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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 丁詩同 | |
dc.contributor.author | Chen-Chen Tai | en |
dc.contributor.author | 戴甄真 | zh_TW |
dc.date.accessioned | 2021-06-08T07:00:14Z | - |
dc.date.copyright | 2009-06-23 | |
dc.date.issued | 2009 | |
dc.date.submitted | 2009-06-15 | |
dc.identifier.citation | Abbas, A. K. 2007. Cellular and molecular immunology. Saunders Elsevier, Philadelphia :.
Akashi, S. et al. 2000. Cutting edge: Cell surface expression and lipopolysaccharide signaling via the toll-like receptor 4-md-2 complex on mouse peritoneal macrophages. J. Immunol. 164: 3471-3475. Al-Khalili, L. et al. 2006. Signaling specificity of interleukin-6 action on glucose and lipid metabolism in skeletal muscle. Mol. Endocrinol. 20: 3364-3375. Andersen, G., K. Harnack, H. F. Erbersdobler, and V. Somoza. 2008. Dietary eicosapentaenoic acid and docosahexaenoic acid are more effective than alpha-linolenic acid in improving insulin sensitivity in rats. Ann. Nutr. Metab. 52: 250-256. Anthonsen, M. W., L. Ronnstrand, C. Wernstedt, E. Degerman, and C. Holm. 1998. Identification of novel phosphorylation sites in hormone-sensitive lipase that are phosphorylated in response to isoproterenol and govern activation properties in vitro. J. Biol. Chem. 273: 215-221. Baeuerle, P. A., and T. Henkel. 1994. Function and activation of nf-kappa b in the immune system. Annu. Rev. Immunol. 12: 141-179. Baltzell, J. K., J. T. Wooten, and D. A. Otto. 1991. Lipoprotein lipase in rats fed fish oil: Apparent relationship to plasma insulin levels. Lipids 26: 289-294. Barber, M. D., K. C. Fearon, and J. A. Ross. 2005. Eicosapentaenoic acid modulates the immune response but has no effect on a mimic of antigen-specific responses. Nutrition 21: 588-593. Bastard, J. P. et al. 2000. Elevated levels of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss. J. Clin. Endocrinol. Metab. 85: 3338-3342. Bastard, J. P. et al. 2002. Adipose tissue il-6 content correlates with resistance to insulin activation of glucose uptake both in vivo and in vitro. J. Clin. Endocrinol. Metab. 87: 2084-2089. Betts, J. C., J. K. Cheshire, S. Akira, T. Kishimoto, and P. Woo. 1993. The role of nf-kappa b and nf-il6 transactivating factors in the synergistic activation of human serum amyloid a gene expression by interleukin-1 and interleukin-6. J. Biol. Chem. 268: 25624-25631. Botolin, D., Y. Wang, B. Christian, and D. B. Jump. 2006. Docosahexaneoic acid (22 : 6, n-3) regulates rat hepatocyte srebp-1 nuclear abundance by erk- and 26s proteasome-dependent pathways. Journal of Lipid Research 47: 181-192. Bousserouel, S., A. Brouillet, G. Bereziat, M. Raymondjean, and M. Andreani. 2003. Different effects of n-6 and n-3 polyunsaturated fatty acids on the activation of rat smooth muscle cells by interleukin-1 beta. J. Lipid Res. 44: 601-611. Bradley, R. L., F. F. Fisher, and E. Maratos-Flier. 2008. Dietary fatty acids differentially regulate production of tnf-alpha and il-10 by murine 3t3-l1 adipocytes. Obesity (Silver Spring) 16: 938-944. Brown, E. R., and P. V. Subbaiah. 1994. Differential effects of eicosapentaenoic acid and docosahexaenoic acid on human skin fibroblasts. Lipids 29: 825-829. Carey, A. L. et al. 2006. Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via amp-activated protein kinase. Diabetes 55: 2688-2697. Carmen, G. Y., and S. M. Victor. 2006. Signalling mechanisms regulating lipolysis. Cell Signal 18: 401-408. Caughey, G. E., E. Mantzioris, R. A. Gibson, L. G. Cleland, and M. J. James. 1996. The effect on human tumor necrosis factor alpha and interleukin 1 beta production of diets enriched in n-3 fatty acids from vegetable oil or fish oil. Am. J. Clin. Nutr. 63: 116-122. Cawthorn, W. P., F. Heyd, K. Hegyi, and J. K. Sethi. 2007. Tumour necrosis factor-alpha inhibits adipogenesis via a beta-catenin/tcf4(tcf7l2)-dependent pathway. Cell Death Differ. 14: 1361-1373. Chang, H. R. et al. 1992. Dietary supplementation with fish oil enhances in vivo synthesis of tumor necrosis factor. Immunol. Lett. 34: 13-17. Chang, H. R., D. Arsenijevic, I. R. Vladoianu, L. Girardier, and A. G. Dulloo. 