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  1. NTU Theses and Dissertations Repository
  2. 管理學院
  3. 財務金融學系
請用此 Handle URI 來引用此文件: http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/26034
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dc.contributor.advisor李存修(Tsun-Siou Lee)
dc.contributor.authorYu-Kai Hungen
dc.contributor.author洪育凱zh_TW
dc.date.accessioned2021-06-08T06:58:53Z-
dc.date.copyright2009-07-14
dc.date.issued2009
dc.date.submitted2009-07-02
dc.identifier.citationBeuzekom, B. van and A. Arundel, 2006, OECD biotechnology
statistics – 2006.
Cassimon, D., P.J. Engelen, L. Thomassen, and M. Van Wouwe, 2004,
The valuation of a NDA using a 6-fold compound option, Research
Policy 33, 41-51.
Cox, J.C., S.A. Ross, and M. Rubinstein, 1979, Option pricing: a simplified approach, Journal of Financial Economics 7, 229-263.
Dickson, M. and J.P. Gagnon, 2004, Key factors in the rising cost of new
drug discovery and development, Nature Reviews 3, 417-429.
DiMasi, J.A., R.W. Hansen, and H.G. Grabowski, 2003, The price of innovation: new estimates of drug development costs, Journal of Health Economics 22 (2003) 151–185.
Department Center for Biotechnology, 2003, Year book of biotechnology 2003.
Ernst & Young, 2008, Beyond borders: the global biotechnology
report 2008.
Geske, R., 1979, The valuation of compound options, Journal of Financial Economics 7 (1), 63-81.
Hartmann, M. and A. Hassan, 2006, Application of real options analysis for pharmaceutical R&D project valuation—empirical results from a survey Research Policy 35, 343–354.
Hughes, B., 2008, 2007 FDA drug approvals: a year of flux, Nature Reviews 7, 107-109.
Kaitin, K.I., 2008, Obstacles and opportunities in new drug development, Clinical Pharmacology & Therapeutics 83 (2), 210-212.
Kellog, D. and J.M. Charnes, 2000, Real-options valuation for a biotechnology company, Financial Analysts Journal May-June, 76-84.
Luehrman, T.A., 1994, Capital projects as real options: an
introduction, Harvard Business School Technical Note.
Myers, S.C., 1977, Determinants of corporate borrowing, Journal of Financial Economics 5, 147-175.
National Science Council, 2006, Indicators of Science and Technology 2006.
The International Service for the Acquisition of Agri-Biotech Applications, 2008, Global status of commercialized biotech/GM crops 2008.
Thomassen, L. and M. Van Wouwe, 2001, The n-fold compound option, Research Paper.
Trigeorgis, L, 1993, The nature of option interactions and the valuation of investments with multiple real options, The Journal of Financial and Quantitative Analysis 28 (1), 1-20.
Walsh, G., 2006, Biopharmaceutical benchmarks 2006, Nature Biotechnology 24, 769-778.
dc.identifier.urihttp://tdr.lib.ntu.edu.tw/jspui/handle/123456789/26034-
dc.description.abstract生技製藥產業不同於傳統產業,其研發投入成本龐大且開發時程長,加上研發過程中的高失敗率,使獲利具高度不確定性;然而,經理人可藉由決策的調整適時放棄或出售投資計畫,提高計畫價值。傳統評價方法(如淨現值法)無法反應計畫過程中的決策彈性,有鑑於此,本論文採用複合實質選擇權評價概念(compound real option),建立二元樹模型,將生技製藥階段性研發的特質、放棄及出售的選擇權納入考量,希望有助於未來生技製藥公司進行資本預算評估、計畫授權時的評價。zh_TW
dc.description.abstractBiopharmaceutical industry has been regarded as a highly risky business because of the characteristics such as high capital investment, long developing time, and low success rates. During the developing process, however, managers have the flexibility to adjust the investment project. For example, the R&D project can be abandoned or sold to other companies. The managerial flexibilities can contribute to the project value. Traditional valuation methods are unable to fully capture the value created by the biopharmaceutical R&D project because they ignore these opportunities. Therefore, we apply the compound real option concept and present the binomial lattice model with options to abandon and sell, so as to evaluate the R&D project value.en
dc.description.provenanceMade available in DSpace on 2021-06-08T06:58:53Z (GMT). No. of bitstreams: 1
ntu-98-R96723001-1.pdf: 1117933 bytes, checksum: 1ef26dfdefc325b2499a7489c67880df (MD5)
Previous issue date: 2009
en
dc.description.tableofcontents口試委員會審定書 i
誌謝 i
摘要 iii
Abstract iv
Table of Contents iv
Tables vi
Figures vi
I. Introduction - 1 -
II. Current Status of Biotechnology and Biopharmaceutical Industry - 3 -
II.1 Overview of biotechnology industry - 3 -
II.2 Biopharmaceutical industry - 6 -
II.3 The new drug development process in the United States - 10 -
III. Real Options Embedded in the New Drug Application - 12 -
IV. The Compound Option Model for Biopharmaceutical R&D - 16 -
IV.1 Risk neutral binomial lattice - 16 -
IV.2 Real option valuation-the basic case - 18 -
IV.3 R&D project with option to sell - 21 -
V. Application for a biopharmaceutical R&D project and Sensitivity Analysis - 24 -
V.1 The value of a small biopharmaceutical company R&D project with option to abandon - 24 -
V.2 The value of a small biopharmaceutical company R&D project with option to sell and abandon - 25 -
V.3 Sensitivity analysis - 26 -
VI. Conclusion - 28 -
References - 30 -
dc.language.isoen
dc.subject複合實質選擇權zh_TW
dc.subject二元樹zh_TW
dc.subject生技製藥zh_TW
dc.subjectcompound real optionen
dc.subjectbiopharmaceuticalen
dc.subjectbinomial treeen
dc.title生技製藥研發計畫之實質選擇權評價zh_TW
dc.titleReal Option Valuation of Biopharmaceutical R&D projecten
dc.typeThesis
dc.date.schoolyear97-2
dc.description.degree碩士
dc.contributor.oralexamcommittee廖咸興(Hsien-Hsing Liao),石百達(Pai-Ta Shih)
dc.subject.keyword生技製藥,複合實質選擇權,二元樹,zh_TW
dc.subject.keywordbiopharmaceutical,compound real option,binomial tree,en
dc.relation.page31
dc.rights.note未授權
dc.date.accepted2009-07-02
dc.contributor.author-college管理學院zh_TW
dc.contributor.author-dept財務金融學研究所zh_TW
顯示於系所單位:財務金融學系

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