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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 闕玲玲 | |
dc.contributor.author | Da-Jie Tang | en |
dc.contributor.author | 唐大傑 | zh_TW |
dc.date.accessioned | 2021-06-08T04:17:15Z | - |
dc.date.copyright | 2010-08-05 | |
dc.date.issued | 2010 | |
dc.date.submitted | 2010-07-29 | |
dc.identifier.citation | Addie, D.D., 2004, Feline coronavirus--that enigmatic little critter. Vet J 167, 5-6.
Addie, D.D., Jarrett, J.O., 1992a, Feline coronavirus antibodies in cats. Vet Rec 131, 202-203. Addie, D.D., Jarrett, O., 1992b, A study of naturally occurring feline coronavirus infections in kittens. Vet Rec 130, 133-137. Addie, D.D., Jarrett, O., 2001, Use of a reverse-transcriptase polymerase chain reaction for monitoring the shedding of feline coronavirus by healthy cats. Vet Rec 148, 649-653. Addie, D.D., Schaap, I.A., Nicolson, L., Jarrett, O., 2003, Persistence and transmission of natural type I feline coronavirus infection. J Gen Virol 84, 2735-2744. Addie, D.D., Toth, S., Murray, G.D., Jarrett, O., 1995, Risk of feline infectious peritonitis in cats naturally infected with feline coronavirus. Am J Vet Res 56, 429-434. Bell, E.T., Toribio, J.A., White, J.D., Malik, R., Norris, J.M., 2006, Seroprevalence study of feline coronavirus in owned and feral cats in Sydney, Australia. Aust Vet J 84, 74-81. Brian, D.A., Baric, R.S., 2005, Coronavirus genome structure and replication. Curr Top Microbiol Immunol 287, 1-30. Brown, M.A., Troyer, J.L., Pecon-Slattery, J., Roelke, M.E., O'Brien, S.J., 2009, Genetics and pathogenesis of feline infectious peritonitis virus. Emerg Infect Dis 15, 1445-1452. Can-Sahna, K., Soydal Ataseven, V., Pinar, D., Oguzoglu, T.C., 2007, The detection of feline coronaviruses in blood samples from cats by mRNA RT-PCR. J Feline Med Surg 9, 369-372. Chang, H.W., de Groot, R.J., Egberink, H.F., Rottier, P.J., 2010, Feline infectious peritonitis: insights into feline coronavirus pathobiogenesis and epidemiology based on genetic analysis of the viral 3c gene. J Gen Virol 91, 415-420. Chesney, M.A., Ickovics, J., Hecht, F.M., Sikipa, G., Rabkin, J., 1999, Adherence: a necessity for successful HIV combination therapy. AIDS 13 Suppl A, S271-278. Chesney, M.A., Morin, M., Sherr, L., 2000, Adherence to HIV combination therapy. Soc Sci Med 50, 1599-1605. Chomczynski, P., Sacchi, N., 1987, Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162, 156-159. Cornelissen, E., Dewerchin, H.L., Van Hamme, E., Nauwynck, H.J., 2007, Absence of surface expression of feline infectious peritonitis virus (FIPV) antigens on infected cells isolated from cats with FIP. Vet Microbiol 121, 131-137. Cotter, S.M., Gilmore, C.E., Rollins, C., 1973, Multiple cases of feline leukemia and feline infectious peritonitis in a household. J Am Vet Med Assoc 162, 1054-1058. De Groot, R.J., Andeweg, A.C., Horzinek, M.C., Spaan, W.J., 1988, Sequence analysis of the 3'-end of the feline coronavirus FIPV 79-1146 genome: comparison with the genome of porcine coronavirus TGEV reveals large insertions. Virology 167, 370-376. Dewerchin, H.L., Cornelissen, E., Nauwynck, H.J., 2005, Replication of feline coronaviruses in peripheral blood monocytes. Arch Virol 150, 2483-2500. Dong, B.Q., Liu, W., Fan, X.H., Vijaykrishna, D., Tang, X.C., Gao, F., Li, L.F., Li, G.J., Zhang, J.X., Yang, L.Q., Poon, L.L., Zhang, S.Y., Peiris, J.S., Smith, G.J., Chen, H., Guan, Y., 2007, Detection of a novel and highly divergent coronavirus from asian leopard cats and Chinese ferret badgers in Southern China. J Virol 81, 6920-6926. Dye, C., Siddell, S.G., 2005, Genomic RNA sequence of Feline coronavirus strain FIPV WSU-79/1146. J Gen Virol 86, 2249-2253. Dye, C., Siddell, S.G., 2007, Genomic RNA sequence of feline coronavirus strain FCoV C1Je. J Feline Med Surg 9, 202-213. Dye, C., Temperton, N., Siddell, S.G., 2007, Type I feline coronavirus spike glycoprotein fails to recognize aminopeptidase N as a functional receptor on feline cell lines. J Gen Virol 88, 1753-1760. Evermann, J.F., Heeney, J.L., McKeirnan, A.J., O'Brien, S.J., 1989, Comparative features of a coronavirus isolated from a cheetah with feline infectious peritonitis. Virus Res 13, 15-27. Flexner, C., 1998, HIV-protease inhibitors. N Engl J Med 338, 1281-1292. Foley, J.E., Lapointe, J.M., Koblik, P., Poland, A., Pedersen, N.C., 