1995. Fish oil enhances macrophage tumor necrosis factor-alpha mrna expression at the transcriptional level. Metabolism 44: 800-805. Chang, W. C., C. H. Chen, W. T. K. Cheng, and S. T. Ding. 2007. The effect of dietary docosahexaenoic acid enrichment on the expression of porcine hepatic genes. Asian-Australasian Journal of Animal Sciences 20: 768-774. Chen, C. H. et al. 2008. Serum amyloid a protein regulates the expression of porcine genes related to lipid metabolism. J. Nutr. 138: 674-679. Chinery, R., J. A. Brockman, D. T. Dransfield, and R. J. Coffey. 1997. Antioxidant-induced nuclear translocation of ccaat/enhancer-binding protein beta. A critical role for protein kinase a-mediated phosphorylation of ser299. J. Biol. Chem. 272: 30356-30361. Clarke, S. D. 2000. Polyunsaturated fatty acid regulation of gene transcription: A mechanism to improve energy balance and insulin resistance. Br. J. Nutr. 83 Suppl 1: S59-66. Cornelius, P., S. Enerback, G. Bjursell, T. Olivecrona, and P. H. Pekala. 1988. Regulation of lipoprotein lipase mrna content in 3t3-l1 cells by tumour necrosis factor. Biochem. J. 249: 765-769. Delerive, P. et al. 1999. Peroxisome proliferator-activated receptor alpha negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors nf-kappab and ap-1. J. Biol. Chem. 274: 32048-32054. Ding, S. T., R. L. McNeel, and H. J. Mersmann. 2002. Modulation of adipocyte determination and differentiation-dependent factor 1 by selected polyunsaturated fatty acids. In Vitro Cell Dev. Biol. Anim. 38: 352-357. Dubois, M., M. Picq, G. Nemoz, M. Lagarde, and A. F. Prigent. 1993. Inhibition of the different phosphodiesterase isoforms of rat heart cytosol by free fatty acids. J. Cardiovasc. Pharmacol. 21: 522-529. Ferrucci, L. et al. 2006. Relationship of plasma polyunsaturated fatty acids to circulating inflammatory markers. J. Clin. Endocrinol. Metab. 91: 439-446. Fon Tacer, K., D. Kuzman, M. Seliskar, D. Pompon, and D. Rozman. 2007. Tnf-alpha interferes with lipid homeostasis and activates acute and proatherogenic processes. Physiol. Genomics 31: 216-227. Fried, S. K., D. A. Bunkin, and A. S. Greenberg. 1998. Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: Depot difference and regulation by glucocorticoid. J. Clin. Endocrinol. Metab. 83: 847-850. Frost, R. A., G. J. Nystrom, and C. H. Lang. 2002. Lipopolysaccharide regulates proinflammatory cytokine expression in mouse myoblasts and skeletal muscle. Am. J Physiol. Regul. Integr. Comp. Physiol. 283: R698-709. Gani, O. A., and I. Sylte. 2008. Molecular recognition of docosahexaenoic acid by peroxisome proliferator-activated receptors and retinoid-x receptor alpha. J. Mol. Graph Model 27: 217-224. Gomez-Ambrosi, J., C. Azcona, A. Patino-Garcia, and G. Fruhbeck. 2008. Serum amyloid a concentration is increased in obese children and adolescents. J. Pediatr. 153: 71-75. Gomez-Ambrosi, J. et al. 2006. Increased serum amyloid a concentrations in morbid obesity decrease after gastric bypass. Obes. Surg. 16: 262-269. Gonzalez, G. A., and M. R. Montminy. 1989. Cyclic amp stimulates somatostatin gene transcription by phosphorylation of creb at serine 133. Cell 59: 675-680. Greenberg, A. S. et al. 1991. Perilipin, a major hormonally regulated adipocyte-specific phosphoprotein associated with the periphery of lipid storage droplets. J. Biol. Chem. 266: 11341-11346. Greenberg, A. S. et al. 1992. Interleukin 6 reduces lipoprotein lipase activity in adipose tissue of mice in vivo and in 3t3-l1 adipocytes: A possible role for interleukin 6 in cancer cachexia. Cancer Res. 52: 4113-4116. Griffin, M. E. et al. 1999. Free fatty acid-induced insulin resistance is associated with activation of protein kinase c theta and alterations in the insulin signaling cascade. Diabetes 48: 1270-1274. Grimble, R. F. et al. 2002. The ability of fish oil to suppress tumor necrosis factor alpha production by peripheral blood mononuclear cells in healthy men is associated with polymorphisms in genes that influence tumor necrosis factor alpha production. Am. J. Clin. Nutr. 76: 454-459. Guo, W., W. Xie, T. Lei, and J. A. Hamilton. 2005. Eicosapentaenoic acid, but not oleic acid, stimulates beta-oxidation in adipocytes. Lipids 40: 815-821. Hardardottir, I., and J. E. Kinsella. 