請用此 Handle URI 來引用此文件：
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/23342完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 葉力森,張雅珮 | |
| dc.contributor.author | Pen-Ting Liao | en |
| dc.contributor.author | 廖本庭 | zh_TW |
| dc.date.accessioned | 2021-06-08T04:59:27Z | - |
| dc.date.copyright | 2011-08-22 | |
| dc.date.issued | 2011 | |
| dc.date.submitted | 2011-08-19 | |
| dc.identifier.citation | 1. Simon RP, Greenberg DA, Aminoff MJ. Clinical neurology. New York: Lange Medical Books/McGraw-Hill; 2009.
2. Hu HH, Sheng WY, Chu FL, Lan CF, Chiang BN. Incidence of stroke in taiwan. Stroke. 1992;23:1237-1241 3. Chang KC, Tseng MC. Costs of acute care of first-ever ischemic stroke in taiwan. Stroke. 2003;34:e219-221 4. Reith J, Jorgensen HS, Pedersen PM, Nakayama H, Raaschou HO, Jeppesen LL, Olsen TS. Body temperature in acute stroke: Relation to stroke severity, infarct size, mortality, and outcome. Lancet. 1996;347:422-425 5. Schwab S, Schwarz S, Spranger M, Keller E, Bertram M, Hacke W. Moderate hypothermia in the treatment of patients with severe middle cerebral artery infarction. Stroke. 1998;29:2461-2466 6. van der Worp HB, Sena ES, Donnan GA, Howells DW, Macleod MR. Hypothermia in animal models of acute ischaemic stroke: A systematic review and meta-analysis. Brain. 2007;130:3063-3074 7. Kollmar R, Schwab S. Hypothermia in focal ischemia: Implications of experiments and experience. J Neurotrauma. 2009;26:377-386 8. Schwab S, Georgiadis D, Berrouschot J, Schellinger PD, Graffagnino C, Mayer SA. Feasibility and safety of moderate hypothermia after massive hemispheric infarction. Stroke. 2001;32:2033-2035 9. Nolan JP. Therapeutic hypothermia after cardiac arrest: An advisory statement by the advanced life support task force of the international liaison committee on resuscitation. Circulation. 2003;108:118 10. Safar PJ. Editorial: Therapeutic hypothermia after cardiac arrest. New England Journal of Medicine. 2002;346:612 11. Noguchi Y. A new method of inducing selective brain hypothermia with saline perfusion into the subdural space: Effects on transient cerebral ischemia in cats. Acta Medica Okayama. 2002;56:279 12. Prandini MN. Regional mild hypothermia in the protection of the ischemic brain. Acta Cirurgica Brasileira. 2002;17:232 13. Forte LV. Regional cooling for reducing brain temperature and intracranial pressure. Arquivos de Neuro-Psiquiatria. 2009;67:480 14. Roger VL, Go AS, Lloyd-Jones DM, Adams RJ, Berry JD, Brown TM, Carnethon MR, Dai S, de Simone G, Ford ES, Fox CS, Fullerton HJ, Gillespie C, Greenlund KJ, Hailpern SM, Heit JA, Ho PM, Howard VJ, Kissela BM, Kittner SJ, Lackland DT, Lichtman JH, Lisabeth LD, Makuc DM, Marcus GM, Marelli A, Matchar DB, McDermott MM, Meigs JB, Moy CS, Mozaffarian D, Mussolino ME, Nichol G, Paynter NP, Rosamond WD, Sorlie PD, Stafford RS, Turan TN, Turner MB, Wong ND, Wylie-Rosett J. Heart disease and stroke statistics--2011 update: A report from the american heart association. Circulation. 2011;123:e18-e209 15. Amarenco P, Bogousslavsky J, Caplan LR, Donnan GA, Hennerici MG. Classification of stroke subtypes. Cerebrovasc Dis. 2009;27:493-501 16. Adams HP, Bendixen BH, Kappelle LJ, Biller J, Love BB, Gordon DL, Marsh EE, Kase CS, Wolf PA, Babikian VL, Licatagehr EE, Allen N, Brass LM, Fayad PB, Pavalkis FJ, Weinberger JM, Tuhrim S, Rudolph SH, Horowitz DR, Bitton A, Mohr JP, Sacco RL, Clavijo M, Rosenbaum DM, Sparr SA, Katz P, Klonowski E, Culebras A, Carey G, Martir NI, Ficarra C, Hogan EL, Carter T, Gurecki P, Muntz BK, Ramirezlassepas M, Tulloch JW, Quinones MR, Mendez M, Zhang SM, Ala T, Johnston KC, Anderson DC, Tarrel RM, Nance MA, Budlie SR, Dierich M, Helgason CM, Hier DB, Shapiro RA, Brint S, Hoff J, Karanjia PN, Madden KP, Ruggles KH, Mickel SF, Gottschalk PG, Hansotia PI, Sorenson RW, Jacobson DM, Hiner BC, Mancl K, Gorelick PB, Riskin B, Mirza D, Kelly M, Bijari A, Kofman J, Dollear WC, Gomez CR, Malkoff MD, Riaz G, Schmidt JG, Malik MM, Banet G, Byer JA, Gamboa E, Stacy M, Bonnett A, Feldmann E, Wilterdink JL, Ricks L, Bruno A, Lakind E, Jeffrey DR, Mladinich EK, King M, Chapin JE, Carter S, Fisher M, Ameriso S, Macko RF, Martin A, Rothrock JF, Lyden PD, Brody ML, Kelly NM, Coull BM, Briley DP, Clark WM, Austin T, Degarmo PL, Adams HP, Dyken E, Yasar E, Bendixen B, Wojcieszek J, Kappelle J, Mitchell V, Frank J, Saver JL, Chadwick L, Mayman CI, Warach S, Tijerina ML, Miller A, Keilson M, Drexler E, Morgante L, Mandelbaum MA, Hassan R, Abbas DH, Olmstead CG, Sedlacek L, Gordon DL, Dendinger J, Love BB, Struck LK, Mueller C. Classification of subtype of acute ischemic stroke - definitions for use in a multicenter clinical-trial. Stroke. 