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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 邱麗珠 | |
dc.contributor.author | Chi-Hsiang Chang | en |
dc.contributor.author | 張騏翔 | zh_TW |
dc.date.accessioned | 2021-06-08T04:22:55Z | - |
dc.date.copyright | 2011-10-07 | |
dc.date.issued | 2011 | |
dc.date.submitted | 2011-08-18 | |
dc.identifier.citation | American Psychiatric Association. 1994. Diagnostic and statistical manual of mental disorders: DSM-IV. p. 78. American Psychiatric Association, Washington, D.C.
Abikoff HB, Jensen PS, Arnold LL, Hoza B, Hechtman L, Pollack S, Martin D, Alvir J, March JS, Hinshaw S, Vitiello B, Newcorn J, Greiner A, Cantwell DP, Conners CK, Elliott G, Greenhill LL, Kraemer H, Pelham WE, Jr., Severe JB, Swanson JM, Wells K, Wigal T (2002) Observed classroom behavior of children with ADHD: relationship to gender and comorbidity. J Abnorm Child Psychol 30:349-359. Acosta MT, Arcos-Burgos M, Muenke M (2004) Attention deficit/hyperactivity disorder (ADHD): complex phenotype, simple genotype? Genet Med 6:1-15. Barbelivien A, Ruotsalainen S, Sirvio J (2001) Metabolic alterations in the prefrontal and cingulate cortices are related to behavioral deficits in a rodent model of attention-deficit hyperactivity disorder. Cereb Cortex 11:1056-1063. Barkley RA, DuPaul GJ, McMurray MB (1990) Comprehensive evaluation of attention deficit disorder with and without hyperactivity as defined by research criteria. J Consult Clin Psychol 58:775-789. Barkley RA, Guevremont DC, Anastopoulos AD, DuPaul GJ, Shelton TL (1993) Driving-related risks and outcomes of attention deficit hyperactivity disorder in adolescents and young adults: a 3- to 5-year follow-up survey. Pediatrics 92:212-218. Bauermeister JJ, Shrout PE, Chavez L, Rubio-Stipec M, Ramirez R, Padilla L, Anderson A, Garcia P, Canino G (2007) ADHD and gender: are risks and sequela of ADHD the same for boys and girls? J Child Psychol Psychiatry 48:831-839. Baunez C, Robbins TW (1999) Effects of dopamine depletion of the dorsal striatum and further interaction with subthalamic nucleus lesions in an attentional task in the rat. Neuroscience 92:1343-1356. Beck LH, Bransome ED, Jr., Mirsky AF, Rosvold HE, Sarason I (1956) A continuous performance test of brain damage. J Consult Psychol 20:343-350. Bendel P, Eilam R (1992) Quantitation of ventricular size in normal and spontaneously hypertensive rats by magnetic resonance imaging. Brain Res 574:224-228. Bizot JC, Chenault N, Houze B, Herpin A, David S, Pothion S, Trovero F (2007) Methylphenidate reduces impulsive behaviour in juvenile Wistar rats, but not in adult Wistar, SHR and WKY rats. Psychopharmacology (Berl) 193:215-223. Blondel A, Sanger DJ, Moser PC (2000) Characterisation of the effects of nicotine in the five-choice serial reaction time task in rats: antagonist studies. Psychopharmacology (Berl) 149:293-305. Bolanos CA, Barrot M, Berton O, Wallace-Black D, Nestler EJ (2003) Methylphenidate treatment during pre- and periadolescence alters behavioral responses to emotional stimuli at adulthood. Biol Psychiatry 54:1317-1329. Boschen KE, Fadel JR, Burk JA (2009) Systemic and intrabasalis administration of the orexin-1 receptor antagonist, SB-334867, disrupts attentional performance in rats. Psychopharmacology (Berl) 