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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 林俊彬 | |
dc.contributor.author | Shu-Han Kang | en |
dc.contributor.author | 康舒涵 | zh_TW |
dc.date.accessioned | 2021-06-08T06:27:44Z | - |
dc.date.copyright | 2006-08-04 | |
dc.date.issued | 2006 | |
dc.date.submitted | 2006-07-27 | |
dc.identifier.citation | Abe T ,Tachibana Y, Uemtsu T, Iwamoto M (1995).J Chem Soc Chem Commun 1617
Absi EG, Addy M, Adams D (1987). A study of the patency of dentinal tubules in sensitive and non-sensitive cervical dentine. J Clin Periodontol 14:280-284. Absi EG, Addy M, Adams D (1989). Dentine hypersensitivity: The development and evaluation of a replica technique to study sensitive and non-sensitive cervical dentine. J Clin Periodontol 16:190-195. Absi EG, Addy M, Adams D (1992). Dentine hypersensitivity--the effect of toothbrushing and dietary compounds on dentine in vitro: an SEM study. J Oral Rehabil. 19(2):101-10. Addy M, Absi EG, Adams D (1987). Dentine hypersensitivity: the effects in vitro of acids and dietary substances on root planed and burred dentine. J Clin Periodontol 14:274-279. Addy M, Mostafa P, Newcombe RG (1987). Dentine hypersensitivity: the distribution of recession, sensitivity and plaque. J Dent 15:242-248. Addy M (1990). Etiology and clinical implications of dentine hypersensitivity. Dent Clin North Am 34:503-514. Addy M ,Embery G,Edgar WM,Orchardson R (2000).Tooth Wear and Sensitivity-Clinical advances in restorative dentistry. Martin Dunitz Andersson OH, Kangasniemi I (1991). Calcium phosphate formation at the surface of bioactive glass in vitro. J Biomed Mater Res 25:1019-1030. Arcos D, del RR, Vallet-Regi M (2002). A novel bioactive and magnetic biphasic material.Biomaterials. 23(10):2151-8. Aw TC, Lepe X, Johnson GH, Mancl L (2004). One-year clinical evaluation of an ethanol-based and a solvent-free dentin adhesive. Am J Dent. 7(6):451-6. Bernimoulin J, Curilovie Z (1977). Gingival recession and tooth mobility. J Clin Periodontol. 4(2):107-14. Bhatia S (1990).Zeolite catalysis priciples and application,CRC press,Florida Bonin P, Boivin R, Poulard J (1991).Dentinal permeability of the dog canine after exposure of a cervical cavity to the beam of a CO2 laser. J Endodon 116-118. Brännström M (1963) ,Dentin sensitivity and aspiration of odontoblasts. J Am Dent Assoc. 66:366-70. Brännström M, Linden L, Aström A (1967). The hydrodynamics of dentine and pulp fluid: Its significance in relation to dental pain. Caries research 1:310. Brännström M, Aström A (1972). The hydrodynamics of the dentine: Its possible relationship to dentinal pain. Int Dent J 22:219. Brännström M, Johnson G, Nordenvall KJ (1979). Transmission and control of dentinal pain: Resin impregnation for the desensitization of dentin. J Am Dent Assoc 99:612-618. Brinker CJ, Scherer GW(1989).Sol-Gel Science,11-13,World Scientific Brinker CJ, Scherer GW (1990).Sol-Gel Science: The physics and chemistry of sol-gel processing. Academic Press,New York Boremer H, Deutscher K, Blencke B, Pfeil E and Strunz V (1977). Properties of the bioactive implant material Ceravital. Sci Ceram. 9: 219-255, 1977 Camps J, About I, Van Meerbeek B, Franquin JC (2002). Efficiency and cytotoxicity of resin-based desensitizing agents. Am J Dent. 15(5):300-4. Cant NW, Hall WK (1997) J Phys Chem. 75,2914 Charkraborty B,Pulikottil AC,Viswanathan B (1994),Catal.Lett. 39,63. Chersoni S, Suppa P, Grandini S, Goracci C, Monticelli F, Yiu C, Huang C, Prati C, Breschi L, Ferrari M, Pashley DH, Tay FR(2004). In vivo and in vitro permeability of one-step self-etch adhesives. J Dent Res. 83(6):459-64. Clark DC, Hanley JA, Geoghegan S, Vinet D (1985). The effectiveness of a fluoride varnish and a desensitizing toothpaste in treating dentinal hypersensitivity. J Periodontal Res 20(2):212-9 Chabanski MB, Gillam DG, Bulman JS, Newman HN (1996). Prevalence of cervical dentine sensitivity in a population of patients referred to a specialist Periodontology Department. J Clin Periodontol. 23(11):989-92. Dachi SF (1965). The relationship of pulpitis and hyperemia to thermal sensitivity. Oral Surg Oral Med Oral Pathol. 19:776-85. Davidson DF, Suzuki M (1997). The Gluma bonding system: a clinical evaluation of its various components for the treatment of hypersensitive root dentin. J Can Dent Assoc. 