1993;24:35-41 17. Furie KL, Kasner SE, Adams RJ, Albers GW, Bush RL, Fagan SC, Halperin JL, Johnston SC, Katzan I, Kernan WN, Mitchell PH, Ovbiagele B, Palesch YY, Sacco RL, Schwamm LH, Wassertheil-Smoller S, Turan TN, Wentworth D, Council AHAS, Nursing CC, Cardiology CC, Quality IC. Guidelines for the prevention of stroke in patients with stroke or transient ischemic attack a guideline for healthcare professionals from the american heart association/american stroke association. Stroke. 2011;42:227-276 18. Detweile.Dk, Ratcliff.Hl, Luginbuh.H. Significance of naturally occurring coronary and cerebral arterial disease in animals. Ann Ny Acad Sci. 1968;149:868-& 19. Fankhauser R, Luginbuhl H, McGrath JT. Cerebrovascular disease in various animal species. Ann Ny Acad Sci. 1965;127:817-860 20. Altay UM, Skerritt GC, Hilbe M, Ehrensperger F, Steffen F. Feline cerebrovascular disease: Clinical and histopathologic findings in 16 cats. J Am Anim Hosp Assoc. 2011;47:89-97 21. Garosi LS, McConnell JF. Ischaemic stroke in dogs and humans: A comparative review. J Small Anim Pract. 2005;46:521-529 22. Wessmann A, Chandler K, Garosi L. Ischaemic and haemorrhagic stroke in the dog. Vet J. 2009;180:290-303 23. Platt SR, Garosi L. Canine cerebrovascular disease: Do dogs have strokes? J Am Anim Hosp Assoc. 2003;39:337-342 24. Joseph RJ, Greenlee PG, Carrillo JM, Kay WJ. Canine cerebrovascular-disease - clinical and pathological findings in 17 cases. J Am Anim Hosp Assoc. 1988;24:569-576 25. McConnell JF, Garosi L, Platt SR. Magnetic resonance imaging findings of presumed cerebellar cerebrovascular accident in twelve dogs. Vet Radiol Ultrasoun. 2005;46:1-10 26. Garosi L, McConnell JF, Platt SR, Barone G, Baron JC, de Lahunta A, Schatzberg SJ. Clinical and topographic magnetic resonance characteristics of suspected brain infarction in 40 dogs. J Vet Intern Med. 2006;20:311-321 27. Paul AE, Lenard Z, Mansfield CS. Computed tomography diagnosis of eight dogs with brain infarction. Aust Vet J. 2010;88:374-380 28. Brainin M, Heiss WD, Heiss S. Textbook of stroke medicine. Cambridge, UK ; New York: Cambridge University Press; 2010. 29. Astrup J, Siesjo BK, Symon L. Thresholds in cerebral ischemia - the ischemic penumbra. Stroke; a journal of cerebral circulation. 1981;12:723-725 30. Strong AJ, Anderson PJ, Watts HR, Virley DJ, Lloyd A, Irving EA, Nagafuji T, Ninomiya M, Nakamura H, Dunn AK, Graf R. Peri-infarct depolarizations lead to loss of perfusion in ischaemic gyrencephalic cerebral cortex. Brain. 2007;130:995-1008 31. Phillis JW, SmithBarbour M, ORegan MH. Changes in extracellular amino acid neurotransmitters and purines during and following ischemias of different durations in the rat cerebral cortex. Neurochem Int. 1996;29:115-120 32. Graham SH, Shiraishi K, Panter SS, Simon RP, Faden AI. Changes in extracellular amino-acid neurotransmitters produced by focal cerebral-ischemia. Neurosci Lett. 1990;110:124-130 33. Taoufik E, Probert L. Ischemic neuronal damage. Curr Pharm Des. 2008;14:3565-3573 34. Kumar V, Abbas AK, Fausto N, Robbins SL, Cotran RS. Robbins and cotran pathologic basis of disease. Philadelphia: Elsevier Saunders; 2005. 35. Zhao H, Steinberg GK, Sapolsky RM. General versus specific actions of mild-moderate hypothermia in attenuating cerebral ischemic damage. J Cerebr Blood F Met. 2007;27:1879-1894 36. Choi DW. Ischemia-induced neuronal apoptosis. Curr Opin Neurobiol. 1996;6:667-672 37. Mattson MP, Culmsee C, Yu ZF. Apoptotic and antiapoptotic mechanisms in stroke. Cell Tissue Res. 2000;301:173-187 38. Linnik MD, Zobrist RH, Hatfield MD. Evidence supporting a role for programmed cell-death in focal cerebral-ischemia in rats. Stroke. 1993;24:2002-2008 39. Nakka VP, Gusain A, Mehta SL, Raghubir R. Molecular mechanisms of apoptosis in cerebral ischemia: Multiple neuroprotective opportunities. Molecular neurobiology. 2008;37:7-38 40. Hong SJ, Dawson TM, Dawson VL. Nuclear and mitochondrial conversations in cell death: Parp-1 and aif signaling. Trends Pharmacol Sci. 2004;25:259-264 41. Mehta SL, Manhas N, Rahubir R. Molecular targets in cerebral ischemia for developing novel therapeutics. Brain Res Rev. 2007;54:34-66 42. Hossmann KA. Disturbances of cerebral protein synthesis and ischemic cell death. Prog Brain Res. 1993;96:161-177 43. DeGracia DJ, Montie HL. Cerebral ischemia and the unfolded protein response. Journal of Neurochemistry. 2004;91:1-8 44. Rao RV, Peel A, Logvinova A, del Rio G, Hermel E, Yokota T, Goldsmith PC, Ellerby LM, Ellerby HM, Bredesen DE. Coupling endoplasmic reticulum stress to the cell death program: Role of the er chaperone grp78. Febs Lett. 2002;514:122-128 45. Latchman DS. Protective effect of heat shock proteins in the nervous system. Curr Neurovasc Res. 2004;1:21-27 46. Yenari MA, Liu J, Zheng Z, Vexler ZS, Lee JE, Giffard RG. Antiapoptotic and anti-inflammatory mechanisms of heat-shock protein protection. Ann Ny Acad Sci. 2005;1053:74-83 47. Yenari MA. Heat shock proteins and neuroprotection. In: Alzheimer C, ed. Molecular and cellular biology of neuroprotection in the cns. Kluwer Academic/Plenum Publishers and Landes Bioscience; 2002:281-300. 