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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 蔡懷楨(Huai-Jen Tsai) | |
dc.contributor.author | Dao-Ming Lo | en |
dc.contributor.author | 羅道明 | zh_TW |
dc.date.accessioned | 2021-06-08T04:19:18Z | - |
dc.date.copyright | 2010-07-30 | |
dc.date.issued | 2010 | |
dc.date.submitted | 2010-07-22 | |
dc.identifier.citation | Armstrong, E. J., and Bischoff, J. (2004). Heart valve development: endothelial cell signaling and differentiation. Circulation Research 95, 459-470.
Baldwin, H. S., Lloyd, T. R., and Solursh, M. (1994). Hyaluronate degradation affects ventricular function of the early postlooped embryonic rat heart in situ. Circulation Research 74, 244-252. Bardien-Kruger, S., Wulff, H., Arieff, Z., Brink, P., Chandy, K. G., and Corfield, V. (2002). Characterisation of the human voltage-gated potassium channel gene, KCNA7, a candidate gene for inherited cardiac disorders, and its exclusion as cause of progressive familial heart block I (PFHBI). European Journal of Human Genetics 10, 36-43. Basaria, S., and Cooper, D. S. (2005). Amiodarone and the thyroid. The American Journal of Medicine 118, 706-714. Batlle, E., Sancho, E., Francí, C., Domínguez, D., Monfar, M., Baulida, J., and de Herreros, A. G. (2000). The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells. Nature cell biology 2, 84-89. Baumgartner, H. (2001). Reproductive issues in adults with congenital heart disease: arrhythmias during pregnancy: importance, diagnosis and therapy. The Thoracic and Cardiovascular Surgeon 49, 94-97. Beis, D., Bartman, T., Jin, S. W., Scott, I. C., D'Amico, L. A., Ober, E. A., Verkade, H., Frantsve, J., Field, H. A., Wehman, A., Baier, H., Tallafuss, A., Bally-Cuif, L., Chen, J., Stainier, D. Y. R., and Jungblut, B. (2005). Genetic and cellular analyses of zebrafish atrioventricular cushion and valve development. Development 132, 4193-4204. Blanco, M. J., Barrallo-Gimeno, A., Acloque, H., Reyes, A. E., Tada, M., Allende, M. L., Mayor, R., and Nieto, M. Á. (2007). Snail1a and Snail1b cooperate in the anterior migration of the axial mesendoderm in the zebrafish embryo. Development 134, 4073-4081. Bolos, V., Peinado, H., Perez-Moreno, M. A., Fraga, M. F., Esteller, M., and Cano, A. (2003). The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors. Journal of Cell Science 116, 499-511. Brend, T., and Holley, S. A. (2009). Zebrafish whole mount high-resolution double fluorescent in situ hybridization. Journal of Visualized Experiments. Brian, B., Jessie, F., Bei, L., and Qin, L. (2006). Cadherin2 (N-cadherin) plays an essential role in zebrafish cardiovascular development. BMC Developmental Biology 6, 23. Bruneau, B. G. (2008). The developmental genetics of congenital heart disease. Nature 7181, 943-948. Butcher, J. T., and Markwald, R. R. (2007). Valvulogenesis: the moving target. Philosophical Transactions of the Royal Society B 362, 1489-1503. Camarata, T., Krcmery, J., Snyder, D., Park, S., Topczewski, J., and Simon, H. G. (2010). Pdlim7 (LMP4) regulation of Tbx5 specifies zebrafish heart atrio-ventricular boundary and valve formation. Developmental Biology 337, 233-245. Camenisch, T. D., Spicer, A. P., Brehm-Gibson, T., Biesterfeldt, J., Augustine, M. L., Calabro Jr, A., Kubalak, S., Klewer, S. E., and McDonald, J. A. (2000). Disruption of hyaluronan synthase-2 abrogates normal cardiac morphogenesis and hyaluronan-mediated transformation of epithelium to mesenchyme. Journal of Clinical Investigation 106, 349-360. Cano, A., Pérez-Moreno, M. A., Rodrigo, I., Locascio, A., Blanco, M. J., del Barrio, M. G., Portillo, F., and Nieto, M. Á. (2000). The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nature Cell Biology 2, 76-83. Carl, T. F., Dufton, C., Hanken, J., and Klymkowsky, M. W. (1999). Inhibition of neural crest migration in Xenopus using antisense slug RNA. Developmental Biology 213, 101-115. Charlier, R., Deltour, G., Tondeur, R., and Binon, F. (1962). Studies