1998, Diagnostic features of clinical neurologic feline infectious peritonitis. J Vet Intern Med 12, 415-423. Foley, J.E., Poland, A., Carlson, J., Pedersen, N.C., 1997, Risk factors for feline infectious peritonitis among cats in multiple-cat environments with endemic feline enteric coronavirus. J Am Vet Med Assoc 210, 1313-1318. Haagmans, B.L., Egberink, H.F., Horzinek, M.C., 1996, Apoptosis and T-cell depletion during feline infectious peritonitis. J Virol 70, 8977-8983. Haijema, B.J., Volders, H., Rottier, P.J., 2003, Switching species tropism: an effective way to manipulate the feline coronavirus genome. J Virol 77, 4528-4538. Haijema, B.J., Volders, H., Rottier, P.J., 2004, Live, attenuated coronavirus vaccines through the directed deletion of group-specific genes provide protection against feline infectious peritonitis. J Virol 78, 3863-3871. Hartmann, K., 2005, Feline infectious peritonitis. Vet Clin North Am Small Anim Pract 35, 39-79, vi. Hartmann, K., Binder, C., Hirschberger, J., Cole, D., Reinacher, M., Schroo, S., Frost, J., Egberink, H., Lutz, H., Hermanns, W., 2003, Comparison of different tests to diagnose feline infectious peritonitis. J Vet Intern Med 17, 781-790. Herrewegh, A.A., de Groot, R.J., Cepica, A., Egberink, H.F., Horzinek, M.C., Rottier, P.J., 1995a, Detection of feline coronavirus RNA in feces, tissues, and body fluids of naturally infected cats by reverse transcriptase PCR. J Clin Microbiol 33, 684-689. Herrewegh, A.A., Mahler, M., Hedrich, H.J., Haagmans, B.L., Egberink, H.F., Horzinek, M.C., Rottier, P.J., de Groot, R.J., 1997, Persistence and evolution of feline coronavirus in a closed cat-breeding colony. Virology 234, 349-363. Herrewegh, A.A., Smeenk, I., Horzinek, M.C., Rottier, P.J., de Groot, R.J., 1998, Feline coronavirus type II strains 79-1683 and 79-1146 originate from a double recombination between feline coronavirus type I and canine coronavirus. J Virol 72, 4508-4514. Herrewegh, A.A., Vennema, H., Horzinek, M.C., Rottier, P.J., de Groot, R.J., 1995b, The molecular genetics of feline coronaviruses: comparative sequence analysis of the ORF7a/7b transcription unit of different biotypes. Virology 212, 622-631. Hirschberger, J., Hartmann, K., Wilhelm, N., Frost, J., Lutz, H., Kraft, W., 1995, [Clinical symptoms and diagnosis of feline infectious peritonitis]. Tierarztl Prax 23, 92-99. Hohdatsu, T., Izumiya, Y., Yokoyama, Y., Kida, K., Koyama, H., 1998, Differences in virus receptor for type I and type II feline infectious peritonitis virus. Arch Virol 143, 839-850. Hohdatsu, T., Nakamura, M., Ishizuka, Y., Yamada, H., Koyama, H., 1991, A study on the mechanism of antibody-dependent enhancement of feline infectious peritonitis virus infection in feline macrophages by monoclonal antibodies. Arch Virol 120, 207-217. Hohdatsu, T., Okada, S., Ishizuka, Y., Yamada, H., Koyama, H., 1992, The prevalence of types I and II feline coronavirus infections in cats. J Vet Med Sci 54, 557-562. Holzworth, J., 1963, Some important disorder of cats. Cornell Vet, 157-160. Horsburgh, B.C., Brierley, I., Brown, T.D., 1992, Analysis of a 9.6 kb sequence from the 3' end of canine coronavirus genomic RNA. J Gen Virol 73 ( Pt 11), 2849-2862. Horzinek, M.C., Lutz, H., Pedersen, N.C., 1982, Antigenic relationships among homologous structural polypeptides of porcine, feline, and canine coronaviruses. Infect Immun 37, 1148-1155. Horzinek, M.C., Osterhaus, A.D., 1979, Feline infectious peritonitis: a worldwide serosurvey. Am J Vet Res 40, 1487-1492. Ishida, T., Shibanai, A., Tanaka, S., Uchida, K., Mochizuki, M., 2004, Use of recombinant feline interferon and glucocorticoid in the treatment of feline infectious peritonitis. J Feline Med Surg 6, 107-109. Jackwood, M.W., 2006, The relationship of severe acute respiratory syndrome coronavirus with avian and other coronaviruses. Avian Dis 50, 315-320. Jakob, H., 1914, Therapeutsiche, kasuisitische und statistische Mitteolungen aus der klinik fu'r kleine Haustiere an der Reichstierarzneischule in Utrecht (Holland), Jahrgang 1912/13. Z Tiered microbiol Immuno 18, 193. Kaldor, S.W., Kalish, V.J., Davies, J.F., 2nd, Shetty, B.V., Fritz, J.E., Appelt, K., Burgess, J.A., Campanale, K.M., Chirgadze, N.Y., Clawson, D.K., Dressman, B.A., Hatch, S.D., Khalil, D.A., Kosa, M.B., Lubbehusen, P.P., Muesing, M.A., Patick, A.K., Reich, S.H., Su, K.S., Tatlock, J.H., 