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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 陳俊杉 | |
| dc.contributor.author | Tzu-Hsuan Chang | en |
| dc.contributor.author | 張子軒 | zh_TW |
| dc.date.accessioned | 2021-06-08T04:38:13Z | - |
| dc.date.copyright | 2009-08-19 | |
| dc.date.issued | 2009 | |
| dc.date.submitted | 2009-08-17 | |
| dc.identifier.citation | Barnes, J.R., Stephenson, R.J., Welland, M.E., Gerber, C., Gimzewski, J.K. (1994), Photothermal spectroscopy with femtojoule sensitivity using a micromechanical device, Nature 372 (6501), pp. 79-81
Binnig, G., Quate, C.F., Gerber, Ch. (1986), Atomic force microscope, Physical Review Letters 56 (9), pp. 930-933 Binnig, G., Rohrer, H., Gerber, Ch., Weibel, E. (1982), Tunneling through a controllable vacuum gap, Applied Physics Letters 40 (2), pp. 178-180 Berger, R., Delamarche, E., Lang, H.P., Gerber, C., Gimzewski, J.K., Meyer, E., Güntherodt, H.-J. (1997), Surface stress in the self-assembly of alkanethiols on gold, Science 276 (5321), pp. 2021-2024 Burg, T.P., Godin, M., Knudsen, S.M., Shen, W., Carlson, G., Foster, J.S., Babcock, K., Manalis, S.R. (2007), Weighing of biomolecules, single cells and single nanoparticles in fluid, Nature 446 (7139), pp. 1066-1069 Creager, S.E., Hockett, L.A., Rowe, G.K., (1992), Consequences of Microscopic Surface Roughness for Molecular Self –Assembly, Langmuir 8, 854-861 Datskos, P.G., Sauers, I. (1999), Detection of 2-mercaptoethanol using gold-coated micromachined cantilevers, Sensors and Actuators, B: Chemical 61 (1), pp. 75-82 Desikan, R., Armel, S., Meyer III, H.M., Thundat, T. (2007) Effect of chain length on nanomechanics of alkanethiol self-assembly, Nanotechnology 18 (42), art. no. 424028 El-Ali, J., Sorger, J.P.K., Jensen, K.F. (2006), Cells on chip, Nature, 442, 404 Fritz, J., Baller, M.K., Lang, H.P., Rothuizen, H., Vettiger, P., Meyer, E., Güntherodt, H.-J., Gerber, Ch., Gimzewski, J.K. (2000), Translating biomolecular recognition into nanomechanics, Science 288 (5464), pp. 316-318 Genzer, J., Efimenko, K. (2000), Creating long-lived superhydrophobic polymer surfaces through mechanically assembled monolayers, Science 290 (5499), pp. 2130-2133 Godin, M., Williams, P.J., Tabard-Cossa, V., Laroche, O., Beaulieu, L.Y., Lennox, R.B., Grütter, P. (2004), Surface stress, kinetics, and structure of alkanethiol self-assembled monolayers, Langmuir 20 (17), pp. 7090-7096. Heeg, J., Schubert, U., Küchenmeister, F. (1999), Mixed self-assembled monolayers of terminally functionalized thiols at gold surfaces characterized by Angle Resolved X-ray Photoelectron Spectroscopy (ARXPS) studies, Fresenius' Journal of Analytical Chemistry 365 (1-3), pp. 272-276 Hohman, J.N., Zhang, P., Morin, E.I., Han, P., Kim, M., Kurland, A.R., McClanahan, P.D., Balema, V. P., Weiss, P.S. (2009), Self-Assembly of carboranethiol isomers on Au{111}: Intermolecular interactions determined by molecular dipole orientations, ACS Nano 3 (3), pp. 527-536. Igarashi, S., Itakura, A.N., Kitajima, M., Chifen, A.N., Förch, R., Berger, R. (2006), Surface stress control using ultraviolet light irradiation of plasma-polymerized thin films, Applied Physics Letters 88 (14), art. no. 143119 Kiesewetter, L., Zhang, J.