1991. Tumor necrosis factor production by murine resident peritoneal macrophages is enhanced by dietary n-3 polyunsaturated fatty acids. Biochim. Biophys. Acta. 1095: 187-195. Hardardottir, I., and J. E. Kinsella. 1992. Increasing the dietary (n-3) to (n-6) polyunsaturated fatty acid ratio increases tumor necrosis factor production by murine resident peritoneal macrophages without an effect on elicited peritoneal macrophages. J. Nutr. 122: 1942-1951. Hershko, D. D., B. W. Robb, G. Luo, and P. O. Hasselgren. 2002. Multiple transcription factors regulating the il-6 gene are activated by camp in cultured caco-2 cells. Am. J. Physiol. Regul. Integr. Comp. Physiol. 283: R1140-1148. Hotamisligil, G. S., P. Arner, J. F. Caro, R. L. Atkinson, and B. M. Spiegelman. 1995. Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J. Clin. Invest. 95: 2409-2415. Hotamisligil, G. S., N. S. Shargill, and B. M. Spiegelman. 1993. Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance. Science 259: 87-91. Hsu, J. M., and S. T. Ding. 2003. Effect of polyunsaturated fatty acids on the expression of transcription factor adipocyte determination and differentiation-dependent factor 1 and of lipogenic and fatty acid oxidation enzymes in porcine differentiating adipocytes. Br. J. Nutr. 90: 507-513. Huang, Y. J. et al. 1997. Amelioration of insulin resistance and hypertension in a fructose-fed rat model with fish oil supplementation. Metabolism 46: 1252-1258. Ide, T. et al. 2000. Comparative effects of perilla and fish oils on the activity and gene expression of fatty acid oxidation enzymes in rat liver. Biochim. Biophys. Acta. 1485: 23-35. Jellema, A., J. Plat, and R. P. Mensink. 2004. Weight reduction, but not a moderate intake of fish oil, lowers concentrations of inflammatory markers and pai-1 antigen in obese men during the fasting and postprandial state. Eur. J. Clin. Invest. 34: 766-773. Jijon, H. B., K. L. Madsen, J. W. Walker, B. Allard, and C. Jobin. 2005. Serum amyloid a activates nf-kappab and proinflammatory gene expression in human and murine intestinal epithelial cells. Eur. J. Immunol. 35: 718-726. Kelley, D. S. et al. 1999. Docosahexaenoic acid ingestion inhibits natural killer cell activity and production of inflammatory mediators in young healthy men. Lipids 34: 317-324. Kim, H. J., M. Takahashi, and O. Ezaki. 1999. Fish oil feeding decreases mature sterol regulatory element-binding protein 1 (srebp-1) by down-regulation of srebp-1c mrna in mouse liver. A possible mechanism for down-regulation of lipogenic enzyme mrnas. J. Biol. Chem. 274: 25892-25898. Kim, H. K., M. Della-Fera, J. Lin, and C. A. Baile. 2006. Docosahexaenoic acid inhibits adipocyte differentiation and induces apoptosis in 3t3-l1 preadipocytes. J. Nutr. 136: 2965-2969. Koga, T. et al. 2008. Serum amyloid a-induced il-6 production by rheumatoid synoviocytes. FEBS Lett. 582: 579-585. Komatsu, W., K. Ishihara, M. Murata, H. Saito, and K. Shinohara. 2003. Docosahexaenoic acid suppresses nitric oxide production and inducible nitric oxide synthase expression in interferon-gamma plus lipopolysaccharide-stimulated murine macrophages by inhibiting the oxidative stress. Free Radic. Biol. Med. 34: 1006-1016. Kraemer, F. B., and W. J. Shen. 2002. Hormone-sensitive lipase: Control of intracellular tri-(di-)acylglycerol and cholesteryl ester hydrolysis. J. Lipid Res. 43: 1585-1594. Kubota, N. et al. 2002. Disruption of adiponectin causes insulin resistance and neointimal formation. J. Biol. Chem. 277: 25863-25866. Kunesova, M. et al. 2006. The influence of n-3 polyunsaturated fatty acids and very low calorie diet during a short-term weight reducing regimen on weight loss and serum fatty acid composition in severely obese women. Physiol. Res. 55: 63-72. Laurencikiene, J. et al. 2007. Nf-kappab is important for tnf-alpha-induced lipolysis in human adipocytes. J. Lipid Res. 48: 1069-1077. Le Meur, Y. et al. 1999. Whole blood production of monocytic cytokines (il-1beta, il-6, tnf-alpha, sil-6r, il-1ra) in haemodialysed patients. Nephrol. Dial Transplant 14: 2420-2426. Lee, J. Y. et al. 2004. Saturated fatty acid activates but polyunsaturated fatty acid inhibits toll-like receptor 2 dimerized with toll-like receptor 6 or 1. J. Biol. Chem. 279: 