206:205-213. Braun JM, Kahn RS, Froehlich T, Auinger P, Lanphear BP (2006) Exposures to environmental toxicants and attention deficit hyperactivity disorder in U.S. children. Environ Health Perspect 114:1904-1909. Brookes KJ, Mill J, Guindalini C, Curran S, Xu X, Knight J, Chen CK, Huang YS, Sethna V, Taylor E, Chen W, Breen G, Asherson P (2006) A common haplotype of the dopamine transporter gene associated with attention-deficit/hyperactivity disorder and interacting with maternal use of alcohol during pregnancy. Arch Gen Psychiatry 63:74-81. Bull E, Reavill C, Hagan JJ, Overend P, Jones DN (2000) Evaluation of the spontaneously hypertensive rat as a model of attention deficit hyperactivity disorder: acquisition and performance of the DRL-60s test. Behav Brain Res 109:27-35. Carli M, Robbins TW, Evenden JL, Everitt BJ (1983) Effects of lesions to ascending noradrenergic neurones on performance of a 5-choice serial reaction task in rats; implications for theories of dorsal noradrenergic bundle function based on selective attention and arousal. Behav Brain Res 9:361-380. Chemelli RM, Willie JT, Sinton CM, Elmquist JK, Scammell T, Lee C, Richardson JA, Williams SC, Xiong Y, Kisanuki Y, Fitch TE, Nakazato M, Hammer RE, Saper CB, Yanagisawa M (1999) Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell 98:437-451. Cole BJ, Robbins TW (1987) Amphetamine impairs the discriminative performance of rats with dorsal noradrenergic bundle lesions on a 5-choice serial reaction time task: new evidence for central dopaminergic-noradrenergic interactions. Psychopharmacology (Berl) 91:458-466. Cole BJ, Robbins TW (1989) Effects of 6-hydroxydopamine lesions of the nucleus accumbens septi on performance of a 5-choice serial reaction time task in rats: implications for theories of selective attention and arousal. Behav Brain Res 33:165-179. Consoli A, Deniau E, Huynh C, Purper D, Cohen D (2007) Treatments in child and adolescent bipolar disorders. Eur Child Adolesc Psychiatry 16:187-198. Cortese S, Angriman M (2008) Attention-deficit/hyperactivity disorder and obesity: moving to the next research generation. Pediatrics 122:1155; author reply 1155-1156. De Bruin NM, Kiliaan AJ, De Wilde MC, Broersen LM (2003) Combined uridine and choline administration improves cognitive deficits in spontaneously hypertensive rats. Neurobiol Learn Mem 80:63-79. de Lecea L, Kilduff TS, Peyron C, Gao X, Foye PE, Danielson PE, Fukuhara C, Battenberg EL, Gautvik VT, Bartlett FS, 2nd, Frankel WN, van den Pol AN, Bloom FE, Gautvik KM, Sutcliffe JG (1998) The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc Natl Acad Sci U S A 95:322-327. Deutch AY, Bubser M (2007) The orexins/hypocretins and schizophrenia. Schizophr Bull 33:1277-1283. Diana G (2002) Does hypertension alone lead to cognitive decline in spontaneously hypertensive rats? Behav Brain Res 134:113-121. Espana RA, Reis KM, Valentino RJ, Berridge CW (2005) Organization of hypocretin/orexin efferents to locus coeruleus and basal forebrain arousal-related structures. J Comp Neurol 481:160-178. Fadel J, Burk JA (2010) Orexin/hypocretin modulation of the basal forebrain cholinergic system: Role in attention. Brain Res 1314:112-123. Faraone SV, Biederman J (2005) What is the prevalence of adult ADHD? Results of a population screen of 966 