63(1):38-41. Dayton RE, DeMarco TJ, Swedlow D (1974). Treatment of hypersensitive root surfaces with dental adhesive materials. J Periodontol 45:873. Dentsply(1999).Seal & Protect™ Training Manual P13 Dowell P, Addy M (1983). Dentin hypersensitivity- a review. Aetiology, symptoms and the theories of pain production. J Clin Periodontol 10:341-350. Dragolich WE (1993). An in vitro study of dentinal tubule occlusion by ferric oxalate. J Periodontol 64:1045-1051. Fearnhead RW (1961). The neurohistology of human dentine. Proc R Soc Med 54:877-84. Featherstone JDB, Nelson DGA (1987). Laser effects on dental hard tissue. Adv Dent Res 1:21-26. Federick A. Curro (1990). Tooth hypersensitivity. Dent Clin Nor Amer 34:429-438. Felton DA, Bergenholtz G, Kanoy BE(1991) Evaluation of the desensitizing effect of Gluma Dentin Bond on teeth prepared for complete-coverage restorations. Int J Prosthodont. 4(3):292-8. Fischer C, Fischer RG, Wennberg A (1992). Prevalence and distribution of cervical dentine hypersensitivity in a population in Riode Janeiro, Brazil. J Dent 20:272-276. Flynn J, Galloway R, Orchardson R (1985). The incidence of hypersensitive teeth in the West of Scotland. J Dent 13:230-6. Freedman G (2000) Dentistry today Nov.,First Impressions Fukui H, Taki Y, Abe Y (1977). Implantation of new calcium phosphate glass-ceramics. J Dent Res. 56(10):1260. Gangarosa LP Sr (1994). Current strategies for dentist-applied treatment in the management of hypersensitive dentine. Arch Oral Biol 39 Suppl:101S-106S. Review Gbureck U, Barralet JE, Hofmann MP, Thuli R(2004). Nanocrystalline tetracalcium phosphate cement. J Dent Res. 83(5):425-8. Gerschman KA (1994). Low level laser therapy for dentinal tooth hypersensitivity. Austra Dent J 39:353-7. Glickman I(1959). Fact and fad in the surgical treatment of periodontal disease. J Am Dent Assoc. 59(2):241-9. Gillam DG, Bulman JS, Jackson RJ, Newman HN (1996). Efficacy of a potassium nitrate mouthwash in alleviating cervical dentine sensitivity (CDS). J Clin Periodontol. 23(11):993-7. Gillam DG, Coventry JF, Manning RH, Newman HN, Bulman JS(1997). Comparison of two desensitizing agents for the treatment of cervical dentine sensitivity. Endod Dent Traumatol. 13(1):36-9. Gorman WJ(1967). Prevalence and etiology of gingival recession. J Periodontol. 38(4):316-22. Green BL, Green ML, McFall WT Jr (1977). Calcium hydroxide and potassium nitrate as desensitizing agents for hypersensitive root surfaces. J Periodontol 48:667-672. Greenhill JD, Pashley DH (1981). The effects of desensitizing agents on the hydraulic conductance of human dentin in vitro. J Dent Res 60: 686-698. Grossman, LI (1935). A systematic method for the treatment of hypersensitive dentin. JADA 22: 592-602. Gummel J, Holand W, Naumann K, Vogel W(1983). Mechanically processable bioactive glass ceramics--a new biomaterial for bone replacement. Z Exp Chir Transplant Kunstliche Organe. 16(6):338-43 Hansen EK(1992). Dentin hypersensitivity treated with a fluoride-containing varnish or a light-cured glass-ionomer liner. Scand J Dent Res. 100(6):305-9. Hellwig E (1992). Fluoride retention in dentin after topical application of amine fluoride. J Dent Res 71:1558-1560. Hench LL, Splinder RJ, Allen WC, Green TK (1972). Bonding mechanism at the interface of the ceramic prosthetic materials. J Biomed Mater Res 2:117-41. Hench LL (1991). Bioceramics: From Concept to Clinic. J Am Ceram Soc 74:1487-510. Hench LL (2003). J Biomed Mater Res 66A: 110–119,2003 Hodosh M (1974). A superior desensitizer―potassium nitrate. J Am Dent Assoc, 88:831-832. Holland GR, Närhi MN, Addy M (1997). Guidelines for the design and conduct of clinical trials on dentine hypersensitivity. J Clin Periodontol 24:808-13. Holmberg K(2002).Surfactants and polymers in aqueous solution. Wiley Press,England. Imai Y, Akimoto T(1990). New method of treatment for dentin hypersensitivity by precipitation of calcium phosphate in situ. Dent Mater J. 9(2):167-72. Imelik B, Naccache Y, Bentaaiit J, Vedrine JC, Coudurier G, Praliaud H(1980).Catalysis by zeolite,Elesevier,Amostordam Ishikawa S (1969). A clinico-histological study on the hypersensitivity of dentine. J Japan Stomatol Soc 36:68-88. Ishikawa K, Suge T, Yoshiyama M et al (1994). Occlusion of dentinal tubules with calcium phosphate using acidic calcium phosphate solution followed by neutralization. J Dent Res 73:1197-1204. Jarvis D, MacIver MB, Tanelian DL.(1990) Electrophysiologic recording and thermodynamic modeling demonstrate that helium-neon laser irradiation does not affect peripheral Adelta- or C-fiber nociceptors. Pain. 43(2):235-42. Javid B, Barkhorder RA, Bhinda SV (1987). Cyanoacrylate―a new treatment for hypersensitive dentin and cementum. J Amer Dent Assoc 114:486-488. Jensen ME ,Doering JV(1987).A comparative study of two clinical techniques for treatment of root surface hypersensitivity. Gen Dent 35:128-132 Jones JR, Ehrenfried LM, Hench LL (2006).Optimising bioactive glass scaffolds for bone tissue engineering. Biomaterials 27(7):964-73. Kim S (1986). Hypersensitive teeth: desensitization of pulpal sensory nerves.J Endod 12:482-485 Kimura Y, Wilder-Smith P, Krasieva TB, Liaw LH, Matsumoto K (1998). Effects of CO2 laser on human dentin: a confocal laser scanning microscopic study. Lasers in the Life Sciences 8:1-12. Kimura Y, Wilder-Smith P, Yonaga K, Matsumoto K (2000). Treatment of dentine hypersensitivity by lasers: a review. J Clin Periodontol 27:715-721. Knight T (1969). Erosion, abrasion. J Dent Assoc S Afr 24: 310. Klaas de Groot(2000).Bioceramics of Calcium Phosphate. CRC Press,Inc.Boca Raton,Florida. P4 Kokubo T, Ito S, Huang ZT, Hayashi T, Sakka S, Kitsugi T, Yamamuro T(1990). Ca,P-rich layer formed on high-strength bioactive glass-ceramic A-W. J Biomed Mater Res. 24(3):331-43. Kolker JL, Vargas MA, Armstrong SR, Dawson DV(2002). Effect of desensitizing agents on dentin permeability and dentin tubule occlusion. J Adhes Dent. 4(3):211-21. Krauser JT (1986). Hypersensitive teeth. Part II: treatment. The J Prosth Dent 56:307-311 Kresge CT, Leonowicz ME, Roth WJ, Vartuli JC and Beck JS (1992). Nature 359,710. Lee YS , Surjadi D, Rathman JF (1996).Langmuir 12,6202. Levin MP, Yearwood LL, Carpenter WN (1973). The desensitizing effect of calcium hydroxide; and magnesium hydroxide on hypersensitive dentin. Oral Surg 35:741-746. Liebow C (1996). Transient effects of low-energy CO2 laser irradiation on dentinal impedance: implications for treatment of hypersensitive teeth. J Endod 22:526-531 Lin FH, Liao CJ, Liu HC, Chen KS, Sun JS (1997). Behavior of fetal rat osteoblasts cultured in vitro on the DP-bioactive glass substratum. Mater Chem Phys 49:270-276. Lin CP, Lin FH, Tseng YC, Kok SH, Lan WH, Liao JD (2000). Treatment of tooth fracture by medium energy CO2 laser and DP-bioactive glass paste: compositional, structure, and phase changes of DP-bioglass paste after irradiation by CO2 laser. Biomaterials 21:637-643. Lin CP, Tseng YC, Lin FH, Kok SH, Liao JD, Lan WH (2001).Treatment of tooth fracture by medium-energy CO2 laser and DP-bioactive glass paste: the interaction of enamel and DP-bioactive glass paste during irradiation by CO2 laser. Biomaterials 22: 489-96 Lin CP, Lee BS, Kok SH, Lan WH (2000). Treatment of tooth fracture by medium energy CO2 laser and DP-bioactive glass paste:Thermal behavior and phase transformation of human tooth enamel and dentin after irritation by CO2 laser. Journal of materials science: materials in medicine 11: 373-381. Liu HC, Lan WH (1994). The combined effectiveness of the semiconductor laser with Duraphat in the treatment of dentin hypersensitivity. Journal of Clinical Laser Medicine & surgery 12: 315-319. Low T(1981). The treatment of hypersensitive cervical abrasion cavities using ASPA cement. J Oral Rehabil. 8(1):81-9. Markowitz K, Billotto G, Kim S (1991). Decreasing intradental nerve activity in the cat with potassium and divalent cations. Arch Oral Bio 36:1-7. Matsumoto K (2000). Lasers in endodontics: a review. Int Endo J 33:173-185. Minkov B, Marmari I, Gedalia I, Garfunkel A (1975). The effectiveness of sodium fluoride treatment with and without iontophoresis on the reduction of hypersensitive dentine. J Periodont 46:246-249. Moritz A, Gutknecht N, Schoop U, Goharkhay K, Ebrahim D, Wernisch J, Sperr W(1996). The advantage of CO2-treated dental necks, in comparison with a standard method: results of an in vivo study. J Clin Laser Med Surg. 14(1):27-32. Moritz A, Schoop U, Goharkhay K, Aoid M, Reichenbach P, Lothaller MA, Wernisch J, Sperr W(1998). Long-term effects of CO2 laser irradiation on treatment of hypersensitive dental necks: results of an in Vivo study. J Clin Laser Med Surg. 16(4):211-5. Muzzin KB, Johnson R(1989) Effects of potassium oxalate on dentin hypersensitivity in vivo. J Periodontol. 60(3):151-8. Myers TD, McDaniel JD (1991). The pulsed Nd:YAG dental laser: review of clinical applications. J Calif Dent Assoc. 19(11):25-30. Narhi MVO, Haegerstam G (1983). Interdental nerve activity induced by reduced pressure applied to exposed dentin in the cat. Acta Physiol 119:381-386. Neumann R, Khenkin K(1996).Chem Commun 23,2643. Nordenvall KJ, Malmgren B, Brannstrom M (1984). Desensitization of dentin by resin impregnation: a clinical and light-microscopic investigation. J Dent Child 51:274-276. Olsson M, Lindhe J(1991). Periodontal characteristics in individuals with varying form of the upper central incisors. J Clin Periodontol. 