in the benzofuran series. VII. Preliminary pharmacological study of 2-butyl-3-(3, 5-diiodo-4-beta-N-diethylaminoethoxybenzoyl)-benzofuran. Archives Internationales de Pharmacodynamie et de Thérapie 139, 255-264. Cheng, L., Guo, X., Yang, X., Chong, M., Cheng, J., Li, G., Gui, Y., and Lu, D. (2006). δ-sarcoglycan is necessary for early heart and muscle development in zebrafish. Biochemical and Biophysical Research Communications 344, 1290-1299. Cheng, W., Guo, L., Zhang, Z., Soo, H. M., Wen, C., Wu, W., and Peng, J. (2006). HNF factors form a network to regulate liver-enriched genes in zebrafish. Developmental Biology 294, 482-496. Chi, N. C., Shaw, R. M., De Val, S., Kang, G., Jan, L. Y., Black, B. L., and Stainier, D. Y. R. (2008). Foxn4 directly regulates tbx2b expression and atrioventricular canal formation. Genes & Development 22, 734-739. Ciriaco, P., Mazzone, P., Canneto, B., and Zannini, P. (2000). Supraventricular arrhythmia following lung resection for non-small cell lung cancer and its treatment with amiodarone. European Journal of cardio-thoracic Surgery 18, 12-16. Creighton, C. J., Bromberg-White, J. L., Misek, D. E., Monsma, D. J., Brichory, F., Kuick, R., Giordano, T. J., Gao, W., Omenn, G. S., Webb, C. P., and Hanash, S. M. (2005). Analysis of tumor-host interactions by gene expression profiling of lung adenocarcinoma xenografts identifies genes involved in tumor formation. Molecular Cancer Research 3, 119-129. de la Cruz, M. V., Giménez-Ribotta, M., Saravalli, O., and Cayré, R. (1983). The contribution of the inferior endocardial cushion of the atrioventricular canal to cardiac septation and to the development of the atrioventricular valves: study in the chick embryo. American Journal of Anatomy 166, 63-72. Deltour, G., Binon, F., Tondeur, R., Goldenberg, C., Henaux, F., Sion, R., Deray, E., and Charlier, R. (1962). Studies in the benzofuran series. VI. Coronary-dilating activity of alkylated and aminoalkylated derivatives of 3-benzoylbenzofuran. Archives Internationalesde Pharmacodynamie et de Thérapie 139, 247-254. Dor, Y., Klewer, S. E., McDonald, J. A., Keshet, E., and Camenisch, T. D. (2003). VEGF modulates early heart valve formation. The Anatomical Record 271A, 202-208. Eroglu, B., Wang, G., Tu, N., Sun, X., and Mivechi, N. F. (2006). Critical role of Brg1 member of the SWI/SNF chromatin remodeling complex during neurogenesis and neural crest induction in zebrafish. Developmental Dynamics 235, 2722-2735. Gierten, J., Ficker, E., Bloehs, R., Schweizer, P. A., Zitron, E., Scholz, E., Karle, C., Katus, H. A., and Thomas, D. (2010). The human cardiac K2P3.1 (TASK-1) potassium leak channel is a molecular target for the class III antiarrhythmic drug amiodarone. Naunyn-Schmiedeberg's Archives of Pharmacology 381, 261-270. Grau, Y., Carteret, C., and Simpson, P. (1984). Mutations and chromosomal rearrangements affecting the expression of snail, a gene involved in embryonic patterning in Drosophila melanogaster. Genetics 108, 347-360. Hammerschmidt, M., and Nusslein-Volhard, C. (1993). The expression of a zebrafish gene homologous to Drosophila snail suggests a conserved function in invertebrate and vertebrate gastrulation. Development 119, 1107-1118. Heger, J. J., Prystowsky, E. N., Miles, W. M., and Zipes, D. P. (1984). Clinical use and pharmacology of amiodarone. The Medical Clinics of North America 68, 1339-1366. Hemavathy, K., Meng, X., and Ip, Y. T. (1997). Differential regulation of gastrulation and neuroectodermal gene expression by Snail in the Drosophila embryo. Development 124, 3683-3691. Henderson, D. J., and Copp, A. J. (1998). Versican expression is associated with chamber specification, septation, and valvulogenesis in the developing mouse heart. Circulation Research 83, 523-532. Henderson, D. J., Ybot-Gonzalez, P., and Copp, A. J. (1997). Over-expression of the chondroitin sulphate proteoglycan versican is associated with defective neural crest migration in the Pax3 mutant mouse (splotch). Mechanisms