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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 徐治平(Jyh-Ping Hsu) | |
dc.contributor.author | Keng-Chao Wu | en |
dc.contributor.author | 吳庚釗 | zh_TW |
dc.date.accessioned | 2021-06-08T06:11:44Z | - |
dc.date.copyright | 2007-07-16 | |
dc.date.issued | 2007 | |
dc.date.submitted | 2007-07-03 | |
dc.identifier.citation | (1) K. P. R. Chowdary; R. M. A. Sri, “Microencapsulation in pharmacy”, Indian Drugs, 25, 389, (1998).
(2) R. B. Aristi ; K. Costas, “Synthesis and release studies of oil-containing poly (vinyl alcohol) microcapsules prepared by coacervation”, Journal of Controlled Release, 38, 49, (1996). (3) R. B. Aristi; J. B. Costas; K.Costas, “Production of oil-containing crossslinked poly(vinyl alcohol) microcapsules by phase separation: effect of process parameters on the capsules size distribution”, Journal of Applied Polymer Science, 60, 9, (1996). (4) J. Lazko; Y. Popineau; J. Legrand, “Soy glycinin microcapsules by simple coacervation method”, Colloids and Surface B: Biointerfaces, 37, 1, (2004). (5) S. Alexandridou; K. Costas; J. Fransaer; J. P. Celis, “On the synthesis of oil-containing microcapsules and their electrolytic codeposition”, Surface and Coatings Technology, 71, 267, (1995). (6) H. L. Guo; X. P. Zhao; J. P. Wang, “The relation between narrow-dispersed microcapsules and surfactants”, Journal of Microencapsulation, 22, 853, (2005). (7) 張思琳, 微觀化學工程專刊 第二期, 1995 (8) H. Sakaoka, United States Patent, US3948597, (1976). (9) D. K. Brain; M. T. Cummins, United States Patent, US4145184, (1979). (10) J. D. McGalliard, United States Patent, US4152784, (1979). (11)江家臨, 人造纖維理論與技術, 253-314, 徐氏基金會, 民國61年. (12) C. K. Yeom; K. H. Lee, “Pervaporation separation of water-acetic acid mixtures through poly(vinyl alcohol)” , Journal of Membrane Science, 109, 257, (1996). (13) T. H. Young; W. Y. Chuang; N. K. Yao; L. W. Chen, “Use of a diffusion model for assessing the performance of poly(vinyl alcohol) bioartificial pancrease”, Journal of Biomedical Materials Research, 40, 385, (1998). (14) W. Paul; C. P. Sharma, “Acetylsalicylic acid loaded poly(vinyl alcohol) hemodialysis membranes: effect of drug release on blood compatibility and permeability”, Journal of Biomaterials Science. Polymer Edition, 8, 755, (1997). (15) K. Burczak; E. Gamian; A. Kochman, “Long-term in vivo performance and biocompatibility of poly(vinyl alcohol) hydrogel microcapsules for hybrid-type artificial pancreas”, Biomaterials, 17, 2351,(1996). (16) I. Sakurada, “Polyvinyl alcohol fibers” Marcel Dekker, Inc. New York and Basel, (1985). (17) 廖盛焜; 王奕勝; 簡瑞宏; 蔡宗偉, “不同乳化劑對包覆香精油之三聚氰胺甲醛樹脂微膠囊製備之形態觀察”, Journal of Chinese Colloid & Interface Society, 24, 11, (2002). (18) 張廖慧平; 張志鵬, “相分離法製備包覆精油微膠囊及其制放性之研究”, 華岡紡織期刊, 9, 4, 392, (2002). (19) 柳聰立, 張志鵬, “海藻酸鈣包覆尤加利精油微膠囊之製備與緩效性之探討”,華岡紡織期刊, 10, 2, 215, (2003). (20) 胡建斌, 張志鵬, “聚乙烯醇微膠囊包覆薰衣草精油製備與其制放性之探討”,華岡紡織期刊, 10, 3, 264, (2003). (21) 梁文菁, 張志鵬, “明膠包覆精油微膠囊之製備及其制放性之探討”, 華岡紡織期刊, 10, 2, 174, (2003). (22) 趙承琛, 界面科學基礎, 復文書局, (2001). (23) 林清安; 林德培; 丁幸一, 界面活性劑化學, 逢甲書局, (1979). (24) 林宗華, 織物整理工程學, 大學圖書供應社, (1996). (25) 陳崇賢, “乳液概論” , 界面科學會誌, 19, 1, 1, (1996). (26) 沈宗禮, 制放技術與微粒包覆, 高立圖書有限公司, (1980). (27) H.F. Mark; N. G. Gaylord; N. M. Bikales, “Encyclopedia of polymer science and technology: plastic, resins, rubbers, fibers”, New York, Interscience Publishers, 14, 156, (1977). (28) W. O. Herrmann; W. Haehnel, United States Patent, US2265283, (1941). (29)黃坤山,“交鏈濕式法紡製高強度聚乙烯醇纖維結構與物性之研究“, 逢甲大學紡織工程研究所博士學位論文, 23, 民國83年 | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/25395 | - |