18(1):78-82. Orchardson R, Collins WJN (1987). Thresholds of hypersensitive teeth to two forms of controlled stimulation. J Clin Periodontol 14:68-73. Pashley DH, Livingston MJ, Greenhill JD (1978). Regional resistance to fluid flow in human dentine in vitro. Arch Oral Biol 23:807-810. Pashley DH, Livingston MJ, Greenhill JD, Reeder OW, Homer J (1978). Effects of the degree of tubule occlusion on the permeability of human dentine in vitro. Arch Oral Biol 23:1127-1133. Pashley DH, Galloway SE (1985). The effects of oxalate treatment on the smear layer of ground surfaces of human dentine. Arch Oral Biol 30:731-737. Pashley DH (1986). Dentin permeability, dentin sensitivity, and treatment through tubule occlusion. J Endod 12:465-474. Pashley DH (1986). Sensitivity of dentin to chemical stimuli. Endod Dent Traumatol 2:130-137. Pashley DH (1992). Dentin permeability and dentin sensitivity. Proc Finn Dent Soc 88 suppl 1:31-37. Pashley DH, Mathews WG (1993). The effects of outward forced convective flow on inward diffusion in human dentine in vitro. Arch Oral Biol 38:577-582. Pashley DH (1996). Dynamics of the pulpo-dentin complex. Crit Rev Oral Biol Med 7:104-133. Pashley DH (1999) .Durability of resin-dentin bonds. J Adhes Dent. 1(3):211-8 Peacock JM, Orchardson R (1995). Effects of potassium ions on action potential conduction in A- and C-fibers of rat spinal nerves. J Dent Res 74:634-641. Pearce NX, Addy M, Newcombe RG (1994). Dentine hypersensitivity: a clinical trial to compare 2 strontium densensitizing toothpastes with a conventional fluoride toothpaste. J Periodontol. 65(2):113-9. Plagmann HC (1997). A clinical study comparing two high-fluoride dentifrices for the treatment of dentinal hypersensitivity. Quin Int 28:403-408. Powell LV, Gordon GE, Johnson GH (1990). Sensitivity restored of ClassV abrasion/erosion lesions. J Am Dent Assoc. 121(6):694-6. Rapp R, Avery JK, Strachan DS (1967). The distribution of nerves in human primary teeth. Anat Rec. 159(1):89-103. Regina M, Filgueras T, Torre G, Hench LL (1993). Solution effects on the surface reactions of three bioactive glass compositions. J Biomed MaterRes 27:1485-1493. Rochkind S, Nissan M, Razon N, Schwartz M, Bartal A(1986). Electrophysiological effect of HeNe laser on normal and injured sciatic nerve in the rat. Acta Neurochir (Wien). 83(3-4):125-30. Sandholm L, Niemi ML, Ainamo J(1982). Identification of soft tissue brushing lesions. A clinical and scanning electron microscopic study. J Clin Periodontol. 9(5):397-401. Salvato AR, Clark GE, Gingold J, Curro FA (1992). Clinical effectiveness of a dentifrice containing potassium chloride as a desensitizing agent. Am J Dent. 5(6):303-6. Saravanapavan P , Larry L. Hench LL(2003). Mesoporous calcium silicate glasses I. Synthesis Journal of Non-Crystalline Solids 318 1–13. Sayari A (1996).Chem mater. 8,1840. Scheutzel P (1996). Etiology of dental erosion--intrinsic factors. Eur J Oral Sci. 104(2 ( Pt 2)):178-90. Schluger S (1977). Periodontics today: dentistry tomorrow. J Dist Columbia Dent Soc. Fall;:6-8. Seka W, et al (1995). Light deposition in dentinal hard tissue and simulated thermal response. J Dent Res 74:1086-1092. Siegel RW, Hu E, Roco MC (1999).Nanostructure science and technology: R&D status and trends in nanoparticles,Nanostructured materials,and nanodevices, Silverstone LM (1974). Fissure sealants: laboratory studies. Caries Res 8:2. Shono Y, Terashita M, Shimada J, Kozono Y, Carvalho RM, Russell CM, Smith RG (1997). Gingival recession. Reappraisal of an enigmatic condition and a new index for monitoring. J Clin Periodontol. 24(3):201-5. Stabholz A (1993). Effect of ArF-193 nm excimer laser on human dentinal tubules. Oral Surg 75:90-94 Stabholz A(1995). Efficacy of XeC1 308-nm excimer laser in reducing dye penetration through coronal dentinal tubules. J Endodon 21:266-268. Suda R, Andoh Y, Shionome M et al (1990). Clinical evaluation of the sedative effect of HEMA solution on the hypersensitivity of dentin. Dent Mater J 9:163-166. Suge T (1995). Effects of fluoride on the calcium phosphate precipitation method for dentinal tubule occlusion. J Dent Res 74:1079-1085. Tagami J, Hosoda H, Imai Y, Masuhara E(1987). Evaluation of a new adhesive liner as an adhesive promoter and a desensitizer on hypersensitive dentin. Dent Mater J. 6(2):201-8. Tani Y, Kawada (1987). Effects of laser irradiation on dentin. 1. Effect on smear layer. J Dent Mater 6:127-134. Tarbet WJ, Silverman G, Stolman JM, Fraterangelo PA (1979). An evaluation of two methods for the quantitation of dentinal hypersensitivity. J Am Dent Assoc 98:914-918. Tarbet WJ, Silverman G, Fraterangelo PA, Kanapka JA (1982). Home treatment for dentinal hypersensitivity: a comparative study. J Am Dent Assoc 105:227-230. Touyz LZG (1999). Hypersensitive dentinal pain attenuation with potassium nitrate. Gener Dent Jan-Feb:42-45. Trowbridge HO, Silver DR(1990). A review of current approaches to in-office management of tooth hypersensitivity.Dent Clin North Am. 34(3):561-81. Tsang SC, davis JJ, Green MLH., Hill HAO, Leung YC, Sadler PJ (1995). J Chem Soc Chem Commun 1803 Tung MS, Bowen HJ, Derkson GD, Pashley DH (1993). Effects of calcium phosphate solutions on dentin permeability. J Endodon 19:383-387. Tuominen M, Tuominen R (1991). Dental erosion and associated factors among factory workers exposed to inorganic acid fumes. Proc Finn Dent Soc. 87(3):359-64. Turkun LS (2005). The clinical performance of one- and two-step self-etching adhesive systems at one year. J Am Dent Assoc. 