請用此 Handle URI 來引用此文件:
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/21559
完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 張惠婷(Hui-Ting Chang) | |
dc.contributor.author | Ju-Yu Cheng | en |
dc.contributor.author | 鄭如彧 | zh_TW |
dc.date.accessioned | 2021-06-08T03:37:54Z | - |
dc.date.copyright | 2019-07-23 | |
dc.date.issued | 2019 | |
dc.date.submitted | 2019-07-19 | |
dc.identifier.citation | 莊榮輝 (2005) 生物化學課程講義。4-4 - 4-5 頁。
蔡倉吾 (2010) 實驗動物管理與使用指南。行政院農業委員會。台北。第181-183 頁。 黃琪雅 (2013) 黃連木葉子精油抑制黃嘌呤氧化酶之活性研究。臺灣大學森林環境 暨資源學研究所學位論文:1-101. Adams, R. P. (2007) Identification of essential oil components by gas chromatography/mass spectrometry. Allured Publishing Corporation. Carol Stream. 456 pp. Alma, M. H., S. Nitz, H. Kollmannsberger, M. Digrak, F. T. Efe, and N. Yilmaz (2004) Chemical composition and antimicrobial activity of the essential oils from the gum of Turkish pistachio (Pistacia vera L.). Journal of Agricultural and Food Chemistry 52:3911-3914. Angioni, A., A. Barra, V. Coroneo, S. Dessi, and P. Cabras (2006) Chemical composition, seasonal variability, and antifungal activity of Lavandula stoechas L. ssp. stoechas essential oils from stem/leaves and flowers. Journal of Agricultural and Food Chemistry 54:4364-4370. Arung, E. T., K. Shimizu, and R. Kondo (2006) Inhibitory effect of artocarpanone from Artocarpus heterophyllus on melanin biosynthesis. Biological and Pharmaceutical Bulletin 29:1966-1969. Barbazuk, W. B., I. Korf, C. Kadavi, J. Heyen, S. Tate, E. Wun, J. A. Bedell, J. D. McPherson, and S. L. Johnson (2000) The syntenic relationship of the zebrafish and human genomes. Genome Research 10:1351-1358. Bozorgi, M., Z. Memariani, M. Mobli, M. H. Salehi Surmaghi, M. R. Shams-Ardekani, and R. Rahimi (2013) Five Pistacia species (P. vera, P. atlantica, P. terebinthus, P. khinjuk, and P. lentiscus): a review of their traditional uses, phytochemistry, and pharmacology. The Scientific World Journal 2013. Cha, S. H., S. C. Ko, D. Kim, and Y. J. Jeon (2011) Screening of marine algae for potential tyrosinase inhibitor: those inhibitors reduced tyrosinase activity and melanin synthesis in zebrafish. The Journal of Dermatology 38:354-363. Chakraborty, A. K., Y. Funasaka, M. Komoto, and M. Ichihashi (1998) Effect of arbutin on melanogenic proteins in human melanocytes. Pigment Cell Research 11:206-212. Chang, T. S. (2009) An updated review of tyrosinase inhibitors. International Journal of Molecular Sciences 10:2440-2475. Choi, T. Y., J. H. Kim, D. H. Ko, C. H. Kim, J. S. Hwang, S. Ahn, S.Y . Kim, C. D. Kim, J. H. Lee, and T. J. Yoon (2007) Zebrafish as a new model for phenotype-based screening of melanogenic regulatory compounds. Pigment Cell Research 20:120-127. Cohen, S. M., G. Eisenbrand, S. Fukushima, N. J. Gooderham, F. P. Guengerich, S. S. Hecht, I. M. Rietjens, J. M. Davidsen, C. L. Harman, and S. V. Taylor (2018) Updated procedure for the safety evaluation of natural flavor complexes used as ingredients in food. Food and Chemical Toxicology 