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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
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dc.contributor.advisor | 陳秀男 | |
dc.contributor.author | Shih-Ya Wen | en |
dc.contributor.author | 文詩雅 | zh_TW |
dc.date.accessioned | 2021-06-08T07:11:41Z | - |
dc.date.copyright | 2008-08-06 | |
dc.date.issued | 2008 | |
dc.date.submitted | 2008-07-31 | |
dc.identifier.citation | 水野卓、川合正允原著,賴慶亮譯,1997。菇類的化學•生化學。國立編譯館。
林欣穎,2002。裂褶多醣體的濃度分析及其對小白鼠之抗氧化活性測試。國立台灣大學動物學研究所碩士論文。 吳政翰,2004。β-葡萄多聚醣對小白鼠吞噬細胞之吞噬作用和細胞素的影響。國立台灣大學動物學研究所碩士論文。 吳銘鴻,2006。菇蕈高分子多醣體對小鼠的免疫反應及移殖腫瘤細胞之影響。國立台灣大學漁業科學研究所碩士論文。 陳豪勇,1995。癌症免疫療法的新方向-生物反應修飾物質 ( BRM )。健康世界 124(244):55-59。 賀駿業,2003。靈芝多醣體最佳培養條件及對小白鼠之免疫反應研究。國立台灣大學動物學研究所碩士論文。 潘子明,2003。機能性發酵製品-低聚醣與真菌多醣。生技產業 Bioindustry Vol. 14 No. 2. http://www.doh.gov.tw/statistic/data/衛生統計叢書2/95/上冊/表1.xls Akira S, Takeda K, Kaisho T (2001) Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol 2:675 Borchers AT, Stern JS, Hackman RM, Keen CL, Gershwin EM (1999) Mushrooms, tumors, and immunity. Soc Exp Biol Med 221:281-293 Brandau S (2001) Activation of Natural Killer Cells by Bacillus Calmette-Guerin. Eur Urol 39:518-524 Brown GD, Gordon S (2003) Fungal beta-glucans and mammalian immunity. Immunity 19: 311-315 Burnet FM (1957) Cancer- a biological approach. BMJ 1:841–847 Cambell (1999) Biology 4th ed. Pearson Education, Inc. New York Chang ST, Miles PG (1992) Mushroom biology- a new discipline. Mycologist 6:64-65 Chang ST (1999) Global impact of edible and medicinal mushrooms on human welfare in the 21st century: nongreen revolution. Int J Med Mushrooms 1:1-8 Czop JK, Austen KF (1985) Properties of glycans that activate the human alternate complement pathway and interact with human monocytes beta glucan receptors. J Immunol 135: 3388-3393 Di Luzio NR, Williams DL, Mcnamee RB, Edwards BF, Kitahama A (1979) Comparative tumor-in Hibitory and anti-bacterial activity of soluble and particular glucan. Int J Cancer 24: 773-779 Ehrlich KC, Cotty PJ (2002) Variability in nitrogen regulation of aflatoxin production by Aspergillus flavus strains. Appl Microbiol Biotechnol 60:174-178 Foxwell BM, Willcocks JL, Taylor DA, Kulig K, Ryffel B, Londei M (1993) Inhibition of activation induced change in the structure of the T cell interleukin-7 receptor by cyclosporine A and FK 506. Eur J Immunol 23:85-89 Hobbs C (1995) Medicinal mushrooms: an exploration of tradition, healthing and culture. Botanica Press, Santa Cruz, Calif, U.S.A. Hofer M, Pospisil M (1997) Glucan as stimulator of hematopoiesis in normal and gamma-irradiated mice. A survey of the authors’ results. Int J Immunopharmacol 19: 607-609 Ikekawa T (2001) Beneficial effects of edible and medicinal mushrooms in health care. Int J Med Mushrooms 3:291-298 Kaneno R, Fontanari LM, Santos SA, Di Stasi LC, Rodrigues F, Eira AF (2004) Effects of extracts from Brazilian sun-mushroom (Agaricus blazei ) on the NK activity and lymphoproliferative responsivened of Ehrlich tumor-bearing mice. Food Chem Toxicol 42: 909-916 Kiessling R, Klein E, Migzell H (1975a) Natural killer cells in the mouse 1, cytotoxic cells with specificity for mouse moloney leukemia cells. Specificity and distribution according to genotype. Eur J Immunol 5:112-117 Kiessling R, Klein E, Pross H, Migzell H (1975b) Natural killer cells in the mouse 2, cytotoxic cells with specificity for mouse moloney leukemia cells. Characteristic of the Killer Cell. Eur J Immunol 5:117-121 Kiho T, Yoshida I, Katsuragawa M, Sakushima M, Usui S, Ukai S (1994) polysaccharides in fungi : A polysaccharide from the fruiting bodies of Amanita muscaria and the antitumor activity of its carboxymethylated product. Biol Pharm Bull 17:1460-1462 Kimbrell DA, Beutler B (2001) The evolution and genetics of innate immuniity. Nature Rev Genet 2:256 Kuby J (2000) Immunology. 