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| ???org.dspace.app.webui.jsptag.ItemTag.dcfield??? | Value | Language |
|---|---|---|
| dc.contributor.advisor | 林琬琬(Wan-Wan Lin) | |
| dc.contributor.author | Yu-Cheng Tu | en |
| dc.contributor.author | 涂育誠 | zh_TW |
| dc.date.accessioned | 2021-06-08T07:12:31Z | - |
| dc.date.copyright | 2011-10-07 | |
| dc.date.issued | 2011 | |
| dc.date.submitted | 2011-08-11 | |
| dc.identifier.citation | Adli, M., and Baldwin, A.S. (2006). IKK-i/IKKepsilon controls constitutive,
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/26496 | - |
| dc.description.abstract | PMA 為一已知的蛋白磷酸激酶C (PKC) 活化劑, 可活化轉錄因子NF-kappaB及c-Fos蛋白表現。我們欲探討此兩條活化路徑的關係，因此比較腫瘤壞死因子-alpha (TNF-alpha) 和PMA在不同種細胞的作用。首先，我們發現PMA所誘導的p65蛋白絲胺酸 (Serine) 536磷酸化需要IKKalpha及IKKbeta，而TNF-alpha的作用則非如此。除此之外，在多種細胞我們發現TNF-alpha 會引起強烈IKKalpha/beta 活性區的絲胺酸176及絲胺酸177磷酸化，相反的，PMA偏好於IKKalpha/beta活性區的絲胺酸180及絲胺酸181產生磷酸化，並且此磷酸化作用與PKC-MEK-ERK路徑有關，但與RSK及MSK無關。然而，此種磷酸化作用並未參與PMA所誘導的IkappaBalpha蛋白降解、p65蛋白絲胺酸536磷酸化、p65蛋白進入細胞核以及轉錄因子NF-kappaB的活化。出乎意料，我們發現PMA所誘導的c-Fos蛋白表現需要IKKalpha/IKKbeta/IKKgamma複合物，而此種相依性也在p65蛋白缺陷的老鼠胚胎纖維母細胞 (MEF) 中發現。更進一步，我們在老鼠c-fos基因啟動子 (promoter) 區域中找到了一個可能被轉錄因子NF-kappaB所結合的區域。經由實驗證明，在PMA的刺激之下，p65蛋白同質雙聚體 (p65 homodimer) 可以和CBP/p300蛋白結合到此區域進行基因調控，而此種調控與TCF-SRF-SRE複合物相關之調控無關。簡而言之，此篇研究發現IKKalpha/beta蛋白磷酸化的新機制，也證實PMA所誘導的c-fos基因調控需要IKKalpha/beta蛋白參與，而c-fos基因啟動子之轉錄因子NF-kappaB結合位置的發現，將可對於轉錄因子NF-kappaB及轉錄因子AP-1兩者之間的關係，提供一個新的思考點及研究方針。 | zh_TW |
| dc.description.abstract | Phorbol 12-myristate 13-acetate (PMA) is a PKC activator known for triggering NF-kappaB activation and c-fos expression. To further understand the functional link of both events, we compared the actions of TNF-alpha and PMA in various cell types. We found that PMA- but not TNF-alpha-induced p65 Ser536 phosphorylation in mouse embryonic fibroblast (MEF) is IKKalpha/beta dependent. Additionally, compared to TNF-alpha, which induced dramatically IKKalpha/beta phosphorylation at Ser176/177, PMA preferentially induced IKKalpha/beta phosphorylation at Ser180/181 within its active loop, and this phosphorylation of IKKalpha/beta by PMA is through a novel mechanism depending on PKC-MEK-ERK axis but not RSK or MSK. Moreover, this phosphorylation does not contribute to PMA-induced IkappaBalpha degradation, p65 Ser536 phosphorylation, p65 nuclear translocation and NF-kappaB activation. Surprisingly, we found that PMA-induced immediately early gene c-fos expression is suppressed in IKKalpha-/-, IKKbeta-/-, IKKgamma-/- and p65-/- MEF, suggesting the involvement of NF-kappaB in c-fos gene transcription. Furthermore, we indentified a previously uncharacterized NF-kappaB binding site located in the mouse c-fos promoter. Under PMA stimulation, p65 homodimer in association with CBP/p300 is capable of binding to this site, and this action is independent of TCF-SRF-SRE ternary complex regulation. In summary, this study provides different views of IKK phosphorylation mechanism. Importantly, the requirement of IKK complex in PMA-induced c-fos expression and the NF-kappaB binding site found in c-fos promoter shed light on the crosstalk between NF-kappaB and AP-1 transcription factors. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-08T07:12:31Z (GMT). No. of bitstreams: 1 ntu-100-R98443005-1.pdf: 5341539 bytes, checksum: e712eef44814a4068d90a06483c04374 (MD5) Previous issue date: 2011 | en |
| dc.description.tableofcontents | Abbreviations.…………………………………………………………I
Abstract…………………………………………………………………VI 中文摘要…………………………………………………………………IV Introduction……………………………………………………………1 Materials and Methods………………………………………………23 Results…………………………………………………………………35 Discussion……………………………………………………………51 Figures…………………………………………………………………65 Appendix………………………………………………………………90 References……………………………………………………………105 | |
| dc.language.iso | en | |
| dc.subject | 啟動子 | zh_TW |
| dc.subject | 磷酸化 | zh_TW |
| dc.subject | 絲胺酸 | zh_TW |
| dc.subject | 轉錄因子 | zh_TW |
| dc.subject | NF-kappaB | en |
| dc.subject | c-fos | en |
| dc.subject | PMA | en |
| dc.subject | IKK | en |
| dc.title | 探討IKK調控PMA誘導c-fos基因表現之機轉 | zh_TW |
| dc.title | Study on the IKK-dependent regulation of PMA-induced c-fos gene expression | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 99-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 符文美(Wen-Mei Fu),蘇銘嘉(Ming-Jai Su),徐立中(Li-Chung Hsu),曾炳輝(Ping-Hui Tseng) | |
| dc.subject.keyword | 轉錄因子,磷酸化,啟動子,絲胺酸, | zh_TW |
| dc.subject.keyword | IKK,NF-kappaB,PMA,c-fos, | en |
| dc.relation.page | 128 | |
| dc.rights.note | 未授權 | |
| dc.date.accepted | 2011-08-11 | |
| dc.contributor.author-college | 醫學院 | zh_TW |
| dc.contributor.author-dept | 藥理學研究所 | zh_TW |
| Appears in Collections: | 藥理學科所 | |
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| ntu-100-1.pdf Restricted Access | 5.22 MB | Adobe PDF |
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