136(5):656-64 Wakabayashi H, Hamba M, Matsumoto K, Tachibana H (1993). Effect of irradiation by semiconductor laser on responses evoked in trigeminal caudal neurons by tooth pulp stimulation. Lasers Surg Med. 13(6):605-10. Ward WJ (1984).Molecular sieve catalysts in applied industrial catalysis,Vol.3, Academic press,New York. Watson PJ(1984). Gingival recession. J Dent. 12(1):29-35. West NX, Addy M, Jackson RJ, Ridge DB(1997) Dentine hypersensitivity and the placebo response. A comparison of the effect of strontium acetate, potassium nitrate and fluoride toothpastes. J Clin Periodontol. 24(4):209-15. West NX, Addy M, Hughes J (1998). Dentine hypersensitivity: the effects of brushing desensitizing toothpastes, their solid and liquid phases, and detergents on dentine and acrylic: studies in vitro. J Oral Rehabil 25:885-895. Whitters CJ, Hall A, Creanor SL, Moseley H, Gilmour WH, Strang R, Saunders WP, Orchardson R (1995). A clinical study of pulsed Nd: YAG laser-induced pulpal analgesia. J Dent. 23(3):145-50. Woofter C (1969). The prevalence and etiology of gingival recession. Periodontal Abstr. 17(2):45-50. Yates R, Owens J, Jackson R, Newcombe RG, Addy M (1998). A split-mouth placebo-controlled study to determine the effect of amorphous calcium phosphate in the treatment of dentine hypersensitivity. J Clin Periodontol. 25(8):687-92. Yonaga K, Kimura Y, Matsumoto K (1999) Treatment of cervical dentin hypersensitivity by various methods using pulsed Nd:YAG laser. J Clin Laser Med Surg. 17(5):205-10. Yoshiyama M, Ozaki K, Ebisu S (1992). Morphological characterization of hypersensitive human radicular dentin and the effect of a light-curing resin liner on tubular occlusion. Proc Finn Dent Soc. 88 Suppl 1:337-44. Zach L, Cohen G (1965). Pulp responses to externally applied heat. Oral Surg 19: 515-530. Zero DT(1996). Etiology of dental erosion--extrinsic factors. Eur J Oral Sci. 104(2 ( Pt 2)):162-77. 林景正(2001).奈米材料技術與發展,電子月刊,3月 陳朝楠(2002).合成高均勻度之中孔洞氧化矽球,成大化學系碩士論文 陳東文(2002).以油界面活性劑水微乳液為模板製備囊泡狀中孔洞材料,成大化學系碩士論文 樂文禮(2000).聚醯亞胺奈米矽氧複合材料選擇性封裝之研究,成大化工系碩士論文 黃淑娟(2002).奈米粉體製成技術,化工資訊4月,P34-38 陳永志、陳姿秀、陳致源(2002).溶膠凝膠法之研究與技術發展近況(上),工業材料雜誌3月,206期,P169-178 張俊偉(2000). 應用生醫陶瓷玻璃及雷射於牙本質過敏症治療之研究.台大臨床牙醫學研究所碩士論文 蔡心儀 (2001).研發生醫玻璃製劑於治療牙本質過敏症之研究. 台大臨床牙醫學 研究所碩士論文 王尉任 (2005).可分解磁性生醫玻璃於腫瘤熱治療之研究. 臺大醫學工程學研究所碩士論文 王盈錦,林峰輝(2002).生醫陶瓷材料-生物醫學材料 合記圖書出版社, 278-279 | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/25743 | - |
dc.description.abstract | 牙本質過敏症為臨床上常遭遇的問題,目前以封閉牙本質小管為主要治療方式之一。市售牙本質黏著劑及去敏感劑號稱效果卓著,但在臨床使用上仍無法達到持久之療效。然而本團隊研發之DP-bioglass已證實可有效進入並封閉牙本質小管,惟其反應需三天以上,於臨床應用上有其困難。應用奈米技術可製成粒徑小具有孔洞之材料,藉由高表面積可提升材料反應能力,因此我們以溶膠-凝膠(sol-gel)法及含浸法(impregnation)製成材料,以期達到縮短反應時間、方便臨床使用之目標。本研究之第一部份將測試市售之黏著劑及去敏感劑對於牙本質小管之封閉效果。結果發現,除了DP-bioglass以外,其他三種材料Xeno R III、One coat R bond、Seal&Protect R都與管周牙本質之間有縫隙之產生,且無論在封閉深度及百分比方面,DP-bioglass都優於其他三種材料。第二部分則是運用溶膠-凝膠技術,控制催化劑(硝酸、氫氧化鈉、磷酸)及溫度(熱重分析法評估鍛燒溫度)等製成條件以合成生醫玻璃,藉由掃描式電子顯微鏡的觀察、X光繞射分析、能量散射光譜儀元素分析等研究方法,分別進行材料性質分析,評估材料與磷酸混合後之製劑對於封閉牙本質小管的效果,進而推測材料的作用機轉。材料分析部分:硝酸催化之溶膠-凝膠生醫玻璃其化學組成與加入之原料比例相似,表示化學反應完全,其結構為具有200nm~1μm之孔洞,而氫氧化鈉、磷酸催化組之化學組成與加入之原料比例不完全相同,表示化學反應未臻完全,其結構前者為棉絮狀鬆散之外型,後者為顆粒聚集之外形。溶膠-凝膠生醫玻璃粉末與30%磷酸作用後有結晶物質產生,以Ca(H2PO4)2•H2O為主要結晶相,此化合物之水中溶解度高容易滲透進入牙本質小管,反應性高。此外將硝酸、氫氧化鈉、磷酸催化之溶膠-凝膠生醫玻璃及DP-bioglass與30%的磷酸以1:2(g/ml)的比例混合調拌,分別塗佈於40片牙本質切片上,十分鐘後以大量清水將表面材料移除,使用掃描式電子顯微鏡觀察材料進入牙本質小管之深度、封閉百分比與密貼程度發現硝酸催化組之表現優於其他組,最深可達104.90μm,封閉百分比達65.4%且與管週牙本質間緊密貼合。第三部分:使用溶膠-凝膠法合併含浸法锻燒製作含氧化鈣之中孔洞二氧化矽複合材料。在材料分析方面結果顯示為具有排列整齊均勻之40nm中孔洞二氧化矽,其內含有鈣離子,此材料屬非結晶性,其粉末與磷酸作用後有結晶物質產生,由濃度為20%、30%的磷酸所調配之生醫玻璃製劑以Ca(H2PO4)2•H2O為主要結晶相,而由濃度為10%的磷酸及蒸餾水所調配者則以CaHPO4•2H2O為主要結晶相,Ca(H2PO4)2•H2O溶解度較CaHPO4•2H2O高容易滲透進入牙本質小管,反應性高。由牙本質小管封閉效果之觀察,以30%磷酸混合之氧化鈣中孔洞二氧化矽之表現最佳,深度最深可達105.26μm,封閉百分比為75.6%且與管周牙本質間緊密貼合。結論:應用溶膠-凝膠法以硝酸作為催化劑製成之生醫玻璃與合併含浸法製成含氧化鈣之中孔洞氧化矽複合材料,皆為具有奈米等級孔洞之材料,可於10分鐘內有效封閉牙本質小管,具有治療牙本質過敏症之潛力。 | zh_TW |
dc.description.abstract | Our previous studies showed that most of commercialized bonding agents used for the treatment of dentin hypersensitivity were inefficient in the persistent time. Our research group have proved that DP-bioglass mixed with 30 % phosphoric acid could form well-occlusive, recrystallized precipitants inside the dentinal tubules after 3 days. However , it is not practical for clinical use. We made materials which were nano-sized particles, high surface area and high porous in nature by nano technology. The specific aims of this study were to evaluate the efficacy of tubule occlusion with the commercialized bonding agents and a desensitizer, and to produce the porous biomaterials with shorter reaction time for treatment of dentin hypersensitivity by sol-gel and impregnation methods.