113:171-178. Dellai, A., H. Souissi, W. Borgi, A. Bouraoui, and N. Chouchane (2013) Antiinflammatory and antiulcerogenic activities of Pistacia lentiscus L. leaves extracts. Industrial Crops and Products 49:879-882. Dimas, K., S. Hatziantoniou, J. H. Wyche, and P. Pantazis (2009) A mastic gum extract induces suppression of growth of human colorectal tumor xenografts in immunodeficient mice. In Vivo 23:63-68. Ding, H. Y., H. C. Lin, and T. S. Chang (2010) Tyrosinase inhibitors isolated from the roots of Paeonia suffruticosa. International Journal of Cosmetic Science 32:162-162. Dooley, T. P. (1997) Topical skin depigmentation agents: Current products and discovery of novel inhibitors of melanogenesis. Journal of Dermatological Treatment 8:275-279. Dorsam, R. T., and S .P. Kunapuli (2004) Central role of the P2Y12 receptor in platelet activation. The Journal of Clinical Investigation 113:340-345. Duru, M., A. Cakir, S. Kordali, H. Zengin, M. Harmandar, S. Izumi, and T. Hirata (2003) Chemical composition and antifungal properties of essential oils of three Pistacia species. Fitoterapia 74:170-176. El Idrissi, M., M. Barbouchi, M. B. Choukrad, and L. Louzi (2016) Chemical composition and antimicrobial activity of essential oils isolated from leaves and twigs of Pistacia lentiscus L. growing wild in Morocco. World Journal of Pharmacy and Pharmaceutical Sciences 5:516-524. Fassbender, K., D. Lütjohann, M.G. Dik, M. Bremmer, J. König, S. Walter, Y. Liu, M. Letiembre, K. von Bergmann, and C. Jonker (2008) Moderately elevated plant sterol levels are associated with reduced cardiovascular risk—the LASA study. Atherosclerosis 196:283-288. Fiocco, D., D. Fiorentino, L. Frabboni, S. Benvenuti, G. Orlandini, F. Pellati, and A. Gallone (2011) Lavender and peppermint essential oils as effective mushroom tyrosinase inhibitors: a basic study. Flavour and Fragrance Journal 26:441-446. Fiocco, D., M. Arciuli, M.P. Arena, S. Benvenuti, and A. Gallone (2016) Chemical composition and the anti-melanogenic potential of different essential oils. Flavour and Fragrance Journal 31:255-261. Frenk E. (1995) Treatment of melasma with depigmenting agents. Melasma: New Approaches to Treatment. Martin Dunitz Ltd., London. 48pp. Gandhi, G. R., and P. Sasikumar (2012) Antidiabetic effect of Merremia emarginata Burm. F. in streptozotocin induced diabetic rats. Asian Pacific Journal of Tropical Biomedicine 2:281. Goldsmith, P. (2004) Zebrafish as a pharmacological tool: The how, why and when. Current Opinion in Pharmacology 4:504-512. Hermanns, J. F., L. Petit, O. Martalo, C. Piérard-Franchimont, G. Cauwenbergh, and G.E. Piérard (2000) Unraveling the patterns of subclinical pheomelanin-enriched facial hyperpigmentation: Effect of depigmenting agents. Dermatology 201:118-122. Hirata, T., and T. Suga (1977) Biologically active constituents of leaves and roots of Aloe arborescens var. natalensis. Journal of Biosciences 32:731-734. Jones, K., J. Hughes, M. Hong, Q. Jia, and S. Orndorff (2002) Modulation of melanogenesis by aloesin: A competitive