of Development 69, 39-51. Hong, S. K., Haldin, C. E., Lawson, N. D., Weinstein, B. M., Dawid, I. B., and Hukriede, N. A. (2005). The zebrafish kohtalo/trap230 gene is required for the development of the brain, neural crest, and pronephric kidney. Proceedings of the National Academy of Sciences 102, 18473-18478. Hove, J. R., Köster, R. W., Forouhar, A. S., Acevedo-Bolton, G., Fraser, S. E., and Gharib, M. (2003). Intracardiac fluid forces are an essential epigenetic factor for embryonic cardiogenesis. Nature 421, 172-177. Hsiao, C. D., Tsai, W. Y., Horng, L. S., and Tsai, H. J. (2003). Molecular structure and developmental expression of three muscle-type troponin T genes in zebrafish. Developmental Dynamics 227, 266-279. Huang, H., Zhang, B., Hartenstein, P. A., Chen, J., and Lin, S. (2005). NXT 2 is required for embryonic heart development in zebrafish. BMC Developmental Biology 5, 7. Hurlstone, A. F. L., Haramis, A. P. G., Wienholds, E., Begthel, H., Korving, J., van Eeden, F., Cuppen, E., Zivkovic, D., Plasterk, R. H. A., and Clevers, H. (2003). The Wnt/β-catenin pathway regulates cardiac valve formation. Nature 425, 633-637. Ito, K., Shinomura, T., Zako, M., Ujita, M., and Kimata, K. (1995). Multiple forms of mouse PG-M, a large chondroitin sulfate proteoglycan generated by alternative splicing. Journal of Biological Chemistry 270, 958-965. Jiang, R., Lan, Y., Norton, C. R., Sundberg, J. P., and Gridley, T. (1998). The Slug gene is not essential for mesoderm or neural crest development in mice. Developmental Biology 198, 277-285. Jorda, M., Olmeda, D., Vinyals, A., Valero, E., Cubillo, E., Llorens, A., Cano, A., and Fabra, A. (2005). Upregulation of MMP-9 in MDCK epithelial cell line in response to expression of the Snail transcription factor. Journal of Cell Science 118, 3371-3385. Kang, J. S., Oohashi, T., Kawakami, Y., Bekku, Y., Izpisúa-Belmonte, J. C., and Ninomiya, Y. (2004). Characterization of dermacan, a novel zebrafish lectican gene, expressed in dermal bones. Mechanisms of Development 121, 301-312. Kataoka, H., Murayama, T., Yokode, M., Mori, S., Sano, H., Ozaki, H., Yokota, Y., Nishikawa, S. I., and Kita, T. (2000). A novel snail-related transcription factor Smuc regulates basic helix-loop-helix transcription factor activities via specific E-box motifs. Nucleic Acids Research 28, 626-633. Katoh, M. (2003). Identification and characterization of human SNAIL3 (SNAI3) gene in silico. International Journal of Molecular Medicine 11, 383-388. Kawashima, H., Atarashi, K., Hirose, M., Hirose, J., Yamada, S., Sugahara, K., and Miyasaka, M. (2002). Oversulfated chondroitin/dermatan sulfates containing GlcAβ1/IdoAα1-3GalNAc (4, 6-O-disulfate) interact with L-and P-selectin and chemokines. Journal of Biological Chemistry 277, 12921-12930. Kern, C. B., Twal, W. O., Mjaatvedt, C. H., Fairey, S. E., Toole, B. P., Iruela-Arispe, M. L., and Argraves, W. S. (2006). Proteolytic cleavage of versican during cardiac cushion morphogenesis. Developmental Dynamics 235, 2238-2247. Kishimoto, J., Ehama, R., Wu, L., Jiang, S., Jiang, N., and Burgeson, R. E. (1999). Selective activation of the versican promoter by epithelial-mesenchymal interactions during hair follicle development. Proceedings of the National Academy of Sciences of the United States of America 96, 7336-7341. Kodama, I., Kamiya, K., and Toyama, J. (1999). Amiodarone: ionic and cellular mechanisms of action of the most promising class III agent. The American Journal of Cardiology 84, 20-28. Kokudo, T., Suzuki, Y., Yoshimatsu, Y., Yamazaki, T., Watabe, T., and Miyazono, K. (2008). Snail is required for TGFβ-induced endothelial-mesenchymal transition of embryonic stem cell-derived endothelial cells. Journal of Cell Science 121, 3317-3324. Kudo-Saito, C., Shirako, H., Takeuchi, T., and Kawakami, Y. (2009). Cancer metastasis is accelerated through immunosuppression during Snail-induced EMT of cancer cells. Cancer Cell 15, 195-206. Kurrey, N. K., Amit, K., and