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???org.dspace.app.webui.jsptag.ItemTag.dcfield??? | Value | Language |
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dc.contributor.advisor | 葉力森(Lih-Seng Yeh) | |
dc.contributor.author | Kwo-Chen Hu | en |
dc.contributor.author | 胡國誠 | zh_TW |
dc.date.accessioned | 2021-06-12T17:58:27Z | - |
dc.date.available | 2009-02-01 | |
dc.date.copyright | 2008-02-01 | |
dc.date.issued | 2008 | |
dc.date.submitted | 2008-01-29 | |
dc.identifier.citation | Chapter 1-4
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Factors Influencing Vascular and Hepatic Enhancement at CT: Experimental Study on Injection Protocol Using a Canine Model. Journal of computer assisted tomography 2000;24: 400-406. 27. Davidson C, Stacul F, McCullough PA, Tumlin J, Adam A, Lameire N, et al. Contrast medium use. THe american journal of cardiology 2006;98: 42K-58K. 28. Musante F, Zandrino F, Biondetti P. Optimal contrast agent administration protocol for hepatic and aortic multidetector-row computed tomography; clinical experience with iomeprol. Second Bracco Symposium on MDCT. Barcelona, 2001;1-4. 29. Dominik F. Contrast medium injection protocols for CT angiography. Controversies and consensus in imaging and intervention 2006;4: 22-26. 30. Garcia P, Genin G, Bret PM, Bonaldi VM, Reinhold C, Atri M. Hepatic CT enhancement: effect of the rate and volume of contrast medium injection in an animal model. Abdominal Imaging 1999;24: 597-603. Capter 5 1. Dawson P. Multi-slice CT contrast enhancement regimens. Clinical Radiology 2004;59: 1051-1060. 2. Herman S. Computed tomography contrast enhancement principles and the use of high-concentration contrast media. Journal of computer assisted tomography 2004;28: S7-S11. 3. Bae KT, Heiken JP, Brink JA. Aortic and hepatic peak enhancement at CT: effect of contrast medium injection rate-- pharmacokinetic analysis and experimental porcine model. Radiology 1998;206: 455-464. 4. Bae KT, Heiken JP, Brink JA. Aortic and hepatic contrast medium enhancement at CT. Part I. Prediction with a computer model. Radiology 1998;207: 647-655. 5. Fleischmann D, Rubin GD, Bankier AA. Improved uniformity of aortic enhancement with customized contrast medium injection protocols at CT angiography. Radiology 2000;214: 363-371. 6. Kim T, Murakami T, Takahashi S. Effects of injection rates of contrast material on arterial phase hepatic CT. American Journal of Roentgenology 1998;171: 429-432. 7. Platt JF, Reige KA, Ellis JH. Aortic enhancement during abdominal CT angiography: correlation with test injections, flow rates, and patient demographics. American Journal of Roentgenology 1999;172: 53-56. 8. Bertolini G, Rolla EC, Zotti A, Caldin M. Three-dimensional multislice helical computed tomography techniques f canine exrta-hepatic portosystemic shunt assessment. Journal of veterinary radiology & ultrasound 2006;47: 439-443. 9. Càceres AV, Zwingenberger AL, Hardam E, Lucena JM, Schwarz T. Helical computed tomographic angiography of the normal canine pancreas. Journal of veterinary radiology & ultrasound 2006;47: 270-278. 10. Zwingenberger AL, Schwarz T, Saunders HM. Helical computed tomographic angiography of canine portosystemic shunts. Journal of veterinary radiology & ultrasound 2005;46: 27-32. 11. Kalinowski M, Goldmann K, Gotthardt M, M MR, Pfestroff A, Klose KJ, et al. Effectiveness and renal tolerance of multidetector helical CT with gadobutrol: results of a comparative porcine study. Radiology 2007;244: 457-463. 