4th ed. W. H. Freeman Co., New York, U.S.A. Leaf C (2004) Why we’re losing the war on cancer (and how to win it). Fortune 149:84–86 Liu JJ, Huang TS, Hsu ML, Chen CC, Lin WS, Lu FJ, Chang Wh (2004) Antitumor effects of the partially purified polysaccharides from Antrodia camphorate and the mechanicsm of its action. Toxicol Appl Pharmacol 201: 186-193 Lorenzen K, Anke T (1998) Basidiomycetes as a source for new bioactive natural products. Curr Org Chem 2:329-364 Lotzova E, Gutterman JU (1979) Effect on natural killer (NK) cells: further comparison between NK cell and bone marrow effector cell activities. J Immunol 123: 607-611 Maruyama H, Yamazaki K, Murofushi S, Konda C, Ikekawa T (1989) Antitumor activity of Sarcodon aspratus and Ganoderma licidum Karst. J Pharmacobio-Dyn 12: 118-123 Matko C, Sten F, George K (1973) Progressive loss of H-2 antigens with concomitant increase of cellsurface antigens determined by molony leukemia virus in cultured murine lymphomas. J Natl Cancer Inst 50:347-362 Mitchell MS (1988) Combining chemotherapy with biological response modifiers in treatment of cancer. J Natl Cancer Inst 80:1445-1450 Mizuno T (1996) Development of antitumor polysaccharides from mushroom fungi. Foods Food Ingred J Jpn 167:69-85 Mizuno T (1999a) The extraction and development of antitumor-active polysaccharides from medicinal mushrooms in Japan. Int J Med Mushrooms 1:9-29 Mizuno T (1999b) Bioactive substances in Hericium erinaceus Pers., and its medicinal utilization. Int J Med Mushrooms 1:105-119 Mizuno T (2002) Medicinal properties and clinical effects on Agaricus blazei Murr. Int J Med Mushrooms 4:10-25 Ooi VEC, Liu F (1999) A review of pharmacyological activities of mushroom polysaccharides. Int J Med Mushroom 1: 195-206 Reshetnikov SV, Wasser SP, Tan KK (2001) Higher basidiomycota as a source of antitumor and immunostimulating polysaccharides. Int J Med Mushrooms 3:361-394 Rice PJ, Adams EL, Ozment-Skelton T, Gonzalez AJ, Goldman MP, Lockhart BE, Barker LA, Breuel KF, DePonti WK, Kalbfleisch JH, Ensley HE, Brown GD, Gordon S, Williams DL (2005) Oral delivery and gastrointestinal absorption of soluble glucans stimulate increased resistance to infectious challenge. J Pharmacol Exp Ther 314: 1079-1086 Roitt IM, Brostoff A, Male KT (1992) Immunology. Pearson Education, Inc. New York, U.S.A. Ross GD, Vetvicka V, Yan J, Xia Y, Vetvickova J (1999) Therapeutic intervenetion with complement and beta-glucan in cancer. Immunopharmacology 42: 61-74 Richard AG, Thomas JK, Barbara AO, Janis K (2003) Immunology 5th ed. W. H. Freeman Co., New York, U.S.A. Scodras JM, Parhar RS, Kennedy TG, Lala PK (1990) Prostaglandin-mediated inactivation of natural killer cells in the murine decideua. Cell Immunol 127: 352-367 Stamets P (2000) Growing gourmet and medicinal mushrooms 3rd ed. Ten Speed Press, Berkeley, Calif, U.S.A. Tao Y, Zhang L, Cheung CK (2006) Physicochemical properties and antitumor activities of water-soluble native and sulfated hyperbranched mushroom polysaccharides. Carbohydr Res 341: 2261-2269 Taylor PR, Brown GD, Reid DM, Willment JA, Martinez-Pamares L (2002) The beta-glucan receptor, dectin-1, is predominantly expressed on the surface of cells of the monocyte/ macrophage and neutrophil lineages. J Immunol 169:2882-3576 Tenzaki T, Ishiguro T (1989) Response of human lymphocytes to phytohemagglutinin PHA as measured by fluorescence polarization technique difference between malignant conditions and benign or healthy conditions. Journal of the Japan Society for Cancer Therapy 24:817-826 Thornton BP, Vetvicka V, Pitman M, Goldman RC, Ross GD (1996) β-Glucan-binding lectin site of complement receptor type 3 (CD11b/CD18). J Immunol 156:1235-1246 Tzianabos AO (2000) Polysaccharide immunomodulators as theurapeutic agents: structural aspects and biological function. Clin Microbiol Rev 13:523-533 Vetvicka V, Dvorak B, Vetvickova J, Richter J, Krizan J, Sima P, Yvin JC (2006) Orally administered marine (1 -> 3)-β-D-glucan Phycarine stimulates both humoral and cellular immunity. Int J Biol Macromol 40: 291-298 Wang LS, Ha CL, Cheng TL, Cheng ST, Lian TW, Wu MJ (2008) Oral administration of submerged cultivated Grifola frondosa enhances