Bapat, S. A. (2005). Snail and Slug are major determinants of ovarian cancer invasiveness at the transcription level. Gynecologic Oncology 97, 155-165. Lampugnani, M. G., Corada, M., Caveda, L., Breviario, F., Ayalon, O., Geiger, B., and Dejana, E. (1995). The molecular organization of endothelial cell to cell junctions: differential association of plakoglobin, beta-catenin, and alpha-catenin with vascular endothelial cadherin (VE-cadherin). Journal of Cell Biology 129, 203-217. Landolt, R. M., Vaughan, L., Winterhalter, K. H., and Zimmermann, D. R. (1995). Versican is selectively expressed in embryonic tissues that act as barriers to neural crest cell migration and axon outgrowth. Development 121, 2303-2312. Langenbacher, A. D., Dong, Y., Shu, X., Choi, J., Nicoll, D. A., Goldhaber, J. I., Philipson, K. D., and Chen, J. N. (2005). Mutation in sodium-calcium exchanger 1 (NCX1) causes cardiac fibrillation in zebrafish. Proceedings of the National Academy of Sciences of the United States of America 102, 17699-17704. Larson, J. D., Wadman, S. A., Chen, E., Kerley, L., Clark, K. J., Eide, M., Lippert, S., Nasevicius, A., Ekker, S. C., Hackett, P. B., and Essner, J. J. (2004). Expression of VE-cadherin in zebrafish embryos: a new tool to evaluate vascular development. Developmental Dynamics 231, 204-213. Lee, H. C., Chen, J. N., Liao, P. Y., Tsai, W. Y., Lin, K. Y., Chuang, C. C., Sun, C. K., Chang, W. C., and Tsai, H. J. (2007). Glycogen synthase kinase 3α and 3β have distinct functions during cardiogenesis of zebrafish embryo. BMC Developmental Biology 7, 93. Li, X., Shu, R., Filippatos, G., and Uhal, B. D. (2004). Apoptosis in lung injury and remodeling. Journal of Applied Physiology 97, 1535-1542. Link, V., Shevchenko, A., and Heisenberg, C. P. (2006). Proteomics of early zebrafish embryos. BMC Developmental Biology 6, 1. Liu, X., Huang, S., Ma, J., Li, C., Zhang, Y., and Luo, L. (2009). NF-κB and Snail1a coordinate the cell cycle with gastrulation. The Journal of Cell Biology 184, 805-815. Lopes, S. S., Yang, X., Müller, J., Carney, T. J., McAdow, A. R., Rauch, G. J., Jacoby, A. S., Hurst, L. D., Delfino-Machín, M., Haffter, P., Geisler, R., Johnson, S. L., Ward, A., and Kelsh, R. N. (2008). Leukocyte tyrosine kinase functions in pigment cell development. PLoS Genetics 4, e1000026. Ma, L., Lu, M. F., Schwartz, R. J., and Martin, J. F. (2005). Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning. Development 132, 5601-5611. Manzanares, M., Blanco, M. J., and Nieto, M. Á. (2004). Snail3 orthologues in vertebrates: divergent members of the Snail zinc-finger gene family. Development Genes and Evolution 214, 47-53. Marchlinski, F. E., Gansler, T. E. D. S., Waxman, H. L., and Josephson, M. E. (1982). Amiodarone pulmonary toxicity. Annals of Internal Medicine 97, 839-845. Martino, E., Bartalena, L., Bogazzi, F., and Braverman, L. E. (2001). The effects of amiodarone on the thyroid. Endocrine Reviews 22, 240-254. Mason, J. W. (1987). Amiodarone. The New England Journal of Medicine 316, 455-466. Mitchell, I. C., Brown, T. S., Terada, L. S., Amatruda, J. F., and Nwariaku, F. E. (2010). Effect of vascular cadherin knockdown on zebrafish vasculature during development. PloS One 5, e8807. Miyoshi, A., Kitajima, Y., Kido, S., Shimonishi, T., Matsuyama, S., Kitahara, K., and Miyazaki, K. (2005). Snail accelerates cancer invasion by upregulating MMP expression and is associated with poor prognosis of hepatocellular carcinoma. British Journal of Cancer 92, 252-258. Miyoshi, A., Kitajima, Y., Sumi, K., Sato, K., Hagiwara, A., Koga, Y., and Miyazaki, K. (2004). Snail and SIP1 increase cancer invasion by upregulating MMP family in hepatocellular carcinoma cells. British Journal of Cancer 90, 1265-1273. Mjaatvedt, C. H., Yamamura, H., Capehart, A. A., Turner, D., and Markwald, R. R. (1998). The cspg2 gene, disrupted in the hdf mutant, is required for right cardiac chamber and endocardial cushion formation. Developmental Biology 202, 