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標題: | 利用燒結法將鍶添加到硫酸鈣及其在骨填充材之研究 Sintering of Strontium-added Calcium Sulfate Bone Void Filler |
作者: | Ying-Cen Chen 陳映岑 |
指導教授: | 段維新(Wei-Hsing Tuan) |
關鍵字: | 硫酸鈣,鍶離子,生物可吸收,燒結,骨替代材料, calcium sulfate,strontium,bioresorbable,sintering,bone graft substitutes, |
出版年 : | 2021 |
學位: | 博士 |
摘要: | 由於醫療發展的日新月異導致人口平均壽命日益漸增,人口老化進而骨替代材需求逐年增長,本次研究目的為找出最佳比例的骨替代材促進新骨生成。 本次研究以硫酸鈣添加硫酸鍶作為骨替代材之研究,而硫酸鈣具有三種型態,二水硫酸鈣 (CaSO4∙2H2O)、半水硫酸鈣 (CaSO4∙1/2H2O)以及無水硫酸鈣 (CaSO4) 。半水硫酸鈣作為骨填充材已有百年歷史,硫酸鈣不會引起發炎反應,還具有骨融合、骨傳導和生物相容性,以及刺激新骨細胞生成。硫酸鈣為生物陶瓷的一種,可被生物體吸收並且完全降解。過去的研究指出,鍶離子具有抗骨質疏鬆的成效,能刺激成骨前驅細胞分化成熟為成骨細胞以促進新骨生成,同時抑制蝕骨細胞吸收,以達到抑制骨質流失的效果。 本次研究,以燒結法製備無水硫酸鈣及摻雜不同比例鍶的試樣。製程是將1 wt%至50 wt%的硫酸鍶與半水硫酸鈣粉末球磨混合、經乾燥、壓錠並燒結至1100°C後持溫一小時,利用熱處理法將鍶離子與鈣離子置換並形成試樣。將試樣進行材料分析與生物分析,試樣隨時間降解並釋放鍶離子,並且找出最佳促進新骨生成之鍶離子濃度範圍。實驗結果證實,此試樣可做為骨替代材。 Advances in medical treatment help all humanity. With the increase of aging population, a variety of bone diseases are also increased. Nowadays, the artificial bone graft is very important for the patients with osteoporosis. In this work, the calcium sulfate added the strontium sulfate is used as the artificial bone graft. With suitable ratio, the bone graft helps on the formation of new bones. There are three forms for calcium sulfate: calcium sulfate dihydrate (CaSO4 ∙ 2H2O), calcium sulfate hemihydrate (CaSO4 ∙ 1/2H2O) and calcium sulfate anhydrate (CaSO4), in terms of its crystallized water. Calcium sulfate hemihydrate has been used as bone graft substitute for more than 100 years. It exhibits excellent biocompatibility, osseointegration and osteoconduction. Furthermore, calcium sulfate can be resorbed in vivo completely. Strontium ions can relieve osteoporosis by stimulating maturation of preosteoblasts activation, and they can also inhibit bone resorption through inactivating the functionality of osteoclasts. In the present study, sintering technique is used to prepare calcium sulfate anhydrate specimens incorporating strontium ion. The calcium sulfate hemihydrate powder was mixed with various amounts of 1 wt% - 50 wt% of strontium sulfate powder, through ball-milling technique. The bone graft was the prepared by sintering at 1100 °C for 1 hour to form the strontium-substituted calcium sulfate. The degradation results confirm the release of strontium ion during the degradation. In addition, a range of the concentration of strontium ion in calcium sulfate is investigated. The results demonstrate that the strontium-substituted calcium sulfate specimen is a potential antiosteoporotic material which can be used as a bone graft substitute. |
URI: | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/21532 |
DOI: | 10.6342/NTU202100104 |
全文授權: | 未授權 |
顯示於系所單位: | 材料科學與工程學系 |
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