phagocytic activity in normal mice. J Pharm Pharmacol 60: 237-243 Wasser SP (2002) Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides. Appl Microbiol Biotechnol 60:258-274 Wasser SP, Weis AL (1999) Medicinal properties of substances occurring in higher basidiomycetes mushrooms: current perspectives. Int J Med Mushrooms 1:31-62 Woodhouse EC, Chuaqui RF, Liotta LA (1997) General mechanisms of Metastasis. Cancer 80:1529–37 Yoon TJ, Kim TJ, Lee H, Shin KS, Yun YP, Moon WK, Lee KH (2008) Anti-tumor metastatic activity of β-glucan purified from mutated Saccharomyces cerevisiae. Int Immunopharmacol 8: 36-42 Yoshida I, Kiho T, Ushi S, Sakushima M, Ukai S (1996) Polysaccharides in fungi. XXXVII. Immunomodulating activities of carboxymethylated derivatives of linear (1 | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/26475 | - |
dc.description.abstract | 菇蕈類多年來在傳統治療上廣泛被使用,許多食藥用菇之生物活性物質是具有抗癌作用的,目前已知具有抗癌功效之主要有效成分為多醣體。本論文將菇蕈多醣體應用在正常小鼠及擔癌小鼠上,探討菇蕈多醣體對細胞免疫及腫瘤生長之關連性。
結果顯示口服菇蕈多醣體溶液14天後,能提升正常小鼠脾臟自然殺手細胞之毒殺活性,將相同濃度之菇蕈多醣體餵食擔癌小鼠24天後,腫瘤抑制率為67.2%。但在自然殺手毒殺活性和淋巴球增生實驗中,卻並沒有顯著的變化。在多醣體濃度0.03 %到0.12 %範圍中,腫瘤抑制率以及淋巴球細胞之增生率隨著多醣體濃度上升而有提升之效果。將多醣體濃度提升至0.12 %對擔癌小鼠進行擔癌前14天提前餵食之實驗,顯示提前餵食之處理組別的腫瘤抑制率最高,並且也提高了淋巴球細胞的增生倍率。 綜合以上各種結果我們可以發現,菇蕈多醣體可提升小鼠自然殺手細胞之活性,而在擔癌小鼠的應用上,可藉由調高多醣體濃度以及提前餵食多醣體來達到更明顯的抗腫瘤以及提昇免疫反應之功效。 | zh_TW |
dc.description.abstract | Mushroom has a long history of use in folk medicine. It has been report that mushroom contains various biologically active compounds, especially, such as beta-glucan. In the present study, C57BL/6 mice were orally administered mushroom beta-glucan, and antitumor immunity was examined.
The result revealed higher level of NK cell-mediated cytotoxicity after treating with beta-glucan for 14 days in tumor-unbearing mice. The inhibition of tumor growth in Lewis lung carcinoma (LLC)-bearing mice treated with beta-glucan has been observed. Oral administration of mushroom beta-glucan in different concentrations significantly reduced the tumor weight in a dose-dependent manner, with an inhibition more than 70%. It also shows the treatment of the highest concentration of glucan elevated the cytotoxicity of natural killer cell and the mitogen-induced lymphoproliferative activity of spleen cells. In pre- and simultaneous treatment, the inhibition of tumor growth are higher than control group. After pre-treatment of glucan, the proliferation of lymphocytes is significantly increased. In conclusion, the beta-glucan derived from the mushroom could be used as immunomodulator and anti tumor agent in mice. | en |
dc.description.provenance | Made available in DSpace on 2021-06-08T07:11:41Z (GMT). No. of bitstreams: 1 ntu-97-R95b45007-1.pdf: 746497 bytes, checksum: b48d7c641cfc82fbeebd9f346716edf9 (MD5) Previous issue date: 2008 | en |
dc.description.tableofcontents | 目錄
誌謝----------------------------------------------------i 中文摘要-----------------------------------------------ii 英文摘要----------------------------------------------iii 第一章 前言 第一節 文獻整理---------------------------------------1 第二節 實驗動機--------------------------------------22 第二章 實驗材料---------------------------------------23 第三章 實驗方法---------------------------------------25 第四章 結果-------------------------------------------35 第五章 討論-------------------------------------------43 參考文獻-----------------------------------------------51 結果圖表-----------------------------------------------58 | |
dc.language.iso | zh-TW | |
dc.title | 菇蕈多醣體之細胞免疫提升作用之研究 | zh_TW |
dc.title | Studies on the Enhancement of Cellular Immunity Using Mushroom β- Glucan | en |
dc.type | Thesis | |
dc.date.schoolyear | 96-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 冉繁華,王俊順,劉秉忠 | |
dc.subject.keyword | 菇蕈,多醣體,自然殺手細胞,腫瘤,細胞免疫, | zh_TW |
dc.subject.keyword | glucan,NK,tumor,immunity,mushroom, | en |
dc.relation.page | 69 | |
dc.rights.note | 未授權 | |
dc.date.accepted | 2008-07-31 | |
dc.contributor.author-college | 生命科學院 | zh_TW |
dc.contributor.author-dept | 漁業科學研究所 | zh_TW |
顯示於系所單位: | 漁業科學研究所 |
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