inhibitor of tyrosinase. Pigment Cell Research 15:335-340. Kavak, D. D., E. Altıok, O. Bayraktar, and S. Ülkü (2010) Pistacia terebinthus extract: As a potential antioxidant, antimicrobial and possible β-glucuronidase inhibitor. Journal of Molecular Catalysis B: Enzymatic 64:167-171. Kim, J. S., C. S. Kwon, and K. H. Son (2000) Inhibition of alpha-glucosidase and amylase by luteolin, a flavonoid. Bioscience, Biotechnology, and Biochemistry 64:2458-2461. Kimmel, C.B., W. W. Ballard, S. R. Kimmel, B. Ullmann, and T. F. Schilling (1995) Stages of embryonic development of the zebrafish. Developmental Dynamics 203:253-310. Kummer, R., F. C. Fachini-Queiroz, C. F. Estevao-Silva, R. Grespan, E. L. Silva, C. A. Bersani-Amado, and R. K. N. Cuman (2013) Evaluation of anti-inflammatory activity of Citrus latifolia Tanaka essential oil and limonene in experimental mouse models. Evidence-Based Complementary and Alternative Medicine 2013. Lee, D. H., H. J. Cho, H. Y. Kang, M. H. Rhee, and H. J. Park (2012) Total saponin from Korean red ginseng inhibits thromboxane A2 production associated microsomal enzyme activity in platelets. Journal of Ginseng Research 36:40. Lee, S. Y., N. Baek, and T. G. Nam (2016) Natural, semisynthetic and synthetic tyrosinase inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 31:1-13. Leu, Y. L., T. L. Hwang, J. W. Hu, and J. Y. Fang (2008) Anthraquinones from Polygonum cuspidatum as tyrosinase inhibitors for dermal use. Phytotherapy Research 22:552-556. Lim, J. T. E. (1999) Treatment of melasma using kojic acid in a gel containing hydroquinone and glycolic acid. Dermatologic Surgery 25:282-284. Masotti, V., F. Juteau, J.M. Bessière, and J. Viano (2003) Seasonal and phenological variations of the essential oil from the narrow endemic species Artemisia molinieri and its biological activities. Journal of Agricultural and Food Chemistry 51:7115-7121. Masuda, T., D. Yamashita, Y. Takeda, and S. Yonemori (2005) Screening for tyrosinase inhibitors among extracts of seashore plants and identification of potent inhibitors from Garcinia subelliptica. Bioscience, Biotechnology, and Biochemistry 69:197-201. Marinou, K. A., K. Georgopoulou, G. Agrogiannis, T. Karatzas, D. Iliopoulos, A. Papalois, A. Chatziioannou, P. Magiatis, M. Halabalaki, and N. Tsantila (2010) Differential effect of Pistacia vera extracts on experimental atherosclerosis in the rabbit animal model: an experimental study. Lipids in Health and Disease 9:73. Mehenni, C., D. Atmani-Kilani, S. Dumarçay, D. Perrin, P. Gérardin, and D. Atmani (2016) Hepatoprotective and antidiabetic effects of Pistacia lentiscus leaf and fruit extracts. Journal of Food and Drug Analysis 24:653-669. Mitsunaga, T. and K. Yamauchi (2015) Effect of quercetin derivatives on melanogenesis stimulation of melanoma cells. Journal of Wood Science 61:1-13. Murali, R., A. Karthikeyan, and R. Saravanan (2013) Protective effects of D-limonene on lipid peroxidation and antioxidant enzymes in streptozotocin-induced diabetic rats. Basic