1997, Viracept (nelfinavir mesylate, AG1343): a potent, orally bioavailable inhibitor of HIV-1 protease. J Med Chem 40, 3979-3985. Kennedy, M., Boedeker, N., Gibbs, P., Kania, S., 2001, Deletions in the 7a ORF of feline coronavirus associated with an epidemic of feline infectious peritonitis. Vet Microbiol 81, 227-234. Keyaerts, E., Vijgen, L., Pannecouque, C., Van Damme, E., Peumans, W., Egberink, H., Balzarini, J., Van Ranst, M., 2007, Plant lectins are potent inhibitors of coronaviruses by interfering with two targets in the viral replication cycle. Antiviral Res 75, 179-187. Kipar, A., Bellmann, S., Gunn-Moore, D.A., Leukert, W., Kohler, K., Menger, S., Reinacher, M., 1999, Histopathological alterations of lymphatic tissues in cats without feline infectious peritonitis after long-term exposure to FIP virus. Vet Microbiol 69, 131-137. Kipar, A., Kohler, K., Leukert, W., Reinacher, M., 2001, A comparison of lymphatic tissues from cats with spontaneous feline infectious peritonitis (FIP), cats with FIP virus infection but no FIP, and cats with no infection. J Comp Pathol 125, 182-191. Kipar, A., May, H., Menger, S., Weber, M., Leukert, W., Reinacher, M., 2005, Morphologic features and development of granulomatous vasculitis in feline infectious peritonitis. Vet Pathol 42, 321-330. Kiss, I., Kecskemeti, S., Tanyi, J., Klingeborn, B., Belak, S., 2000, Prevalence and genetic pattern of feline coronaviruses in urban cat populations. Vet J 159, 64-70. Kummrow, M., Meli, M.L., Haessig, M., Goenczi, E., Poland, A., Pedersen, N.C., Hofmann-Lehmann, R., Lutz, H., 2005, Feline coronavirus serotypes 1 and 2: seroprevalence and association with disease in Switzerland. Clin Diagn Lab Immunol 12, 1209-1215. Lai, M.M., 1997, RNA-protein interactions in the regulation of coronavirus RNA replication and transcription. Biol Chem 378, 477-481. Lai, M.M., Cavanagh, D., 1997, The molecular biology of coronaviruses. Adv Virus Res 48, 1-100. Lai, M.M., Perlman, S., Anderson, LJ, 2007, Coronaviridae, In: Knipe, D.M., Howley, P.M., Griffin, D.E., Lamb R.A., Martin, M.A., Roizman, B., Straus, S.E.E. (Eds.) Filed Virology . Lippincott Williams and Wilkins, Philadelphia, PA, pp. 1305-1335. Lin, C.N., Su, B.L., Huang, H.P., Lee, J.J., Hsieh, M.W., Chueh, L.L., 2009a, Field strain feline coronaviruses with small deletions in ORF7b associated with both enteric infection and feline infectious peritonitis. J Feline Med Surg 11, 413-419. Lin, C.N., Su, B.L., Wang, C.H., Hsieh, M.W., Chueh, T.J., Chueh, L.L., 2009b, Genetic diversity and correlation with feline infectious peritonitis of feline coronavirus type I and II: a 5-year study in Taiwan. Vet Microbiol 136, 233-239. Lin, C.N., Su, B.L., Wu, C.W., Hsieh, L.E., Chueh, L.L., 2009c, Isolation and Identification of a Novel Feline Coronavirus from a Kitten with Naturally Occurring Feline Infectious Peritonitis in Taiwan. 臺灣獸醫學雜誌 35, 145-152. McHutchison, J.G., Poynard, T., 1999, Combination therapy with interferon plus ribavirin for the initial treatment of chronic hepatitis C. Semin Liver Dis 19 Suppl 1, 57-65. Mochizuki, M., Mitsutake, Y., Miyanohara, Y., Higashihara, T., Shimizu, T., Hohdatsu, T., 1997, Antigenic and plaque variations of serotype II feline infectious peritonitis coronaviruses. J Vet Med Sci 59, 253-258. Montali, R.J., Strandberg, J.D., 1972, Extraperitoneal lesions in feline infectious peritonitis. Vet Pathol 9, 109-121. Motokawa, K., Hohdatsu, T., Aizawa, C., Koyama, H., Hashimoto, H., 1995, Molecular cloning and sequence determination of the peplomer protein gene of feline infectious peritonitis virus type I. Arch Virol 140, 469-480. Motokawa, K., Hohdatsu, T., Hashimoto, H., Koyama, H., 1996, Comparison of the amino acid sequence and phylogenetic analysis of the peplomer, integral membrane and nucleocapsid proteins of feline, canine and porcine coronaviruses. Microbiol Immunol 40, 425-433. Olsen, C.W., Corapi, W.V., Ngichabe, C.K., Baines, J.D., Scott, F.W., 1992, Monoclonal antibodies to the spike protein of feline infectious peritonitis virus mediate antibody-dependent enhancement of infection of feline macrophages. J Virol 66, 956-965. Paltrinieri, S., Cammarata, M.P., Cammarata, G., Comazzi, S., 1998a, Some aspects of humoral and