16971-16979. Leinonen, E. et al. 2003. Insulin resistance and adiposity correlate with acute-phase reaction and soluble cell adhesion molecules in type 2 diabetes. Atherosclerosis 166: 387-394. Li, H. et al. 2005. Epa and dha reduce lps-induced inflammation responses in hk-2 cells: Evidence for a ppar-gamma-dependent mechanism. Kidney Int. 67: 867-874. Liu, B. H., C. F. Kuo, Y. C. Wang, and S. T. Ding. 2005. Effect of docosahexaenoic acid and arachidonic acid on the expression of adipocyte determination and differentiation-dependent factor 1 in differentiating porcine adipocytes. J. Anim. Sci. 83: 1516-1525. Lokesh, B. R., T. J. Sayers, and J. E. Kinsella. 1990. Interleukin-1 and tumor necrosis factor synthesis by mouse peritoneal macrophages is enhanced by dietary n-3 polyunsaturated fatty acids. Immunol. Lett. 23: 281-285. Lopez-Garcia, E. et al. 2004. Consumption of (n-3) fatty acids is related to plasma biomarkers of inflammation and endothelial activation in women. J. Nutr. 134: 1806-1811. Lowell, C. A., R. S. Stearman, and J. F. Morrow. 1986. Transcriptional regulation of serum amyloid a gene expression. J. Biol. Chem. 261: 8453-8461. Lu, M., and J. Y. Shyy. 2006. Sterol regulatory element-binding protein 1 is negatively modulated by pka phosphorylation. Am. J. Physiol. Cell Physiol. 290: C1477-1486. Luo, J. et al. 1998. Moderate intake of n-3 fatty acids for 2 months has no detrimental effect on glucose metabolism and could ameliorate the lipid profile in type 2 diabetic men. Results of a controlled study. Diabetes Care 21: 717-724. Madsen, T. et al. 2001. C-reactive protein, dietary n-3 fatty acids, and the extent of coronary artery disease. Am. J. Cardiol. 88: 1139-1142. Maeda, N. et al. 2002. Diet-induced insulin resistance in mice lacking adiponectin/acrp30. Nat. Med. 8: 731-737. Markovic, O. et al. 2004. Role of single nucleotide polymorphisms of pro-inflammatory cytokine genes in the relationship between serum lipids and inflammatory parameters, and the lipid-lowering effect of fish oil in healthy males. Clin. Nutr. 23: 1084-1095. Martinez-Botas, J. et al. 2000. Absence of perilipin results in leanness and reverses obesity in lepr(db/db) mice. Nat. Genet. 26: 474-479. Metz, R., and E. Ziff. 1991. Camp stimulates the c/ebp-related transcription factor rnfil-6 to trans-locate to the nucleus and induce c-fos transcription. Genes Dev. 5: 1754-1766. Mies, F., V. Shlyonsky, A. Goolaerts, and S. Sariban-Sohraby. 2004. Modulation of epithelial na+ channel activity by long-chain n-3 fatty acids. Am. J. Physiol. Renal Physiol. 287: F850-855. Mishra, A., A. Chaudhary, and S. Sethi. 2004. Oxidized omega-3 fatty acids inhibit nf-kappab activation via a pparalpha-dependent pathway. Arterioscler. Thromb. Vasc. Biol. 24: 1621-1627. Miyoshi, H. et al. 2006. Perilipin promotes hormone-sensitive lipase-mediated adipocyte lipolysis via phosphorylation-dependent and -independent mechanisms. J. Biol. Chem. 281: 15837-15844. Mori, T. A. et al. 2003. Effect of eicosapentaenoic acid and docosahexaenoic acid on oxidative stress and inflammatory markers in treated-hypertensive type 2 diabetic subjects. Free Radic. Biol. Med. 35: 772-781. Morrow, J. F., R. S. Stearman, C. G. Peltzman, and D. A. Potter. 1981. Induction of hepatic synthesis of serum amyloid a protein and actin. Proc. Natl. Acad. Sci. U S A 78: 4718-4722. Musiek, E. S. et al. 2008. Electrophilic cyclopentenone neuroprostanes are anti-inflammatory mediators formed from the peroxidation of the omega-3 polyunsaturated fatty acid docosahexaenoic acid. J. Biol. Chem. 283: 19927-19935. Nakatani, T., H. J. Kim, Y. Kaburagi, K. Yasuda, and O. Ezaki. 2003. A low fish oil inhibits srebp-1 proteolytic cascade, while a high-fish-oil feeding decreases srebp-1 mrna in mice liver: Relationship to anti-obesity. J. Lipid Res. 44: 369-379. Neschen, S. et al. 2002. Contrasting effects of fish oil and safflower oil on hepatic peroxisomal and tissue lipid content. Am. J. Physiol. Endocrinol. Metab. 282: E395-401. Neschen, S. et al. 2007. N-3 fatty acids preserve insulin sensitivity in vivo in a peroxisome proliferator-activated receptor-alpha-dependent manner. Diabetes 56: 1034-1041. Niehof, M., M. P. Manns, and C. Trautwein. 