請用此 Handle URI 來引用此文件:
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/22651
完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 吳焜裕(Kuen-Yuh Wu) | |
dc.contributor.author | Chia-Fang Wu | en |
dc.contributor.author | 吳嘉芳 | zh_TW |
dc.date.accessioned | 2021-06-08T04:23:30Z | - |
dc.date.copyright | 2010-09-13 | |
dc.date.issued | 2010 | |
dc.date.submitted | 2010-06-28 | |
dc.identifier.citation | 1. Leonard, A., et al., Mutagenicity, carcinogenicity, and teratogenicity of acrylonitrile. Mutation Research-Reviews in Mutation Research, 1999. 436(3): p. 263-283.
2. Acrylonitrile. Concise international chemical assessment document 39. 2002, Geneva: World Health Organization (WHO). 3. Acrylonitrile: Inhalation cancer risk assessment final document (v.2). 1997, Toxicology Excellence for Risk Assessment (TERA): Cincinnati. 4. Hoffmann, D., I. Hoffmann, and K. El-Bayoumy, The less harmful cigarette: A controversial issue. A tribute to Ernst L. Wynder. Chemical Research in Toxicology, 2001. 14(7): p. 767-790. 5. Summary of data reported and evaluation, re-evaluation of some organic chemicals, hydrazine and hydrogen peroxide. Vol. 71. 1999: World Health Organization, International Agency for Research on Cancer (IARC). 6. Method development for the biological monitoring of acrylonitrile exposure. 2001, Taiwan: Institute of Occupational Safety and Health (IOSH). 7. NTP technical report on the toxicology and carcinogenesis studies of acrylonitrile in B6C3F1 mice. 2001: National Toxicology Program (NTP), National Institutes of Health. 8. Ghanayem, B.I., et al., Acrylonitrile is a multisite carcinogen in male and female B6C3F1 mice. Toxicological Sciences, 2002. 68(1): p. 59-68. 9. Schuhmacher-Wolz, U., R. Konietzka, and K. Schneider, Using carcinogenic potency ranking to assign air contaminants to emission classes. Regulatory Toxicology and Pharmacology, 2002. 36(3): p. 221-233. 10. Philip Cole, J.S.M., James J. Collins, Acrylonitrile and cancer: A review of the epidemiology. Regulatory Toxicology and Pharmacology, 2008. 52: p. 342-351. 11. Acrylonitrile, Monographs. Vol. 71. 1999: World Health Organization, International Agency for Research on Cancer (IARC). 12. Sampling and analytical methods 37: Acrylonitrile. 2008, United Sates Department of Labor Occupaitonal Safety and Health Administration (OSHA): Washington, DC. 13. NIOSH pocket guide to chemical hazards: 1604 Acrylonitrile. 1994, Center of Disease Control and Prevention, National Institute of Occupational Safety and Health (NIOSH): Atlanta. 14. Kedderis, G.L. and R. Batra, Species-differences in the hydrolysis of 2-cyanoethylene oxide, the epoxide metabolite of acrylonitrile. Carcinogenesis, 1993. 14(4): p. 685-689. 15. Kedderis, G.L., et al., Dose-dependent urinary-excretion of acrylonitrile metabolites by rats and mice. Toxicology and Applied Pharmacology, 1993. 120(2): p. 288-297. 16. Jakubowski, M., et al., 2-Cyanoethylmercapturic acid (CEMA) in the urine as a possible indicator of exposure to acrylonitrile. British Journal of Industrial Medicine, 1987. 44(12): p. 834-840. 17. Oberg, M.T., Epidemiologic-study of workers exposed to acrylonitrile. Journal of Occupational and Environmental Medicine, 1980. 22(4): p. 245-252. 18. Oberg, M.T., et al., Epidemiologic-study of workers exposed to acrylonitrile - An update. Journal of Occupational and Environmental Medicine, 1985. 27(11): p. 835-840. 19. Sakurai, H., Carcinogenicity and other health effects of acrylonitrile with reference to occupational exposure limit. Industrial Health, 2000. 38(2): p. 165-180. 20. Zheng Sponsiello-Wang, E.S., Rolf Weitkunat, Occupational acrylonitrile exposure and lung Cancer: A meta-analysis. Journal of Environmental Science and Health Part C-Environmental Carcinogenesis & Ecotoxicology Reviews, 2006. 24: p. 257-284. 21. Blair, A. and N. Kazerouni, Reactive chemicals and cancer. Cancer Causes and Control, 1997. 