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標題: | 自主神經系統強度檢測技術 A Technology for the Measurement of Autonomic Nervous System Activity |
作者: | Jain-Da Li 李建達 |
指導教授: | 邵耀華 |
關鍵字: | 自主神經病變,夏克氏足,脈波波速,心率變異度,糖尿病, Autonomic neuropathy,Charcot foot,Pulse wave velocity,HRV,Diabetes, |
出版年 : | 2008 |
學位: | 碩士 |
摘要: | 對糖尿病的病患而言,自主神經病變可發生於第一型的糖尿病,也可發生於第二型的糖尿病。自主神經病變可能在患者被診斷為糖尿病時就發生了,其會影響心血管系統、消化道系統、泌尿道系統、排汗功能、代謝性的障礙及瞳孔異常,且與病患的死亡率有關,因此早期的診斷與治療是非常重要的。
本研究在於發展一套臨床設備,以脈波波速、動態心率變異度(DHRV)分析和平均動脈壓(MAP)來檢測自主神經系統的強度。用六個頻道之壓力感測器,同時量測身體六點之脈波,而測量出三組脈波波速,可比較左、右肢或上、下肢之脈波波速,加上心電圖計算其動態心率變異度,並將之推廣於量測自主神經之強度,和比較整體跟週邊對姿態改變的變化程度。 實驗的對象:控制組選擇正常、沒有循環系統疾病的人,共有六人一女五男,年齡23±2歲。糖尿病患組選擇沒有高血壓等其他心血管疾病,共10人七男三女,年齡為54±11歲。還有一組是糖尿病患有Charcot foot的病患2名男性年齡分別是37歲和50歲。當傾斜角度增加,下肢脈波波速變化率比上肢來得大,而且控制組比其他兩組都大。MAP變化率控制組為正,兩組病患為負。兩組病患的DHRV值比控制組小,而患有Chartcot foot的病患其值又比一般的糖尿病患小。 由以上結果顯示,這套非侵入性的檢查設備可以檢測出自主神經的強度。 In diabetes autonomic neuropathy may occur in Type1 and Type2. It may occur before being diagnosized and affect cardiovascular system, digestive system, Genitourinary system, sweat gland and metabolism. Autonomic neuropathy is relative to the mortality of the diabetes, so the early diagnosis and treatment are very important. This study is to measure the mean arterial pressure(MAP), dynamic HRV and the pulse wave simultaneously at four limbs by pressure receptors, and use the electrocardiogram as the reference to synchronize the recorded pulse wave at different vessels. Using the data to calculate the dynamic HRV(DHRV) and the pulse wave velocity(PWV). With the pulse wave velocity of different vessels and DHRV , we can understand the autonomic nerve activity and the local sympathetic nerve activity in different diseases and different sites. I research 6 normal young people with no cardiovascular disease as control group. 5of them are male and 1 is female aged 23±2.The second group contains 10 people(7 males and 3 females), who have Diabetes mellitus(Type 2) without hypertension aged 54±11. The third group has only 2 males aged 50 and 37, are Diabetes mellitus(Type 2) patient with Charcot foot. When the tilt-table tilts the change of PWV of lower limb is greater than upper limb. The change of PWV of lower limb in control group is greater than the other 2 groups. The DHRV of control is greater than the other 2 groups, and the DHRV of the patients with Charcot foot is much smaller. The change of MAP is positive in control, but negative in the other. Then we can prove that this technique can measure the activity of autonomic nervous sysyem. |
URI: | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/27382 |
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顯示於系所單位: | 應用力學研究所 |
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