1997. Creb controls lap/c/ebp beta transcription. Mol. Cell. Biol. 17: 3600-3613. Okamoto, H., Y. Katagiri, A. Kiire, S. Momohara, and N. Kamatani. 2008. Serum amyloid a activates nuclear factor-kappab in rheumatoid synovial fibroblasts through binding to receptor of advanced glycation end-products. J. Rheumatol. 35: 752-756. Osada, S., H. Yamamoto, T. Nishihara, and M. Imagawa. 1996. DNA binding specificity of the ccaat/enhancer-binding protein transcription factor family. J. Biol. Chem. 271: 3891-3896. Panagiotakos, D. B., C. Pitsavos, M. Yannakoulia, C. Chrysohoou, and C. Stefanadis. 2005. The implication of obesity and central fat on markers of chronic inflammation: The attica study. Atherosclerosis 183: 308-315. Perez-Matute, P., N. Perez-Echarri, J. A. Martinez, A. Marti, and M. J. Moreno-Aliaga. 2007. Eicosapentaenoic acid actions on adiposity and insulin resistance in control and high-fat-fed rats: Role of apoptosis, adiponectin and tumour necrosis factor-alpha. Br. J. Nutr. 97: 389-398. Petruschke, T., and H. Hauner. 1993. Tumor necrosis factor-alpha prevents the differentiation of human adipocyte precursor cells and causes delipidation of newly developed fat cells. J. Clin. Endocrinol. Metab. 76: 742-747. Petursdottir, D. H., and I. Hardardottir. 2007. Dietary fish oil increases the number of splenic macrophages secreting tnf-alpha and il-10 but decreases the secretion of these cytokines by splenic t cells from mice. J. Nutr. 137: 665-670. Petursdottir, D. H., I. Olafsdottir, and I. Hardardottir. 2002. Dietary fish oil increases tumor necrosis factor secretion but decreases interleukin-10 secretion by murine peritoneal macrophages. J. Nutr. 132: 3740-3743. Pfaffl, M. W. 2001. A new mathematical model for relative quantification in real-time rt-pcr. Nucleic Acids Res. 29: e45. Picq, M., M. Dubois, A. Grynberg, M. Lagarde, and A. F. Prigent. 1996. Specific effects of n-3 fatty acids and 8-bromo-cgmp on the cyclic nucleotide phosphodiesterase activity in neonatal rat cardiac myocytes. J. Mol. Cell Cardiol. 28: 2151-2161. Prabhakar, U. et al. 2005. Correlation of protein and gene expression profiles of inflammatory proteins after endotoxin challenge in human subjects. DNA Cell Biol. 24: 410-431. Prins, J. B. et al. 1998. Tumor necrosis factor-alpha induces apoptosis of human adipose cells (vol 46, pg 1939, 1997). Diabetes 47: 1978-1978. Pupe, A. et al. 2002. Eicosapentaenoic acid, a n-3 polyunsaturated fatty acid differentially modulates tnf-alpha, il-1alpha, il-6 and pge2 expression in uvb-irradiated human keratinocytes. J. Invest. Dermatol. 118: 692-698. Rahn Landstrom, T., J. Mei, M. Karlsson, V. Manganiello, and E. Degerman. 2000. Down-regulation of cyclic-nucleotide phosphodiesterase 3b in 3t3-l1 adipocytes induced by tumour necrosis factor alpha and camp. Biochem. J 346 Pt 2: 337-343. Ramel, A. et al. 2008. Beneficial effects of long-chain n-3 fatty acids included in an energy-restricted diet on insulin resistance in overweight and obese european young adults. Diabetologia 51: 1261-1268. Ray, A., D. Kumar, and B. K. Ray. 2002. Promoter-binding activity of inflammation-responsive transcription factor saf is regulated by cyclic amp signaling pathway. DNA Cell Biol. 21: 31-40. Ray, A. et al. 2003. Protein kinase a signaling pathway regulates transcriptional activity of saf-1 by unmasking its DNA-binding domains. J. Biol. Chem. 278: 22586-22595. Rees, D. et al. 2006. Dose-related effects of eicosapentaenoic acid on innate immune function in healthy humans: A comparison of young and older men. Am. J. Clin. Nutr. 83: 331-342. Rossi, A. S. et al. 2005. Dietary fish oil positively regulates plasma leptin and adiponectin levels in sucrose-fed, insulin-resistant rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 289: R486-R494. Ruzickova, J. et al. 2004. Omega-3 pufa of marine origin limit diet-induced obesity in mice by reducing cellularity of adipose tissue. Lipids 39: 1177-1185. Ryden, M. et al. 2004. Targets for tnf-alpha-induced lipolysis in human adipocytes. Biochem. Biophys. Res. Commun. 318: 168-175. Schley, P. D., H. B. Jijon, L. E. Robinson, and C. J. Field. 2005. Mechanisms of omega-3 fatty acid-induced growth inhibition in mda-mb-231 human breast cancer cells. Breast Cancer Res. Treat. 