56-66. Moody, S. E., Perez, D., Pan, T., Sarkisian, C. J., Portocarrero, C. P., Sterner, C. J., Notorfrancesco, K. L., Cardiff, R. D., and Chodosh, L. A. (2005). The transcriptional repressor Snail promotes mammary tumor recurrence. Cancer Cell 8, 197–209. Moreno-Bueno, G., Cubillo, E., Sarrio, D., Peinado, H., Rodriguez-Pinilla, S. M., Villa, S., Bolos, V., Jorda, M., Fabra, A., Portillo, F., Palacios, J., and Cano, A. (2006). Genetic profiling of epithelial cells expressing E-cadherin repressors reveals a distinct role for Snail, Slug, and E47 factors in epithelial-mesenchymal transition. Cancer Research 66, 9543-9556. Morton, S. U., Scherz, P. J., Cordes, K. R., Ivey, K. N., Stainier, D. Y. R., and Srivastava, D. (2008). microRNA-138 modulates cardiac patterning during embryonic development. Proceedings of the National Academy of Sciences 105, 17830-17835. Murray, S. A., and Gridley, T. (2006). Snail family genes are required for left-right asymmetry determination, but not neural crest formation, in mice. Proceedings of the National Academy of Sciences 103, 10300-10304. Nakayama, H., Scott, I. C., and Cross, J. C. (1998). The transition to endoreduplication in trophoblast giant cells is regulated by the mSNA zinc finger transcription factor. Developmental Biology 199, 150-163. Nguyen, C. T., Langenbacher, A., Hsieh, M., and Chen, J. N. (2010). The Paf1 complex component Leo1 is essential for cardiac and neural crest development in zebrafish. Developmental Biology 341, 167-175. Nguyen, C. T., Lu, Q., Wang, Y., and Chen, J. N. (2008). Zebrafish as a model for cardiovascular development and disease. Drug Discovery Today: Disease Models 5, 135-140. Nieto, M. Á. (2002). The snail superfamily of zinc-finger transcription factors. Nature Reviews Molecular Cell Biology 3, 155-166. Nieto, M. Á., Sargent, M. G., Wilkinson, D. G., and Cooke, J. (1994). Control of cell behavior during vertebrate development by Slug, a zinc finger gene. Science 264, 835-839. Peal, D. S., Burns, C. G., Macrae, C. A., and Milan, D. (2009). Chondroitin sulfate expression is required for cardiac atrioventricular canal formation. Developmental Dynamics 238, 3103-3110. Peinado, H., Ballestar, E., Esteller, M., and Cano, A. (2004). Snail mediates E-cadherin repression by the recruitment of the Sin3A/histone deacetylase 1 (HDAC1)/HDAC2 complex. Molecular and Cellular Biology 24, 306-319. Pérez-Moreno, M. A., Locascio, A., Rodrigo, I., Dhondt, G., Portillo, F., Nieto, M. Á., and Cano, A. (2001). A new role for E12/E47 in the repression of E-cadherin expression and epithelial-mesenchymal transitions. Journal of Biological Chemistry 276, 27424-27431. Plomp, T. A., Vulsma, T., and de Vijlder, J. J. M. (1992). Use of amiodarone during pregnancy. European Journal of Obstetrics, Gynecology, and Reproductive Biology 43, 201-207. Qu, X., Jia, H., Garrity, D. M., Tompkins, K., Batts, L., Appel, B., Zhong, T. P., and Baldwin, H. S. (2008). Ndrg4 is required for normal myocyte proliferation during early cardiac development in zebrafish. Developmental Biology 317, 486-496. Reischauer, S., Levesque, M. P., Nüsslein-Volhard, C., and Sonawane, M. (2009). Lgl2 executes its function as a tumor suppressor by regulating ErbB signaling in the zebrafish epidermis. PLoS Genetics 5, e1000720. Roden, D. M. (2000). Antiarrhythmic drugs: from mechanisms to clinical practice. Heart 84, 339-346. Romano, L. A., and Runyan, R. B. (2000). Slug is an essential target of TGFβ2 signaling in the developing chicken heart. Developmental Biology 223, 91-102. Rottbauer, W., Wessels, G., Dahme, T., Just, S., Trano, N., Hassel, D., Burns, C. G., Katus, H. A., and Fishman, M. C. (2006). Cardiac myosin light chain-2: a novel essential component of thick-myofilament assembly and contractility of the heart. Circulation Research 99, 323-331. Ruggeri, A., Orsini, G., Mazzoni, A., Nato, F., Papa, V., Piccirilli, M., Putignano, A., Mazzotti, G., de Stefano Dorigo, E., and Breschi, L. (2009). Immunohistochemical