dc.description.abstract | 本實驗使用聚乙烯醇Poly(vinyl alcohol) (PVA)為殼材,以香精油為核材,利用相分離原理,以簡單凝膠法,以戊二醛為交聯劑進行微膠囊包覆。討論攪拌速率、反應溫度、精油及乳化劑體積比率對所製備之微膠囊形態、粒徑分佈及包覆率的影響,並使用Design-expert 5,進行變因間交互影響分析。得知攪拌速率越高,得到粒徑越小,但造成精油揮發較多,易產生PVA聚集的粒子。反應溫度較高時,精油揮發較多,得到粒徑較小,但在精油量足夠時,由於溫度高,交聯反應較快,粒徑較大。精油量若過低,則容易形成PVA聚集,若提高精油量,乳化劑的量也需相對提高,以提供足夠的分散效果與保護。此時精油量越大所製備之微膠囊粒徑越大。由Design-expert 5軟體分析結果顯示,固定乳化劑,對微膠囊粒徑影響的因素重要性為:精油體積>攪拌速率>反應溫度,包覆率影響的因素重要性為:精油重量>反應溫度>攪拌速率。改以精油與乳化劑總體積為油相體積,進行分析,則對粒徑影響的因素重要性為:反應溫度>攪拌速率>油相體積,對包覆率影響的因素重要性為:油相體積>反應溫度,攪拌速率幾乎不影響。 | zh_TW |
dc.description.abstract | Oil-containing poly (vinyl alcohol) (PVA) microcapsules were prepared by simple coacervation followed by the chemical cross-linking of coacervated PVA membrane with glutaric aldehyde through phase separation method. The effect of the process parameters such as agitation speed, temperature and the amount of oil and emulsifier on the capsule size distribution and capacity were investigated and Design-expert 5 was used to find out the interaction between process parameters. It was shown that high agitation rates resulted in a reduction of the size of microcapsules, but more oil evaporated and more PVA aggregation as the effect of higher temperature with less oil . On the contrary, with sufficient oil the higher temperature made the crosslinking rate and the size of microcapsules increase. If more oil is used, more emulsifier was needed to protect the oil droplets so that the capsules size increased. The analysis through Design-expert 5 shown that with constant emulsifier volume, the order of the influence on the capsules size distribution was oil volume ratio>agitation speed>temperature and oil volume ration>temperature>agitation on the capacity. Combining oil and emulsifier as oil phase volume, the order of the influence on the capsules size distribution was temperature>agitation speed>oil phase volume and oil volume ratio>temperature and agitation speed had no effect on the capacity. | en |
dc.description.provenance | Made available in DSpace on 2021-06-08T06:11:44Z (GMT). No. of bitstreams: 1 ntu-96-R94549010-1.pdf: 2019086 bytes, checksum: da9df25e4ed328042134e13fef4120a0 (MD5) Previous issue date: 2007 | en |
dc.description.tableofcontents | 目錄
中文摘要………………………………………………………………………………I 英文摘要……………………………………………………………………………...II 目錄…………………………………………………………………………………..III 圖表目錄……………………………………………………………………………..IV 第一章 緒論…………………………………………………………………………1 第二章 實驗原理……………………………………………………………………3 2.1乳化原理…………………………………………………………………………..3 2.2微膠囊包覆原理…………………………………………………………………..5 2.3微膠囊包覆技術......................................................................................................7 2.4聚乙烯醇的性質與縮醛反應……………………………………………………..8 第三章 實驗方法………………………………………………….……………….10 3.1實驗藥品…………………………………………………………………………10 3.2實驗設備……………………………………………..