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| ???org.dspace.app.webui.jsptag.ItemTag.dcfield??? | Value | Language |
|---|---|---|
| dc.contributor.advisor | 徐善慧 | |
| dc.contributor.author | Kuo-Wei Cheng | en |
| dc.contributor.author | 程國瑋 | zh_TW |
| dc.date.accessioned | 2021-06-08T02:19:01Z | - |
| dc.date.copyright | 2015-08-25 | |
| dc.date.issued | 2015 | |
| dc.date.submitted | 2015-08-20 | |
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/19785 | - |
| dc.description.abstract | Superparamagnetic iron oxide nanoparticles (SPIO NPs) have a wide range of biomedical applications such as in magnetic resonance imaging (MRI), targeting, and hyperthermia therapy. Aggregation of SPIO NPs can occur because of the hydrophobic surface and high surface energy of SPIO NPs. Here, we developed a facile method to encapsulate SPIO NPs in amphiphilic biodegradable polymer. Anionic biodegradable polyurethane nanoparticles (PU NPs) with ~40 nm size and different chemistry were prepared by waterborne processes. SPIO NPs were synthesized from chemical co-precipitation. SPIO NPs were then added in the aqueous dispersion of PU NPs, followed with high frequency (~20 kHz) ultrasonic vibration for 3 min. This method rendered SPIO-PU hybrid NPs (size ~110 nm) suspended in water. SPIO-PU hybrid NPs contained about 50-60 wt% SPIO and retained the superparamagnetic property (evaluated by a magnetometer) as well as high contrast in MRI. Using the same method, hydrophobic drug (Vitamin K3, VK3) or (9-(methylaminomethyl)anthracene, MAMA) could also be encapsulated in PU NPs. The VK3-PU or MAMA-PU hybrid NPs had ~40 nm size and different release profiles for PU with different chemistry. The encapsulation efficiency for VK3 and MAMA was high (~95%) without burst release. The encapsulation mechanism may be attributed to the low Tg and good compliance of PU NPs. The new encapsulation method by waterborne biodegradable PU NPs is simple, rapid, and effective to produce multimodular NP carriers | en |
| dc.description.provenance | Made available in DSpace on 2021-06-08T02:19:01Z (GMT). No. of bitstreams: 1 ntu-104-R02549036-1.pdf: 11703605 bytes, checksum: efe1b3e3064bc1f9ad0a235a7e092e13 (MD5) Previous issue date: 2015 | en |
| dc.description.tableofcontents | 誌謝 i
