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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 林俊彬(Chun-Pin Lin) | |
| dc.contributor.author | Yi-Chieh Hsiao | en |
| dc.contributor.author | 蕭以潔 | zh_TW |
| dc.date.accessioned | 2021-06-08T02:38:43Z | - |
| dc.date.copyright | 2018-08-01 | |
| dc.date.issued | 2018 | |
| dc.date.submitted | 2018-07-15 | |
| dc.identifier.citation | 1. Karpiński TM and Szkaradkiewicz AK, Microbiology of dental caries. J Biol Earth Sci 2013. 3(1): p. M21-M24.
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/20009 | - |
| dc.description.abstract | 本研究製備奈米矽片銀聚氨酯複合材料作為牙科窩隙封劑。實驗分成三個部分：一、首先針對聚氨酯丙烯酸酯（UA），添加適當比例的稀釋單體（TPGDA）與光起始劑（CQ和EDMAB），製備出具有良好流動性與聚合程度的聚氨酯樹脂基質；二、測試冷凍乾燥後的奈米矽片銀，對轉糖鏈球菌的抗菌效果；三、以聚氨酯樹脂基質、矽烷化二氧化矽及奈米矽片銀製備奈米矽片銀聚氨酯複合材料，測試其機械物理性質、生物相容性和抗菌活性。結果顯示50:50 UA/TPGDA能夠得到臨床上可接受的流動性，而光起始劑CQ/EDMAB分別以1/2 phr的比例添加至50:50 UA/TPGDA中，可得到適當的轉化率、聚合深度和交聯程度；而冷凍乾燥後的奈米矽片銀乃具有極佳之抗菌活性，僅需10 ppm即可對轉糖鏈球菌達完全的抗菌效果；奈米矽片銀聚氨酯複合材料在銀濃度為300 ppm時，具有臨床上可接受的機械物理性質和良好的生物相容性，且相對於未添加奈米矽片銀的對照組，其菌量減少為55.82%，顯示奈米矽片銀聚氨酯複合材料具有抗菌效果。然而奈米矽片銀於樹脂中的分散性不佳，可能降低其抗菌活性，因此未來研究應朝此方向著手改良。 | zh_TW |
| dc.description.provenance | Made available in DSpace on 2021-06-08T02:38:43Z (GMT). No. of bitstreams: 1 ntu-107-R04422011-1.pdf: 4559958 bytes, checksum: f2d758358ea8f280311f73fb415cd009 (MD5) Previous issue date: 2018 | en |
| dc.description.tableofcontents | 口試委員會審定書 i
誌謝 ii 摘要 iii Abstract iv 目 錄 vi 圖目錄 xi 表目錄 xiii 第一章 文獻回顧 1 1.1 齲齒的形成 1 1.2 現今齲齒盛生率與表現狀況 1 1.3 牙齒窩隙之形態 2 1.4 窩隙封劑之文獻回顧 3 1.5 含銀製劑的臨床應用 5 1.6 奈米銀 7 1.7 黏土與奈米矽片 10 1.8 奈米矽片銀 12 1.9 聚氨酯樹脂 14 1.9.1 聚氨基甲酸酯 14 1.9.2 聚氨酯丙烯酸酯樹脂 15 1.9.3 光起始劑 15 第二章 實驗動機與目的 17 第三章 實驗材料與方法 18 3.1 實驗架構與流程圖 18 3.2 實驗材料 19 3.3 實驗儀器 21 3.4 聚氨酯樹脂基質之製備 22 3.4.1 聚氨酯丙烯酸酯（UA）之合成 22 3.4.2 稀釋劑的添加與黏稠度測試 24 3.4.3 光起始劑的添加與聚合程度分析 24 3.4.3.1 光起始劑的添加 24 3.4.3.2 轉化率 25 3.4.3.3 聚合深度 27 3.4.3.4 交聯程度 27 3.5 奈米矽片銀之抗菌測試 28 3.5.1 菌株特性與來源 28 3.5.2 菌株培養及保存方法 