cellular immunity in naturally occuring feline infectious peritonitis. Vet Immunol Immunopathol 65, 205-220. Paltrinieri, S., Cammarata Parodi, M., Cammarata, G., Mambretti, M., 1998b, Type IV hypersensitivity in the pathogenesis of FIPV-induced lesions. Zentralbl Veterinarmed B 45, 151-159. Pedersen, N.C., 1976, Serologic studies of naturally occurring feline infectious peritonitis. Am J Vet Res 37, 1449-1453. Pedersen, N.C., 1987, Virologic and immunologic aspects of feline infectious peritonitis virus infection. Adv Exp Med Biol 218, 529-550. Pedersen, N.C., 2009, A review of feline infectious peritonitis virus infection: 1963-2008. J Feline Med Surg 11, 225-258. Pedersen, N.C., Allen, C.E., Lyons, L.A., 2008, Pathogenesis of feline enteric coronavirus infection. J Feline Med Surg 10, 529-541. Pedersen, N.C., Black, J.W., 1983, Attempted immunization of cats against feline infectious peritonitis, using avirulent live virus or sublethal amounts of virulent virus. Am J Vet Res 44, 229-234. Pedersen, N.C., Black, J.W., Boyle, J.F., Evermann, J.F., McKeirnan, A.J., Ott, R.L., 1984, Pathogenic differences between various feline coronavirus isolates. Adv Exp Med Biol 173, 365-380. Pedersen, N.C., Boyle, J.F., Floyd, K., Fudge, A., Barker, J., 1981, An enteric coronavirus infection of cats and its relationship to feline infectious peritonitis. Am J Vet Res 42, 368-377. Pedersen, N.C., Floyd, K., 1985, Experimental studies with three new strains of feline infectious peritonotos virus. Comp Cont Edu Pract Vet 7, 1001-1011. Pedersen, N.C., Ward, J., Mengeling, W.L., 1978, Antigenic relationship of the feline infections peritonitis virus to coronaviruses of other species. Arch Virol 58, 45-53. Poland, A.M., Vennema, H., Foley, J.E., Pedersen, N.C., 1996, Two related strains of feline infectious peritonitis virus isolated from immunocompromised cats infected with a feline enteric coronavirus. J Clin Microbiol 34, 3180-3184. Reynolds, D.J., Garwes, D.J., Gaskell, C.J., 1977, Detection of transmissible gastroenteritis virus neutralising antibody in cats. Arch Virol 55, 77-86. Rohrbach, B.W., Legendre, A.M., Baldwin, C.A., Lein, D.H., Reed, W.M., Wilson, R.B., 2001, Epidemiology of feline infectious peritonitis among cats examined at veterinary medical teaching hospitals. J Am Vet Med Assoc 218, 1111-1115. Rottier, P.J., Nakamura, K., Schellen, P., Volders, H., Haijema, B.J., 2005, Acquisition of macrophage tropism during the pathogenesis of feline infectious peritonitis is determined by mutations in the feline coronavirus spike protein. J Virol 79, 14122-14130. Sawicki, S.G., Sawicki, D.L., 2005, Coronavirus transcription: a perspective. Curr Top Microbiol Immunol 287, 31-55. Shiba, N., Maeda, K., Kato, H., Mochizuki, M., Iwata, H., 2007, Differentiation of feline coronavirus type I and II infections by virus neutralization test. Vet Microbiol 124, 348-352. Spaan, W., Cavanagh, D., Horzinek, M.C., 1988, Coronaviruses: structure and genome expression. J Gen Virol 69 ( Pt 12), 2939-2952. Sparkes, A.H., Gruffydd-Jones, T.J., Howard, P.E., Harbour, D.A., 1992, Coronavirus serology in healthy pedigree cats. Vet Rec 131, 35-36. Stoddart, M.E., Gaskell, R.M., Harbour, D.A., Gaskell, C.J., 1988, Virus shedding and immune responses in cats inoculated with cell culture-adapted feline infectious peritonitis virus. Vet Microbiol 16, 145-158. Takano, T., Azuma, N., Satoh, M., Toda, A., Hashida, Y., Satoh, R., Hohdatsu, T., 2009, Neutrophil survival factors (TNF-alpha, GM-CSF, and G-CSF) produced by macrophages in cats infected with feline infectious peritonitis virus contribute to the pathogenesis of granulomatous lesions. Arch Virol 154, 775-781. Takano, T., Hohdatsu, T., Hashida, Y., Kaneko, Y., Tanabe, M., Koyama, H., 2007a, A 'possible' involvement of TNF-alpha in apoptosis induction in peripheral blood lymphocytes of cats with feline infectious peritonitis. Vet Microbiol 119, 121-131. Takano, T., Hohdatsu, T., Toda, A., Tanabe, M., Koyama, H., 2007b, TNF-alpha, produced by feline infectious peritonitis virus (FIPV)-infected macrophages, upregulates expression of type II FIPV receptor feline aminopeptidase N in feline macrophages. Virology 364, 64-72. Timmann, D., Cizinauskas, S., Tomek, A., Doherr, M., Vandevelde, M., Jaggy, A., 2008, Retrospective analysis of seizures