92: 187-195. Schmocker, C. et al. 2007. Omega-3 fatty acids alleviate chemically induced acute hepatitis by suppression of cytokines. Hepatology 45: 864-869. Sewter, C. P., J. E. Digby, F. Blows, J. Prins, and S. O'Rahilly. 1999. Regulation of tumour necrosis factor-alpha release from human adipose tissue in vitro. J. Endocrinol. 163: 33-38. Shahbakhti, H. et al. 2004. Influence of eicosapentaenoic acid, an omega-3 fatty acid, on ultraviolet-b generation of prostaglandin-e2 and proinflammatory cytokines interleukin-1 beta, tumor necrosis factor-alpha, interleukin-6 and interleukin-8 in human skin in vivo. Photochem. Photobiol. 80: 231-235. Shi, H. et al. 2006. Tlr4 links innate immunity and fatty acid-induced insulin resistance. J. Clin. Invest. 116: 3015-3025. Sipe, J. D., S. N. Vogel, J. L. Ryan, K. P. McAdam, and D. L. Rosenstreich. 1979. Detection of a mediator derived from endotoxin-stimulated macrohpages that induces the acute phase serum amyloid a response in mice. J. Exp. Med. 150: 597-606. Sjoholm, K. et al. 2005. A microarray search for genes predominantly expressed in human omental adipocytes: Adipose tissue as a major production site of serum amyloid a. J. Clin. Endocrinol. Metab. 90: 2233-2239. Song, M. J., K. H. Kim, J. M. Yoon, and J. B. Kim. 2006. Activation of toll-like receptor 4 is associated with insulin resistance in adipocytes. Biochem. Biophys. Res. Commun. 346: 739-745. Souza, S. C. et al. 1998. Overexpression of perilipin a and b blocks the ability of tumor necrosis factor alpha to increase lipolysis in 3t3-l1 adipocytes. J. Biol. Chem. 273: 24665-24669. Stafford, J. B., and L. J. Marnett. 2008. Prostaglandin e2 inhibits tumor necrosis factor-alpha rna through pka type i. Biochem. Biophys. Res. Commun. 366: 104-109. Suganami, T. et al. 2007a. Attenuation of obesity-induced adipose tissue inflammation in c3h/hej mice carrying a toll-like receptor 4 mutation. Biochem. Biophys. Res. Commun. 354: 45-49. Suganami, T. et al. 2007b. Role of the toll-like receptor 4/nf-kappab pathway in saturated fatty acid-induced inflammatory changes in the interaction between adipocytes and macrophages. Arterioscler. Thromb. Vasc. Biol. 27: 84-91. Szentandrassy, N., M. R. Perez-Bido, E. Alonzo, N. Negretti, and S. C. O'Neill. 2007. Protein kinase a is activated by the n-3 polyunsaturated fatty acid eicosapentaenoic acid in rat ventricular muscle. J. Physiol. 582: 349-358. Sztalryd, C. et al. 2003. Perilipin a is essential for the translocation of hormone-sensitive lipase during lipolytic activation. J Cell Biol 161: 1093-1103. Tansey, J. T. et al. 2003. Functional studies on native and mutated forms of perilipins. A role in protein kinase a-mediated lipolysis of triacylglycerols. J. Biol. Chem. 278: 8401-8406. Tansey, J. T. et al. 2001. Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity. Proc. Natl. Acad. Sci. U S A 98: 6494-6499. Tappia, P. S., W. J. Man, and R. F. Grimble. 1995. Influence of unsaturated fatty acids on the production of tumour necrosis factor and interleukin-6 by rat peritoneal macrophages. Mol. Cell. Biochem. 143: 89-98. Thorn, C. F., and A. S. Whitehead. 2002. Differential glucocorticoid enhancement of the cytokine-driven transcriptional activation of the human acute phase serum amyloid a genes, saa1 and saa2. J. Immunol. 169: 399-406. Tominaga, S., T. Yamaguchi, S. Takahashi, F. Hirose, and T. Osumi. 2005. Negative regulation of adipogenesis from human mesenchymal stem cells by jun n-terminal kinase. Biochem. Biophys. Res. Commun. 326: 499-504. Trebble, T. et al. 2003. Inhibition of tumour necrosis factor-alpha and interleukin 6 production by mononuclear cells following dietary fish-oil supplementation in healthy men and response to antioxidant co-supplementation. Br. J. Nutr. 90: 405-412. Uhlar, C. M., and A. S. Whitehead. 1999. Serum amyloid a, the major vertebrate acute-phase reactant. Eur. J. Biochem. 265: 501-523. van Hall, G. et al. 2003. Interleukin-6 stimulates lipolysis and fat oxidation in humans. J. Clin. Endocrinol. Metab. 88: 3005-3010. Vassiliou, E., H. Jing, and D. Ganea. 2003. Prostaglandin e2 inhibits tnf production in murine bone marrow-derived dendritic cells. Cell Immunol. 