In part I, we examed the efficacy of the tubule occlusion of the commercialized bonding agents and a desensitizer as well as DP-bioglass by scanning electron microscopy (SEM) observation. In part II, we developed the sol-gel bioglass with the catalyst HNO3,NaOH or H3PO4 at 800℃ followed by mixing with 30% phosphoric acid. In part III, we produced nano@CaO mesoporous silica by modified sol-gel and impregnation methods. Four nano@CaO mesoporous silica pastes were prepared from nano@CaO mesoporous silica powder by mixing with distilled water, 10%, 20%, and 30% phosphoric acid, respectively. In part II and part III, the microstructure, phase transformation, and overall qualitative analysis of materials were conducted by SEM, X-ray diffractometer (XRD), and energy dispersive spectrometer (EDS). TEM was applied in Part III for the measurement of pore size. The results indicated that: (1) gaps were noted between peritubular dentin and resin tags of bonding agents but no gap was found between DP-bioglass and the tubules wall. (2) HNO3 catalyzed sol-gel bioglass was the most porous under SEM observation. (3) pore size of nano@CaO mesoporous silica were 40nm. (4) The chemical compositions of HNO3 catalyzed sol-gel bioglass was similar to DP-bioglass. (5)Ca(H2PO4)2•H2O was the major crystalline phase in the HNO3,NaOH or H3PO4 catalyzed sol-gel bioglass mixed with 30 % phosphoric acid. However, the major crystalline phase in the DP-bioglass mixed with 30 % phosphoric acid was CaHPO4•2H2O. (6) Ca(H2PO4)2•H2O was the major crystalline phase observed in the nano@CaO mesoporous silica mixed with 30 % and 20 % phosphoric acid. However, the major crystalline phase of the bioglass mixed with distilled water and 10 % phosphoric acid was CaHPO4•2H2O. (7) well-occlusive, recrystalline precipitants could noted in dentin tubules after sol-gel bioglass pastes and nano@CaO mesoporous silica pastes applied on dentin surface. (8) in 10 mins, HNO3,NaOH or H3PO4 catalyzed sol-gel bioglass pastes demonstrated higher percentage of tubular occlusion and penetration depth compared with DP-bioglass. 65% of dentin tubules were occluded by the recrystalline precipitants of HNO3 catalyzed sol-gel bioglass paste and the penetration depth in dentin tubule was 104.9μm. The percentage of tubule occlusion and penetration depth of nano@CaO mesoporous silica mixed with 30% H3PO4 for 10 minutes were significantly higher than nano@CaO mesoporous silica mixed with distilled water,10% or 20% H3PO4. The maximum depth was 105.26μm and the percentage was 75%. Conclusion: Both of the sol-gel bioglass and nano@CaO mesoporous silica were porous materials, they could occlude the dentinal tubules in 10 minutes. These new porous materials have potential for the treatment of dentin hypersensitivity. | en |
dc.description.provenance | Made available in DSpace on 2021-06-08T06:27:44Z (GMT). No. of bitstreams: 1 ntu-95-R92422007-1.pdf: 4863719 bytes, checksum: 1df9620d705b8444f8ab868f0045452e (MD5) Previous issue date: 2006 | en |
dc.description.tableofcontents | 目 錄
中文摘要--------------------------------------------------------------------I 英文摘要--------------------------------------------------------------------III 目錄---------------------------------------------------------------------------------V 圖次-----------------------------------------------------------------------------VIII 表次------------------------------------------------------------------------------XI 第1章 前言--------------------------------------------------------------------------1 第2章 文獻回顧--------------------------------------------------------------------3 2.1牙本質過敏症的定義---------------------------------------------------3 2.2牙本質過敏症的流行病學---------------------------------------------3 2.3牙本質過敏症的成因------------------------------------------------4 2.4牙本質過敏症的基本假說-------------------------------------------5 2.5牙本質過敏症的治療方式-----------------------------------------7 2.6生醫玻璃的應用--------------------------------------------------------11 2.7生醫玻璃之潛力與奈米材料之研發-------------------------------13 2. 8 奈米科技----------------------------------------------------------------------------- 13 2. 