associated with feline infectious peritonitis in cats. J Feline Med Surg 10, 9-15. Tresnan, D.B., Levis, R., Holmes, K.V., 1996, Feline aminopeptidase N serves as a receptor for feline, canine, porcine, and human coronaviruses in serogroup I. J Virol 70, 8669-8674. van der Meer, F.J., de Haan, C.A., Schuurman, N.M., Haijema, B.J., Verheije, M.H., Bosch, B.J., Balzarini, J., Egberink, H.F., 2007, The carbohydrate-binding plant lectins and the non-peptidic antibiotic pradimicin A target the glycans of the coronavirus envelope glycoproteins. J Antimicrob Chemother 60, 741-749. Vennema, H., 1999, Genetic drift and genetic shift during feline coronavirus evolution. Vet Microbiol 69, 139-141. Vennema, H., Heijnen, L., Rottier, P.J., Horzinek, M.C., Spaan, W.J., 1992a, A novel glycoprotein of feline infectious peritonitis coronavirus contains a KDEL-like endoplasmic reticulum retention signal. J Virol 66, 4951-4956. Vennema, H., Heijnen, L., Zijderveld, A., Horzinek, M.C., Spaan, W.J., 1990a, Intracellular transport of recombinant coronavirus spike proteins: implications for virus assembly. J Virol 64, 339-346. Vennema, H., Poland, A., Foley, J., Pedersen, N.C., 1998, Feline infectious peritonitis viruses arise by mutation from endemic feline enteric coronaviruses. Virology 243, 150-157. Vennema, H., Rossen, J.W., Wesseling, J., Horzinek, M.C., Rottier, P.J., 1992b, Genomic organization and expression of the 3' end of the canine and feline enteric coronaviruses. Virology 191, 134-140. Vennema, H., Rossen, J.W., Wesseling, J., Horzinek, M.C., Rottier, P.J., 1993, Genomic organization and expression of the 3' end of the canine and feline enteric coronaviruses. Adv Exp Med Biol 342, 11-16. Vennema, H., Rottier, P.J., Heijnen, L., Godeke, G.J., Horzinek, M.C., Spaan, W.J., 1990b, Biosynthesis and function of the coronavirus spike protein. Adv Exp Med Biol 276, 9-19. Vijaykrishna, D., Smith, G.J., Zhang, J.X., Peiris, J.S., Chen, H., Guan, Y., 2007, Evolutionary insights into the ecology of coronaviruses. J Virol 81, 4012-4020. Walmsley, S., Bernstein, B., King, M., Arribas, J., Beall, G., Ruane, P., Johnson, M., Johnson, D., Lalonde, R., Japour, A., Brun, S., Sun, E., 2002, Lopinavir-ritonavir versus nelfinavir for the initial treatment of HIV infection. N Engl J Med 346, 2039-2046. Watt, N.J., MacIntyre, N.J., McOrist, S., 1993, An extended outbreak of infectious peritonitis in a closed colony of European wildcats (Felis silvestris). J Comp Pathol 108, 73-79. Wege, H., Siddell, S., ter Meulen, V., 1982, The biology and pathogenesis of coronaviruses. Curr Top Microbiol Immunol 99, 165-200. Weiss, R.C., Cox, N.R., Martinez, M.L., 1993, Evaluation of free or liposome-encapsulated ribavirin for antiviral therapy of experimentally induced feline infectious peritonitis. Res Vet Sci 55, 162-172. Weiss, R.C., Cox, N.R., Oostrom-Ram, T., 1990, Effect of interferon or Propionibacterium acnes on the course of experimentally induced feline infectious peritonitis in specific-pathogen-free and random-source cats. Am J Vet Res 51, 726-733. Weiss, R.C., Dodds, W.J., Scott, F.W., 1980, Disseminated intravascular coagulation in experimentally induced feline infectious peritonitis. Am J Vet Res 41, 663-671. Weiss, R.C., Oostrom-Ram, T., 1989, Inhibitory effects of ribavirin alone or combined with human alpha interferon on feline infectious peritonitis virus replication in vitro. Vet Microbiol 20, 255-265. Weiss, R.C., Scott, F.W., 1981a, Antibody-mediated enhancement of disease in feline infectious peritonitis: comparisons with dengue hemorrhagic fever. Comp Immunol Microbiol Infect Dis 4, 175-189. Weiss, R.C., Scott, F.W., 1981b, Pathogenesis of feline infectious peritonitis: nature and development of viremia. Am J Vet Res 42, 382-390. Wise, A.G., Kiupel, M., Garner, M.M., Clark, A.K., Maes, R.K., 2010, Comparative sequence analysis of the distal one-third of the genomes of a systemic and an enteric ferret coronavirus. Virus Res 149, 42-50. Witte, K.H., Tuch, K., Dubenkropp, H., Walther, C., 1977, [Antigenic relationships between feline infectious peritonitis (FIP) and transmissible gastroenteritis (TGE) viruses in swine]. Berl Munch Tierarztl Wochenschr 90, 396-401. Wolfe, L.G., Grieseme, R.A., 1966, Feline infectious peritonitis. Pathol Vet 3, 