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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 張淑惠(Shu-Hui Chang) | |
dc.contributor.author | Chu-Yen Yang | en |
dc.contributor.author | 楊竺諺 | zh_TW |
dc.date.accessioned | 2021-06-08T04:36:28Z | - |
dc.date.copyright | 2009-09-16 | |
dc.date.issued | 2009 | |
dc.date.submitted | 2009-08-18 | |
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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/22985 | - |
dc.description.abstract | 在許多臨床試驗與醫學研究中,每個研究對象的疾病演進過程會在追蹤過程中被監測。通常在研究進行中,除了個體是否發生死亡外,疾病惡化過程的訊息也會被收集,其中包括是否發生與演進過程有關的事件或生物標誌。在臨床上常將疾病惡化過程的訊息作為隨時間變動的解釋變數,利用對比風險模式描述疾病惡化過程對個體存活機率的影響。在本研究中將推廣Xu和O’Quigley的方法,在具時間變動解釋變數的對比風險模式下,利用疾病惡化過程過去的訊息預測後續的存活機率。最後,藉由模擬評估本研究提出之方法的表現。 | zh_TW |
dc.description.abstract | In many clinical trials and medical studies, the course of disease for each individual is monitored during the follow-up period. Information of disease progression including the occurrence of events and biological markers associated with the development of disease as well as its death is often collected in the study. Proportional hazards models incorporating the information of disease progression as time-dependent covariates are frequently used to investigate the effect of disease progression on survival. Here we extend Xu and O’Quigley’s approach to predict the probability of subsequent survival given the past information of disease progression under such time-dependent covariate model. The performance of proposed approach is evaluated by a simulation study. | en |
dc.description.provenance | Made available in DSpace on 2021-06-08T04:36:28Z (GMT). No. of bitstreams: 1 ntu-98-R96842026-1.pdf: 889699 bytes, checksum: 32b5167713ee622ba7e3cc8059e0e452 (MD5) Previous issue date: 2009 | en |
dc.description.tableofcontents | 第一章 導論 1
第一節 前言 1 第二節 資料結構 3 第三節 研究動機 6 第二章 文獻回顧 9 第一節 不考慮臨床因子具時間變動特性的分析偏誤 9 第二節 以具時間變動解釋變數的對比風險模式預測存活率 10 第三節 以疾病惡化過程作為預後標誌推論存活 11 第四節 給定解釋變數值之子集下估計存活函數 12 第三章 方法 15 第一節 以疾病惡化過程為時間變動解釋變數的模式 17 第二節 給定疾病惡化過程訊息下預測後續存活機率 20 第三節 給定疾病惡化過程訊息下以觀察資料預測存活機率 24 第四章 統計模擬 29 第一節 模擬資料情境 29 第二節 模擬資料生成 32 第三節 預測之存活率與理論值比較結果 33 第五章 結果與討論 37 | |
dc.language.iso | zh-TW | |
dc.title | 以疾病惡化過程為具時間變動解釋變數的對比風險模式預測後續存活機率 | zh_TW |
dc.title | Predicting Survival With Disease Progression as a Time-dependent Covariate in Proportional Hazards Model | en |
dc.type | Thesis | |
dc.date.schoolyear | 97-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 戴政(John Jen Tai),陳秀熙(Hsiu-Hsi Chen),王俊毅(Jiun-Yi Wang),嚴明芳(Ming-Fang Yen) | |
dc.subject.keyword | 疾病惡化過程,具時間變動解釋變數,對比風險模式,預測, | zh_TW |
dc.subject.keyword | disease progression,prediction,proportional hazards model,time-dependent covariate, | en |
dc.relation.page | 52 | |
dc.rights.note | 未授權 | |
dc.date.accepted | 2009-08-18 | |
dc.contributor.author-college | 公共衛生學院 | zh_TW |
dc.contributor.author-dept | 流行病學研究所 | zh_TW |
顯示於系所單位: | 流行病學與預防醫學研究所 |
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