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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 段維新(Wei-Hsing Tuan) | |
dc.contributor.author | Man-Lin Syu | en |
dc.contributor.author | 許曼琳 | zh_TW |
dc.date.accessioned | 2021-06-08T03:09:59Z | - |
dc.date.copyright | 2017-07-20 | |
dc.date.issued | 2017 | |
dc.date.submitted | 2017-05-31 | |
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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/20913 | - |
dc.description.abstract | β-三鈣磷酸鹽(β-TCP)具有良好的生物相容性和骨傳導的性質,幫助新骨生成;而硫酸鈣(CS)作為骨替代材也行之有年,特色為降解速率快且在生物體內不會引起發炎反應,因此兩種生物陶瓷作為骨移植物替代物早已得到許多關注。在本研究中,利用固態反應法製備β-TCP粉末,接著探討燒結行為以及機械強度的表現;接著以50wt%的比例製備出β-三鈣磷酸鹽與硫酸鈣複合材料,更進一步去探討機械強度的變化以及生物降解特性。
本實驗結果顯示,TCP試樣的緻密化程度和機械強度之間存在正相關,尤其在燒結溫度為1200℃時,試樣具有較高的相對密度(90%)和高抗壓強度(425MPa);此外,將硫酸鈣添加到β-三鈣磷酸鹽中得到更高相對密度(97%)的複合材料,不僅改善硫酸鈣機械強度較差的問題,也提升了複合材料的生物降解行為。在降解測試的過程中,試樣表面通過鈣離子和磷酸根離子的釋放,可以誘導氫氧基磷灰石(HAp)在表面析出,顯示出此複合材料良好的生物降解性;另外,細胞毒性試驗結果也證明了複合材料的生物相容性。整體而言,在適當的燒結環境下,三鈣磷酸鹽與硫酸鈣的複合材料不僅提升硫酸鈣的機械強度以及增進三鈣磷酸鹽的降解行為,故此複合材料具有良好潛力,能在骨替代生醫陶瓷領域有更進一步的應用。 | zh_TW |
dc.description.abstract | β-tricalcium phosphate (β-Ca3(PO4)2, β-TCP) has attracted a lot of attention as a synthetic bone graft substitute due to its excellent biocompatibility and osteoconductivity. In the present study, β-TCP powder is prepared by solid-state reaction method. The sintering behavior is then studied. Its microstructure and mechanical properties are evaluated. The results demonstrated that there is a strong connection between the degree of densification and mechanical strength for the TCP specimens. As the sintering temperature is 1200℃, TCP specimen is composed of β phase and α phase. It exhibits the highest relative density (90%) and the highest compressive strength (425 MPa). However, the formation of α-TCP may affect the mechanical property.
Calcium sulfate (CaSO4, CS) exhibits biodegradable and osteoconductive characteristics. However, the poor mechanical property and fast resorption rate are the problems for CS substitute. A new composite β-TCP/50wt% CS is prepared. The mechanical property and biodegradation behavior are investigated. The sintering temperature for TCP+CS composite is 1150℃. The composite is composing of β-TCP and calcium sulfate anhydrate (CSA). The addition of CSA into β-TCP improves not only the relative density (97%) but also the degradation behavior. The TCP+CS-1150 specimens show good biodegradability by immediately inducing the precipitation of hydroxyapatite on the surface during degradation test. The cytotoxicity test results also demonstrate the biocompatibility of the composites. All these results suggest that the TCP+CS composite is a potential material as a bone graft substitute. | en |
dc.description.provenance | Made available in DSpace on 2021-06-08T03:09:59Z (GMT). No. of bitstreams: 1 ntu-106-R04527029-1.pdf: 6184207 bytes, checksum: 3289ccbba27209a6e0bc0cf0cd2cd2db (MD5) Previous issue date: 2017 | en |
dc.description.tableofcontents | 口試委員會審定書 #