255-270. Woo, P.C., Wang, M., Lau, S.K., Xu, H., Poon, R.W., Guo, R., Wong, B.H., Gao, K., Tsoi, H.W., Huang, Y., Li, K.S., Lam, C.S., Chan, K.H., Zheng, B.J., Yuen, K.Y., 2007, Comparative analysis of twelve genomes of three novel group 2c and group 2d coronaviruses reveals unique group and subgroup features. J Virol 81, 1574-1585. Yamamoto, N., Yang, R., Yoshinaka, Y., Amari, S., Nakano, T., Cinatl, J., Rabenau, H., Doerr, H.W., Hunsmann, G., Otaka, A., Tamamura, H., Fujii, N., 2004, HIV protease inhibitor nelfinavir inhibits replication of SARS-associated coronavirus. Biochem Biophys Res Commun 318, 719-725. Zook, B.C., King, N.W., Robinson, R.L., McCombs, H.L., 1968, Ultrastructural evidence for viral etiology of feline infectious peritonitis. Pathol Vet 5, 91-95. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/22413 | - |
dc.description.abstract | 貓傳染性腹膜炎 (Feline infectious peritonitis;FIP) 為一致命、免疫性媒介性疾病,其致病原為貓冠狀病毒 (Feline coronavirus;FCoV)。FCoV 廣泛分布於全世界貓群中,但只有 5~12%血清陽性的貓隻會發展成 FIP,大部分 FCoV 感染貓隻臨床上呈現輕微的腸炎或無症狀。截至目前為止,並無任何實驗室診斷的方法可以區分會發展成 FIP 之病毒,臨床上亦無有效的疫苗或治療。本論文針對貓冠狀病毒感染探討抗病毒藥物 Nelfinavir 在臨床上之應用:口服給予 9 隻感染 FCoV 貓隻抗病毒藥物 Nelfinavir 6.25~50 mg/kg, 投予時間最長達 24 週。追蹤其排毒情況發現,9 貓隻中投予藥物前 3 貓隻曾有病毒血症 (viremia),口服藥物後2 貓隻血液中便偵測不到病毒,此外一貓隻自口服藥物兩週後,亦無偵測到病毒存在,然而其餘 8 隻動物其腸道依然在排毒。評估貓隻臨床症狀及血清生化學檢查之結果,並無發現藥物有明顯副作用。此外,由於貓冠狀病毒 3c 基因缺失曾經被懷疑過和病毒毒力相關,本研究藉由分析 19 株來自臨床健康貓及 11 株來自FIP 發病貓之 FCoV 3c 基因 ,探討貓冠狀病毒 3c 基因和 FIP 之間關聯性。結果發現健康貓身上之 FCoV 只有一株具有突變 3c 基因 (1/ 19; 5.3%),且為 in frame 的序列缺失,推測其蛋白功能仍存,來自 FIP 發病貓之 FCoV 則大部分具有突變 3c 基因 ( 9 / 11;81.8%):包括大小不一的序列缺失 (1∼595 nt)、點插入 (insertion)及點突變 (point mutation),這些突變皆導致 3c 蛋白轉譯之提前終止。透過統計分析顯示,FCoV 3c 基因和 FIP 有極顯著的相關性 (P<0.01)。綜合上述實驗結果顯示,單獨投予 Nelfinavir 不具有抑制 FCoV 腸道感染之效應,而 FCoV 3c 基因突變與 FIP 有顯著相關,未來可以偵測此基因是否突變來設計 FCoV 感染發病與否之檢測,作為臨床上診斷 FIP 之依據。 | zh_TW |
dc.description.abstract | Feline infectious peritonitis (FIP) is a fatal, immune-mediated disease in felids caused by feline coronavirus (FCoV). FCoV are widespread, however, only 5-12 % of seropositive cats develop FIP. Most infections are asymptomatic or result to mild enteritis. Up to present, there is no virological assay that can distinguish virulent from avriulent virus, moreover no effective vaccine or therapy is available for FIP. The objectives of this study were to perform a clinical trial for antiviral agents recently identified to be effective against FCoV infection in vitro, and to correlate the integrity of 3c gene of FCoV with FIP. Nine clinically healthy FCoV shedding cats from three multi-cat families were monitored. After taking Nelfinavir 6.25~50 mg/kg for up to 24 weeks, one infected cat stop shedding virus and two infected cats were no longer viremia, however most of the cats continue to shed FCoV from enteric tract. Through assessment of clinical signs and blood chemistry, no significant side effect was found. Deletions of FCoV 3c gene were reported to associate with viral virulence. In this study, 3c genes of FCoV were analyzed from 19 asymptomatic and 11 FIP cats. Of the 19 sequences analyzed, most are intact except one (5.3%) with a 3-nucleotide in frame deletion. Among the 3c genes from 11 FIP cats, only 2 were intact; the majority (81.8%) exhibited serious aberrations, including various deletions (1-595nt), insertion and point mutation. All these mutations result in premature termination of translation and truncation of the 3c polypeptide. Through statistical analysis, mutation of 3c gene demonstrates a significantly higher correlation with FIP (p<0.01).The preliminary results from clinical trial indicates that Nelfinavir when administrated alone can not eliminate viral shedding from chronic FCoV shedders. As the associating mutation of with FIP has been confirmed base on this finding, it is possible to develop an diagnostic assay for FIP in the near future. | en |
dc.description.provenance | Made available in DSpace on 2021-06-08T04:17:15Z (GMT). No. of bitstreams: 1 ntu-99-R97629017-1.pdf: 11277198 bytes, checksum: 8937ec425d356d1acd60868abd3dd6ae (MD5) Previous issue date: 2010 | en |
dc.description.tableofcontents | 中文摘要........................................................................................................V