-M., Houdeau, D., Steckenborn, A. (1992), Determination of Young's moduli of micromechanical thin films using the resonance method, Sensors and Actuators: A. Physical 35 (2), pp. 153-159 Lavrik, N.V., Sepaniak, M.J., Datskos, P.G. (2004), Cantilever transducers as a platform for chemical and biological sensors, Review of Scientific Instruments 75 (7), pp. 2229-2253 Leites, L.A. (1992), Vibrational spectroscopy of carboranes and parent boranes and its capabilities in carborane chemistry, Chemical Reviews 92 (2), pp. 279-323 Marie, R., Jensenius, H., Thaysen, J., Christensen, C.B., Boisen, A. (2002), Adsorption kinetics and mechanical properties of thiol-modified DNA-oligos on gold investigated by microcantilever sensors, Ultramicroscopy 91 (1-4), pp. 29-36 Mertens, J. (2007), Role of the gold film nanostructure on the nanomechanical response of microcantilever sensors, Journal of Applied Physics 101. Meyer, G. and Amer, N.M. (1988), Novel optical approach to atomic force microscopy, Applied Physics Letters 53 (12), pp. 1045-1047 Morrison, R.T. and Boyd, R.N. (1972), Organic Chemistry, 2nd ed., Allyn and Bacon Inc. Peterlinz, K.A. and Georgiadis, R. (1996), In situ kinetics of self-Assembly by surface plasmon resonance spectroscopy, Langmuir 12 (20), pp. 4731-4740 Porter, M.D., Bright, T.B., Allara, D.L., Chidsey, C.E.D. (1987), Spontaneously organized molecular assemblies. 4. Structural characterization of n-alkyl thiol monolayers on gold by optical ellipsometry, infrared spectroscopy, and electrochemistry, Journal of the American Chemical Society 109 (12), pp. 3559-3568 Raorane, D., Lim, S.-H., Majumdar, A. (2008), Nanomechanical assay to investigate the selectivity of binding interactions between volatile benzene derivatives, Nano Letters 8 (8), pp. 2229-2235 Ron, H., Matlis, S., and Rubinstein, I. (1998), Self-assembled monolayers on oxidized metals. 2. Gold surface oxidative pretreatment, monolayer properties, and depression formation, Langmuir 14, 1116-1121. Shuttleworth, R. (1950), The surface tension of solids, Proceedings of the Physical Society. Section A 63 (5), art. no. 302, pp. 444-457 Stoney, G. G., (1909), The Tension of Metallic Films deposited by Electrolysis, Proc. R. Soc. London Ser. A 82, 172. Timoshenko, S.P., (1925), Analysis of bi-metal thermostats, J. Opt. Soc. Am. 11, 233-255 Vericat, C., Vela, M.E., Salvarezza, R.C., (2005), Self-assembled monolayers