致謝 i 中文摘要 ii ABSTRACT iii CONTENTS iv LIST OF FIGURES viii LIST OF TABLES xv Chapter 1 Introduction 1 Chapter 2 Literature review 3 2.1 Basic of bones 3 2.2 Bioceramics and bone graft substitutes 7 2.3 Use of tricalcium phosphate as bioceramics 10 2.3.1 Preparation techniques for tricalcium phosphate 10 2.3.2 Chemical and physical properties of tricalcium phosphate 15 2.3.3 Biological properties and clinical applications of tricalcium phosphate 18 2.4 Use of calcium sulfate as bioceramics 22 2.4.1 Chemical and physical properties of calcium sulfate 22 2.4.2 Biological properties and clinical applications of calcium sulfate 26 2.5 Combination of tricalcium phosphate and calcium sulfate 28 Chapter 3 Experimental procedures 31 3.1 β-Tricalcium phosphate 31 3.1.1 Starting materials 31 3.1.2 Processing 31 3.1.3 Characterization 33 3.1.3.1 Physical properties 33 3.1.3.2 Mechanical properties 34 3.1.3.3 Biological properties 35 3.2 Tricalcium phosphate/calcium sulfate composite 41 3.2.1 Starting materials 41 3.2.2 Processing 41 3.2.3 Characterization 43 3.2.3.1 Physical properties 43 3.2.3.2 Mechanical properties 44 3.2.3.3 Biological properties 44 Chapter 4 Results 45 4.1 Tricalcium phosphate 45 4.1.1 Physical properties 45 4.1.1.1 Phase analysis 45 4.1.1.2 Density and weight loss 47 4.1.1.3 Thermalgravimetric analysis (TGA) 48 4.1.1.4 Microstructure observation 50 4.1.2 Mechanical properties 52 4.1.2.1 Compressive test 52 4.1.2.2 Biaxial four-ball test 53 4.1.3 Biological properties 55 4.1.3.1 ISO 10993-14 degradation test 55 4.1.3.2 28 days degradation test 62 4.1.3.3 Cytotoxicity- test by direct contact 67 4.2 Tricalcium phosphate/calcium sulfate composite 69 4.2.1 Physical properties 69 4.2.1.1 Phase analysis 69 4.2.1.2 Density and weight loss 70 4.2.1.3 Thermalgravimetric analysis (TGA) 72 4.2.1.4 Microstructure observation 73 4.2.2 Mechanical properties 74 4.2.2.1 Compressive test 74 4.2.2.2 Biaxial four-ball test 75 4.2.3 Biological properties 77 4.2.3.1 ISO 10993-14 degradation test 77 4.2.3.2 28 days degradation test 83 4.2.3.3 Cytotoxicity-test by direct contact 90 Chapter 5 Discussion 92 5.1 Synthesis of β-tricalcium phosphate 92 5.2 Physical properties 93 5.2.1 Density measurement 93 5.2.2 Phase identification 94 5.2.3 Microstructure observation 96 5.3 Mechanical properties 98 5.3.1 Compressive test 98 5.3.2 Biaxial four-ball test 101 5.4 Biological properties 103 5.4.1 ISO 10993-14 degradation test 103 5.4.2 28 days degradation test 108 5.4.3 Cytotoxicity- test by direct contact 117 Chapter 6 Conclusions 119 REFERENCES 121 Appendix A Degradation behavior for a short time 138 Appendix B Precipitates analysis by FTIR 143 Appendix C Compressive test after degradation 144 | |
dc.language.iso | en | |
dc.title | 探討以固態合成法製備β-三鈣磷酸鹽與其複合材料的機械性質與降解特性 | zh_TW |
dc.title | Preparation of β-Tricalcium Phosphate and its Composite by Solid-State Reaction Method | en |
dc.type | Thesis | |
dc.date.schoolyear | 105-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 劉典謨,賴伯亮 | |
dc.subject.keyword | 三鈣磷酸鹽,硫酸鈣,燒結,抗壓強度,生物降解, | zh_TW |
dc.subject.keyword | tricalcium phosphate,calcium sulfate,sintering,compressive strength,degradation, | en |
dc.relation.page | 144 | |
dc.identifier.doi | 10.6342/NTU201700855 | |
dc.rights.note | 未授權 | |
dc.date.accepted | 2017-05-31 | |
dc.contributor.author-college | 工學院 | zh_TW |
dc.contributor.author-dept | 材料科學與工程學研究所 | zh_TW |
顯示於系所單位: | 材料科學與工程學系 |
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