Abstract........................................................................................................VI 第一章、序言..................................................................................................1 第二章、文獻探討............................................................................................2 第一節 貓傳染性腹膜炎研究之歷史背景...............................................................2 2.1.1貓傳染性腹膜炎的發現..............................................................................2 2.1.2 貓腸道型冠狀病毒...................................................................................3 2.1.3 貓冠狀病毒之宿主範圍.............................................................................3 第二節 貓冠狀病毒特徵.....................................................................................4 2.2.1 貓冠狀病毒分類.......................................................................................4 2.2.2 基因體特性及病毒蛋白質功能....................................................................5 第三節 貓冠狀病毒感染之流行病學.....................................................................8 2.3.1 流行病學................................................................................................8 2.3.2 多貓家庭排毒模式....................................................................................8 2.3.3 貓冠狀病毒之分型....................................................................................9 第四節 貓冠狀病毒與疾病.................................................................................10 2.4.1 致病機制及免疫反應...............................................................................10 2.4.2 臨床症狀...............................................................................................11 2.4.3 臨床病理學所見.....................................................................................12 2.4.4 實驗室診斷...........................................................................................12 2.4.5 病理學診斷...........................................................................................13 第五節 治療以及預防.......................................................................................14 2.5.1 臨床上之治療........................................................................................14 2.5.2 預防與控制...........................................................................................15 第六節 研究目的.............................................................................................16 第三章、材料與方法.......................................................................................18 第一節 抗病毒藥物 Nelfinavir 於臨床上應用.......................................................18 3.1.1 臨床感染 FCoV 貓隻之篩選.....................................................................18 3.1.2 檢體製備及反轉錄反應............................................................................18 3.1.3 FCoV 之篩選.........................................................................................19 3.1.4 PCR產物電泳分析..................................................................................20 3.1.5 抗病毒藥物 Nelfinavir 之投藥及監控計畫..................................................20 第二節 3c 基因與 FIP 關聯性之分析..................................................................21 3.2.1 臨床檢體之採集及FCoV之篩選................................................................21 3.2.2 檢體之製備及反轉錄反應........................................................................21 3.2.3 FIP 發病貓檢體之分型............................................................................22 3.2.4 3c gene 之巢式反轉錄聚合酶連鎖反應.....................................................22 3.2.5 PCR產物定序及序列分析.........................................................................23 3.2.6 統計分析...............................................................................................23 第四章、結果.................................................................................................24 第一節 Nelfinavir 於臨床上之應用....................................................................24 4.1.1 投藥計畫及RT-nPCR 排毒監控之結果......................................................24 4.1.2 血液生化學檢查之結果............................................................................25 第二節 FCoV 3c 基因與 FIP 關聯性之分析..........................................................25 4.2.1 貓冠狀病毒感染貓隻...............................................................................25 4.2.2 FCoV 3c 基因之分析 (健康貓).................................................................26 4.2.3 FCoV 3c 基因之分析 (FIP貓)...................................................................26 4.2.4 FIP 