示於系所單位： | 應用力學研究所 | |
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