………………………...…11 3.3實驗步驟…………………………………………………………………………12 3.3-1實驗流程………………………………………………………………….…12 3.3-2微膠囊形態觀察………………………………………………………….…13 3.3-3微膠囊粒徑測量………………………………………………………….…13 3.3-4微膠囊包覆率測量……………………………………………………….…13 第四章 結果與討論……………………………………………………………..…14 4.1攪拌速率對微膠囊形態與粒徑之影響…………………………………………14 4.2反應溫度對微膠囊形態與粒徑之影響…………………………………………14 4.3精油及乳化劑比率對微膠囊形態之影響………………………………………15 4.4以Design-Expert 5分析實驗變因間對粒徑及包覆率之交互影響……………16 第五章 結論……………………………………………………………………..…20 第六章 參考文獻……………………………………………………..……………21 圖表目錄 表1.不同HLB值之應用………………………………………………………….…23 表2.微膠囊製備理論與方法………………………………..………………………23 表3.改變攪拌速率、反應溫度及精油體積比實驗結果……..……………………..24 表4.改變攪拌速率、反應溫度及油相體積比實驗結果……..……………………..24 圖2-1蒸汽凝結法…………………………………………….…………………...…25 圖2-2電分散法……………………………………………….…………………...…25 圖2-3自然乳化法…………………………………………….…………………...…26 圖2-4乳液各種現象………………………………………….…………………...…26 圖2-5界面活性劑分子……………………………………….…………………...…27 圖2-6微膠囊的各種型態……………………………………………………………27 圖2-7黏著功與凝聚功示意圖………………………….………………………...…27 圖2-8物理化學法……………………………………….……………………...……28 圖2-9化學法…………………………………………….………………………...…28 圖2-10機械法…………………………..……………….………………………...…29 圖2-11聚乙烯醇結構式……………………….….…….………………………...…29 圖2-12聚乙烯醇製造反應……………………..………………………….……...…29 圖2-13分子內縮甲醛化反應…………………..……………………………………30 圖2-14分子間縮甲醛化反應……………………..…………………………………30 圖2-15分子間雙醛縮合反應…………………..……………………………………31 圖2-16分子內雙醛縮合反應………………..………………………………………31 圖3-1 LS230裝置圖…………………………………..………………………....…..32 圖3-2微膠囊製備流程圖……………………………………………………………33 圖3-3測量微膠囊包覆率流程圖……………………………………………………34 圖4-1反應溫度25℃製備之微膠囊OM (560X) ……………………….………….35 圖4-2反應溫度25℃製備之微膠囊OM (560X) …………………….…………….36 圖4-3反應溫度40℃製備之微膠囊OM (560X) ………………..……………….…37 圖4-4反應溫度40℃製備之微膠囊OM (560X) ………………..………………….38 圖4-5不同攪拌速率下微膠囊粒徑分布………………………..…………………..39 圖4-6不同攪拌速率下微膠囊粒徑分布………………………....…………………40 圖4-7不同攪拌速率下微膠囊粒徑分布……………………………………………41 圖4-8不同攪拌速率下微膠囊粒徑分布……………………………………………42 圖4-9不同反應溫度下微膠囊粒徑分布……………………………………………43 圖4-10不同反應溫度下微膠囊粒徑分布…………………………………………..44 圖4-11不同反應溫度下微膠囊粒徑分布…………………………………………..45 圖4-12不同反應溫度下微膠囊粒徑分布…………………………………………..46 圖4-13不同精油與乳化劑比率之微膠囊粒徑分布……………………………..…47 圖4-14不同精油與乳化劑比率之微膠囊粒徑分布………………………………..48 圖4-15攪拌速率、反應溫度及精油體積比對微膠囊影響……………………..…49 圖4-16攪拌速率、反應溫度及精油體積比實驗結果Outlier T圖…………………50 圖4-17攪拌速率與反應溫度對粒徑及包覆率Interaction Graph………………….51 圖4-18攪拌速率與精油體積比對粒徑及包覆率Interaction Graph………….……52 圖4-19反應溫度與精油體積比對粒徑及包覆率Interaction Graph……………….53 圖4-20攪拌速率、反應溫度及油相體積比對微膠囊影響…………………………54 圖4-21攪拌速率、反應溫度及油相體積比實驗結果Outlier T圖…………………55 圖4-22攪拌速率與反應溫度對粒徑及包覆率Interaction Graph………………….56 圖4-23攪拌速率與油相體積比對粒徑及包覆率Interaction Graph……………….57 圖4-24反應溫度與油相體積比對粒徑及包覆率Interaction Graph……………….58 | |
dc.language.iso | zh-TW | |
dc.title | 以相分離法製備微膠囊包覆精油 | zh_TW |
dc.title | Preparation of Oil-containing Poly (vinyl alcohol)
Microcapsules through Phase Separation | en |
dc.type | Thesis | |
dc.date.schoolyear | 95-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 曾琇瑱,張有義,林松華,郭勇志 | |
dc.subject.keyword | 微膠囊,相分離法,聚乙烯醇, | zh_TW |
dc.subject.keyword | microcapsules,phase separation,poly(vinyl alchol), | en |
dc.relation.page | 59 | |
dc.rights.note | 未授權 | |
dc.date.accepted | 2007-07-03 | |
dc.contributor.author-college | 工學院 | zh_TW |
dc.contributor.author-dept | 高分子科學與工程學研究所 | zh_TW |
顯示於系所單位: | 高分子科學與工程學研究所 |
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