12. Lee CH, Goo JM, Bae KT, Lee HJ, Kim KG, Chun EJ, et al. CTA contrast enhancement of the aorta and pulmonary artery: the effect of saline chase injected at two different rates in a canine experimental model. Investigative Radiology 2007;42: 486-490. 13. Macari M, MIsrael GM, Berman P, Lisi M, Tolia AJ, Adelman M, et al. Infrarenal abdominal aortic aneurysms at multi-detector row CT angiography: intravascular enhancement without a timing acquisition. Radiology 2001;220: 519-523. 14. Sheiman RG, Raptopoulos V, Caruso P, Vrachliotis T, Pearlman J. Comparison of tailored and empiric scan delays for CT angiography of the abdomen. American Journal of Roentgenology 1996;167: 725-729. 15. Awai K, Hiraishi K, Hori S. Effect of contrast material injection duration and rate on aortic peak time and peak enhancement at dynamic CT involving injection protocol with dose tailored to patient Weight. Radiology 2004;230: 142-150. 16. Haage P, Schmitz-Rode T, Hubner D. Reduction of contrast material dose and artifacts by a saline flush using a double power injector in helical CT of the thorax. American Journal of Roentgenology 2000;174: 1049-1053. 17. Irie T, Kajitani M, Yamaguchi M. Contrast-enhanced CT with saline flush technique using two automated injectors: how much contrast medium does it save? Journal of computer assisted tomography 2002;26: 287-291. 18. Cademartiri F, Lugt Avd, Luccichenti G, Paovne P, Krestin GP. Parameters affecting bolus geometery in CTA: A review. Journal of computer assisted tomography 2002;26: 598-607. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/27225 | - |
dc.description.abstract | 研究目的:
本研究以16多列式電腦斷層掃描儀探討於兩種情況下顯影劑在犬隻後大動脈顯影的特性,包括: 1. 相同體重群犬隻,以不同顯影劑注射速率 2. 不同體重群犬隻,以相同顯影劑注射速率 期望瞭解顯影劑於犬隻血管顯影之特性,以擴大應用檢查範圍與標準化影像品質,進而增進獸醫臨床診療品質。 研究對象: 19隻臨床篩選非心臟血管疾病的犬隻,分為三組,A組與B組為統計上體重無明顯差異的犬隻,B組與C組為統計上體重呈現明顯差異的犬隻(C組>B組)。 研究方法: 將犬隻全身麻醉,腹側躺於多列式電腦斷層檢查台上,並以500mg I/kg之劑量經由頭靜脈給予濃度370mgI/ ml之非離子性顯影劑,同時在位於支氣管分叉同一平面之後大動脈處間隔掃描50次,所得影像以軟體計算出該處後大動脈顯影與時間之關係,三組施打顯影劑之速率如下:A組3ml/sec., B組4ml/sec.,和C組4ml/sec.。 研究結果: 三組顯影與時間的關係以直條圖和時間顯影曲線表示,在A組與B組中,B組較快到達最適顯影值(7.43 ± 1.01 秒),且有較高的最大顯影值(566.41 ± 56.13 HU),而A組有較長的最適顯影期間(12.8 ± 3.31 秒)。在B組與C組中,C組較慢達到最大顯影值時間(23.75 ± 2.7 秒),而B組的最適顯影期間較短(11.18 ± 2.47 秒)。 研究結論: 較快之顯影劑注射速率可較快達到最適掃描顯影值,且比低注射速率時能出現較高之最大顯影值,然而最適掃描期間會相對縮短。而越重之犬隻,達到最適掃描顯影值時間會延後,但其最適掃描期間較體重輕者較久。三組分別以時間顯影曲線顯示,其整體特性與人醫文獻之結果相類似,但明顯不同之處是時間顯影曲線明顯往左偏移。 | zh_TW |
dc.description.abstract | Objective:
To evaluate the effects of contrast medium in canine caudal aorta under 16- row multidetector computed tomography (MDCT) within two controlled variations, including: 1. Different contrast medium injection rate in two groups of similar body weight. 2. Two groups with different body weight administrate the same injection rate of contrast medium We expect to figure out the properties of contrast enhancement in the canine vascular system to improve the quality of contrast imaging, and to extend the applications of MDCT use in clinical veterinary medicine. Animals: Nineteen clients owned dogs without cardiovascular system diseases were collected and classified into three groups in this study. Group A and B were no statistically significant difference in body weight, and Group C were heavy than Group B. Material and method: All dogs were anesthetized and positioned in sternal recumbency under 16-MDCT scanning. The total dose 500mg I/kg non-ionic contrast medium (370mg I/ml) were then administrated via cephalic vein. The injection