adults. J Atten Disord 9:384-391. Faraone SV, Perlis RH, Doyle AE, Smoller JW, Goralnick JJ, Holmgren MA, Sklar P (2005) Molecular genetics of attention-deficit/hyperactivity disorder. Biol Psychiatry 57:1313-1323. Faraone SV, Sergeant J, Gillberg C, Biederman J (2003) The worldwide prevalence of ADHD: is it an American condition? World Psychiatry 2:104-113. Frederick-Duus D, Guyton MF, Fadel J (2007) Food-elicited increases in cortical acetylcholine release require orexin transmission. Neuroscience 149:499-507. Fry JM (1998) Treatment modalities for narcolepsy. Neurology 50:S43-48. Ganjavi H, Shapiro CM (2007) Hypocretin/Orexin: a molecular link between sleep, energy regulation, and pleasure. J Neuropsychiatry Clin Neurosci 19:413-419. Goldman LS, Genel M, Bezman RJ, Slanetz PJ (1998) Diagnosis and treatment of attention-deficit/hyperactivity disorder in children and adolescents. Council on Scientific Affairs, American Medical Association. JAMA 279:1100-1107. Grottick AJ, Higgins GA (2000) Effect of subtype selective nicotinic compounds on attention as assessed by the five-choice serial reaction time task. Behav Brain Res 117:197-208. Grottick AJ, Higgins GA (2002) Assessing a vigilance decrement in aged rats: effects of pre-feeding, task manipulation, and psychostimulants. Psychopharmacology (Berl) 164:33-41. Hahn B, Shoaib M, Stolerman IP (2003) Involvement of the prefrontal cortex but not the dorsal hippocampus in the attention-enhancing effects of nicotine in rats. Psychopharmacology (Berl) 168:271-279. Hallmayer J, Faraco J, Lin L, Hesselson S, Winkelmann J, Kawashima M, Mayer G, Plazzi G, Nevsimalova S, Bourgin P, Hong SC, Honda Y, Honda M, Hogl B, Longstreth WT, Jr., Montplaisir J, Kemlink D, Einen M, Chen J, Musone SL, Akana M, Miyagawa T, Duan J, Desautels A, Erhardt C, Hesla PE, Poli F, Frauscher B, Jeong JH, Lee SP, Ton TG, Kvale M, Kolesar L, Dobrovolna M, Nepom GT, Salomon D, Wichmann HE, Rouleau GA, Gieger C, Levinson DF, Gejman PV, Meitinger T, Young T, Peppard P, Tokunaga K, Kwok PY, Risch N, Mignot E (2009) Narcolepsy is strongly associated with the T-cell receptor alpha locus. Nat Genet 41:708-711. Harris GC, Wimmer M, Aston-Jones G (2005) A role for lateral hypothalamic orexin neurons in reward seeking. Nature 437:556-559. Hendley ED, Wessel DJ, Atwater DG, Gellis J, Whitehorn D, Low WC (1985) Age, sex and strain differences in activity and habituation in SHR and WKY rats. Physiol Behav 34:379-383. Higgins GA, Grzelak ME, Pond AJ, Cohen-Williams ME, Hodgson RA, Varty GB (2007) The effect of caffeine to increase reaction time in the rat during a test of attention is mediated through antagonism of adenosine A2A receptors. Behav Brain Res 185:32-42. Hofvander B, Ossowski D, Lundstrom S, Anckarsater H (2009) Continuity of aggressive antisocial behavior from childhood to adulthood: The question of phenotype definition. Int J Law Psychiatry 32:224-234. Hwang LL, Wang CH, Li TL, Chang SD, Lin LC, Chen CP, Chen CT, Liang KC, Ho IK, Yang WS, Chiou LC (2010) Sex differences in high-fat diet-induced obesity, metabolic alterations and learning, and synaptic plasticity deficits in mice. Obesity (Silver Spring) 18:463-469. Jentsch JD (2005) Impaired visuospatial divided attention in the spontaneously hypertensive rat. Behav Brain Res 157:323-330. Kahn