48. Yenari MA. Heat shock proteins and neuroprotection. Adv Exp Med Biol. 2002;513:281-299 49. Nowak TS, Jr., Jacewicz M. The heat shock/stress response in focal cerebral ischemia. Brain Pathol. 1994;4:67-76 50. Chopp M, Li Y, Dereski MO, Levine SR, Yoshida Y, Garcia JH. Neuronal injury and expression of 72-kda heat-shock protein after forebrain ischemia in the rat. Acta Neuropathol. 1991;83:66-71 51. Suwanwela N, Koroshetz WJ. Acute ischemic stroke: Overview of recent therapeutic developments. Annu Rev Med. 2007;58:89-106 52. Marler JR, Brott T, Broderick J, Kothari R, Odonoghue M, Barsan W, Tomsick T, Spilker J, Miller R, Sauerbeck L, Jarrell J, Kelly J, Perkins T, Mcdonald T, Rorick M, Hickey C, Armitage J, Perry C, Thalinger K, Rhude R, Schill J, Becker PS, Heath RS, Adams D, Reed R, Klei M, Hughes S, Anthony J, Baudendistel D, Zadicoff C, Rymer M, Bettinger I, Laubinger P, Schmerler M, Meirose G, Lyden P, Rapp K, Babcock T, Daum P, Persona D, Brody M, Jackson C, Lewis S, Liss J, Mahdavi Z, Rothrock J, Tom T, Zweifler R, Dunford J, Zivin J, Kobayashi R, Kunin J, Licht J, Rowen R, Stein D, Grisolia J, Martin F, Chaplin E, Kaplitz N, Nelson J, Neuren A, Silver D, Chippendale T, Diamond E, Lobatz M, Murphy D, Rosenberg D, Ruel T, Sadoff M, Schim J, Schleimer J, Atkinson R, Wentworth D, Cummings R, Frink R, Heublein P, Grotta JC, Degraba T, Fisher M, Ramirez A, Hanson S, Morgenstern L, Sills C, Pasteur W, Yatsu F, Andrews K, Villarcordova C, Pepe P, Bratina P, Greenberg L, Rozek S, Simmons K, Kwiatkowski TG, Horowitz SH, Libman R, Kanner R, Silverman R, Lamantia J, Mealie C, Duarte R, Donnarumma R, Okola M, Cullin V, Mitchell E, Levine SR, Lewandowski CA, Tokarski G, Ramadan NM, Mitsias P, Gorman M, Zarowitz B, Kokkinos J, Dayno J, Verro P, Gymnopoulos C, Dafer R, Dolhaberriague L, Sawaya K, Daley S, Mitchell M, Frankel M, Mackay B, Barch C, Braimah J, Faherty B, Macdonald J, Sailor S, Cook A, Karp H, Nguyen B, Washington J, Weissman J, Williams M, Williamson T, Kozinn M, Hellwick L, Haley EC, Bleck TP, Cail WS, Lindbeck GH, Granner MA, Wolf SS, Gwynn MW, Mettetal RW, Chang CWJ, Solenski NJ, Brock DG, Ford GF, Kongable GL, Parks KN, Wilkinson SS, Davis MK, Sheppard GL, Zontine DW, Gustin KH, Crowe NM, Massey SL, Meyer M, Gaines K, Payne A, Bales C, Malcolm J, Barlow R, Wilson M, Cape C, Bertorini T, Misulis K, Paulsen W, Shepard D, Tilley BC, Welch KMA, Fagan SC, Lu M, Patel S, Masha E, Verter J, Boura J, Main J, Gordon L, Maddy N, Chociemski T, Windham J, Zadeh HS, Alves W, Keller MF, Wenzel JR, Raman N, Cantwell L, Warren A, Smith K, Bailey E, Welch KMA, Tilley BC, Froehlich J, Breed J, Easton JD, Hallenbeck JF, Lan G, Marsh JD, Walker MD. Tissue-plasminogen activator for acute ischemic stroke. New England Journal of Medicine. 1995;333:1581-1587 53. Kapral MK, Laupacis A, Phillips SJ, Silver FL, Hill MD, Fang JM, Richards J, Tu JV, St IRC. Stroke care delivery in institutions participating in the registry of the canadian stroke network. Stroke. 2004;35:1756-1762 54. Suwanwela NC, Phanthumchinda K, Likitjaroen Y. Thrombolytic therapy in acute ischemic stroke in asia: The first prospective evaluation. Clin Neurol Neurosur. 2006;108:549-552 55. Bateman BT, Schumacher HC, Boden-Albala B, Berman MF, Mohr JP, Sacco RL, Pile-Spellman J. Factors associated with in-hospital mortality after administration of thrombolysis in acute ischemic stroke patients - an analysis of the nationwide inpatient sample 1999 to 2002. Stroke. 2006;37:440-446 56. Hacke W, Kaste M, Fieschi C, Toni D, Lesaffre E, Vonkummer R, Boysen G, Bluhmki E, Hoxter G, Mahagne MH, Hennerici M. Intravenous thrombolysis with recombinant tissue-plasminogen activator for acute hemispheric stroke - the european cooperative acute stroke study (ecass). Jama-J Am Med Assoc. 1995;274:1017-1025 57. Hacke W, Kaste M, Fieschi C, von Kummer R, Davalos A, Meier D, Larrue V, Bluhmki E, Davis S, Donnan G, Schneider D, Diez-Tejedor E, Trouillas P, Study SEAAS. Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ecass ii). Lancet. 1998;352:1245-1251 58. Clark WM, Wissman S, Albers GW, Jhamandas JH, Madden KP, Hamilton S, Investigators AS. Recombinant tissue-type plasminogen activator (alteplase) for ischemic stroke 3 to 5 hours after symptom onset - the atlantis study: A randomized controlled trial. Jama-J Am Med Assoc. 1999;282:2019-2026 59. Hacke W, Kaste M, Bluhmki E, Brozman M, Davalos A, Guidetti D, Larrue V, Lees KR, Medeghri Z, Machnig T, Schneider D, von Kummer R, Wahlgren N, Toni D, Investigators E. Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. New England Journal of Medicine. 