8(3): p. 473-490. 22. Mastrangelo, G., R. Serena, and V. Marzia, Mortality from tumors in workers in an acrylic fiber factory. Occupational Medicine-Oxford, 1993. 43(3): p. 155-158. 23. Delzell, E. and R.R. Monson, Mortality among rubber workers .6. Men with potential exposure to acrylonitrile. Journal of Occupational and Environmental Medicine, 1982. 24(10): p. 767-769. 24. Werner, J.B. and J.T. Carter, Mortality of United-Kingdom acrylonitrile polymerization workers. British Journal of Industrial Medicine, 1981. 38(3): p. 247-253. 25. Manno, M., et al., Biomonitoring for occupational health risk assessment (BOHRA) Introduction. Toxicology Letters, 2010. 192(1): p. 3-16. 26. Biologic markers in rrinary toxicology. 1995, Washington, D.C.: National Research Council (NRC), National Academies Press. 27. Vermeulen, N.P.E., Analysis of mercapturic acids as a tool in biotransformation, biomonitoring and toxicological studies. Trends in Pharmacological Sciences, 1989. 10(5): p. 177-181. 28. Nelson, E., Determination of mercapturic acid excretions in exposure control to toxicants. Critical Reviews in Toxicology, 1992. 22(5-6): p. 371-389. 29. Sakurai, H., et al., Health effects of acrylonitrile in acrylic fiber factories. British Journal of Industrial Medicine, 1978. 35(3): p. 219-225. 30. Danny Houthuijs, B.R., Han Willems, Jan Boleij, Klaas Biersteker, Biologic monitoring of acrylonitrile exposure. American Journal of Industrial Medicine, 1982. 3(3): p. 313-320. 31. Chen, J.L., et al., Cancer incidence and mortality among workers exposed to acrylonitrile. American Journal of Industrial Medicine, 1987. 11(2): p. 157-163. 32. Chen, J.L., W.E. Fayerweather, and S. Pell, Cancer incidence of workers exposed to dimethylformamide and or acrylonitrile. Journal of Occupational and Environmental Medicine, 1988. 30(10): p. 813-818. 33. Chen, J.L., W.E. Fayerweather, and S. Pell, Mortality study of worekrs exposed to dimethylformamide and or acrylonitrile. Journal of Occupational and Environmental Medicine, 1988. 30(10): p. 819-821. 34. Starr, T.B., et al., A risk assessment for occupational acrylonitrile exposure using epidemiology data. Risk Analysis, 2004. 24(3): p. 587-601. 35. Symons, J.M., et al., Mortality among workers exposed to acrylonitrile in fiber production: An update. Journal of Occupational and Environmental Medicine, 2008. 50(5): p. 550-560. 36. Benn, T. and K. Osborne, Mortality of United Kingdom acrylonitrile workers - An extended and updated study. Scandinavian Journal of Work Environment & Health, 1998. 24: p. 17-24. 37. Collins, J.J. and J.F. Acquavella, Review and meta-analysis of studies of acrylonitrile workers. Scandinavian Journal of Work Environment & Health, 1998. 24: p. 71-80. 38. Blair, A., et al., Mortality of industrial workers exposed to acrylonitrile. Scandinavian Journal of Work Environment & Health, 1998. 24: p. 25-41. 39. Marsh, G.M., et al., Mortality among chemical plant workers exposed to acrylonitrile and other substances. American Journal of Industrial Medicine, 1999. 36(4): p. 423-436. 40. Swaen, G.M.H., et al., Mortality of workers exposed to acrylonitrile. Journal of Occupational and Environmental Medicine, 1992. 34(8): p. 801-809. 41. Swaen, G.M.H., et al., Mortality update of workers exposed to acrylonitrile in the Netherlands. Scandinavian Journal of Work Environment & Health, 1998. 24: p. 10-16. 42. Swaen, G.M.H., et al., Mortality update of workers exposed to acrylonitrile in the Netherlands. Journal of Occupational and Environmental Medicine, 2004. 46(7): p. 691-698. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/22651 | - |