28 3.5.3 菌液吸光值與濃度關係 29 3.5.4 抗菌測試 29 3.6 奈米矽片銀聚氨酯複合材料製備 30 3.6.1 二氧化矽的矽烷化處理 30 3.6.2 複合材料的製備 31 3.7 奈米矽片銀聚氨酯複合材料的機械物理性質 31 3.7.1 聚合深度 31 3.7.2 表面硬度 31 3.7.3 抗壓強度 32 3.7.4 流動性比較 33 3.8 奈米矽片銀聚氨酯複合材料之生物相容性測試 33 3.8.1 3T3細胞培養 33 3.8.2 實驗樣本與萃取液製備 34 3.8.3 細胞存活率分析 35 3.8.4 細胞毒性測試 36 3.9 奈米矽片銀聚氨酯複合材料之抗菌測試 38 3.9.1 抗菌測試 38 3.9.2 細菌形態觀察 40 3.10 數據統計與分析方法 41 第四章 實驗結果 42 4.1 聚氨酯樹脂基質之製備 42 4.1.1 稀釋劑的添加與黏稠度測試 42 4.1.2 光起始劑的添加與聚合程度分析 42 4.1.2.1 轉化率 42 4.1.2.2 聚合深度 43 4.1.2.3 交聯程度 44 4.2 奈米矽片銀之抗菌測試 46 4.2.1 菌液吸光值與濃度的關係 46 4.2.2 抗菌測試 47 4.3 奈米矽片銀聚氨酯複合材料的機械物理性質 47 4.3.1 聚合深度 47 4.3.2 表面硬度 48 4.3.3 抗壓強度 49 4.3.4 流動性比較 50 4.4 奈米矽片銀聚氨酯複合材料的生物相容性 51 4.4.1 細胞存活率分析 51 4.4.2 細胞毒性 52 4.5 奈米矽片銀聚氨酯複合材料之抗菌測試 53 4.5.1 抗菌測試 53 4.5.2 細菌形態觀察 53 第五章 討論 55 5.1 聚氨酯樹脂基質之製備 55 5.1.1 稀釋劑的添加與黏稠度測試 55 5.1.2 光起始劑的添加與聚合程度分析 55 5.2 奈米矽片銀之抗菌測試 56 5.3 奈米矽片銀聚氨酯複合材料的機械物理性質 57 5.3.1 聚合深度 57 5.3.2 表面硬度 57 5.3.3 抗壓強度 58 5.3.4 流動性比較 59 5.4 奈米矽片銀聚氨酯複合材料的生物相容性 60 5.5 奈米矽片銀聚氨酯複合材料之抗菌測試 60 第六章 結論 63 參考文獻 65 | |
| dc.language.iso | zh-TW | |
| dc.title | 奈米矽片銀聚氨酯複合材料作為牙齒窩隙封劑之研究 | zh_TW |
| dc.title | Polyurethane Composites with Silver Nanoparticles Immobilized on Nanoscale Silicate Platelets as Pit and Fissure Sealants | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 106-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 王姻麟(Yin-Lin Wang),謝明佑,李志偉 | |
| dc.subject.keyword | 窩隙封劑,奈米矽片,奈米銀粒子,聚氨酯,複合材料,抗菌活性,生物相容性, | zh_TW |
| dc.subject.keyword | pit and fissure sealant,nanoscale silicate platelets,silver nanoparticles,polyurethane,composite material,antibacterial activity,biocompatibility, | en |
| dc.relation.page | 69 | |
| dc.identifier.doi | 10.6342/NTU201801556 | |
| dc.rights.note | 未授權 | |
| dc.date.accepted | 2018-07-16 | |
| dc.contributor.author-college | 醫學院 | zh_TW |
| dc.contributor.author-dept | 臨床牙醫學研究所 | zh_TW |
| 顯示於系所單位： | 臨床牙醫學研究所 | |
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