發病貓之檢體分型.............................................................................27 4.2.5 統計分析結果........................................................................................27 第五章、討論.................................................................................................28 第一節 Nelfinavir 於臨床上之應用....................................................................28 第二節 FCoV 3c 基因與 FIP 關聯性之分析..........................................................31 第六章、參考文獻...........................................................................................35 附表..............................................................................................................48 附圖..............................................................................................................61 附錄一、........................................................................................................70 附錄二、........................................................................................................71 表目錄 表一 九隻感染 FCoV的貓隻基本資料........................................................................................................48 表二、四十一隻感染 FCoV的健康貓基本資料......................................................................................49 表三、FIP 發病貓隻之基本資料..................................................................................................................50 表四、增幅 FCoV 3c 基因片段所使用之特異性引子..........................................................................51 表五、A 家庭 RT-nPCR 檢驗結果及服藥計畫......................................................................................52 表六、B 家庭 RT-nPCR 檢驗結果及服藥計畫......................................................................................53 表七、C 家庭 RT-nPCR 檢驗結果及服藥計畫......................................................................................54 表八、C1 血清生化學檢驗結果...................................................................................................................55 表九、C2 血清生化學檢驗結果...................................................................................................................56 表十、C3 血清生化學檢驗結果...................................................................................................................57 表十一、FIP 發病貓檢體病毒之分型結果..............................................................................................58 表十二、全世界之 FCoV 3c 基因定序及胺基酸缺失大小之結果.................................................59 表十三、全世界 FIP 發病貓 3c 基因突變株之比較...........................................................................60 圖目錄 圖一、引子設計之示意圖及 FCoV 3c 基因電泳圖..........................................................................62 圖二、FIP 發病貓之臟器............................................................................................................................63 圖三、健康貓 FCoV 3c 基因示意圖.......................................................................................................64 圖四、健康貓 FCoV 3c 蛋白示意圖.......................................................................................................65 圖五、發病貓 FCoV 3c 基因示意圖.......................................................................................................66 圖六、發病貓 FCoV 3c 蛋白示意圖.......................................................................................................67 圖七、19 株 FCoV 3c 之核苷酸比對結果 (健康貓)..........................................................................68 圖八、19 株FCoV 3c 之胺基酸比對結果 (健康貓)............................................................................69 | |
dc.language.iso | zh-TW | |
dc.title | 貓冠狀病毒感染:抗病毒藥物之臨床試驗及貓冠狀病毒3c基因之突變與貓傳染性腹膜炎關連性之探討 | zh_TW |
dc.title | Feline coronavirus infection: antiviral agent in clinical trial and
correlation of feline coronavirus 3c gene mutation with feline infectious peritonitis | en |
dc.type | Thesis | |
dc.date.schoolyear | 98-2 | |
dc.description.degree | 碩士 | |
dc.contributor.coadvisor | 蘇璧伶 | |
dc.contributor.oralexamcommittee | 黃偉邦,王金和,許翠英,張瑞宜,伍安怡 | |
dc.subject.keyword | 貓冠狀病毒,3c基因突變,貓傳染性腹膜炎, | zh_TW |
dc.subject.keyword | Feline coronavirus,Mutation of 3c gene,Feline infectious peritonitis, | en |
dc.relation.page | 71 | |
dc.rights.note | 未授權 | |
dc.date.accepted | 2010-07-30 | |
dc.contributor.author-college | 獸醫專業學院 | zh_TW |
dc.contributor.author-dept | 獸醫學研究所 | zh_TW |
顯示於系所單位: | 獸醫學系 |
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