223: 120-132. Vega-Lopez, S. et al. 2004. Supplementation with omega3 polyunsaturated fatty acids and all-rac alpha-tocopherol alone and in combination failed to exert an anti-inflammatory effect in human volunteers. Metabolism 53: 236-240. Wallace, F. A., E. A. Miles, and P. C. Calder. 2000. Activation state alters the effect of dietary fatty acids on pro-inflammatory mediator production by murine macrophages. Cytokine 12: 1374-1379. Wang, Y., A. H. Moser, J. K. Shigenaga, C. Grunfeld, and K. R. Feingold. 2005. Downregulation of liver x receptor-alpha in mouse kidney and hk-2 proximal tubular cells by lps and cytokines. J. Lipid Res. 46: 2377-2387. Wang, Y. C. et al. 2009. Docosahexaenoic acid regulates serum amyloid a protein to promote lipolysis through down regulation of perilipin. J. Nutr. Biochem. Weldon, S. M., A. C. Mullen, C. E. Loscher, L. A. Hurley, and H. M. Roche. 2007. Docosahexaenoic acid induces an anti-inflammatory profile in lipopolysaccharide-stimulated human thp-1 macrophages more effectively than eicosapentaenoic acid. J. Nutr. Biochem. 18: 250-258. Wellen, K. E., and G. S. Hotamisligil. 2005. Inflammation, stress, and diabetes. J. Clin. Invest. 115: 1111-1119. Wright, S. D., R. A. Ramos, P. S. Tobias, R. J. Ulevitch, and J. C. Mathison. 1990. Cd14, a receptor for complexes of lipopolysaccharide (lps) and lps binding protein. Science 249: 1431-1433. Wu, A., Z. Ying, and F. Gomez-Pinilla. 2008. Docosahexaenoic acid dietary supplementation enhances the effects of exercise on synaptic plasticity and cognition. Neuroscience 155: 751-759. Wu, H. et al. 2009. Docosahexaenoic acid induces erk1/2 activation and neuritogenesis via intracellular reactive oxygen species production in human neuroblastoma sh-sy5y cells. Biochim. Biophys. Acta. 1791: 8-16. Xu, J., M. T. Nakamura, H. P. Cho, and S. D. Clarke. 1999. Sterol regulatory element binding protein-1 expression is suppressed by dietary polyunsaturated fatty acids. A mechanism for the coordinate suppression of lipogenic genes by polyunsaturated fats. J. Biol. Chem. 274: 23577-23583. Yamamoto, T. et al. 2007. Protein kinase a suppresses sterol regulatory element-binding protein-1c expression via phosphorylation of liver x receptor in the liver. J. Biol. Chem. 282: 11687-11695. Yang, R. Z. et al. 2006. Acute-phase serum amyloid a: An inflammatory adipokine and potential link between obesity and its metabolic complications. PLoS. Med. 3: e287. Yu, C. et al. 2002. Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (irs-1)-associated phosphatidylinositol 3-kinase activity in muscle. J. Biol. Chem. 277: 50230-50236. Zhang, H. H., M. Halbleib, F. Ahmad, V. C. Manganiello, and A. S. Greenberg. 2002. Tumor necrosis factor-alpha stimulates lipolysis in differentiated human adipocytes through activation of extracellular signal-related kinase and elevation of intracellular camp. Diabetes 51: 2929-2935. Zhao, Y., S. Joshi-Barve, S. Barve, and L. H. Chen. 2004. Eicosapentaenoic acid prevents lps-induced tnf-alpha expression by preventing nf-kappab activation. J. Am. Coll. Nutr. 23: 71-78. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/26101 | - |
dc.description.abstract | 血清澱粉狀蛋白A ( serum amyloid A, SAA) 能減少人類肝細胞和脂肪細胞中脂肪堆積並且SAA在這些細胞的表現會因二十二碳六烯酸 ( docosahexaenoic acid, DHA) 處理而增加。藉由了解DHA是否媒介SAA以及以何種機制來減少脂肪堆積將有助於發展對抗肥胖和脂肪肝的新策略。本試驗先對數種常用的肝癌細胞株進行篩選,結果顯示DHA處理後SAA1在SK-HEP-1表現會增加,在PLC/PRF/5和Hep3B會減少。因為先前發現富含DHA的飼糧會增加豬隻肝臟SAA的表現,所以SK-HEP-1便被用於下列的實驗。SK-HEP-1細胞處理100及200 μM的DHA會增加SAA1和其上游調控因子CCAAT/enhancer binding protein beta ( C/EBPβ ) mRNA的表現。利用啟動子刪除分析法可得知在SAA1啟動子上為於-242 and -102的片段對DHA所調控的SAA1表現很重要,而此片段包含有C/EBPβ結合點。當突變C/EBPβ結合點上的DNA序列使其失去與C/EBPβ結合的能力後,因DHA處理所增加的promoter activity就會受到抑制,這顯示出此C/EBPβ結合點參與DHA對SAA1的調控。本試驗亦發現因DHA處理所增加SAA和C/EBPβ蛋白質表現會因PKA抑制劑 (H89) 的添加而受到抑制,此可顯示C/EBPβ是經由PKA所媒介而參與DHA對SAA1的調控。除此之外對於DHA減少脂肪細胞和肝細胞中脂肪堆積的機制也進行相關研究。DHA處理會增加脂肪細胞甘油的釋出。為了解DHA對脂肪肝的效應,SK-HEP-1在5 mM oleic acid處理2天後,細胞內脂質堆積明顯增加。以100 μM DHA處理這些脂肪肝細胞後,其細胞內的三酸甘油脂會減少。DHA對抑制人類肝細胞和脂肪細胞中脂肪堆積的效應亦會因H89的添加而消失,顯示DHA對脂肪堆積的效應也是由PKA所媒介。綜言之,由於DHA對SAA1的正向調控和脂肪堆積的負向調控皆經由PKA這條路徑,所以可以推論DHA可能是藉由SAA1減少脂肪堆積。這些發現對於了解DHA所調控的脂肪代謝機制提供了新線索,此將有助於DHA在改善人類健康上的應用。 | zh_TW |