2008;359:1317-1329 60. Molina CA, Ribo M, Rubiera M, Montaner J, Santamarina E, Delgado-Mederos R, Arenillas JF, Huertas R, Purroy F, Delgado P, Alvarez-Sabin J. Microbubble administration accelerates clot lysis during continuous 2-mhz ultrasound monitoring in stroke patients treated with intravenous tissue plasminogen activator. Stroke. 2006;37:425-429 61. Hacke W, Zeumer H, Ferbert A, Bruckmann H, Delzoppo GJ. Intra-arterial thrombolytic therapy improves outcome in patients with acute vertebrobasilar occlusive disease. Stroke. 1988;19:1216-1222 62. Furlan A, Higashida R, Wechsler L, Gent M, Rowley H, Kase C, Pessin M, Ahuja A, Callahan F, Clark WM, Silver F, Rivera F, Investigators P. Intra-arterial prourokinase for acute ischemic stroke - the proact ii study: A randomized controlled trial. Jama-J Am Med Assoc. 1999;282:2003-2011 63. Smith WS, Sung G, Starkman S, Saver JL, Kidwell CS, Gobin YP, Lutsep HL, Nesbit GM, Grobelny T, Rymer MM, Silverman IE, Higashida RT, Budzik RF, Marks MP, Investigators MT. Safety and efficacy of mechanical embolectomy in acute ischemic stroke - results of the merci trial. Stroke. 2005;36:1432-1438 64. Levy EI, Ecker RD, Horowitz MB, Gupta R, Hanel RA, Sauvageau E, Jovin TG, Guterman LR, Hopkins LN. Stent-assisted intracranial recanalization for acute stroke: Early results. Neurosurgery. 2006;58:458-462 65. Levy EI, Sauvageau E, Hanel RA, Paciorek AM, Hopkins LN. Self-expanding versus balloon-mounted stent-assisted recanalization of embolic occlusion: An in vivo study. Neurosurgery. 2006;58:399-400 66. Hagerdal M, Harp J, Nilsson L, Siesjou BK. The effect of induced hypothermia upon oxygen consumption in the rat brain. Journal of Neurochemistry. 1975;24:311-316 67. Palmer C, Vannucci RC, Christensen MA, Brucklacher RM. Regional cerebral blood flow and glucose utilization during hypothermia in newborn dogs. Anesthesiology. 1989;71:730-737 68. Ehrlich MP, McCullough JN, Zhang N, Weisz DJ, Juvonen T, Bodian CA, Griepp RB. Effect of hypothermia on cerebral blood flow and metabolism in the pig. Ann Thorac Surg. 2002;73:191-197 69. Sano T, Drummond JC, Patel PM, Grafe MR, Watson JC, Cole DJ. A comparison of the cerebral protective effects of isoflurane and mild hypothermia in a model of incomplete forebrain ischemia in the rat. Anesthesiology. 1992;76:221-228 70. Nakashima K, Todd MM, Warner DS. The relation between cerebral metabolic rate and ischemic depolarization: A comparison of the effects of hypothermia, pentobarbital, and isoflurane. Anesthesiology. 1995;82:1199-1208 71. Polderman KH. Mechanisms of action, physiological effects, and complications of hypothermia. Crit Care Med. 2009;37:S186-202 72. Todd MM, Warner DS. A comfortable hypothesis reevaluated. Cerebral metabolic depression and brain protection during ischemia. Anesthesiology. 1992;76:161-164 73. Maier CM, Steinberg GK. Hypothermia and cerebral ischemia : Mechanisms and clinical applications. Totowa, N.J.: Humana Press; 2004. 74. Busto R, Dietrich WD, Globus MYT, Valdes I, Scheinberg P, Ginsberg MD. Small differences in intraischemic brain temperature critically determine the extent of ischemic neuronal injury. J Cerebr Blood F Met. 1987;7:729-738 75. Kristian T, Katsura K, Siesjo BK. The influence of moderate hypothermia on cellular calcium uptake in complete ischaemia: Implications for the excitotoxic hypothesis. Acta Physiol Scand. 1992;146:531-532 76. Mitani A, Kadoya F, Kataoka K. Temperature dependence of hypoxia-induced calcium accumulation in gerbil hippocampal slices. Brain Res. 1991;562:159-163 77. Chen Q, Chopp M, Bodzin G, Chen H. Temperature modulation of cerebral depolarization during focal cerebral ischemia in rats: Correlation with ischemic injury. J Cereb Blood Flow Metab. 1993;13:389-394 78. Sick TJ, Xu G, Perez-Pinzon MA. Mild hypothermia improves recovery of cortical extracellular potassium ion activity and excitability after middle cerebral artery occlusion in the rat. Stroke; a journal of cerebral circulation. 1999;30:2416-2421; discussion 2422 79. Lo EH, Steinberg GK, Panahian N, Maidment NT, Newcomb R. Profiles of extracellular amino acid changes in focal cerebral ischaemia: Effects of mild hypothermia. Neurol Res. 1993;15:281-287 80. Winfree CJ, Baker CJ, Connolly ES, Jr., Fiore AJ, Solomon RA. Mild hypothermia reduces penumbral glutamate levels in the rat permanent focal cerebral ischemia model. Neurosurgery. 1996;38:1216-1222 81. Busto R, Globus MY, Dietrich WD, Martinez E, Valdes I, Ginsberg MD. Effect of mild hypothermia on ischemia-induced release of neurotransmitters and free fatty acids in rat brain. Stroke; a journal of cerebral circulation. 1989;20:904-910 82. Dietrich WD, Busto R, Alonso O, Globus MYT, Ginsberg MD. Intraischemic but not postischemic brain hypothermia protects chronically following global forebrain ischemia in rats. J Cereb Blood Flow Metab. 1993;13:541-549 83. Huh PW, Belayev L, Zhao WZ, Koch S, Busto R, Ginsberg MD. Comparative neuroprotective efficacy of prolonged moderate intraischemic and postischemic hypothermia in focal cerebral ischemia. J Neurosurg. 