RS, Khoury J, Nichols WC, Lanphear BP (2003) Role of dopamine transporter genotype and maternal prenatal smoking in childhood hyperactive-impulsive, inattentive, and oppositional behaviors. J Pediatr 143:104-110. Lahey BB, Goodman SH, Waldman ID, Bird H, Canino G, Jensen P, Regier D, Leaf PJ, Gordon R, Applegate B (1999) Relation of age of onset to the type and severity of child and adolescent conduct problems. J Abnorm Child Psychol 27:247-260. Lambe EK, Liu RJ, Aghajanian GK (2007) Schizophrenia, hypocretin (orexin), and the thalamocortical activating system. Schizophr Bull 33:1284-1290. Lambe EK, Olausson P, Horst NK, Taylor JR, Aghajanian GK (2005) Hypocretin and nicotine excite the same thalamocortical synapses in prefrontal cortex: correlation with improved attention in rat. J Neurosci 25:5225-5229. Langley K, Marshall L, van den Bree M, Thomas H, Owen M, O'Donovan M, Thapar A (2004) Association of the dopamine D4 receptor gene 7-repeat allele with neuropsychological test performance of children with ADHD. Am J Psychiatry 161:133-138. Lecendreux M, Konofal E, Bouvard M, Falissard B, Mouren-Simeoni MC (2000) Sleep and alertness in children with ADHD. J Child Psychol Psychiatry 41:803-812. Leo D, Sorrentino E, Volpicelli F, Eyman M, Greco D, Viggiano D, di Porzio U, Perrone-Capano C (2003) Altered midbrain dopaminergic neurotransmission during development in an animal model of ADHD. Neurosci Biobehav Rev 27:661-669. Levy F, Swanson JM (2001) Timing, space and ADHD: the dopamine theory revisited. Aust N Z J Psychiatry 35:504-511. Lin YF, Xu X, Cape A, Li S, Li XJ (2010) Huntingtin-associated protein-1 deficiency in orexin-producing neurons impairs neuronal process extension and leads to abnormal behavior in mice. J Biol Chem 285:15941-15949. Markowitz JS, DeVane CL, Pestreich LK, Patrick KS, Muniz R (2006) A comprehensive in vitro screening of d-, l-, and dl-threo-methylphenidate: an exploratory study. J Child Adolesc Psychopharmacol 16:687-698. Meng Q, Li N, Han X, Shao F, Wang W (2010) Peri-adolescence isolation rearing alters social behavior and nociception in rats. Neurosci Lett 480:25-29. Mignot E (2001) A commentary on the neurobiology of the hypocretin/orexin system. Neuropsychopharmacology 25:S5-13. Mill J, Sagvolden T, Asherson P (2005) Sequence analysis of Drd2, Drd4, and Dat1 in SHR and WKY rat strains. Behav Brain Funct 1:24. Minzenberg MJ, Carter CS (2008) Modafinil: a review of neurochemical actions and effects on cognition. Neuropsychopharmacology 33:1477-1502. Mirza NR, Stolerman IP (1998) Nicotine enhances sustained attention in the rat under specific task conditions. Psychopharmacology (Berl) 138:266-274. Mitler MM (1994) Evaluation of treatment with stimulants in narcolepsy. Sleep 17:S103-106. Neuman RJ, Lobos E, Reich W, Henderson CA, Sun LW, Todd RD (2007) Prenatal smoking exposure and dopaminergic genotypes interact to cause a severe ADHD subtype. Biol Psychiatry 61:1320-1328. Newman LA MT, McGaughy JA (2007) In Annual meeting of Society for Neuroscience, Program # 839.8. Abstract CD : San Diego. Okamoto K, Aoki K (1963) Development of a strain of spontaneously hypertensive rats. Jpn Circ J 27:282-293. Pare WP (1989) Stress ulcer and open-field behavior of spontaneously hypertensive, normotensive, and Wistar rats. Pavlov J