and biochemical assay of versican in human sound predentine/dentine matrix. European Journal of Histochemistry 53, 125-134. Russell, D. L., Doyle, K. M. H., Holley, S. A., Sandy, J. D., and Richards, J. A. S. (2003). Processing and localization of ADAMTS-1 and proteolytic cleavage of versican during cumulus matrix expansion and ovulation. Journal of Biological Chemistry 278, 42330-42339. Scherz, P. J., Huisken, J., Sahai-Hernandez, P., and Stainier, D. Y. R. (2008). High-speed imaging of developing heart valves reveals interplay of morphogenesis and function. Development 135, 1179-1187. Sefton, M., Sanchez, S., and Nieto, M. Á. (1998). Conserved and divergent roles for members of the Snail family of transcription factors in the chick and mouse embryo. Development 125, 3111-3121. Sehnert, A. J., Huq, A., Weinstein, B. M., Walker, C., Fishman, M., and Stainier, D. Y. R. (2002). Cardiac troponin T is essential in sarcomere assembly and cardiac contractility. Nature Genetics 31, 106-110. Shahrara, S., Drvota, V., and Sylven, C. (1999). Organ specific expression of thyroid hormone receptor mRNA and protein in different human tissues. Biological and Pharmaceutical Bulletin 22, 1027-1033. Sheng, W., Wang, G., La Pierre, D. P., Wen, J., Deng, Z., Wong, C. K. A., Lee, D. Y., and Yang, B. B. (2006). Versican mediates mesenchymal-epithelial transition. Molecular Biology of the Cell 17, 2009-2020. Shinomura, T., Zako, M., Ito, K., Ujita, M., and Kimata, K. (1995). The gene structure and organization of mouse PG-M, a large chondroitin sulfate proteoglycan. Journal of Biological Chemistry 270, 10328-10333. Shu, X., Cheng, K., Patel, N., Chen, F., Joseph, E., Tsai, H. J., and Chen, J. N. (2003). Na, K-ATPase is essential for embryonic heart development in the zebrafish. Development 130, 6165-6173. Soma, T., Tajima, M., and Kishimoto, J. (2005). Hair cycle-specific expression of versican in human hair follicles. Journal of Dermatological Science 39, 147-154. Sone, S., Nakamura, M., Maruya, Y., Takahashi, I., Mizoguchi, I., Mayanagi, H., and Sasano, Y. (2005). Expression of versican and ADAMTS during rat tooth eruption. Journal of Molecular Histology 36, 281-288. Speirs, C. K., Jernigan, K. K., Kim, S. H., Cha, Y. I., Lin, F., Sepich, D. S., DuBois, R. N., Lee, E., and Solnica-Krezel, L. (2010). Prostaglandin Gβγ signaling stimulates gastrulation movements by limiting cell adhesion through Snai1a stabilization. Development 137, 1327-1337. Stainier, D. Y. R. (2001). Zebrafish genetics and vertebrate heart formation. Nature Reviews Genetics 2, 39-48. Stankunas, K., Hang, C. T., Tsun, Z. Y., Chen, H., Lee, N. V., Wu, J. I., Shang, C., Bayle, J. H., Shou, W., Iruela-Arispe, M. L., and Chang, C. P. (2008). Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment for myocardial morphogenesis. Developmental Cell 14, 298-311. Thiery, J. P., and Sleeman, J. P. (2006). Complex networks orchestrate epithelial-mesenchymal transitions. Nature Reviews Molecular Cell Biology 7, 131-142. Thisse, C., and Thisse, B. (1999). Antivin, a novel and divergent member of the TGFβ superfamily, negatively regulates mesoderm induction. Development 126, 229-240. Thisse, C., and Thisse, B. (2007). High-resolution in situ hybridization to whole-mount zebrafish embryos. Nature Protocols 3, 59-69. Thisse, C., Thisse, B., Halpern, M. E., and Postlethwait, J. H. (1994). Goosecoid expression in neurectoderm and mesendoderm is disrupted in zebrafish cyclops gastrulas. Developmental Biology 164, 420-429. Thisse, C., Thisse, B., and Postlethwait, J. H. (1995). Expression of snail2, a second member of the zebrafish snail family, in cephalic mesendoderm and presumptive neural crest of wild-type and spadetail mutant embryos. Developmental Biology 172, 86-99. Thisse, C., Thisse, B., Schilling, T. F., and Postlethwait, J. H. (1993). Structure of the zebrafish snail1 gene and its expression in wild-type, spadetail and no tail mutant embryos. Development 119, 1203-1215. Timmerman, L. A., Grego-Bessa, J., Raya, A., Bertrán, E., Pérez-Pomares, J. M., Díez, J., Aranda, S., Palomo, S., McCormick, F., Izpisúa-Belmonte, J. C., and de la Pompa, J. L. (2004). Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation. Genes & Development 18, 99-115. Tu, C. T., Yang, T. C., and Tsai, H. J. (2009). Nkx2. 7 and Nkx2. 5 Function Redundantly and Are Required for Cardiac Morphogenesis of Zebrafish Embryos. PLoS One 4, e4249. Valensise, H., Civitella, C., Garzetti, G. G., and Romanini, C. (1992). Amiodarone treatment in pregnancy for dilatative cardiomyopathy with ventricular malignant extrasystole and normal maternal and neonatal outcome. Prenatal Diagnosis 12, 705-708. Vaughan Williams, E. M. (1970). Classification of antiarrhythmic drugs. In Symposium on Cardiac Arrhythmias pp. 449-472. Walsh, E. C., and Stainier, D. Y. R. (2001). UDP-glucose dehydrogenase required for cardiac valve formation in zebrafish. Science 293, 1670-1673. Wight, T. N., Heinegard, D. K., and Hascall, V. C. (1991). Proteoglycans: structure and function. Cell Biology of Extracellular Matrix 45-78. Wu, Y., Chen, L., Zheng, P. S., and Yang, B. B. (2002). β1-Integrin-mediated glioma cell adhesion and free radical-induced apoptosis are regulated by binding to a C-terminal domain of PG-M/versican. Journal of Biological Chemistry 277, 12294-12301. Wyatt, L., Wadham, C., Crocker, L. A., Lardelli, M., and Khew-Goodall, Y. (2007). The protein tyrosine phosphatase Pez regulates TGFβ, epithelial mesenchymal transition, and organ development. Journal of Cell Biology 178, 1223-1235. Zhang, Y., Cao, L., Yang, B. L., and Yang, B. B. (1998). The G3 domain of versican enhances cell proliferation via epidermial growth factor-like motifs. Journal of Biological Chemistry 273, 21342-21351. Zheng, P. S., Vais, D., LaPierre, D., Liang, Y. Y., Lee, V., Yang, B. L., and Yang, B. B. (2004). PG-M/versican binds to P-selectin glycoprotein ligand-1 and mediates leukocyte aggregation. Journal of Cell Science 117, 5887-5895. Zheng, P. S., Wen, J., Ang, L. C., Sheng, W., Viloria-Petit, A., Wang, Y., Wu, Y., Kerbel, R. S., and Yang, B. B. (2004). Versican/PG-M G3 domain promotes tumor growth and angiogenesis. Journal of the Federation of American Societies for Experimental Biology 18, 754-756. Zimmermann, D. R., and Ruoslahti, E. (1989). Multiple domains of the large fibroblast proteoglycan, versican. The EMBO Journal 8, 2975-2981. 陳大淵(2008)。抗心律不整藥物Amiodarone藉由抑制表皮間質轉換而干擾斑馬魚胚胎心臟瓣膜發育。台灣大學分子與細胞生物學研究所碩士論文。 黃昱愷(2007)。抗心律不整藥物Amiodarone影響斑馬魚胚胎心臟瓣膜的發育。台灣大學分子與細胞生物學研究所碩士論文。 | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/22501 | - |
dc.description.abstract | 斑馬魚胚胎透明,易於觀察胚胎發育時組織或器官形成,胚胎也易於浸泡藥物,本實驗以斑馬魚研究Amiodarone(第三型抗心律不整藥物)對心臟發育影響。以15 μM Amiodarone從10 hours postfertilization (hpf)浸泡斑馬魚胚胎至72 hpf觀察,可見心臟血液逆流,心臟瓣膜無法發育,並以whole mount in situ hybridization發現在wild-type中,只於atrioventricular canal (AV canal) myocardium表現之similar to versican b (s-vcanb),經浸泡Amiodarone後會異位性地在myocardium過量表現。針對瓣膜發育時期,分段進行浸泡Amiodarone,發現Amiodarone主要影響55至72 hpf之瓣膜發育,此時期為endocardial cells進行endothelial-to-mesenchymal transition,或稱invagination。偵測invagination時,endocardium需下降VE-cadherin (cdh5)基因的表現,但是浸泡Amiodarone後cdh5於AV canal endocardium卻會過量表現。進一步實驗地發現,浸泡Amiodarone的胚胎,可由注射cdh5 morpholino oligonucleotide (MO)挽救瓣膜缺失的缺陷,顯示Amiodarone藉由過量表現cdh5抑制invagination。另一方面,Snail family 的snai1b為cdh5可能之repressor,我們也發現浸泡Amiodarone後,snai1b於AV canal endocardium會消退,而且浸泡Amiodarone的胚胎,也可由過量表現snai1b致使cdh5表現下降,而挽救瓣膜的缺失。同樣地,若注射s-vcanb-MO,並浸泡Amiodarone之胚胎,cdh5表現量也會下降,瓣膜因而生成;相反地,過量表現s-vcanb的胚胎,其cdh5會over-expression,造成瓣膜缺失,顯示cardiac jelly有訊息傳遞至endocardium。進一步地,若注射snai1b-MO,則發現s-vcanb與cdh5異位過量表現,且同時注射snai1b-MO與s-vcanb-MO後,cdh5會過量異位表現,證明了s-vcanb在snai1b上游,並顯示snai1b除了扮演cdh5 repressor外,亦可使s-vcanb被回饋抑制。綜合以上得知,我們發現了一條斑馬魚心臟瓣膜發育pathway,即AV canal myocardium表現s-vcanb,造成分泌至AV canal之cardiac jelly處的s-vcanb增多,而s-vcanb進而限制AV canal endocardium表現snai1b,snai1b再調控AV canal endocardium的cdh5基因,使Cdh5蛋白質減少,並負回饋限制s-vcanb表現,最後使瓣膜順利進行invagination;而Amiodarone則藉由myocardium異位性地表現s-vcanb,使snai1b變少,進而阻斷invagination,導致瓣膜缺失。 | zh_TW |
