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http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/22285完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 程蘊菁(Yen-Ching Chen) | |
| dc.contributor.author | Hui-Chi Cheng | en |
| dc.contributor.author | 鄭慧琪 | zh_TW |
| dc.date.accessioned | 2021-06-08T04:14:55Z | - |
| dc.date.copyright | 2010-09-09 | |
| dc.date.issued | 2010 | |
| dc.date.submitted | 2010-08-10 | |
| dc.identifier.citation | References
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Diabetes Care 29(12): 2688-2693. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/22285 | - |
| dc.description.abstract | 背景：基底前腦的膽鹼性神經退化是阿茲海默症主要病徵之一。膽鹼性神經的減少可能歸因於神經成長因子接受器所引發的凋亡前訊號所導致。至今，只有一篇文獻探討神經成長因子接受器基因多型性( Nerve growth factor receptor, NGFR) 跟阿茲海默症之間的關係。
方法：此研究為病例對照研究。個案收集從2007年起至2010年，自北部三間教學醫院收集了278位阿茲海默症病人，422對照組來自臺大醫院健檢參與者及志工。本研究選取NGFR五個常見的 (frequency 5%) haplotype-tagging 單核苷酸多型性 (htSNPs)，以探討NGFR基因多型性與阿茲海默症之關係。 結果：調整年齡、性別及Apolipoprotein E (ApoE) 4對偶基因後，帶有rs734194一個或兩個變異的對偶基因者，其阿茲海默症的危險性較降低 [TG vs. TT: OR = 0.86，95% confidence interval (CI) = 0.59-1.24；GG vs. TT：OR = 0.45，95% CI = 0.26-0.95]。由五個htSNPs 共可組合成7 個單倍體型 (haplotype)。帶有一個或兩個變異的Haplotype GCGCG者相對於未帶者，其阿茲海默症的危險性相對減少。 (1 vs. 0變異：OR = 0.9，95% CI = 0.62-1.31；2 vs. 0變異：OR=0.39，95% CI = 0.17-0.88)。根據性別及ApoE 4分層後，阿茲海默症與NGFR沒有顯著相關性存在。 結論：在此亞洲族群中，NGFR的基因多型性對於阿茲海默症的風險扮演著重要的角色。 | zh_TW |
| dc.description.abstract | Background. Degeneration of basal forebrain cholinergic neurons (BFCN) is a characteristic of Alzheimer’s disease (AD). Loss of BFCN is attributable to the proapoptotic signaling induced by nerve growth factor receptor (NGFR). Only one study has investigated the association between NGFR polymorphisms and the risk of human AD.
Methods. This case-control study recruited 278 AD patients from three teaching hospitals and 422 controls from Health Checkup Department and volunteers of the hospital in 2007 - 2010. Five common (frequency 5%) haplotype-tagging single nucleotide polymorphisms (htSNPs) were selected from NGFR gene to test the association between sequence variants of NGFR and the risk of AD. Results. Either one copy or two copies of variant rs734194 was associated with a decreased risk of AD, respectively [TG vs. TT: odds ratio (OR) = 0.86, 95% confidence interval (CI) = 0.59-1.24; GG vs. TT: OR = 0.45, 95% CI = 0.26-0.95], after adjusting for age, sex and Apolipoprotein E (ApoE) 4 status. Seven common haplotypes were identified. Haplotype GCGCG was associated with a decreased risk of AD (1 vs. 0 copies: OR = 0.9, 95% CI = 0.62-1.31; two vs. 0 copies: OR = 0.39, 95%CI = 0.17-0.88). No significant association was observed for AD after stratification by sex and ApoE 4 status. Conclusion. The genetic polymorphisms of NGFR play a significant role on the risk of AD in this Asian population. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-08T04:14:55Z (GMT). No. of bitstreams: 1 ntu-99-R97842021-1.pdf: 789167 bytes, checksum: a3ead38c2657d03e273465a072f05415 (MD5) Previous issue date: 2010 | en |
| dc.description.tableofcontents | CONTENT
致 謝 i 中文摘要 ii ABSTRACT iii LIST OF FIGURES vi LIST OF TABLES vii 1. Introduction 1 1.1 Alzheimer’s Disease 1 1.2 Nerve Growth Factor Receptor 1 1.3 NGFR Polymorphisms and the Risk of Alzheimer’s Disease 2 1.4 Type 2 Diabetes and Alzheimer’s Disease 2 1.5 Aims 3 2. Materials and Methods 4 2.1 Study Population 4 2.2 Data Collection 4 2.3 Ascertainment of Dementia 5 2.4 Selection of Single Nucleotide Polymorphisms (SNP) 5 2.5 Lab Work 6 2.6 Statistical Analysis 6 3. Results 8 3.1 Demographic factors 8 3.2 NGFR Polymorphisms and AD Risk 8 3.3 Effect Modification by Type 2 Diabetes 9 4. Discussion 10 4.1 Main Findings 10 4.2 NGFR and AD risk 10 4.3 NGFR, Type 2 Diabetes and AD Risk 11 4.4 Strengthens and Limitations 12 5. Conclusion 12 References 13 LIST OF FIGURES Figure 1. Flowchart of subject recruitment. 23 Figure 2. Flowchart of dementia ascertainment. 24 Figure 3. NGFR linkage disequilibrium (LD) plot. 25 Figure 4. NGFR-mediated neuronal signaling pathway. 26 Figure 5. Possible relationship between type 2 diabetes and AD. 27 LIST OF TABLES Table 1. Characteristics of NGFR SNPs 28 Table 2. Characteristics of the study population 29 Table 3. ApoE 4 status and the risk of AD stratified by sex 30 Table 4. NGFR allele and genotype frequencies for AD and controls 31 Table 5. NGFR SNPs and the risk of AD 32 Table 6. NGFR haplotypes and the risk of AD 33 Table 7. Model comparisons for association of rs734194 and Hap1 with the risk of AD 34 Table 8. Effect modification by type 2 diabetes on the association between NGFR genotype and the risk of AD stratified by ApoE 4 status 35 Table 9. Effect modification by type 2 diabetes on the association between NGFR haplotypes and the risk of AD stratified by ApoE 4 status 36 | |
| dc.language.iso | en | |
| dc.title | 神經成長因子接受器基因多型性與阿茲海默症風險之關聯性研究 | zh_TW |
| dc.title | Genetic Polymorphisms of Nerve Growth Factor Receptor (NGFR) and the Risk of Alzheimer’s Disease | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 98-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.coadvisor | 陳為堅(Wei J. Chen) | |
| dc.contributor.oralexamcommittee | 李文宗(Wen-Chung Lee),宋鴻樟(Fung-Chang Sung),簡國龍(Kuo-Liong Chien) | |
| dc.subject.keyword | 神經成長因子接受器,失智症,阿茲海默症,單核苷,酸多型性,單倍體型, | zh_TW |
| dc.subject.keyword | NGFR,dementia,Alzheimer’s disease,SNP,haplotype, | en |
| dc.relation.page | 37 | |
| dc.rights.note | 未授權 | |
| dc.date.accepted | 2010-08-10 | |
| dc.contributor.author-college | 公共衛生學院 | zh_TW |
| dc.contributor.author-dept | 流行病學研究所 | zh_TW |
| 顯示於系所單位： | 流行病學與預防醫學研究所 | |
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