摘要 ii Abstract iii 目錄 v 圖目錄 viii 表目錄 x 第一章 文獻回顧 1 1.1. 磁性奈米粒子與生醫應用 1 1.2. 超順磁氧化鐵奈米粒子的表面改質 1 1.3. 磁性奈米粒子的熱療應用 2 1.4. 磁奈米粒子在藥物載體的應用 2 1.5. 多功能合一的磁奈米粒子 3 1.6. 抗癌藥物的奈米載體進行標靶應用 4 1.7. 高分子包覆磁奈米粒子對細胞攝取的毒性 5 1.8. 聚胺酯 6 1.9. 水性聚胺酯奈米粒子的生醫應用 6 1.10. 可生物降解聚胺酯作為藥物載體的應用 7 1.11. 水性PU Ns包覆磁性奈米粒子及藥物 8 1.12. 研究動機與目的 11 第二章 研究方法 12 2.1. 研究架構 12 2.2. 水性生物可降解聚胺酯奈米粒子超音波震盪法包覆超順磁氧化鐵奈米粒子之合成與製備 14 2.2.1. 水性生物可降解聚胺酯奈米粒子(Waterborne biodegradable polyurethane nanoparticles, PU NPs)的合成 14 2.2.2. 水性生物可降解聚胺酯薄膜製備與水膨潤率測試 17 2.2.3. 超順磁氧化鐵奈米粒子(SPIO NPs)的合成 17 2.2.4. 以超音波震盪法包覆超順磁奈米粒子於水性聚胺酯奈米粒子 18 2.3. 以超音波震盪法製備的SPIO-PU NPs之物化性質分析 20 2.3.1. 粒徑與界面電位分析 20 2.3.2. 穿透式電子顯微鏡分析 20 2.3.3. 衰減全反射傅立葉紅外線光譜分析 20 2.3.4. 熱重分析儀分析 21 2.3.5. 磁化性質與磁滯曲線分析 21 2.3.6. 核磁共振影像儀測量( MRI分析) 21 2.3.7. 高週波磁場加熱分析 22 2.4. 以超音波震盪法製備drug-PU NPs與drug-SPIO-PU NPs之方法、藥物釋放與細胞毒性分析 22 2.4.1. 以超音波震盪法包覆疏水性藥物於水性聚胺酯奈米粒子 22 2.4.2. 藥物釋放實驗 23 2.4.3. 以超音波震盪法同時包覆疏水性藥物與磁性奈米粒子於水性聚胺酯奈米粒子(drug-SPIO-PU NPs) 23 2.4.4. 多功能奈米載體(MAMA-SPIO-PU)之細胞毒性與攝取實驗 24 2.5. 統計分析 26 第三章 實驗結果 27 3.1. 水性生物可降解聚胺酯經超音波震盪法包覆超順磁氧化鐵奈米粒子之合成製備與物化性質分析 27 3.1.1. 水性生物可降解聚胺酯奈米粒子( PU NPs)的製備 27 3.1.2. 水性生物可降解聚胺酯薄膜製備與水膨潤率測試 27 3.1.3. 超順磁奈米氧化鐵粒子(SPIO-NPs)的製備 27 3.1.4. 以超音波震盪法包覆SPIO NPs於PU NPs 28 3.1.5. 粒徑與界面電位分析 28 3.1.6. 穿透式電子顯微鏡分析 28 3.1.7. 傅立葉紅外線光譜(FTIR)分析 29 3.1.8. 熱重性質(TGA)分析 29 3.1.9. 磁化性質(SQUID)分析 30 3.1.10. 核磁共振顯影(MRI)分析 30 3.1.11. 高週波磁場加熱實驗 30 3.2. 以超音波震盪法製備drug-PU NPs與drug-SPIO-PU NPs之方法、藥物釋放與細胞毒性分析 31 3.2.1. 以超音波震盪法製備的drug-PU NPs 粒徑與界面電位分析 31 3.2.2. 以超音波震盪法製備的drug-PU NPs之藥物釋放分析 31 3.2.3. 以超音波震盪法製備的MAMA-SPIO-PU NPs之藥物釋放分析 32 3.2.4. MAMA-SPIO-PU之細胞毒性與攝取分析 33 第四章 討論 34 4.1. 水性生物可降解聚胺酯經超音波震盪法包覆超順磁氧化鐵奈米粒子之合成製備與物化性質分析 34 4.1.1. 水性生物可降解聚胺酯奈米粒子(PU NPs)的合成 34 4.1.2. 以超音波震盪法包覆SPIO NPs於PU NPs 34 4.1.3. 穿透式電子顯微鏡(TEM)分析 35 4.1.4. 傅立葉紅外光吸收光譜(FTIR)分析 35 4.1.5. 熱重性質(TGA)分析 36 4.1.6. 磁化性質(SQUID)分析 36 4.1.7. 核磁共振顯影(MRI)分析 37 4.1.8. 高週波磁場加熱分析 37 4.2. 以超音波震盪法製備drug-PU NPs與drug-SPIO-PU NPs之方法、藥物釋放與細胞毒性分析 38 4.2.1.以超音波震盪法製備的drug-PU NPs之藥物釋放分析 38 4.2.2.以超音波震盪法製備的MAMA-SPIO-PU NPs之藥物釋放分析 39 4.2.3. MAMA-SPIO-PU之細胞毒性與攝取分析 39 第五章 結論 41 參考文獻 54 | |
| dc.language.iso | zh-TW | |
| dc.title | 利用超音波震盪法包覆超順磁氧化鐵奈米粒子與疏水性藥物於水性生物可降解聚胺酯奈米粒子之製備與性質分析 | zh_TW |
| dc.title | A facile method to prepare superparamagnetic iron oxide and hydrophobic drug encapsulated biodegradable polyurethane nanoparticles | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 103-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 張振榮,黃彥彰 | |
| dc.subject.keyword | 超順磁奈米氧化鐵粒子；生物可降解聚胺酯奈米粒子；藥物釋放；混成奈米粒子, | zh_TW |
| dc.subject.keyword | superparamagnetic iron oxide (SPIO)； polyurethane；drug release；hybrid nanoparticles, | en |
| dc.relation.page | 60 | |
| dc.rights.note | 未授權 | |
| dc.date.accepted | 2015-08-21 | |
| dc.contributor.author-college | 工學院 | zh_TW |
| dc.contributor.author-dept | 高分子科學與工程學研究所 | zh_TW |
| Appears in Collections: | 高分子科學與工程學研究所 | |
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