and Clinical Pharmacology and Toxicology 112:175-181. Nakagawa, M., K. Kawai, and K. Kawai (1995) Contact allergy to kojic acid in skin care products. Contact Dermatitis 32:9-13. Namjoyan, F., M. Farasat, M. Alishahi, A. Jahangiri, and H. Mousavi (2019) The Anti-melanogenesis Activities of Some Selected Red Macroalgae from Northern Coasts of the Persian Gulf. Iranian Journal of Pharmaceutical Research: IJPR 18:383. Niwa, Y., and H. Akamatsu (1991) Kojic acid scavenges free radicals while potentiating leukocyte functions including free radical generation. Inflammation 15:303-315. Park, J. Y., M. Hong, Q. Jia, Y. C. Lee, T. Yayeh, E. Hyun, D. M. Kwak, J. Y. Cho, and M. H. Rhee (2012) Pistacia chinensis methanolic extract attenuated MAPK and Akt Phosphorylations in ADP stimulated rat platelets In vitro. Evidence-Based Complementary and Alternative Medicine 2012: 895729. Park, H., K. H. Song, P. M. Jung, J. E. Kim, H. Ro, M. Y. Kim, and J. Y. Ma (2013) Inhibitory effect of arctigenin from Fructus arctii extract on melanin synthesis via repression of tyrosinase expression. Evidence-Based Complementary and Alternative Medicine 2013:965312. Perona, J. S., R. Cabello-Moruno, and V. Ruiz-Gutierrez (2006) The role of virgin olive oil components in the modulation of endothelial function. The Journal of Nutritional Biochemistry 17:429-445. Pillaiyar, T., M. Manickam, and V. Namasivayam (2017) Skin whitening agents: medicinal chemistry perspective of tyrosinase inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 32:403-425. Rababah, T. M., N. S. Hettiarachchy, and R. Horax (2004) Total phenolics and antioxidant activities of fenugreek, green tea, black tea, grape seed, ginger, rosemary, gotu kola, and ginkgo extracts, vitamin E, and tert-butylhydroquinone. Journal of Agricultural and Food Chemistry 52:5183-5186. Rajaei, A., M. Barzegar, A. M. Mobarez, M. A. Sahari, and Z. H. Esfahani (2010) Antioxidant, anti-microbial and antimutagenicity activities of pistachio (Pistachia vera) green hull extract. Food and Chemical Toxicology 48:107-112. Rajopadhye, A. A., A. S. Upadhye, C. N. Dandge, and D. G. Naik (2016) Essential oil from leaf galls on Pistacia chinensis ssp. integerrima: chemical composition, in vitro and in vivo antioxidant and hepatoprotective activity. Journal of Essential Oil Bearing Plants 19:1648-1659. Remila, S., D. Atmani-Kilani, S. Delemasure, J. L. Connat, L. Azib, T. Richard, and D. Atmani (2015) Antioxidant, cytoprotective, anti-inflammatory and anticancer activities of Pistacia lentiscus (Anacardiaceae) leaf and fruit extracts. European Journal of Integrative Medicine 7:274-286. Satil, F., N. Azcan, and K. Baser (2003) Fatty acid composition of pistachio nuts in Turkey. Chemistry of Natural Compounds 39:322-324. Stratford, M. R. L., C. A. Ramsden, and P. A. Riley (2013) Mechanistic studies of the inactivation of tyrosinase by resorcinol. Bioorganic and Medicinal Chemistry 21:1166-1173. Sugimoto, K., T. Nishimura, K. Nomura, K. Sugimoto, and T. Kuriki (2003) Syntheses of