of alkanethiols on Au(111): surface structures, defects and dynamics, Phys . Chem. Chem. Phys ., 7, 3258-3268 Von Preissig, F.J. (1989), Applicability of the classical curvature-stress relation for thin films on plate substrates, Journal of Applied Physics 66 (9), pp. 4262-4268 Winchell, A.N. (2007), Elements Of Optical Mineralogy - An Introduction To Microscopic Petrography. Wu, G., Datar, R.H., Hansen, K.M., Thundat, T., Cote, R.J., Majumdar, A. (2001), Bioassay of prostate-specific antigen (PSA) using microcantilevers, Nature Biotechnology 19 (9), pp. 856-860 Yang, Y.W., Fan, L.J. (2002), High resolution XPS study of decanethiol on Au(111): Single sulfur-gold bonding interaction, Langmuir 18 (4), pp. 1157-1164 Yang, J., Ono, T., Esashi, M. (2000), Mechanical behavior of ultrathin microcantilever, Sensors and Actuators, A: Physical 82 (1), pp. 102-107 Yue, M., Lin, H., Dedrick, D.E., Satyanarayana, S., Majumdar, A., Bedekar, A.S., Jenkins, J.W., Sundaram, S. (2004), A 2-D microcantilever array for multiplexed biomolecular analysis, Journal of Microelectromechanical Systems 13 (2), pp. 290-299 Zamborini, F.P., Crooks, R.M. (1998), Corrosion passivation of gold by n-alkanethiol self-assembled monolayers: Effect of chain length and end group, Langmuir 14 (12), pp. 3279-3286 Zhang, R., Best, A., Berger, R., Cherian, S., Lorenzoni, S., MacIs, E., Raiteri, R., Cain, R. (2007), Multiwell micromechanical cantilever array reader for biotechnology, Review of Scientific Instruments 78 (8), art. no. 084103 黃榮章 (2006)，A Study on Analysis of Biomolecular Recognition Using a Nanomechanics-based Biosensor，國立台灣大學應用力學研究所博士論文 (黃榮山副教授指導) 黃建穎 (2006)，高效率辨識元蛋白固定之 具電場操控型微懸臂梁生物感測器，國立台灣大學應用力學研究所碩士論文(黃榮山副教授與張正憲教授聯合指導) 周佳靚 (2008)，以多尺度模擬分析吸附現象在懸臂樑式生物微感測器的變形行為，國立台灣大學土木工程學系電腦輔助工程組碩士論文 (陳俊杉副教授指導) | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/23023 | - |
| dc.description.abstract | 自從80年代微機電產業蓬勃發展，人類開始利用微小尺寸的機械裝置當作感測器探索微米甚至是奈米尺度的世界。其中微懸臂梁式生物感測器可將各式各樣的物理以及化學反應轉換為力學上撓曲行為，有著高靈敏度以及容易偵測等優點成為生化研究領域的利器。
本研究以微懸臂梁式感測器搭配光學偵測平台，量測自組裝分子(self-assembled monolayers, SAMs )吸附於金表面所造成的表面應力，並且設計了可任意切換氣體以及液體的推進系統，可用於測試當實驗的環境發生改變時對自組裝分子所造成的表面應力的影響，歸納出當環境中存在著極性分子，會和自組裝分子本身的極性互相影響，改變微懸臂梁原本應有的變化表現。同時，本研究也測試了不同自組裝分子溶液的濃度吸附於金表面造成的撓曲，發現當自組裝分子溶液濃度越高時，所造成的變面應力會越大。此外，進行了在酒精溶液中不同碳鏈長的自組裝分子吸附在金表面的實驗，觀察到碳鏈越短在酒精中會造成金膜產生越大的向上表面應力。 完成自組裝分子吸附實驗之微懸臂梁晶片將搭配表面科學分析的驗證以及討論。利用X光繞射能譜(X-Ray Diffraction, XRD)可以觀測金表面的晶格面，本研究發現當自組裝分子吸附在金表面時，會使X光繞射能譜的訊號改變；而藉由X光光電子能譜(X-ray Photoelectron Spectroscopy, XPS)觀測到金硫的鍵結，可以確認撓曲訊號是由自組裝分子吸附作用所造成而非雜訊干擾。最後，提出與本研究相關的儀器與實驗設計上的改進，作為自組裝分子量測平台未來發展的參考。 | zh_TW |
| dc.description.abstract | The microcantilever sensor is one of the most promising platforms for the next-generation label-free biosensing applications. It outperforms other conventional label-free detection methods in terms of portability and parallelization.