dc.description.abstract | Acrylonitrile (AN) is a probable human carcinogen and is also a widely-used monomer in industries. Workers might be exposed to AN in workplace. Tobacco smoke has been shown as the major source for non-occupational exposure. The objective of the study was to develop an ultra-performance liquid chromatography coupled with tandem mass spectrometry (UPLC-MS/MS) method to simultaneously and quantitatively profile the major mercapturic acids (MAs) of AN: N-acetyl-S-(2-cyanoethyl)cysteine (CEMA), N-acetyl-S-(2-hydroxyethyl)cysteine (HEMA), and N-acetyl-S-(1-cayno-2-hydroxyethyl)cysteine (CHEMA), and cotinine (COT), the major metabolite of nicotine in samples collected from occupationally-exposed people in order to validate MAs as proper biological markers for AN exposures and to study AN metabolism in humans. This UPLC-MS/MS method was successfully developed with excellent reproducibility, specificity, and sensitivity with limits of quantification (LOQ) at 0.1, 0.1, 1, 0.05 μg/L for HEMA, CEMA, CHEMA, and COT, respectively. The results from profiling MAs showed that the exposed workers excreted significantly higher MAs than the non-exposed workers. Analysis of data with linear regression demonstrated linear correlations between AN exposure and MAs concentrations. Further analysis with multiple regression revealed that personal AN exposures, COT levels, and working shift were significantly associated with these urinary MAs. By using the ratios of (HEMA+CHEMA)/CEMA and CHEMA/CEMA, the proportions of AN absorbed that metabolized to 2-cyanoethylene oxide (CEO) could be approximately estimated. Our analysis first reported that both ratio among 26 workers with detectable AN exposures were significantly higher at the post-shift than those at the pre-shift.
In summary, our results not only validate that CEMA and CHEMA+HEMA can serve as biological markers for AN exposures either in workplaces and from tobacco smoke, but also suggest that potential induction of cytochrome p450 2E1 (CYP2E1) by low AN exposures which may have important implication in assessment of cancer risk for AN. | en |
dc.description.provenance | Made available in DSpace on 2021-06-08T04:23:30Z (GMT). No. of bitstreams: 1 ntu-99-R97841019-1.pdf: 726418 bytes, checksum: e1cb86c4b8f33071ab3abf40505938c3 (MD5) Previous issue date: 2010 | en |
dc.description.tableofcontents | Acknowledgement (I)
Abstract (II) Contents (IV) Tables and figures (VI) Chapter I Introduction (1) Introduction (1) References (6) Tables and figures (12) Chapter II An UPLC-MS/MS method for quantitatively profiling the major urinary metabolites of acrylonitrile for the general public (17) Abstract (18) 1.Introduction (20) 2.Materials and methods (23) 3.Results and discussions (29) 4.Conclusions (37) Acknowledgement (38) References (39) Tables and figures (45) Chapter III Mercapturic Acids as Probable Biological Markers for Acrylonitrile Exposures (52) Abstract (53) 1.Introduction (55) 2.Materials and methods (57) 3.Results (61) 4.Discussions (65) Acknowledgement (68) References (69) Tables and figures (75) Chapter IV Conclusions and recommendations (88) Appendix (i) Appendix I The permission of the Institutional Review Board (IRB) committee (i) Appendix II Questionnaire (ii) | |
dc.language.iso | en | |
dc.title | 丙烯腈暴露勞工之尿液生物指標研究 | zh_TW |
dc.title | Study of Urinary Biological Markers in Acrylonitrile-Exposed Workers | en |
dc.type | Thesis | |
dc.date.schoolyear | 98-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 鄭尊仁(Tsun-Jen Cheng),陳家揚(Chia-Yang Chen),林靖愉(Ching-yu Lin),汪禧年(Shi-Nian Uang) | |
dc.subject.keyword | 極致效能液相層析儀串聯質譜儀,丙烯腈,硫醇酸,生物指標,職業暴露, | zh_TW |
dc.subject.keyword | UPLC-MS/MS,acrylonitrile (AN),mercapturic acid (MA),biological markers,occupational exposure, | en |
dc.relation.page | 89 | |
dc.rights.note | 未授權 | |
dc.date.accepted | 2010-06-28 | |
dc.contributor.author-college | 公共衛生學院 | zh_TW |
dc.contributor.author-dept | 職業醫學與工業衛生研究所 | zh_TW |
顯示於系所單位: | 職業醫學與工業衛生研究所 |
文件中的檔案:
檔案 | 大小 | 格式 | |
---|---|---|---|
ntu-99-1.pdf 目前未授權公開取用 | 709.39 kB | Adobe PDF |
系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。