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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 林?輝 | |
| dc.contributor.author | Fu-Yi Chen | en |
| dc.contributor.author | 陳福義 | zh_TW |
| dc.date.accessioned | 2021-06-08T04:16:45Z | - |
| dc.date.copyright | 2010-08-06 | |
| dc.date.issued | 2010 | |
| dc.date.submitted | 2010-07-30 | |
| dc.identifier.citation | 1. 行政院衛生署, 97年死因統計結果分析. 2009.
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Abbaschian, 分析方法, in 物理冶金, 劉偉隆, et al., Editors. 1992, 全華科技圖書股份有限公司. p. 2-1 - 2-35. 65. Malvern Instruments - Zetasizer. Available from: http://www.malvern.com/zetasizer. 66. wikipedia. Einstein relation (kinetic theory). 2010; Available from: http://www.malvern.com/zetasizer. 67. 武東興. 真空電子顯微量測儀(SEM)機台資料. Available from: http://web.nchu.edu.tw/~dsw/. 68. Josephson, B.D., The Discovery of Tunneling Supercurrents. Science, 1974. 184(4136): p. 527-530. 69. SHOJI, A., Development of Josephson Junctions for Liquid-Helium Free Voltage Standard System. AIST TODAY, 2001. 1(3): p. 5-7. 70. Callister, W.D., Magnetic properties, in Materials Science and Engineering: An Introduction. 1999, John Wiley & Sons. p. 693. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/22389 | - |
| dc.description.abstract | 氫氧基磷灰石(hydroxyapatite, HAP)，和氯化亞鐵以共沉澱法製作出的磁性顆粒由於結構和人體內骨頭和牙齒類似，又具良好生物相容性及合適的生物分解速率，是一種有潛力的磁性物質，可做為熱治療或磁振照影(Magnetic resonance imaging, MRI)。
但為了延長在血液中的流通時間，和提高標靶的成功率，表面改質是必需的。在本研究中，須將聚乙二醇(PEG)和葉酸(FA)兩個分子固定於磁性顆粒表面，所以在磁性氫氧基磷灰石另外接聚丙烯酸(PAA)當連結分子，使PEG-FA可以改質於磁性氫氧基磷灰石上。 利用31P NMR、FTIR 和TGA 可以顯現合成的PEG-FA分子可以成功接枝於磁性氫氧基磷灰石表面。經LDH測試可知FeHAP-PAA-PEG-FA 奈米顆粒具低細胞毒性，且在WST-1測試可以證實FeHAP-PAA-PEG-FA對於細胞增生只有些微的影響。再經由鐵含量測試， 細胞膜上有過量表現葉酸受體的MDA-MB-231細胞可以比3T3細胞攝入更多的FeHAP-PAA-PEG-FA 奈米粒子，且攝入的FeHAP-PAA-PEG-FA 奈米粒子比未接枝的FeHAP 奈米粒子為多。 | zh_TW |
| dc.description.provenance | Made available in DSpace on 2021-06-08T04:16:45Z (GMT). No. of bitstreams: 1 ntu-99-R97548035-1.pdf: 2313301 bytes, checksum: d6c86d7fa7357140011127aae6df9fa0 (MD5) Previous issue date: 2010 | en |
| dc.description.tableofcontents | Abstract I
摘要 II 目錄 III 圖目錄 VII 表目錄 X 第一章 簡介 1 1.1 前言 1 1.2 癌症簡介 3 1.3 癌症治療法 4 1.3.1 外科手術(Surgery) 4 1.3.2 放射線療法(Radiation Therapy) 5 1.3.3 化學藥物療法(Chemotherapy) 6 1.3.4 免疫療法(Immunotherapy) 6 1.3.5 基因療法(Gene Therapy) 7 1.3.6 熱治療(Hyperthermia) 8 1.4 熱療法機制 9 1.5 應用於癌症熱治療的磁性顆粒 12 1.6 磁性熱療法比較 14 動脈栓塞熱療(Arterial Embolization Hyperthermia) 14 直接注入熱治療(Direct Injection Hyperthermia) 14 細胞內熱療(Intracellular Hyperthermia) 14 1.7 研究目的 15 第二章 基礎理論 16 2.1 磁性概述 16 2.1.1 磁性來源 16 2.1.2 磁性材料 18 2.1.3 發熱機制 22 2.2 磁場熱治療 24 2.3.1 磁性氫氧基磷灰石(Magnetic Hydroxyapatite, FeHAP) 26 2.3.2聚乙二醇(Polyethylene Glycol, PEG) 26 2.3.3葉酸(Folic Acid, FA) 27 2.3.4表面改質FeHAP 28 第三章 材料與方法 29 3.1 實驗儀器 29 3.2 實驗藥品 31 3.3 材料製備 33 3.3.1 FeHAP製備 34 3.3.2 FeHAP表面改質 35 3.3.3 PEG-FA的合成 36 3.3.4 接枝PEG-FA於FeHAP-PAA上 37 3.4 材料分析 38 核磁共振分析(Nuclear magnetic resonance, NMR) 38 傅立葉轉換紅外線光譜分析(Fourier Transform Infrared Spectrometry, FTIR) 39 熱重分析(Thermogravimetric Analysis, TGA) 40 晶體結構繞射分析(X-ray Diffractmeter, XRD) 41 粒徑分析(Sizer) 42 掃描式電子顯微鏡(Scanning electron microscope, SEM) 43 超導量子干涉儀(Superconducting Quantum Interference Device, SQUID) 44 交流磁場加熱器 45 3.5 生物相容性測試 47 WST-1 47 LDH 48 3.6 體外測試(In vitro Test) 50 鐵離子測定 50 第四章 結果與討論 51 4.1 材料分析 51 31P NMR 51 FTIR Spectrums 52 TGA 54 XRD 55 Size 57 SEM 58 SQUID 59 交流磁場加熱器 60 4.2 生物相容性測試 61 WST-1 61 LDH 63 4.3 In vitro Test 65 鐵離子測定 65 熱治療 67 第五章 結論 68 參考文獻 69 | |
| dc.language.iso | zh-TW | |
| dc.subject | 表面改質 | zh_TW |
| dc.subject | 氫氧基磷灰石 | zh_TW |
| dc.subject | 聚乙二醇 | zh_TW |
| dc.subject | 葉酸 | zh_TW |
| dc.subject | 高溫腫瘤熱治療 | zh_TW |
| dc.subject | hydroxyapatite | en |
| dc.subject | surface modify | en |
| dc.subject | hyperthermia | en |
| dc.subject | folic acid | en |
| dc.subject | polyethylene glycol | en |
| dc.title | 利用聚乙二醇和葉酸接枝於磁性氫氧基磷灰石奈米粒子作癌症熱治療之研究 | zh_TW |
| dc.title | Immobilization of PEG and Folic Acid on the Surface of Magnetic Hydroxyapatite Nanoparticles for Cancer Hyperthermia | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 98-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 姚俊旭,張淑真,王子威,吳錫芩 | |
| dc.subject.keyword | 氫氧基磷灰石,聚乙二醇,葉酸,高溫腫瘤熱治療,表面改質, | zh_TW |
| dc.subject.keyword | hydroxyapatite,polyethylene glycol,folic acid,hyperthermia,surface modify, | en |
| dc.relation.page | 74 | |
| dc.rights.note | 未授權 | |
| dc.date.accepted | 2010-08-02 | |
| dc.contributor.author-college | 工學院 | zh_TW |
| dc.contributor.author-dept | 醫學工程學研究所 | zh_TW |
| 顯示於系所單位： | 醫學工程學研究所 | |
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