arbutin-α-glycosides and a comparison of their inhibitory effects with those of α-arbutin and arbutin on human tyrosinase. Chemical and Pharmaceutical Bulletin 51:798-801. Sun, J. (2007) D-Limonene: safety and clinical applications. Alternative Medicine Review 12:259. Tamil, I. G., B. Dineshkumar, M. Nandhakumar, M. Senthilkumar, and A. Mitra (2010) In vitro study on α-amylase inhibitory activity of an Indian medicinal plant, Phyllanthus amarus. Indian Journal of Pharmacology 42:280-282. Traboulsi, A. F., K. Taoubi, S. El‐Haj, J. M. Bessiere, and S. Rammal (2002) Insecticidal properties of essential plant oils against the mosquito Culex pipiens molestus (Diptera: Culicidae). Pest Management Science 58:491-495. Wang, H. M., C. Y. Chen, and Z. H. Wen (2011) Identifying melanogenesis inhibitors from Cinnamomum subavenium with in vitro and in vivo screening systems by targeting the human tyrosinase. Experimental Dermatology 20:242-248. Zhang, X. Z., L. Wang, D. W. Liu, G. Y. Tang, and H. Y. Zhang (2014) Synergistic inhibitory effect of berberine and d-limonene on human gastric carcinoma cell line MGC803. Journal of Medicinal Food 17:955-962. Zhu, B., Q. Wang, E. F. Roge, P. Nan, Z. Liu, and Y. Zhong (2006) Chemical variation in leaf oils of Pistacia chinensis from five locations in China. Chemistry of natural compounds 42:422-425. Zohary, M. (1952) A monographical study of the genus Pistacia. Palestine Journal of Botany 5:187-228. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/21559 | - |
dc.description.abstract | 本研究使用水蒸餾法萃取黃連木(Pistacia chinensis )葉子精油,以氣相層析法分析其中成分,其中最主要的成分為Limonene,占精油總量之57.06%,而精油中其他含量較多的化合物,依序為3-Carene(12.36%)、Selinene(5.65%)、Caryophyllene(5.08%)、Caryophyllene oxide(2.68%)等化合物。Limonene為黃連木葉子精油中最主要成分,而在自然界中以兩種不同光學異構物存在,右旋構型的D-Limonene及左旋構型的L-Limonene,本研究分別以黃連木葉子精油、D-Limonene及L-Limonene評估其黑色素生成抑制效果。
蕈類酪胺酸活性抑制分析,以L-Tyrosine或L-DOPA為基質時,黃連木葉子精油、D-Limonene及L-Limonene皆能產生良好的抑制效果,以L-Tyrosine為基質時,黃連木葉子精油及D-Limonene為對於酪胺酸酶為混合型抑制劑,L-Limonene則為競爭型抑制物;以 L-DOPA 為基質時,黃連木葉子精油及D-Limonene 為競爭型抑制劑,L-Limonene 則為混合型抑制物。由斑馬魚胚胎黑色素生成的評估結果,黃連木葉子精油、D-Limonene及L-Limonene在不對斑馬魚胚胎生長發育造成影響的情況下,對其體內的黑色素生成有明顯的抑制效果,IC50值依序為38.16 μg/mL 、44.83 μg/mL及72.87 μg/mL。 綜合上述結果,黃連木葉子精油與其成分D-Limonene及L-Limonene,皆對於黑色素生成有顯著的抑制效果,相當具有發展潛能之天然成分,希望未來能夠進一步研究作用機制,將其應用在相關領域當中。 | zh_TW |
dc.description.abstract | In this study, the leaf essential oil of Pistacia chinensis was extracted by water distillation. The components were analyzed by gas chromatography, and the main component was Limonene with the relative content of 57.06%. Other compounds with a high relative content was 3-Carene (12.36%), Selinene (5.65%), Caryophyllene (5.08%), and Caryophyllene oxide (2.68%). Limonene is the main component of P. chinensis leaf essential oil, and it exists in nature in two different optical isomers, D-Limonene in the right-handed configuration and L-Limonene in the left-handed configuration. Therefore, the inhibitory effect of melanin is evaluated by the leaf essential oil of P. chinensis, D-Limonene and L-Limonene.
