請用此 Handle URI 來引用此文件:
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/23769
標題: | Nak透過胞飲作用促進樹突生長 Nak promotes dendrite growth through endocytosis |
作者: | Wei-Kang Yang 楊維康 |
指導教授: | 簡正鼎 |
關鍵字: | 樹狀樹突神經元,樹突,胞飲作用,籠形蛋白,籠形蛋白轉接器, Nak,endocytosis,clathrin,adaptin,Nrg,dendrite,da neuron, |
出版年 : | 2011 |
學位: | 博士 |
摘要: | During development, dendrites arborize in a field several hundred folds of their soma size, a process regulated by intrinsic transcription programs and cell adhesion molecule (CAM)-mediated dendrodendritic interaction. However, underlying cellular machineries that govern distal higher-order dendrite extension remain largely unknown. Here, I show that Nak, a clathrin adaptor-associated kinase, promotes higher-order dendrite growth through endocytosis. In nak mutants, the number and length of higher-order dendrites are reduced, which are phenocopied by compromising clathrin-mediated internalization. Nak genetically interacts with genes involved in endocytosis, colocalizes with clathrin puncta and is required for localization of clathrin puncta in distal dendrites. Furthermore, these clathrin structures preferentially localize to branching points and dendritic tips that are undergoing active growth. I present evidence to show that the Drosophila L1-CAM homolog Neuroglian is a relevant cargo of Nak-dependent internalization, suggesting that localized clathrin-mediated endocytosis of CAMs facilitates the extension of nearby higher-order dendrites. |
URI: | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/23769 |
全文授權: | 未授權 |
顯示於系所單位: | 分子醫學研究所 |
文件中的檔案:
檔案 | 大小 | 格式 | |
---|---|---|---|
ntu-100-1.pdf 目前未授權公開取用 | 16.34 MB | Adobe PDF |
系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。