9 奈米材料----------------------------------------------------------------------------- 14 2.10奈米效應------------------------------------------------------------------------------14 2.11奈米製程:溶膠凝膠技術----------------------------------------------------------16 2.12奈米孔洞材料:含氧化鈣中孔洞二氧化矽-------------------------------------18 2.13孔洞材料原理介紹------------------------------------------------------------------19 第3章 動機與目的------------------------------------------------------------------------ 21 第4章 材料與方法-------------------------------------------------------------------- 23 4.1 觀察及比較三種市售牙本質黏著劑及去敏感劑與DP-bioglass對於牙本 質小管的滲透深度與封閉效果之評估---------------------------------------23 4.1.1牙本質試片的製備------------------------------------------------------------23 4.1.2實驗分組與條件設定-------------------------------------------------------- 23 4.1.3掃描式電子顯微鏡的觀察-------------------------------------------------- 24 4.2 溶膠-凝膠生醫玻璃與溶膠凝膠生醫玻璃製劑之研發及其性質分析和對 於牙本質小管的滲透深度與封閉效果之評估---------------------------- 25 4.2.1溶膠-凝膠生醫玻璃的製作--------------------------------------------------25 4.2.2溶膠-凝膠生醫玻璃製劑的製作與性質分析----------------------------27 4.2.3溶膠-凝膠生醫玻璃製劑對於牙本質小管的滲透深度與封閉效果之 評估----------------------------------------------------------------------------28 4.3 含氧化鈣中孔洞二氧化矽與含氧化鈣中孔洞二氧化矽製劑之研發及其 性質分析和對於牙本質小管的滲透深度與封閉效果之評估------------- 29 4.3.1含氧化鈣中孔洞二氧化矽的製作與性質分析---------------------------29 4.3.2氧化鈣中孔洞二氧化矽製劑的製作與性質分析-----------------------31 4.3.3氧化鈣中孔洞二氧化矽製劑對於牙本質小管的滲透深度與封閉效 果之評估---------------------------------------------------------------------- 32 第5章 結果-------------------------------------------------------------------------34 5.1 觀察及比較三種市售牙本質黏著劑及去敏感劑與DP-bioglass對於牙本 質小管的滲透深度與封閉效果之評估------------------------------------------34 5.1.1掃描式電子顯微鏡的觀察-------------------------------------------------- 34 5.2 溶膠-凝膠生醫玻璃與生醫玻璃製劑之研發及其性質分析和對於牙本質 小管的滲透深度與封閉效果之評估---------------------------------------------35 5.2.1溶膠-凝膠生醫玻璃粉末的性質分析-------------------------------------35 5.2.2溶膠-凝膠生醫玻璃製劑的性質--------------------------------------36 5.2.3溶膠-凝膠生醫玻璃製劑對於牙本質小管的滲透深度與封閉 百分比之評估-------------------------------------------------------- 37 5.3含氧化鈣中孔洞二氧化矽與含氧化鈣中孔洞二氧化矽製劑之研發及其 性質分析和對於牙本質小管的滲透深度之評估---------------------------- 38 5.3.1含氧化鈣中孔洞二氧化矽粉末的性質分析-----------------------------38 5.3.2含氧化鈣中孔洞二氧化矽製劑的性質分析-----------------------------39 5.3.3 含氧化鈣中孔洞二氧化矽製劑對於牙本質小管的滲透深度 與封閉百分比之評估-------------------------------------------------------40 第6 章 討論 ---------------------------------------------------------------------------------42 第7章 結論-------------------------------------------------------------------------56 第8章 未來研究方向-------------------------------------------------------------58 參考文獻------------------------------------------------------------------------------60 圖 次 第4章 圖 4-1 掃描式電子顯微鏡(Topcon ABT-60,Japan)------------------------------72 圖 4-2 X光繞射分析儀(Regaku Geigerflex, Japan) ----------------------------72 圖 4-3 能量分散光譜儀(LEO 1530, USA)-------------------------------------- -73 圖 4-4 箱型高溫爐(UF-K5F-20*20*25) ------------------------------------------73 圖 4-5 熱重分析儀(thermogravimetn’c analysis;TGA)-------------------------74 圖 4-6 慢速鋸片機(Isomet low speed saw)---------------------------------------74 圖 4-7 場發射鎗穿透式電子顯微鏡(75kV)Hitachi H-7100------------------75 圖 4-8 離子覆膜機(sputter coater)--------------------------------------------------75 第5章 圖 5-1(a),(b) 牙本質黏著劑Xeno III在牙本質試片表面光照作用後樹脂突 進入之情況(1000X),(2000X)----------------------------------------------76 圖 5-2 (a),(b) 牙本質黏著劑One Coat Bond在牙本質試片表面光照作用後樹脂 突進入之情況(1000X),(2000X)-------------------------------------------77 圖 5-3 (a),(b) 牙本質黏著劑Seal& Protect在牙本質試片表面光照作用後樹脂 突進入之情況(1000X),(2000X)-------------------------------------------78 圖 5-4(a),(b) 生醫玻璃製劑在牙本質試片表面作用 3天後,牙本質小管內在結晶沉澱物的形成情形(1000X),(2000X)----------------------------------79 圖 5-5 牙本質黏著劑與牙本質脫離之觀察(1000X)----------------------------80 圖 5-6 各種牙本質黏著劑或去敏感劑對於牙本質小管之封閉效果--------81 圖 5-7 各種溶膠-凝膠生醫玻璃之熱重損失分析-------------------------------82 圖 5-8(a),(b) 硝酸催化之溶膠-凝膠生醫玻璃粉末之掃瞄式電子顯微鏡 觀察(500x),(2000x)----------------------------------------------------------83 圖 5-9(a),(b) 氫氧化鈉催化之溶膠-凝膠生醫玻璃粉末之掃瞄式電子顯 微鏡觀察(500x),(2000x)----------------------------------------------------84 圖 5-10(a),(b)磷酸催化之溶膠-凝膠生醫玻璃粉末之掃瞄式電子顯微鏡 觀察(500x),(2000x)---------------------------------------------------------85 圖5-11(a),(b) 生醫玻璃(DP-bioglass)粉末之掃瞄式電子顯微鏡觀察(500x),(2000x)---------------------------------------------------------------86 圖5-12(a),(b) 硝酸催化之溶膠-凝膠生醫玻璃粉末與30%磷酸作用後形成 之結晶形態(500x),(2000x)------------------------------------------------87 圖5-13(a),(b) 氫氧化鈉催化之溶膠-凝膠生醫玻璃粉末與30%磷酸作用後 