dc.description.abstract | Serum amyloid A (SAA) reduces fat deposition in adipocytes and hepatocytes. Human SAA1 mRNA is increased by docosahexaenoic acid (DHA) treatment in human cells. These studies asked whether DHA decreases fat deposition through SAA1 and explored the corresponding mechanisms. We demonstrated that DHA increased human SAA1 and C/EBPβ mRNA expression in human hepatoma cells, SK-HEP-1. Utilizing promoter deletion assay, we found that a C/EBPβ binding site in the SAA1 promoter region between -242 and -102 bp is critical for DHA-mediated SAA1 expression. When we mutated the putative C/EBPβ binding site, the DHA-induced SAA1 promoter activity was suppressed, suggesting that this binding sequence was very important for the DHA regulated transcription activation. The addition of the protein kinase A inhibitor, H89, negated the DHA-induced increase in C/EBPβ protein expression. The up-regulation of SAA1 mRNA and protein by DHA was inhibited by H89 treatment, as well. We further demonstrated that DHA increased protein kinase A (PKA) activities. These data suggest that C/EBPβ is involved in the DHA-regulated increase in SAA1 expression via PKA-dependent mechanisms. Furthermore, the suppressive effect of DHA on triacylglycerol accumulation was abolished by H89 treatment in hepatocytes and adipocytes indicating that DHA reduces lipid accumulation via PKA as well. The phenomena of increased SAA1 expression coupled with reduced fat accumulation mediated by DHA via PKA suggest that SAA1 is involved in DHA-induced triacylglycerol breakdown. These findings provide new insights into the complicated regulatory network in DHA-mediated lipid metabolism and may be useful in developing new therapeutic approaches to reduce body fat deposition and fatty liver. | en |
dc.description.provenance | Made available in DSpace on 2021-06-08T07:00:14Z (GMT). No. of bitstreams: 1 ntu-98-R96626009-1.pdf: 1131024 bytes, checksum: 18c614bd696116304b4db17ae615cd05 (MD5) Previous issue date: 2009 | en |
dc.description.tableofcontents | Contents
Page 口試委員會審定書…………………………………………………………………… i Acknowledgement…………………………………………………………………….. ii Chinese Abstract……………………………………………………………………... iii English Abstract………………………………………………………………………... iv Contents……………………………………………………………………………....... vi List of Figures………………………………………………………………………... viii List of Tables………………………………………………………………………….. ix Chapter 1 Literature Review………………………………………………………… 1 1.1 Introduction 1.2 n-3 PUFA on lipid metabolism 1.3 Inflammation mediators involved in n-3 PUFA-regulated lipid metabolism 1.4 Inflammation mechanisms of n-3 PUFA 1.5 Summary Chapter 2 Special aims………………………………………………………….. 23 Chapter 3 Materials and Methods……………………………………………….. 24 3.1 Hepatoma cells and culture media 3.2 Human adipose tissue samples and adipocytes isolation and differentiation 3.3 Real-time PCR 3.4 Western blotting and ELISA 3.5 Plasmid construction, Transient transfection and Dual Luciferase Assay 3.6 PKA activity 3.7 Staining 3.8 Triacylglycerol measurements 3.9 Statistical analysis Chapter 4 Results……………………………………………………………………. 34 4.1 Effect of DHA on SAA1 expression 4.2 Effect of DHA on SAA1 upstream regulatory transcription factor 4.3 Role of C/EBPβ in DHA-mediated SAA1 promoter activity 4.4 Role of PKA in DHA-mediated SAA1 and C/EBPβ expression 4.5 Effect of DHA on PKA activities 4.6 In vitro fatty hepatocyte model setup 4.7 Effect of DHA on triacylglycerol breakdown Chapter 5 Discussion………………………………………………………………… 48 Chapter 6 References………………………………………………………………… 53 | |
dc.language.iso | en | |
dc.title | 二十二碳六烯酸媒介PKA增加血清澱粉狀蛋白A之機制 | zh_TW |
dc.title | Docosahexaenoic acid enhances hepatic serum amyloid A expression via protein kinase A-dependent mechanism | en |
dc.type | Thesis | |
dc.date.schoolyear | 97-2 | |
dc.description.degree | 碩士 | |
dc.contributor.coadvisor | 李宣書 | |
dc.contributor.oralexamcommittee | 陳洵一,李財坤 | |
dc.subject.keyword | 血清澱粉狀蛋白A,二十二碳六烯酸,C/EBPβ,脂解作用,脂肪肝, | zh_TW |
dc.subject.keyword | C/EBPβ,DHA,fatty liver,SAA, | en |
dc.relation.page | 64 | |
dc.rights.note | 未授權 | |
dc.date.accepted | 2009-06-15 | |
dc.contributor.author-college | 生物資源暨農學院 | zh_TW |
dc.contributor.author-dept | 動物科學技術學研究所 | zh_TW |
顯示於系所單位: | 動物科學技術學系 |
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