The objective of this thesis is to investigate the coupling between self-assembled monolayers (SAMs) interactions and microcantilever responses. To this end, a dual compact optical microcantilever sensing platform was built to ease conducting biosensing experiments in gas-phase environments or in solutions. The thermal bimorph effect was used and found to be an effective nanomanipulator for the microcantilever platform calibration. The study of the alkanethiol SAM chain length effect revealed that the 1-octanethiol (C8H17SH) induced larger deflection than that from 1-dodecanethiol (C12H25SH) and 1-tetradecanethiol (C14H29SH) in solutions. We also observed that higher concentration of SAMs in solutions led to higher surface stresses. In comparing with absorption experiments conducted in air and in solutions, we observed significant change of surface stresses. In surface characterization part, by using the XRD (X-Ray Diffraction) analysis, we found that the gold surface was dominated by the (111) crystalline plane. With the XPS (X-ray Photoelectron Spectroscopy) analysis, we confirmed that the Au-S covalent bonds were occurred in SAM absorption. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-08T04:38:13Z (GMT). No. of bitstreams: 1 ntu-98-R96521605-1.pdf: 2317329 bytes, checksum: b51eb4c9daf8a76513bcc0a94bba5adc (MD5) Previous issue date: 2009 | en |
| dc.description.tableofcontents | 誌謝 i
摘要 iii Abstract v 圖目錄 xi 表目錄 xvi 第1章 緒論 1 1.1 研究背景與動機 1 1.2 文獻回顧 3 1.2.1 烷基硫醇分子自組裝於金表面 3 1.2.2 利用表面科學分析觀測微懸臂梁 5 1.2.3 自組裝分子之相關應用 7 1.3 研究方法 8 1.4 論文組織 9 第2章 微懸臂梁式感應器 11 2.1 微懸臂梁式感測器之種類 11 2.2 Stoney’s formula 13 2.3 微懸臂梁量測技術 14 第3章 實驗架構 17 3.1 微懸臂梁晶片設計與製作 17 3.2 光學觀測系統 20 3.3 流(氣)體推進系統 22 第4章 實驗流程與結果討論 25 4.1 晶片前處理 25 4.2 試品準備 26 4.3 PSD讀值校正與轉換 27 4.4 自組裝分子在溶液中吸附於金表面實驗 32 4.4.1 實驗器材架設 32 4.4.2 自組裝分子吸附實驗 33 4.5 自組裝分子在空氣中吸附於金表面實驗 37 4.5.1 實驗器材架設 37 4.5.2 自組裝分子吸附實驗 38 第5章 表面科學分析 41 5.1 X光繞射能譜 41 5.1.1 原理 41 5.1.2 X光繞射能譜實驗 42 5.2 X光光電子能譜 47 5.2.1 原理 47 5.2.2 X光光電子能譜實驗 48 第6章 實驗結果討論 54 6.1 不同濃度的自組裝分子溶液對表面應力的影響 54 6.2 自組裝分子在溶液中對微懸臂梁的影響 56 6.3 自組裝分子所造成的表面應力 59 第7章 論文總結與建議 61 7.1 結論 61 7.2 建議 62 參考文獻 65 作者簡歷 72 | |
| dc.language.iso | zh-TW | |
| dc.subject | 表面科學分析 | zh_TW |
| dc.subject | 生物感測 | zh_TW |
| dc.subject | 微懸臂梁 | zh_TW |
| dc.subject | 自組裝分子 | zh_TW |
| dc.subject | 表面應力 | zh_TW |
| dc.subject | self-assembled monolayers | en |
| dc.subject | surface characterization | en |
| dc.subject | surface stress | en |
| dc.subject | biosensing | en |
| dc.subject | microcantilever | en |
| dc.title | 烷基硫醇分子自組裝於微懸臂梁之金表面:吸附分析與撓曲量測 | zh_TW |
| dc.title | Alkanethiols on Gold-coated Micro-cantilever:Absorption Characterization and Deflection Measurement | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 97-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.coadvisor | 黃榮山 | |
| dc.contributor.oralexamcommittee | 謝宗霖,李世元 | |
| dc.subject.keyword | 生物感測,微懸臂梁,自組裝分子,表面應力,表面科學分析, | zh_TW |
| dc.subject.keyword | biosensing,microcantilever,self-assembled monolayers,surface stress,surface characterization, | en |
| dc.relation.page | 72 | |
| dc.rights.note | 未授權 | |
| dc.date.accepted | 2009-08-17 | |
| dc.contributor.author-college | 工學院 | zh_TW |
| dc.contributor.author-dept | 土木工程學研究所 | zh_TW |
| 顯示於系所單位： | 土木工程學系 | |
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