Results showed that when L-Tyrosine or L-DOPA was used as the substrate in the antityrosinase activity test, the leaf essential oil of P. chinensis, D-limonene and L-limonene exhibited great inhibitory effects. In antimelanogenesis test of zebrafish embryos, the leaf essential oil of P. chinensis, D-limonene and L-limonene had excellent inhibitory effect on the melanin production of zebrafish embryo without affecting its body growth and development, and IC50 values were 38.16 μg/mL (essential oil of P. chinensis), 44.83 μg/mL (D-limonene) and 72.87 μg/mL (L-limonene). Accordingly, the leaf essential oil of P. chinensis is a melanin inhibitor with development potential, and we hope that it can be applied in related fields in the future. | en |
dc.description.provenance | Made available in DSpace on 2021-06-08T03:37:54Z (GMT). No. of bitstreams: 1 ntu-108-R05625060-1.pdf: 1430727 bytes, checksum: 1dc40e92c4bbfb406776614c8042feb0 (MD5) Previous issue date: 2019 | en |
dc.description.tableofcontents | 摘要 - I
Abstract - II 圖目錄 - VI 表目錄 - VIII 壹、前言 - 01 貳、文獻回顧 - 03 ㄧ、黑色素作用機制 - 03 (ㄧ)、黑色素生成反應 - 03 (二)、酪胺酸酶作用機制 - 03 (三)、抑制黑色素生成機制- 04 二、植物天然物對黑色素生成抑制作用介紹 - 04 (ㄧ)多酚類 - 05 (二)、醛類 - 06 (三)、其他類 - 06 (四)、產業應用實例- 07 三、黃連木屬植物抽出物及其生物活性 - 08 (ㄧ)、黃連木屬植物簡介 - 08 (二)、黃連木屬植物抽出物生物活性 - 08 1. 抗氧化活性 - 10 2. 抗菌活性 - 11 3. 抗發炎活性 - 12 4. 抗癌活性- 12 5. 抗血小板凝集活性 - 13 6. 抗動脈粥硬化活性 - 13 7. 抗糖尿病活性 - 14 參、材料與方法 - 16 一、試驗藥品及溶劑 - 16 (一)、試驗藥品 - 16 (二)、試驗溶劑 - 16 二、試驗方法 - 16 (一)、抽出物萃取 - 16 (二)、精油成分分析 - 16 (三)、蕈類酪胺酸酶活性試驗 - 17 1. 以L-Tyrosine為基質時 - 17 2. 以L-DOPA為基質時 - 17 (四)、酵素動力學試驗 - 18 1. 以L-Tyrosine為基質時 - 18 2. 以L-DOPA為基質時 - 19 (五)、斑馬魚胚胎黑色素試驗 - 19 1. 斑馬魚之培養條件 - 19 2. 斑馬魚美白能力評估 - 20 (六)、統計分析- 20 肆、結果與討論 - 21 ㄧ、黃連木葉子精油成分分析 - 21 二、黃連木葉子精油抑制蕈類酪胺酸酶活性之探討 - 25 (ㄧ)、黃連木葉子精油之抗蕈類酪胺酸酶活性 - 25 (二)、黃連木葉子精油對蕈類酪胺酸酶之酵素酵素動力學分析 - 29 三、黃連木葉子精油抑制斑馬魚黑色素生成活性評估 - 36 伍、結論 - 41 陸、參考文獻 - 43 | |
dc.language.iso | zh-TW | |
dc.title | 黃連木葉子精油抑制黑色素生成之活性 | zh_TW |
dc.title | Antimelanogensis Activity of Leaf Essential Oil
of Pistacia chinensis | en |
dc.type | Thesis | |
dc.date.schoolyear | 107-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 張上鎮,葉汀峰 | |
dc.subject.keyword | 抑制黑色素生成活性,黃連木,精油,檸檬烯,黑色素,斑馬魚, | zh_TW |
dc.subject.keyword | Antimelanogensis activities,Essential oil,Limonene,Melanin,Pistacia chinensis,Zebrafish, | en |
dc.relation.page | 50 | |
dc.identifier.doi | 10.6342/NTU201901600 | |
dc.rights.note | 未授權 | |
dc.date.accepted | 2019-07-19 | |
dc.contributor.author-college | 生物資源暨農學院 | zh_TW |
dc.contributor.author-dept | 森林環境暨資源學研究所 | zh_TW |
顯示於系所單位: | 森林環境暨資源學系 |
文件中的檔案:
檔案 | 大小 | 格式 | |
---|---|---|---|
ntu-108-1.pdf 目前未授權公開取用 | 1.4 MB | Adobe PDF |
系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。