Biol Sci 24:54-57. Pasumarthi RK, Fadel J (2008) Activation of orexin/hypocretin projections to basal forebrain and paraventricular thalamus by acute nicotine. Brain Res Bull 77:367-373. Peyron C, Faraco J, Rogers W, Ripley B, Overeem S, Charnay Y, Nevsimalova S, Aldrich M, Reynolds D, Albin R, Li R, Hungs M, Pedrazzoli M, Padigaru M, Kucherlapati M, Fan J, Maki R, Lammers GJ, Bouras C, Kucherlapati R, Nishino S, Mignot E (2000) A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. Nat Med 6:991-997. Pliszka SR (2003) Psychiatric comorbidities in children with attention deficit hyperactivity disorder: implications for management. Paediatr Drugs 5:741-750. Pliszka SR, McCracken JT, Maas JW (1996) Catecholamines in attention-deficit hyperactivity disorder: current perspectives. J Am Acad Child Adolesc Psychiatry 35:264-272. Puumala T, Ruotsalainen S, Jakala P, Koivisto E, Riekkinen P, Jr., Sirvio J (1996) Behavioral and pharmacological studies on the validation of a new animal model for attention deficit hyperactivity disorder. Neurobiol Learn Mem 66:198-211. Raskin LA, Shaywitz SE, Shaywitz BA, Anderson GM, Cohen DJ (1984) Neurochemical correlates of attention deficit disorder. Pediatr Clin North Am 31:387-396. Reja V, Goodchild AK, Pilowsky PM (2002) Catecholamine-related gene expression correlates with blood pressures in SHR. Hypertension 40:342-347. Resnick RJ (2005) Attention deficit hyperactivity disorder in teens and adults: they don't all outgrow it. J Clin Psychol 61:529-533. Robbins TW (2002) The 5-choice serial reaction time task: behavioural pharmacology and functional neurochemistry. Psychopharmacology (Berl) 163:362-380. Roman T, Rohde LA, Hutz MH (2004) Polymorphisms of the dopamine transporter gene: influence on response to methylphenidate in attention deficit-hyperactivity disorder. Am J Pharmacogenomics 4:83-92. Russell V, Allie S, Wiggins T (2000) Increased noradrenergic activity in prefrontal cortex slices of an animal model for attention-deficit hyperactivity disorder--the spontaneously hypertensive rat. Behav Brain Res 117:69-74. Russell VA (2003) Dopamine hypofunction possibly results from a defect in glutamate-stimulated release of dopamine in the nucleus accumbens shell of a rat model for attention deficit hyperactivity disorder--the spontaneously hypertensive rat. Neurosci Biobehav Rev 27:671-682. Russell VA (2007) Neurobiology of animal models of attention-deficit hyperactivity disorder. J Neurosci Methods 161:185-198. Russell VA, Sagvolden T, Johansen EB (2005) Animal models of attention-deficit hyperactivity disorder. Behav Brain Funct 1:9. Sagvolden T (2000) Behavioral validation of the spontaneously hypertensive rat (SHR) as an animal model of attention-deficit/hyperactivity disorder (AD/HD). Neurosci Biobehav Rev 24:31-39. Sagvolden T, Aase H, Zeiner P, Berger D (1998) Altered reinforcement mechanisms in attention-deficit/hyperactivity disorder. Behav Brain Res 94:61-71. Sagvolden T, Hendley ED, Knardahl S (1992a) Behavior of hypertensive and hyperactive rat strains: hyperactivity is not unitarily determined. Physiol Behav 52:49-57. Sagvolden T, Johansen EB, Aase H, Russell VA (2005a) A dynamic developmental theory of attention-deficit/hyperactivity disorder (ADHD) predominantly hyperactive/impulsive and combined