形成之結晶形態(500x),(2000x)----------------------------------------88 圖5-14(a),(b) 磷酸酸催化之溶膠-凝膠生醫玻璃粉末與30%磷酸作用後 形成之結晶形態(500x),(2000x)------------------------------------------89 圖5-15(a),(b) DP-bioglass粉末與30%磷酸作用後形成之結晶形態 (500x),(2000x)---------------------------------------------------------------90 圖5-16 不同催化劑之溶膠-凝膠生醫玻璃粉末之X光繞射分析-----------91 圖5-17 不同催化劑之溶膠-凝膠生醫玻璃粉末與30%磷酸作用後之X光 繞射分析圖------------------------------------------------------------------92 圖5-18(a),(b) 硝酸催化之溶膠-凝膠生醫玻璃製劑在牙本質試片表面作用 10分鐘後再結晶沉澱物的形成情形(1000x),(2000X)---------------93 圖5-19(a),(b) 氫氧化鈉催化之溶膠-凝膠生醫玻璃製劑在牙本質試片表面作用 10分鐘後再結晶沉澱物的形成情形(1000x),(2000X)---------------94 圖5-20(a),(b) 磷酸催化之溶膠-凝膠生醫玻璃製劑在牙本質試片表面作用 10分鐘後再結晶沉澱物的形成情(1000x),(2000X)--------------------95 圖5-21(a),(b) 生醫玻璃製劑在牙本質試片表面作用 10分鐘後再結晶沉澱物的形 成情形 (1000x),(2000X)-------------------------------------------------96 圖5-22 各種生醫玻璃製劑對於牙本質小管之封閉效果---------------------97 圖5-23 含氧化鈣中孔洞二氧化矽之掃描式電子顯微鏡觀察---------------98 圖5-24 中孔洞二氧化矽之穿透式電子顯微鏡觀察---------------------------98 圖5-25(a),(b) 含氧化鈣中孔洞二氧化矽之穿透式電子顯微鏡觀察 (80000x),(200000x)---------------------------------------------------------99 圖5-26(a),(b) 含氧化鈣中孔洞二氧化矽粉末與蒸餾水作用後形成之結晶 形態(500x),(2000X)--------------------------------------------------------100 圖5-27(a),(b) 含氧化鈣中孔洞二氧化矽粉末與10%磷酸作用後形成之結晶 形態(500x),(2000X)--------------------------------------------------------101 圖5-28(a),(b) 含氧化鈣中孔洞二氧化矽粉末與20%磷酸作用後形成之結晶 形態(500x),(2000X)--------------------------------------------------------102 圖5-29(a),(b) 含氧化鈣中孔洞二氧化矽粉末與30%磷酸作用後形成之結晶 形態(500x),(2000X)-------------------------------------------------------103 圖5-30 含氧化鈣二氧化矽粉末及其與不同磷酸濃度作用後之X光繞射 分析圖-----------------------------------------------------------------------104 圖5-31(a),(b) 含氧化鈣二氧化矽粉末與蒸餾水調配在牙本質試片表面作用 10分鐘後再結晶沉澱物的形成情形(1000x),(2000x)---------------105 圖5-32(a),(b) 含氧化鈣二氧化矽粉末與10%磷酸調配在牙本質試片表面作用 10分鐘後再結晶沉澱物的形成情形(1000x),(2000x)---------------106 圖5-33(a),(b) 含氧化鈣二氧化矽粉末與20%磷酸調配在牙本質試片表面作用 10分鐘後再結晶沉澱物的形成情形(1000x),(2000x)---------------107 圖5-34(a),(b) 含氧化鈣二氧化矽粉末與30%磷酸調配在牙本質試片表面作用 10分鐘後再結晶沉澱物的形成情形(1000x),(2000x)--------------108 圖5-35 各種濃度磷酸與含氧化鈣中孔洞二氧化矽混合製劑對於牙本質小管之封閉效果-------------------------------------------------------------109 表 次 第2章 表2-1 奈米技術有關bottom up及top down之原理說明--------------------110 表2-2 孔洞尺寸的分類 -----------------------------------------------------------110 第4章 表4-1 各種本實驗所使用之牙本質黏著劑或去敏感劑之成分及使用方111 表4-2 溶膠-凝膠生醫玻璃使用各種催化劑製備之原料名稱及重量-----112 表4-3 本研究中所使用之化學藥品---------------------------------------------113 表4-4 本研究所使用之相關儀器------------------------------------------------114 第5章 表5-1 生醫玻璃製劑與各類去敏感劑關於牙本質小管封閉情況之比較116 表 5-2 各種市售黏著劑/去敏感劑封閉牙本質小管之百分比的 統計分析 -----------------------------------------------------------------117 表 5-3 各種市售黏著劑/去敏感劑封閉牙本質小管之深度的統計分析118 表 5-4 掃描式電子顯微鏡觀察各種粉末與各種製劑之比較-------------119 表5-5(a) DP-bioglass之元素組成分析---------------------------------------------119 表5-5(b) 各種催化劑之溶膠-凝膠生醫玻璃粉末之元素組成分析-----------119 表5-6 DP-bioglass與各種催化劑之溶膠-凝膠生醫玻璃製劑關於牙本質 小管封閉情況之比較---------------------------------------------------120 表5-7 各種催化劑製成之溶膠-凝膠生醫玻璃製劑封閉牙本質小管之百分 比的統計分析表----------------------------------------------------------121 表5-8 各種催化劑製成之溶膠-凝膠生醫玻璃製劑封閉牙本質小管之深度 的統計分析表--------------------------------------------------------------122 表5-9 含氧化鈣二氧化矽粉末及其與各種濃度磷酸混合製劑於掃瞄式 電子顯微鏡下觀察之比較-----------------------------------------------123 表5-10 含氧化鈣二氧化矽與各種濃度磷酸關於牙本質小管封閉情況之 比較--------------------------------------------------------------------123 表5-11 各種磷酸濃度與含氧化鈣中孔洞二氧化矽混合製劑封閉牙本質小管之百分比的統計分析表----------------------------------------------124 表5-12 各種磷酸濃度與含氧化鈣中孔洞二氧化矽混合製劑封閉牙本質小管之深度的統計分析表-------------------------------------------------125 | |
dc.language.iso | zh-TW | |
dc.title | 以溶膠-凝膠技術研發孔洞材料應用於治療牙本質過敏症 | zh_TW |
dc.title | Development of Sol-Gel Porous Materials for the
Treatment of Dentin Hypersensitivity | en |
dc.type | Thesis | |
dc.date.schoolyear | 94-2 | |
dc.description.degree | 碩士 | |
dc.contributor.coadvisor | 藍萬烘 | |
dc.contributor.oralexamcommittee | 林峰輝 | |
dc.subject.keyword | 溶膠-凝膠技術,生醫玻璃,中孔洞,牙本質過敏症, | zh_TW |
dc.subject.keyword | Sol-gel technique,bioglass,mesoporous,dentin hypersensitivity, | en |
dc.relation.page | 125 | |
dc.rights.note | 未授權 | |
dc.date.accepted | 2006-07-27 | |
dc.contributor.author-college | 醫學院 | zh_TW |
dc.contributor.author-dept | 臨床牙醫學研究所 | zh_TW |
顯示於系所單位: | 臨床牙醫學研究所 |
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