2000;92:91-99 84. Maier CM, Sun GH, Kunis D, Yenari MA, Steinberg GK. Delayed induction and long-term effects of mild hypothermia in a focal model of transient cerebral ischemia: Neurological outcome and infarct size. J Neurosurg. 2001;94:90-96 85. Fischer S, Clauss M, Wiesnet M, Renz D, Schaper W, Karliczek GF. Hypoxia induces permeability in brain microvessel endothelial cells via vegf and no. The American journal of physiology. 1999;276:C812-820 86. Huang ZG, Xue D, Preston E, Karbalai H, Buchan AM. Biphasic opening of the blood-brain barrier following transient focal ischemia: Effects of hypothermia. Can J Neurol Sci. 1999;26:298-304 87. Fischer S, Renz D, Wiesnet M, Schaper W, Karliczek GF. Hypothermia abolishes hypoxia-induced hyperpermeability in brain microvessel endothelial cells. Brain Res Mol Brain Res. 1999;74:135-144 88. Kollmar R, Schabitz WR, Heiland S, Georgiadis D, Schellinger PD, Bardutzky J, Schwab S. Neuroprotective effect of delayed moderate hypothermia after focal cerebral ischemia: An mri study. Stroke; a journal of cerebral circulation. 2002;33:1899-1904 89. Szaflarski J, Burtrum D, Silverstein FS. Cerebral hypoxia-ischemia stimulates cytokine gene-expression in perinatal rats. Stroke. 1995;26:1093-1100 90. Buttini M, Sauter A, Boddeke HW. Induction of interleukin-1 beta mrna after focal cerebral ischaemia in the rat. Brain Res Mol Brain Res. 1994;23:126-134 91. Deng H, Han HS, Cheng D, Sun GH, Yenari MA. Mild hypothermia inhibits inflammation after experimental stroke and brain inflammation. Stroke; a journal of cerebral circulation. 2003;34:2495-2501 92. Toyoda T, Suzuki S, Kassell NF, Lee KS. Intraischemic hypothermia attenuates neutrophil infiltration in the rat neocortex after focal ischemia-reperfusion injury. Neurosurgery. 1996;39:1200-1205 93. Globus MY, Busto R, Lin B, Schnippering H, Ginsberg MD. Detection of free radical activity during transient global ischemia and recirculation: Effects of intraischemic brain temperature modulation. Journal of Neurochemistry. 1995;65:1250-1256 94. Kil HY, Zhang J, Piantadosi CA. Brain temperature alters hydroxyl radical production during cerebral ischemia/reperfusion in rats. J Cereb Blood Flow Metab. 1996;16:100-106 95. Ohta H, Terao Y, Shintani Y, Kiyota Y. Therapeutic time window of post-ischemic mild hypothermia and the gene expression associated with the neuroprotection in rat focal cerebral ischemia. Neurosci Res. 2007;57:424-433 96. Alzaga AG, Cerdan M, Varon J. Therapeutic hypothermia. Resuscitation. 2006;70:369-380 97. Polderman KH, Herold I. Therapeutic hypothermia and controlled normothermia in the intensive care unit: Practical considerations, side effects, and cooling methods. Crit Care Med. 2009;37:1101-1120 98. Jordan JD, Carhuapoma JR. Hypothermia: Comparing technology. Journal of the neurological sciences. 2007;261:35-38 99. Tang XN, Yenari MA. Hypothermia as a cytoprotective strategy in ischemic tissue injury. Ageing Research Reviews. 2010;9:61-68 100. Sessler DI. Thermoregulatory defense mechanisms. Crit Care Med. 2009;37:S203-S210 101. Krieger DW, Yenari MA. Therapeutic hypothermia for acute ischemic stroke: What do laboratory studies teach us? Stroke; a journal of cerebral circulation. 2004;35:1482-1489 102. RIDENOUR, #160, R. T, WARNER, S. D, TODD, M. M, MCALLISTER, C. A. Mild hypothermia reduces infarct size resulting from temporary but not permanent focal ischemia in rats. Hagerstown, MD, ETATS-UNIS: Lippincott Williams & Wilkins; 1992. 103. van der Worp HB, Sena ES, Donnan GA, Howells DW, Macleod MR. Hypothermia in animal models of acute ischaemic stroke: A systematic review and meta-analysis. Brain : a journal of neurology. 2007;130:3063-3074 104. Froehler MT, Ovbiagele B. Therapeutic hypothermia for acute ischemic stroke. Expert review of cardiovascular therapy. 2010;8:593-603 105. Zhao WH, Ji XM, Ling F, Ding YC, Xing CH, Wu H, Guo M, Xuan Y, Guan B, Jiang LL. Local mild hypothermia induced by intra-arterial cold saline infusion prolongs the time window of onset of reperfusion injury after transient focal ischemia in rats. Neurol Res. 2009;31:43-51 106. Kollmar R, Blank T, Han JL, Georgiadis D, Schwab S. Different degrees of hypothermia after experimental stroke: Short- and long-term outcome. Stroke; a journal of cerebral circulation. 2007;38:1585-1589 107. Den Hertog HM, van der Worp HB, Tseng MC, Dippel DW. Cooling therapy for acute stroke. Cochrane Database Syst Rev. 2009:CD001247 108. Wei G, Hartings JA, Yang X, Tortella FC, Lu XC. Extraluminal cooling of bilateral common carotid arteries as a method to achieve selective brain cooling for neuroprotection. J Neurotraum. 2008;25:549-559 109. Schwartz AE, Stone JG, Finck AD, Sandhu AA, Mongero LB, Adams DC, Jonassen AE, Young WL, Michler RE. Isolated cerebral hypothermia by single carotid artery perfusion of extracorporeally cooled blood in baboons. Neurosurgery. 