subtypes. Behav Brain Sci 28:397-419; discussion 419-368. Sagvolden T, Metzger MA, Schiorbeck HK, Rugland AL, Spinnangr I, Sagvolden G (1992b) The spontaneously hypertensive rat (SHR) as an animal model of childhood hyperactivity (ADHD): changed reactivity to reinforcers and to psychomotor stimulants. Behav Neural Biol 58:103-112. Sagvolden T, Pettersen MB, Larsen MC (1993) Spontaneously hypertensive rats (SHR) as a putative animal model of childhood hyperkinesis: SHR behavior compared to four other rat strains. Physiol Behav 54:1047-1055. Sagvolden T, Russell VA, Aase H, Johansen EB, Farshbaf M (2005b) Rodent models of attention-deficit/hyperactivity disorder. Biol Psychiatry 57:1239-1247. Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richardson JA, Kozlowski GP, Wilson S, Arch JR, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu WS, Terrett JA, Elshourbagy NA, Bergsma DJ, Yanagisawa M (1998) Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92:573-585. Samson WK, Bagley SL, Ferguson AV, White MM (2010) Orexin receptor subtype activation and locomotor behaviour in the rat. Acta Physiol (Oxf) 198:313-324. Scammell TE, Estabrooke IV, McCarthy MT, Chemelli RM, Yanagisawa M, Miller MS, Saper CB (2000) Hypothalamic arousal regions are activated during modafinil-induced wakefulness. J Neurosci 20:8620-8628. Smith KM, Daly M, Fischer M, Yiannoutsos CT, Bauer L, Barkley R, Navia BA (2003) Association of the dopamine beta hydroxylase gene with attention deficit hyperactivity disorder: genetic analysis of the Milwaukee longitudinal study. Am J Med Genet B Neuropsychiatr Genet 119B:77-85. Stillman A, Ercan-Sencicek AG, State MW (1993) Tourette Disorder Overview. Swanson JM, Flodman P, Kennedy J, Spence MA, Moyzis R, Schuck S, Murias M, Moriarity J, Barr C, Smith M, Posner M (2000) Dopamine genes and ADHD. Neurosci Biobehav Rev 24:21-25. Swanson JM, Kinsbourne M, Nigg J, Lanphear B, Stefanatos GA, Volkow N, Taylor E, Casey BJ, Castellanos FX, Wadhwa PD (2007) Etiologic subtypes of attention-deficit/hyperactivity disorder: brain imaging, molecular genetic and environmental factors and the dopamine hypothesis. Neuropsychol Rev 17:39-59. Thapar A, Langley K, Asherson P, Gill M (2007) Gene-environment interplay in attention-deficit hyperactivity disorder and the importance of a developmental perspective. Br J Psychiatry 190:1-3. van den Bergh FS, Bloemarts E, Chan JSW, Groenink L, Olivier B, Oosting RS (2006) Spontaneously hypertensive rats do not predict symptoms of attention-deficit hyperactivity disorder. Pharmacology Biochemistry and Behavior 83:380-390. Viggiano D, Grammatikopoulos G, Sadile AG (2002) A morphometric evidence for a hyperfunctioning mesolimbic system in an animal model of ADHD. Behav Brain Res 130:181-189. Viggiano D, Vallone D, Sadile A (2004) Dysfunctions in dopamine systems and ADHD: evidence from animals and modeling. Neural Plast 11:97-114. Volkow ND, Wang GJ, Kollins SH, Wigal TL, Newcorn JH, Telang F, Fowler JS, Zhu W, Logan J, Ma Y, Pradhan K, Wong C, Swanson JM (2009) Evaluating dopamine reward pathway in ADHD: clinical implications. JAMA 302:1084-1091. Waring ME, Lapane KL (2008) Overweight in children and adolescents in relation to attention-deficit/hyperactivity disorder: results from a national sample. Pediatrics 122:e1-6. Watanabe