dc.description.abstract | Due to the transparent zebrafish embryo makes the dynamic observation possible, and also makes the facilitation to study the influence of drug by soaking. We study the effect of Amiodarone, a type III anti-arrhythmia drug, on heart development. After treating embryos with 15 μM Amiodarone from 10 to 72 hours post-fertilization (hpf), a blood regurgitation between ventricle and atrium was observation owing to the defect of valves. Using whole-mount in situ hybridization, we found similar to versican b (s-vcanb), a specific gene at the myocardium of atrioventricular canal (AV canal), where the valves develop at, was ectopically over-expressed in myocardium at the Amiodarone-treated embryos. Furthermore, we treated Amiodarone on zebrafish embryos at different developmental stage, and we found Amiodarone affected the endocardial cells progressing during invagination from 55 to 72 hpf. The transcript of VE-cadherin (cdh5), which is down-regulated at endocardium through invagination, was also over-expressed at the AV canal endothelium in Amiodarone-treated embryos. In addition, knockdown of cdh5 by injecting cdh5-specific morpholino oligonucleotide (MO) can rescue the defective valves induced by Amiodarone, indicating Amiodarone may inhibit invagination by over-expressing cdh5. Besides, the transcript of snai1b, one of Snail family, was decreased at the AV canal endocardium of Amiodarone-treated embryos. But the down-regulation of cdh5 and the rescue of valves defects were observed in Amiodarone-treated embryos by over-expression of snai1b, so were by injection of s-vcanb-MO in Amiodarone-treated embryos. On contrast, the up-regulation of cdh5 and the lack of valves in wild-type embryos by over-expression of s-vcanb. Moreover, we observed that both s-vcanb and cdh5 were over-expressed after microinjection with snai1b-MO; whereas cdh5 was over-expressed after microinjection with snai1b-MO accompanied by s-vcanb-MO, suggesting snai1b functions as a repressor of cdh5 and a feedback inhibition of s-vcanb, which is an upstream modulator of snai1b. Taken together, we found a novel pathway involved in zebrafish cardiac valves formation, in which the AV canal myocardium expresses s-vcanb and secrets s-vcanb gene in cardiac jelly to regulate snai1b expressing at AV canal endocardium. After cdh5 is down-regulated by snai1b, the invagination to generate valves is processed. Therefore, we concluded that Amiodarone may inhibit the development of valves by ectopically expressing s-vcanb at the whole myocardium, promoting the down-regulating of snai1b, and causing over-expressing of s-vcanb by failing to feedback inhibition of snai1b, which in turn, the invagination is block to form cardiac valves. | en |
dc.description.provenance | Made available in DSpace on 2021-06-08T04:19:18Z (GMT). No. of bitstreams: 1 ntu-99-R97b43017-1.pdf: 14000033 bytes, checksum: 468f8aecbd0631da44a4258903a06784 (MD5) Previous issue date: 2010 | en |
dc.description.tableofcontents | 中文摘要----- 1
英文摘要----- 2 文獻回顧----- 4 前言-------10 實驗材料與方法--12 結果-------22 討論-------31 總結-------38 參考文獻-----39 圖表-------55 附錄-------71 | |
dc.language.iso | zh-TW | |
dc.title | 抗心律不整藥物Amiodarone抑制斑馬魚胚胎心臟瓣膜發育之分子機制 | zh_TW |
dc.title | The Molecular Mechanism of Amiodarone, an Anti-arrhythmia Drug, to Inhibit the Cardiac Valves Formation during the Embryogenesis of Zebrafish | en |
dc.type | Thesis | |
dc.date.schoolyear | 98-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 吳建春,陳曜鴻,顏裕庭 | |
dc.subject.keyword | Amiodarone,心臟瓣膜,斑馬魚,s-vcanb,snai1b,cdh5, | zh_TW |
dc.subject.keyword | Amiodarone,cardiac valves,zebrafish,s-vcanb,snai1b,cdh5, | en |
dc.relation.page | 79 | |
dc.rights.note | 未授權 | |
dc.date.accepted | 2010-07-22 | |
dc.contributor.author-college | 生命科學院 | zh_TW |
dc.contributor.author-dept | 分子與細胞生物學研究所 | zh_TW |
顯示於系所單位: | 分子與細胞生物學研究所 |
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