1996;39:577-581 110. Ding YC, Li J, Rafols JA, Phillis JW, Diaz FG. Prereperfusion saline infusion into ischemic territory reduces inflammatory injury after transient middle cerebral artery occlusion in rats. Stroke. 2002;33:2492-2498 111. Ding YC, Li L, Luan XD, Lai Q, McAllister JP, Phillis JW, Clark JC, Guthikonda M, Diaz FG. Local saline infusion into ischemic territory induces regional brain cooling neuroprotection in rats with transient middle cerebral artery occlusion. Neurosurgery. 2004;54:956-964 112. Allers M, Boris-Moller F, Lunderquist A, Wieloch T. A new method of selective, rapid cooling of the brain: An experimental study. Cardiovasc Inter Rad. 2006;29:260-263 113. Noguchi Y, Nishio S, Kawauchi M, Asari S, Ohmoto T. A new method of inducing selective brain hypothermia with saline perfusion into the subdural space: Effects on transient cerebral ischemia in cats. Acta Medica Okayama. 2002;56:279-286 114. Forte LV, Peluso CM, Prandini MN, Godoy R, Rojas SS. Regional cooling for reducing brain temperature and intracranial pressure. Arquivos de Neuro-Psiquiatria. 2009;67:480-487 115. Cheng H, Shi J, Zhang L, Zhang Q, Yin H, Wang L. Epidural cooling for selective brain hypothermia in porcine model. Acta Neurochir. 2006;148:559-564 116. Zhang LH, Cheng HL, Shi JX, Chen J. Focal epidural cooling reduces the infarction volume of permanent middle cerebral artery occlusion in swine. Surg Neurol. 2007;67:117-121 117. Wagner KR, Zuccarello M. Local brain hypothermia for neuroprotection in stroke treatment and aneurysm repair. Neurol Res. 2005;27:238-245 118. Wagner KR, Beiler S, Beiler C, Kirkman J, Casey K, Robinson T, Larnard D, de Courten-Myers GM, Linke MJ, Zuccarello M. Delayed profound local brain hypothermia markedly reduces interleukin-1beta gene expression and vasogenic edema development in a porcine model of intracerebral hemorrhage. Acta neurochirurgica. Supplement. 2006;96:177-182 119. King C, Robinson T, Dixon CE, Rao GR, Larnard D, Nemoto CEM. Brain temperature profiles during epidural cooling with the chillerpad in a monkey model of traumatic brain injury. J Neurotraum. 2010;27:1895-1903 120. Tooley JR, Eagle RC, Satas S, Thoresen M. Significant head cooling can be achieved while maintaining normothermia in the newborn piglet. Arch Dis Child-Fetal. 2005;90:262-266 121. Iwata O, Iwata S, Tamura M, Nakamura T, Sugiura M, Ogiso Y. Brain temperature in newborn piglets under selective head cooling with minimal systemic hypothermia. Pediatr Int. 2003;45:163-168 122. Diao C, Zhu L. Temperature distribution and blood perfusion response in rat brain during selective brain cooling. Med Phys. 2006;33:2565-2573 123. Wang H, Olivero W, Lanzino G, Elkins W, Rose J, Honings D, Rodde M, Burnham J, Wang D. Rapid and selective cerebral hypothermia achieved using a cooling helmet. J Neurosurg. 2004;100:272-277 124. Battin MR, Penrice J, Gunn TR, Gunn AJ. Treatment of term infants with head cooling and mild systemic hypothermia (35.0 degrees c and 34.5 degrees c) after perinatal asphyxia. Pediatrics. 2003;111:244-251 125. Jacobs S, Hunt R, Tarnow-Mordi W, Inder T, Davis P. Cooling for newborns with hypoxic ischaemic encephalopathy. Cochrane Database Syst Rev. 2007:- 126. Bryk JP, White RJ, Wolin LR, Massopust LC, Takaoka Y. Deep brain hypothermia by means of high-flow biventricular cooling. Resuscitation. 1976;5:223-228 127. Clark DL, Colbourne F. A simple method to induce focal brain hypothermia in rats. J Cereb Blood Flow Metab. 2007;27:115-122 128. Clark DL, Penner M, Wowk S, Orellana-Jordan I, Colbourne F. Treatments (12 and 48 h) with systemic and brain-selective hypothermia techniques after permanent focal cerebral ischemia in rat. Experimental Neurology. 2009;220:391-399 129. Dohi K, Jimbo H, Abe T, Aruga T. Positive selective brain cooling method: A novel, simple, and selective nasopharyngeal brain cooling method. Acta neurochirurgica. Supplement. 2006;96:409-412 130. Einer-Jensen N, Khorooshi MH, Petersen MB, Svendsen R. Rapid brain cooling in intubated pigs through nasal flushing with oxygen: Prevention of brain hyperthermia. Acta Vet Scand. 2001;42:459-464 131. Busch Hj Fau - Eichwede F, Eichwede F Fau - Fodisch M, Fodisch M Fau - Taccone FS, Taccone Fs Fau - Wobker G, Wobker G Fau - Schwab T, Schwab T Fau - Hopf HB, Hopf Hb Fau - Tonner P, Tonner P Fau - Hachimi-Idrissi S, Hachimi-Idrissi S Fau - Martens P, Martens P Fau - Fritz H, Fritz H Fau - Bode C, Bode Ch Fau - Vincent JL, Vincent Jl Fau - Inderbitzen B, Inderbitzen B Fau - Barbut D, Barbut D Fau - Sterz F, Sterz F Fau - Janata A, Janata A. Safety and feasibility of nasopharyngeal evaporative cooling in the emergency department setting in survivors of cardiac arrest. Resuscitation. 