Y, Fujita M, Ito Y, Okada T, Kusuoka H, Nishimura T (1997) Brain dopamine transporter in spontaneously hypertensive rats. J Nucl Med 38:470-474. Weinberg WA, Harper CR (1993) Vigilance and its disorders. Neurol Clin 11:59-78. Wilkinson RT (1963) Interaction of Noise with Knowledge of Results and Sleep Deprivation. J Exp Psychol 66:332-337. Wolraich ML, Hannah JN, Baumgaertel A, Feurer ID (1998) Examination of DSM-IV criteria for attention deficit/hyperactivity disorder in a county-wide sample. J Dev Behav Pediatr 19:162-168. Wolraich ML, Hannah JN, Pinnock TY, Baumgaertel A, Brown J (1996) Comparison of diagnostic criteria for attention-deficit hyperactivity disorder in a county-wide sample. J Am Acad Child Adolesc Psychiatry 35:319-324. Wultz B, Sagvolden T (1992) The hyperactive spontaneously hypertensive rat learns to sit still, but not to stop bursts of responses with short interresponse times. Behav Genet 22:415-433. Wultz B, Sagvolden T, Moser EI, Moser MB (1990) The spontaneously hypertensive rat as an animal model of attention-deficit hyperactivity disorder: effects of methylphenidate on exploratory behavior. Behav Neural Biol 53:88-102. Zhu J, Reith ME (2008) Role of the dopamine transporter in the action of psychostimulants, nicotine, and other drugs of abuse. CNS Neurol Disord Drug Targets 7:393-409. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/22632 | - |
dc.description.abstract | 注意力不足過動症(Attention-deficit hyperactivity disorder; ADHD)是一種在兒童期常見的認知行為失調,主要症狀為注意力不集中(inattention)、衝動(impulsivity)和過動(hyperactivity)。此病在全世界之盛行率約5%~10%,其中大約有60%的病人,其症狀會持續到成年之後。目前ADHD的動物模式種類仍有限,但自發性高血壓大鼠 (Spontaneous Hypertension Rats, SHR),已被證實是一良好之ADHD動物模式。本實驗使用SHR大鼠測試其在五洞鼻觸注意力測試儀(5-Choice Serial Reaction Time Task;5-CSRTT)、開放空間(open field)、社交行為實驗(social interaction)中之表現,並比較其對照組WKY大鼠在這些試驗中之表現
Orexins(食慾素,或稱下視丘素Hypocretins)為一種胜肽類激素,包含Orexin A和B(Hypocretin-1和2)。Orexin受體為一G蛋白偶合受體,可分為OX1和OX2兩種,其內生性致效劑為食慾素(Orexins)。最近的研究指出Orexin系統的活化可投射到基底前腦,而造成該腦區內膽鹼系統的活化以及乙烯膽鹼(acetylcholine)的釋放。普遍認為基底前腦(basal forebrain)的膽鹼系統(cholinergic system)在注意力的表現中扮演著重要角色。 因此在本研究中,藉由給予OX1受體之選擇性拮抗劑SB-334867 (5mg/kg)以及OX2受體之拮抗劑TCS-OX2-29 (10mg/kg),並以大鼠五洞鼻觸注意力測試儀(5-CSRTT)、開放空間(open field) 社交行為實驗(social interaction)等實驗來探討orexin在SHR與WKY大鼠之注意力、衝動性、活動力以及社交行為中的角色, 實驗發現: (1) SHR大鼠在5-CSRTT中表現較多錯誤率以及衝動行為。腹腔注射SB-334867 (5mg/kg) 會造成SHR以及WKY大鼠的注意力表現產生缺失,顯示此藥物引起之降低注意力之作用不具物種專一性;此外腹腔給予TCS-OX2-29 (10mg/kg) 也能夠造成一定程度之注意力缺損。 (2) SHR大鼠在開放空間中表現出過動行為。在給予SB-334867之後穿越格線(crossing)與後腿直立(rearing)之次數明顯減少;此外給予TCS-OX2-29之後後腿直立之次數明顯減少,但並不影響穿越格線之次數。 (3) SHR大鼠在社交行為實驗中表現社交行為缺損和具有攻擊性。腹腔注射SB-334867會降低WKY大鼠的社交行為時間,但不影響SHR大鼠之社交行為。 因此在本文中實驗證實不只OX1受體的拮抗能造成注意力的缺損,OX2受體可能也在注意力的機制中扮演重要的角色。此外,給予Orexin的拮抗劑可以造成活動力的減低以及社交行為的缺損,也說明了orexin系統在這些行為上具有一定程度之重要性。 | zh_TW |
dc.description.abstract | Attention-deficit/hyperactivity disorder (ADHD) characterized with three main symptoms, inattention, impulsivity and hyperactivity, is a behavioral disorder affecting 5%-10% of children worldwide and remains in the adulthood in 60% of them. An ideal animal model for ADHD is lacking but spontaneous hypertension rats (SHR) has been proposed to be one. In this study, we evaluated the performance of SHR and their strain control, Wistar Kyoto rats (WKY), in the 5-choice serial reaction time task (5-CSRTT), open field test and social interaction.
