研發分子篩催化劑在牙齒漂白治療上的應用

Abstract

一般診間牙齒漂白多是利用30-35% H2O2高濃度的過氧化氫，配合光源或是熱進行催化達到快速牙齒漂白的效果。提高過氧化氫的濃度雖然可得到較佳的牙齒漂白效果，可是對牙髓組織的刺激性以及對牙齒本身所產生的影響及傷害也就越大。因此本實驗的目的在於尋求較佳的牙齒漂白催化劑，除了可以降低過氧化氫使用的濃度，更希望進而減低漂白過程中對牙齒的刺激及傷害。在實驗中我們選用了六種過渡金屬離子(Fe3+, Mn2+, Zn2+, Ni 2+, Cu2+, V4+)，並利用不同的載負體(Kalimate, Sodium-Y)合成金屬離子催化劑，催化低濃度的過氧化氫(10mM)，並以紫外光/可見光分光光譜儀檢測其漂白催化效果。進一步更利用Histidine合成金屬錯合物置入中孔洞分子篩(Al-MCM41)，合成中孔洞分子篩催化劑。並利用不同的實驗環境條件的調控藉以尋求最佳的漂白催化條件，同時更利用ICP-AES、TGA、EA等對金屬離子催化劑進行成份分析。在實驗結果，我們可以發現，不同的載負體所合成之金屬離子催化劑其漂白效率亦有所不同，其中以中孔洞分子篩(MCM41)最佳，Sodium-Y次之。在一般環境中Fe-Histidine@Al-MCM41和Mn-Histidine@Al-MCM41兩種金屬離子催化劑的漂白催化效果相去不遠，但在酸性環境中以Fe-Histidine@Al-MCM41的催化效果較佳，鹼性環境中則是Mn-Histidine@Al-MCM41的催化效果較佳。在過氧化氫的濃度上，我們發現當過氧化氫濃度增加時，漂白的反應速率雖然會提升，但當過氧化氫濃度高於10mM時所提升的量漸趨不明顯。利用中孔洞分子篩合成金屬離子催化劑確實能有效的催化低濃度的過氧化氫達到漂白的效果，將來或可以應用在牙齒美白治療上來升牙齒漂白速率，及降低漂白過程中牙齒的傷害！

Using light sources or heat to accelerate the bleaching of 30-35% H2O2 is getting popular for in-office bleaching. However, high-concentration H2O2 has been reported to be detrimental to tooth hard tissue as well as pulp tissue, and then post-bleaching pain ensues. The aim of this study was to search for appropriate catalysts to promote the effectiveness of tooth bleaching with low concentration of H2O2. We utilized six metal ions (Fe3+, Mn2+, Zn2+, Ni 2+, Cu2+, V4+) and Sodium-Y to catalyze the reaction rate of 10mM H2O2. Spectrophotometer was used to determine the most efficient metal ions in our established tooth stain model. The determined metal ion was anchored with Histidine and subsequently incorporated into Mesorporous-MCM41 to improve bleaching ability. The results revealed that Fe3+@Sodium-Y, had the greatest bleaching ability followed by Mn2+@Sodium-Y and orthers. Histidine can improve the catalyzing ability of metal ions and exhibit no toxic effect, while mesorporous-MCM41 can increase the reaction surface area. The Fe-Histidine@Al-MCM-41 and Mn-Histidine@Al-MCM41 complex was the most useful regimen that can promote the bleaching efficiency of H2O2. Conclusion:By using Fe-Histidine@Al-MCM41 and Mn-Histidine@Al-MCM41 as the catalyst of H2O2, we may enhance the efficiency of tooth bleaching with less working-time, and thereby, decrease the potential damage of H2O2 to tooth during tooth bleaching.