2010;81:943-949 132. Natale JA, D'Alecy LG. Protection from cerebral ischemia by brain cooling without reduced lactate accumulation in dogs. Stroke; a journal of cerebral circulation. 1989;20:770-777 133. Hagioka S, Takeda Y, Takata K, Morita K. Nasopharyngeal cooling selectively and rapidly decreases brain temperature and attenuates neuronal damage, even if initiated at the onset of cardiopulmonary resuscitation in rats. Crit Care Med. 2003;31:2502-2508 134. Covaciu L, Allers M, Enblad P, Lunderquist A, Wieloch T, Rubertsson S. Intranasal selective brain cooling in pigs. Resuscitation. 2008;76:83-88 135. Hagioka S Fau - Takeda Y, Takeda Y Fau - Takata K, Takata K Fau - Morita K, Morita K. Nasopharyngeal cooling selectively and rapidly decreases brain temperature and attenuates neuronal damage, even if initiated at the onset of cardiopulmonary resuscitation in rats. 136. Harris BA, Andrews PJD. Direct brain cooling. In: Mayer SA, Sessler DI, eds. Therapeutic hypothermia. New York: Marcel Dekker.; 2005:323-386. 137. Barone FC, Feuerstein GZ, White RF. Brain cooling during transient focal ischemia provides complete neuroprotection. Neurosci Biobehav R. 1997;21:31-44 138. Lo EH, Steinberg GK. Effects of hypothermia on evoked potentials, magnetic resonance imaging, and blood flow in focal ischemia in rabbits. Stroke; a journal of cerebral circulation. 1992;23:889-893 139. Clark Dl Fau - Penner M, Penner M Fau - Wowk S, Wowk S Fau - Orellana-Jordan I, Orellana-Jordan I Fau - Colbourne F, Colbourne F. Treatments (12 and 48 h) with systemic and brain-selective hypothermia techniques after permanent focal cerebral ischemia in rat. 140. Kudo M, Aoyama A, Ichimori S, Fukunaga N. An animal-model of cerebral infarction - homologous blood-clot emboli in rats. Stroke. 1982;13:505-508 141. Kaneko D, Nakamura N, Ogawa T. Cerebral infarction in rats using homologous blood emboli - development of a new experimental-model. Stroke. 1985;16:76-84 142. Tamura A, Graham DI, Mcculloch J, Teasdale GM. Focal cerebral-ischemia in the rat .1. Description of technique and early neuropathological consequences following middle cerebral-artery occlusion. J Cerebr Blood F Met. 1981;1:53-60 143. Bederson JB, Pitts LH, Tsuji M, Nishimura MC, Davis RL, Bartkowski H. Rat middle cerebral-artery occlusion - evaluation of the model and development of a neurologic examination. Stroke. 1986;17:472-476 144. Wang Y, Chang CF, Morales M, Chiang YH, Harvey BK, Su TP, Tsao LI, Chen SY, Thiemermann C. Diadenosine tetraphosphate protects against injuries induced by ischemia and 6-hydroxydopamine in rat brain. J Neurosci. 2003;23:7958-7965 145. Yanamoto H, Nagata I, Hashimoto N, Kikuchi H. Three-vessel occlusion using a micro-clip for the proximal left middle cerebral artery produces a reliable neocortical infarct in rats. Brain Res Protoc. 1998;3:209-220 1 | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/23342 | - |
| dc.description.abstract | 系統性低溫已經被證實對中風的病患具有治療效果，但許多併發症像是感染、心律不整以及凝血異常等等，往往增加致死率以及致病率，導致系統性低溫的治療效果大打折扣。隨著中風的疾
病生理機制以及對治療性低溫保護機制的日漸了解，局部治療性低溫的概念被提出及研究。本實驗的目的為利用大鼠的大腦局部性缺血模式，評估一個新發展出來的降溫裝置是否具有神經保護效果。 實驗使用十五隻體重300至400公克的Spraque-Dawley公鼠。本實驗依水流溫度分成14℃、26℃和無水流通過的對照組共三組，每組五隻大鼠。經開顱手術暴露出左側的近端中腦動脈後，利用雙極電燒器將其永久性阻斷。接著，將雙側總頸動脈暫時性阻斷三小時。恢復總頸動脈血流後半小時內，利用立體定位儀將降溫裝置放置於左前側大腦，靠近缺血核心處，並讓低溫水流經過裝置兩小時，接著立刻犧牲大鼠，並盡速將腦部組織取下，以腦切片盒將大腦切成厚度為2mm共八片之冠狀切片。再以0.05%，37℃的triphenyltetrazolium chloride (TTC)進行半小時染色。染色後，以10%福馬林固定至少24小時，並在48小時內利用數位相機記錄，之後利用電腦軟體分析。數位相機記錄後，隨機選每組三隻大鼠的腦切片進行石蠟包埋，再以Fluoro Jade C(FJC)、H&E染色進行組織病理分析。 TTC染色的結果顯示兩低溫組相較於控制組，在靠近缺血核心以及降溫裝置的前側大腦，都表現出顯著神經保護效果，但後側大腦只有26℃依舊表現顯著之神經保護效果。FJC染色的結果則和TTC有些許出入，FJC染色的結果顯示，在後側大腦同樣只有26℃表現顯著的神經保護效果，但前側大腦則兩降溫組皆無顯著神經保護效果。至於H&E染色則各組之間無顯著差異。根據上述結果，本次使用的降溫裝置當輸入水溫為26℃時，在相對的後側大腦，明確的表現出神經保護效果。因此認為，此降溫裝置具有未來發展潛力。 | zh_TW |
| dc.description.abstract | Systemic hypothermia has been considered beneficial to stroke patients. However, numerous complications ensued. The aim of this study is to evaluate the effect of a new invasive regional cooling device in cerebral ischemic injury in rat model.
A total of 15 adult male Spraque-Dawley rats, weighted 300-400 gram, were randomly assigned into three groups - cooling device applied at 14 | en |
| dc.description.provenance | Made available in DSpace on 2021-06-08T04:59:27Z (GMT). No. of bitstreams: 1 ntu-100-R98643009-1.pdf: 3705989 bytes, checksum: 71d7b2c31ec3fca493baeec2b5d69489 (MD5) Previous issue date: 2011 | en |
| dc.description.tableofcontents | 目錄