rate was 3ml/sec., 4ml/sec. and 4ml/sec. for Group A, B and C, respectively. We measured the attenuation values in Hounsfield Unit (HU) for the caudal aorta at the level of trachea bifurcation which can be showed on the image. Result: In Group A and B, while group B (7.43 ± 1.01 sec) is faster than group A (9.35 ± 0.61 sec.) in achieving at the point of optimal enhancement and also has higher maximum enhancement attenuation (566.41 ± 56.13 HU) , Group A has longer period for optimal enhancement (12.8 ± 3.31 sec.). Compare Group B to Group C, Group C (13.74 ± 0.83 sec.) is slower than Group B (7.43 ± 1.01 sec.) in achieving at the point of enhancement, and Group B has shorter period for optimal enhancement (11.18 ± 2.47 sec.) Discussion: With similar body weight, the faster injection rate (4ml/sec.), the shorter time to reach the attenuation of initial optimal enhancement as well as the higher attenuation of maximum enhancement and the shorter optimal enhancement period. At the same injection rate the heavy dogs delayed the initial time of optimal enhancement, but has longer optimal enhancement period. The results of three groups were showed in time-enhancement curve within which the entire properties were similar to the relative reports of human medicine. However, an obvious difference is that the time- enhancement curve shift leftward. | en |
dc.description.provenance | Made available in DSpace on 2021-06-12T17:58:27Z (GMT). No. of bitstreams: 1 ntu-97-R94629009-1.pdf: 1981643 bytes, checksum: 35d008fc5d0b1be4710c9a51a89b8b7b (MD5) Previous issue date: 2008 | en |
dc.description.tableofcontents | 目錄....................i
表次....................iv 圖次.................... v 中文摘要................ vii 英文摘要................ ix 第一章 序論 1 1.1 前言 1 1.2 研究背景與動機 1 第二章 電腦斷層掃描儀介紹 3 2.1 傳統電腦斷層掃描儀的演進 3 2.1.1 第一代電腦斷層掃描儀 4 2.1.2 第二代電腦斷層掃描儀 5 2.1.3 第三代電腦斷層掃描儀 6 2.1.4 第四代電腦斷層掃描儀 7 2.2 螺旋式電腦斷層掃描儀介紹 9 2.2.1 Slip-ring 掃描裝置 11 2.2.2 高能量X光球管 12 2.2.3 內插演算法 13 2.2.4 16多列式電腦斷層掃描儀 14 2.3 影像顯示與電腦斷層值(CT Number) 17 2.3.1 定義 17 2.3.2 參考數值 18 第三章 用於電腦斷層檢查的含碘顯影劑 19 3.1目的 19 3.2顯影劑藥物動力學 20 3.2.1 分佈(distribution) 21 3.2.2 代謝(Metabolism) 22 3.2.3 排除(Elimination) 23 3.3 含碘顯影劑之顯影原理 24 3.4 演進與分類 26 第四章 含碘顯影劑顯影效果之影響因素 31 4.1含碘顯影劑注射濃度 31 4.2含碘顯影劑注射速率 34 4.3含碘顯影劑與體重之關係 40 4.4時間顯影曲線於人醫與獸醫研究中的差異 42 4.5 結論 43 參考文獻 46 第五章 以16多列式電腦斷層掃描儀評估顯影劑注射速率與體重於犬後大動脈顯影特性之研究 49 5.1 摘要(Abstract) 50 5.2 前言(Introduction) 52 5.3 材料與方法(Materials and methods) 54 5.3.1 實驗動物篩選(Animals) 54 5.3.2 電腦斷層技術(Computed tomography technique) 55 5.3.3 資料分析(Quantitative Analysis) 57 5.3.4 統計方法(Statistical Analysis) 59 5.4 結果(Result) 60 5.5 討論(Discussion) 68 5.6 參考文獻(References) 71 | |
dc.language.iso | zh-TW | |
dc.title | 以16多列式電腦斷層掃描儀評估顯影劑注射速率與體重影響於犬後大動脈顯影特性之研究 | zh_TW |
dc.title | The Imaging Effects of Body Weight and Contrast Injection Rate on Canine Caudal Aorta under 16-row Multidetector Computed Tomography | en |
dc.type | Thesis | |
dc.date.schoolyear | 96-1 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 林中天,陳良光(Liang-Kuang Chen) | |
dc.subject.keyword | 多列式電腦斷層掃描,非離子性顯影劑,犬,後大動脈,時間顯影曲線, | zh_TW |
dc.subject.keyword | Multidetector computed tomography,MDCT,non-ionic contrast medium,dog,caudal aorta,time-enhancement curve, | en |
dc.relation.page | 73 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2008-01-29 | |
dc.contributor.author-college | 生物資源暨農學院 | zh_TW |
dc.contributor.author-dept | 獸醫學研究所 | zh_TW |
Appears in Collections: | 獸醫學系 |
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