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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 李存修(Tsun-Siou Lee) | |
| dc.contributor.author | Yu-Kai Hung | en |
| dc.contributor.author | 洪育凱 | zh_TW |
| dc.date.accessioned | 2021-06-08T06:58:53Z | - |
| dc.date.copyright | 2009-07-14 | |
| dc.date.issued | 2009 | |
| dc.date.submitted | 2009-07-02 | |
| dc.identifier.citation | Beuzekom, B. van and A. Arundel, 2006, OECD biotechnology
statistics – 2006. Cassimon, D., P.J. Engelen, L. Thomassen, and M. Van Wouwe, 2004, The valuation of a NDA using a 6-fold compound option, Research Policy 33, 41-51. Cox, J.C., S.A. Ross, and M. Rubinstein, 1979, Option pricing: a simplified approach, Journal of Financial Economics 7, 229-263. Dickson, M. and J.P. Gagnon, 2004, Key factors in the rising cost of new drug discovery and development, Nature Reviews 3, 417-429. DiMasi, J.A., R.W. Hansen, and H.G. Grabowski, 2003, The price of innovation: new estimates of drug development costs, Journal of Health Economics 22 (2003) 151–185. Department Center for Biotechnology, 2003, Year book of biotechnology 2003. Ernst & Young, 2008, Beyond borders: the global biotechnology report 2008. Geske, R., 1979, The valuation of compound options, Journal of Financial Economics 7 (1), 63-81. Hartmann, M. and A. Hassan, 2006, Application of real options analysis for pharmaceutical R&D project valuation—empirical results from a survey Research Policy 35, 343–354. Hughes, B., 2008, 2007 FDA drug approvals: a year of flux, Nature Reviews 7, 107-109. Kaitin, K.I., 2008, Obstacles and opportunities in new drug development, Clinical Pharmacology & Therapeutics 83 (2), 210-212. Kellog, D. and J.M. Charnes, 2000, Real-options valuation for a biotechnology company, Financial Analysts Journal May-June, 76-84. Luehrman, T.A., 1994, Capital projects as real options: an introduction, Harvard Business School Technical Note. Myers, S.C., 1977, Determinants of corporate borrowing, Journal of Financial Economics 5, 147-175. National Science Council, 2006, Indicators of Science and Technology 2006. The International Service for the Acquisition of Agri-Biotech Applications, 2008, Global status of commercialized biotech/GM crops 2008. Thomassen, L. and M. Van Wouwe, 2001, The n-fold compound option, Research Paper. Trigeorgis, L, 1993, The nature of option interactions and the valuation of investments with multiple real options, The Journal of Financial and Quantitative Analysis 28 (1), 1-20. Walsh, G., 2006, Biopharmaceutical benchmarks 2006, Nature Biotechnology 24, 769-778. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/26034 | - |
| dc.description.abstract | 生技製藥產業不同於傳統產業,其研發投入成本龐大且開發時程長,加上研發過程中的高失敗率,使獲利具高度不確定性;然而,經理人可藉由決策的調整適時放棄或出售投資計畫,提高計畫價值。傳統評價方法(如淨現值法)無法反應計畫過程中的決策彈性,有鑑於此,本論文採用複合實質選擇權評價概念(compound real option),建立二元樹模型,將生技製藥階段性研發的特質、放棄及出售的選擇權納入考量,希望有助於未來生技製藥公司進行資本預算評估、計畫授權時的評價。 | zh_TW |
| dc.description.abstract | Biopharmaceutical industry has been regarded as a highly risky business because of the characteristics such as high capital investment, long developing time, and low success rates. During the developing process, however, managers have the flexibility to adjust the investment project. For example, the R&D project can be abandoned or sold to other companies. The managerial flexibilities can contribute to the project value. Traditional valuation methods are unable to fully capture the value created by the biopharmaceutical R&D project because they ignore these opportunities. Therefore, we apply the compound real option concept and present the binomial lattice model with options to abandon and sell, so as to evaluate the R&D project value. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-08T06:58:53Z (GMT). No. of bitstreams: 1 ntu-98-R96723001-1.pdf: 1117933 bytes, checksum: 1ef26dfdefc325b2499a7489c67880df (MD5) Previous issue date: 2009 | en |
| dc.description.tableofcontents | 口試委員會審定書 i
誌謝 i 摘要 iii Abstract iv Table of Contents iv Tables vi Figures vi I. Introduction - 1 - II. Current Status of Biotechnology and Biopharmaceutical Industry - 3 - II.1 Overview of biotechnology industry - 3 - II.2 Biopharmaceutical industry - 6 - II.3 The new drug development process in the United States - 10 - III. Real Options Embedded in the New Drug Application - 12 - IV. The Compound Option Model for Biopharmaceutical R&D - 16 - IV.1 Risk neutral binomial lattice - 16 - IV.2 Real option valuation-the basic case - 18 - IV.3 R&D project with option to sell - 21 - V. Application for a biopharmaceutical R&D project and Sensitivity Analysis - 24 - V.1 The value of a small biopharmaceutical company R&D project with option to abandon - 24 - V.2 The value of a small biopharmaceutical company R&D project with option to sell and abandon - 25 - V.3 Sensitivity analysis - 26 - VI. Conclusion - 28 - References - 30 - | |
| dc.language.iso | en | |
| dc.subject | 複合實質選擇權 | zh_TW |
| dc.subject | 二元樹 | zh_TW |
| dc.subject | 生技製藥 | zh_TW |
| dc.subject | compound real option | en |
| dc.subject | biopharmaceutical | en |
| dc.subject | binomial tree | en |
| dc.title | 生技製藥研發計畫之實質選擇權評價 | zh_TW |
| dc.title | Real Option Valuation of Biopharmaceutical R&D project | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 97-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 廖咸興(Hsien-Hsing Liao),石百達(Pai-Ta Shih) | |
| dc.subject.keyword | 生技製藥,複合實質選擇權,二元樹, | zh_TW |
| dc.subject.keyword | biopharmaceutical,compound real option,binomial tree, | en |
| dc.relation.page | 31 | |
| dc.rights.note | 未授權 | |
| dc.date.accepted | 2009-07-02 | |
| dc.contributor.author-college | 管理學院 | zh_TW |
| dc.contributor.author-dept | 財務金融學研究所 | zh_TW |
| 顯示於系所單位: | 財務金融學系 | |
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