口試委員會審定書 i 中文摘要 i 英文摘要 i 第一章 、序言 1 第一節 、前言與研究動機 1 第二節 、研究目的 1 第二章 、文獻探討 2 第一節 、大腦缺血性傷害的原因、病生理以及各式治療 2 第一項 、原因及風險因子 2 第二項 、腦缺血性傷害的病生理機制 3 第三項 、各式治療方法及效果 9 第二節 、治療性低溫於腦缺血性傷害的過往與現況 10 第一項 、治療性低溫的保護機制 10 第二項 、系統性治療性低溫 13 第四項 、局部性治療性低溫 17 第三節 、局部腦缺血性傷害大鼠動物模式-方法、優缺點 19 第三章 、實驗一 22 第一節 、實驗一之目的 22 第二節 、實驗一之材料及方法 22 第一項 、實驗設計 22 第二項 、實驗動物 23 第三項 、麻醉與監控 23 第四項 、放置降溫裝置及溫度計 23 第五項 、降溫裝置原理 24 第三節 、實驗一之結果 25 第四章 、實驗二 27 第一節 、實驗二之目的 27 第一節 、實驗二之材料及方法 27 第一項 、實驗設計 27 第二項 、實驗動物 27 第三項 、麻醉與監控 27 第四項 、局部腦部缺血 28 第五項 、放置降溫裝置 29 第六項 、動物犧牲及樣本處理 29 第七項 、組織病理分析 29 第八項 、結果分析 30 第九項 、統計分析 30 第三節 、實驗二之結果 30 第一項 、生理數值 30 第二項 、TTC染色結果 31 第二項 、灰階值比較 31 第三項 、H&E染色結果: 34 第四項 、Fluoro Jade C染色比較 40 第五章 、討論 43 第一節 、降溫裝置對腦部的降溫效率 43 第二節 、實驗二的溫度選擇 43 第三節 、使用TTC和Fluoro Jade C染色評估結果 44 第四項 、比較其他實驗結果 46 第五節 、實驗設計的限制 49 第一項 、犧牲時間點 49 第二項 、無行為評估 49 第六章 、結論 50 第七章 、參考資料 51 圖目錄 圖2-1、TOAST分類之特徵(源自Adams et al. Classification of subtype of acute ischemic stroke - definitions for use in a multicenter clinical-trial. Stroke. 1993;24:35-41) 2 圖2-1、簡述腦缺血性傷害病生理機制。 5 圖2-3、Unfolded protein response pathway (源自DeGracia DJ, Montie HL. Cerebral ischemia and the unfolded protein response. Journal of Neurochemistry. 2004;91:1-8) 6 圖2-4、HSPs被引發的機制。當細胞內蛋白質變性後，會和平時抑制HSPs的heat shock factors(HSFs)結合，使HSPs被釋放發揮功能，並進到細胞核內促使基因表現，進而增加。(源自 Yenari MA. Heat shock proteins and neuroprotection. In: Alzheimer C, ed. Molecular and cellular biology of neuroprotection in the cns. Kluwer Academic/Plenum Publishers and Landes Bioscience; 2002:281-300.) 7 圖2-5、Hsp70抗細胞凋零以及抗發炎機制。(源自Yenari MA, Liu J, Zheng Z, Vexler ZS, Lee JE, Giffard RG. Antiapoptotic and anti-inflammatory mechanisms of heat-shock protein protection. Ann Ny Acad Sci. 2005;1053:74-83) 8 圖2-6、大鼠利用血管內纖維形成局部缺血示意圖(源自 Kohno et al. A modified rat model of middle cerebral-artery thread occlusion under electrophysiological control for magnetic-resonance investigations. Magn Reson Imaging. 1995;13:65-71) 21 圖3-1、大鼠固定於立體定位實際照片，左上為俯照圖，右上為後照圖，左下為側照圖。固定經由門齒以及雙側耳道三點，固定整個頭部。 22 圖3-2、數位化溫度計。 24 圖3-3、降溫裝置與溫度計放置位置實際情況俯看圖。上方為鑽洞前，下方為鑽洞後。箭頭所指是bregma的位置，1、2、3代表洞1、洞2和洞3。 24 圖3-4、降溫裝置實際使用情形。箭號指的是放置於靠近降溫裝置進水口的溫度計， 箭頭代表水流方向。 25 圖3-5、降溫裝置原理以及循環水流示意圖，下方為點滴加壓器包覆於點滴袋外，上方為延長管及降溫裝置，下圖為降溫裝置，箭號代表水流方向。 25 圖3-6、降溫裝置於正常腦組織之降溫效率示意圖，橫軸除了最左邊為體溫，其他皆為輸入水溫。縱軸為腦部溫度。由左至右分別代表靜止腦溫、26、20、14和10℃輸入水溫得到的穩定降低腦溫。同一輸入水溫時，左邊直條為洞3位置紀錄之溫度，離洞1降溫裝置處約為3mm。右邊直條為洞2位置紀錄之溫度，離洞1降溫裝置處約為6mm。直條上方標示同樣英文字母時，代表為同質子集，也就是無顯著差異。 26 圖4-1、實驗二之實驗設計。 27 圖4-2、PE 50 tube合併6/0 尼龍縫線形成圈套(snare)阻斷總頸動脈(箭號)血流示意圖(左)，以及實際情況(右)。 28 圖4-3、TTC染色結果，由左至右分別是control，14℃，26℃。 31 圖4-4、三組的每一片平均值以直條圖表現。直條圖上方字母相同，代表無統計上顯著差異。橫軸腦切片數字下方標計＊，代表該組間有統計上顯著差異。組間具統計上顯著差異者為第2片、第3片以及第5片。 33 圖4-5、控制組第六片腦切片缺血交界處，可明顯發現圖中右側的缺血範圍內嗜伊紅性較弱。 35 圖4-6、H&E染色缺血交界處，上排為第3腦切片下排為第6腦切片，由左至右分別是控制組、14℃組和26℃組。圖片中下方為缺血範圍，可見交界處neuropil空泡化的現象更為明顯。 36 圖4-7、控制組H&E染色結果，第三片腦切片的缺血側是A和a ，正常側是B和b。第六腦切片的缺血側是C和c，正常側是D和d。可以看到缺血側的neuropil有明顯的空泡化以及perikarya明顯的濃縮。 37 圖4-8、14℃組H&E染色結果，第三片腦切片的缺血側是A和a ，正常側是B和b。第六腦切片的缺血側是C和c，正常側是D和d。可以看到缺血側的neuropil有明顯的空泡化以及perikarya明顯的濃縮。 38 圖4-9、26℃組H&E染色結果，第三片腦切片的缺血側是A和a ，正常側是B和b。第六腦切片的缺血側是C和c，正常側是D和d。可以看到缺血側的neuropil有明顯的空泡化以及perikarya明顯的濃縮。 39 圖4-10、Fluoro Jade C染色結果，左側為缺血側圖，右側為正常側對照圖。A為控制組前側，a為控制組後側；B為14組前側，14控制組後側；C為26組前側，c為26組後側。 41 圖4-11、Fluoro Jade C染色分析結果，橫軸為前後側分別，1為前側，2為後側，縱軸為缺血側平均值及正常側平均值之比值，數字越大代表陽性反應面積越大。直條上方同樣英文字母代表無統計上差異，為同質子集。可見前側14℃組明顯陽性反應。 42 圖5-1、使用pMCAO模式並於缺血開始前或缺血發生中開始降溫的實驗結果。(源自Krieger DW, Yenari MA. Therapeutic hypothermia for acute ischemic stroke: What do laboratory studies teach us? Stroke; a journal of cerebral circulation. 2004;35:1482-1489 46 圖 2-2、使用pMCAO模式並於缺血開始後開始降溫的實驗結果。(源自Krieger DW, Yenari MA. Therapeutic hypothermia for acute ischemic stroke: What do laboratory studies teach us? Stroke; a journal of cerebral circulation. 2004;35:1482-1489) 48 表目錄 表3-1、腦部溫度量測值的敘述性統計量表。 26 表4-1、三組生理數值平均值，P value＞0.05時，各組之間無統計上顯著差異。 31 表4-2、三組切片1到切片8的mean GL/R的描述性統計量表。 32 表4-3、第1到第8片的mean GL/R 集合比較，p＜0.05表示有統計上差異。 34 表4-4、第1到第5片的mean GL/R 集合比較，p＜0.05表示有統計上差異。 34 表4-5、第6到第8片的mean GL/R 集合比較，p＜0.05表示有統計上差異。 34 表4-6、第2、3片的Fluoro Jade C染色影像分析結果。 42 表4-7、第6、7片的Fluoro Jade C染色影像分析結果。 42 | |
| dc.language.iso | zh-TW | |
| dc.subject | 局部性 | zh_TW |
| dc.subject | 局部永久性大腦缺血 | zh_TW |
| dc.subject | 系統性 | zh_TW |
| dc.subject | 中風 | zh_TW |
| dc.subject | 神經保護 | zh_TW |
| dc.subject | 治療性低溫 | zh_TW |
| dc.subject | stroke | en |
| dc.subject | neuroprotection | en |
| dc.subject | permanent middle cerebral artery occlusion | en |
| dc.subject | rat | en |
| dc.subject | selective | en |
| dc.subject | regional | en |
| dc.subject | systemic | en |
| dc.subject | hypothermia | en |
| dc.title | 局部性低溫於大鼠永久性局部腦缺血模式之影響 | zh_TW |
| dc.title | The effect of regional hypothermia in permanent focal cerebral ischemic injury in rats | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 99-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 劉逸軒,林中天 | |
| dc.subject.keyword | 中風,局部永久性大腦缺血,治療性低溫,系統性,局部性,神經保護, | zh_TW |
| dc.subject.keyword | stroke,hypothermia,systemic,regional,selective,rat,permanent middle cerebral artery occlusion,neuroprotection, | en |
| dc.relation.page | 62 | |
| dc.rights.note | 未授權 | |
| dc.date.accepted | 2011-08-19 | |
| dc.contributor.author-college | 獸醫專業學院 | zh_TW |
| dc.contributor.author-dept | 臨床動物醫學研究所 | zh_TW |
| 顯示於系所單位： | 臨床動物醫學研究所 | |
文件中的檔案：
| 檔案 | 大小 | 格式 | |
|---|---|---|---|
| ntu-100-1.pdf 未授權公開取用 | 3.62 MB | Adobe PDF |
系統中的文件，除了特別指名其著作權條款之外，均受到著作權保護，並且保留所有的權利。