Orexins, consisting of orexin A and B (also named hypocretin 1or 2), are endogenous peptide agonists of a couple of G protein-coupled receptors, OX1 and OX2. Orexin neurons have been reported to project to the basal forebrain. Activation of the cholinergic system in the basal forebrain is believed to play an important role in the attention process. Therefore, in this study, we also investigated the role of endogenous orexins in attention, impulsivity, locomotor activity and social interaction in SHR and WKY by examining effects of the selective OX1 and OX2 antagonists, SB-334867 and TCS-OX2-29, respectively, on the performance of 5-CSRTT, open-field and social interaction. (1) In the 5-CSRTT, as compared with WKY, SHR displayed higher incorrect response rate and impulsivity, but had the same correct response rate. Systemic SB-334867 (5 mg/kg., i.p) significantly increased the correct latency and omission, decreased correct response in both SHR and WKY. TCS-OX2-29 (10 mg/kg., i.p) slightly decreased the correct response rate in SHR and increased the correct latency in WKY. (2) SHR also had more exploring acitivty and higher locomotor activity in the open field test than WKY. Systemic SB-334867 decreased the number of crossing and rearing in SHR. TCS-OX2-29 decreased the number of rearing. (3) In the social interaction test, SHR displayed less social exploration but had more aggressive behaviors in social interaction test than WKY. The duration of social interaction of WKY were decreased in both SB-334867 and TCS-OX2-29 treatment groups. These results suggest that endogenous orexins play a role in the performance of attention, social ability and locomotor activity in both strains and this effect is mainly mediated by OX1 receptors and also involves OX2 receptors. | en |
dc.description.provenance | Made available in DSpace on 2021-06-08T04:22:55Z (GMT). No. of bitstreams: 1 ntu-100-R98443020-1.pdf: 1225605 bytes, checksum: fedcdd249a1dd82aec9fb7af92e27d4b (MD5) Previous issue date: 2011 | en |
dc.description.tableofcontents | 口試委員會審定書………………………………………… I
誌謝………………………………………………………… II 中文摘要……………………………………………………III Abstract……………………………………………………V Introduction………………………………………………1 Materials and Methods…………………………………15 Results……………………………………………………25 Discussion………………………………………………37 Figures……………………………………………………46 References………………………………………………83 | |
dc.language.iso | en | |
dc.title | Orexin系統在ADHD動物模式之注意力、衝動性、活動力及社交行為中所扮演之角色 | zh_TW |
dc.title | Role of the orexin system in attention, impulsivity, locomotor activity and social interaction in SHR ─ an ADHD animal model | en |
dc.type | Thesis | |
dc.date.schoolyear | 99-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 黃玲玲,李季湜,賴文崧,劉亞平 | |
dc.subject.keyword | 注意力,衝動,社交行為,注意力不足過動症,自發性高血壓大鼠,食慾素, | zh_TW |
dc.subject.keyword | attention,impulsivity,social interaction,ADHD,SHR,orexin, | en |
dc.relation.page | 100 | |
dc.rights.note | 未授權 | |
dc.date.accepted | 2011-08-18 | |
dc.contributor.author-college | 醫學院 | zh_TW |
dc.contributor.author-dept | 藥理學研究所 | zh_TW |
顯示於系所單位: | 藥理學科所 |
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