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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
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dc.contributor.advisor | 謝銘鈞(Ming-Jium Shieh) | |
dc.contributor.author | Ping-Fang Chiang | en |
dc.contributor.author | 江秉芳 | zh_TW |
dc.date.accessioned | 2021-06-08T02:09:10Z | - |
dc.date.copyright | 2016-03-08 | |
dc.date.issued | 2016 | |
dc.date.submitted | 2016-01-29 | |
dc.identifier.citation | 1. Pisani P, Parkin DM, Ferlay J. Estimates of the world wide mortality from eighteen major cancers in 1985. Implications for prevention and projections of future burden. Int J Cancer, 1993. 55(6): 891-903.
2. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int. J. Cancer, 2010. 127(12): 2893-2917. 3. El-Serag HB. Hepatocellular carcinoma. New England J. Med, 2011. 365(12): 1118-1127. 4. Liu, L. X., Zhang WH, Jiang HC. Current treatment for liver metastases from colorectal cancer. World J. Gastroenterol, 2003. 9(2): 193-200. 5. Kumar A, Srivastava DN, Chau TT, Long HD, Bal C, Chandra P, and et al. Inoperable hepatocellular carcinoma: Transarterial 188Re HDD-labeled iodized oil for treatment--prospective multicenter clinical trial. Radiology, 2007. 243(2): 509-19. 6. Kennedy, A. S., Nutting C, Coldwell D, Gaiser J, Drachenberg C. Pathological response and microdosimetry of 90Y microspheres in man: review of four explanted whole livers. Int. J. Radiat. Oncol. biol. phys, 2004. 60(5): 1552-1563. 7. Ackerman NB. Experimental studies on the circulation dynamics of intrahepatic tumor blood supply. Cancer, 1972. 29(2): 435-439. 8. Biolato M, Marrone G, Racco S, and et al. Transarterial chemoembolization (TACE) for unresectable HCC: a new life begins? Eur Rev Med Pharmacol Sci, 2010. 14(4): 356-362. 9. Grosso M, Pedrazzini F, Balderi A, Antonietti A, Peano E, Ferro L , Sortino D. Transarterial Chemoembolization for HCC with Drug-Eluting Microspheres. Hepatocellular Carcinoma - Clinical Research, Dr. Joseph W.Y. Lau (Ed.), 2012. ISBN: 978-953-51-0112-3, p.265-274. 10. Lewandowski RJ, Geschwind JF, Liapi E, Salem R. Transcatheter intraarterial therapies: rationale and overview. Radiology, 2011. 259(3): 641-657. 11. Kennedy A, Coldwell D, Sangro B, Wasan H, Salem R. Radioembolization for the treatment of liver tumors general principles. Am J Clin Oncol, 2012. 35(1): 91-99. 12. Edeline J, Gilabert M, Garin E, Boucher E, Raoul JL. Yttrium-90 microsphere radioembolization for hepatocellular carcinoma. Liver Cancer, 2015. 4(1):16-25. 13. Namur J, Pascale F, Maeda N, Sterba M, Ghegediban SH, Verret V, Paci A, Seck A, Osuga K, Wassef M, Reb P, Laurent A. Safety and Efficacy Compared between Irinotecan-Loaded Microspheres HepaSphere and DC Bead in a Model of VX2 Liver Metastases in the Rabbit. J Vasc Interv Radiol, 2015. 26(7): 1067-1075. 14. Fukuoka Y, Tanaka T, Nishiofuku H, Sato T, Kichikawa K. Compatibility of an Ultraselective Microcatheter and Epirubicin Loaded 300-500-μm DC Bead in Ex Vivo Study. Cardiovasc Intervent Radiol, 2015. 38(5):1284-1287. 15. Song do S, Choi JY, Yoo SH, Kim HY, Song MJ, Bae SH, Yoon SK, Chun HJ, Choi BG, Lee HG. DC Bead Transarterial Chemoembolization Is Effective in Hepatocellular Carcinoma Refractory to Conventional Transarteral Chemoembolization: A Pilot Study. Gut Liver, 2013. 7(1):89-95. 16. Mitra A, Dey B. Chitosan Microspheres in Novel Drug Delivery Systems. Indian J Pharm Sci, 2011. 73(4): 355–366. 17. Ni HC, Yu CY, Chen SJ, Chen LC, Lin CH, Lee WC, Chuang CH, Ho CL, Chang CH, Lee TW. Preparation and imaging of rhenium-188 labeled human serum albu- min microsphere in orthotopic hepatoma rats. Appl Radiat Isot, 2015. 99:117-121. 18. Yang Sun, Yanjie Wang, Chengcheng Niu, Eric M. Strohm, Yuanyi Zheng, Haitao Ran, Rongzhong Huang, and et al. Laser-Activatable PLGA Microspheres for Image-Guided Cancer Therapy In Vivo. Adv. Funct. Mater, 2014. DOI: 10.1002/adfm.201402631. 19. Khemani M, Sharon M, Sharon M. pH Dependent Encapsulation of Doxorubicin in PLGA. Annals of Biological Research, 2012. 3(9):4414-4419 20. Tacar O, Sriamornsak P, Dass CR. Doxorubicin: an update on anticancer molecular action, toxicity and novel drug delivery systems. J Pharm Pharmacol, 2013. 65(2): 157-170. 21. Chatterjee K, Zhang J, Honbo N, Karliner JS. Doxorubicin Cardiomyopathy. Cardiology, 2010. 115(2): 155-162. 22. Argyrou M, Valassi A, Andreou M, Lyra M. Rhenium-188 Production in Hospitals, by W-188/Re-188 Generator, for Easy Use in Radionuclide Therapy. International Journal of Molecular Imaging, 2013. DOI:10.1155/2013/290750. 23. Bhangoo MS, Karnani DR, Hein PN, Giap H, Knowles H, Issa C, Steuterman S, Pockros P, Frenette C. Radioembolization with Yttrium-90 microspheres for patients with unresectable hepatocellular carcinoma. J Gastrointest Oncol, 2015. 6(5):469-478. 24. Shamim SA, Kumar R, Halanaik D, Kumar A, Shandal V, Shukla J, Kumar A, Trikha V, Chandra P, Bandopadhayaya G, Malhotra A. Role of rhenium-188 tin colloid radiosynovectomy in patients with inflammatory knee joint conditions refractory to conventional therapy. Nucl Med Commun, 2010. 31(9):814-820. 25. Sheu AY, Zhang Z, Omary RA, Larson AC. Invasive catheterization of the hepatic artery for preclinical investigation of liver-directed therapies in rodent models of liver cancer. Am J Transl Res, 2013. 5(3):269-278. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/19622 | - |
dc.description.abstract | The purpose of this study is to develop biodegradable microspheres which combined with chemotherapy and radiotherapy for transcatheter arterial embolization/chemoembolization (TAE/TACE) or local injectable forms. By locally and slowly release of chemotherapeutic agents, the effect of cancer treatment can be extended.
In the experiment, we used biodegradable and biocompatible polymer Poly(D,L-lactide-co-glycolide)(PLGA) to prepare micron particles. Through double emulsion, the microspheres contain water-soluble polymers, including carboxymethylcellulose sodium salt, poly(sodium 4-styrenesulfonate), poly(4-styrenesulfonic acid) ammonium salt solution and Poly(vinylsulfonic acid, sodium salt) solution. The functional groups of those polymers will dissociate into -SO3- or -COO- in water. Doxorubicin can be loaded into the beads using an interaction process between the protonated primary amine on the drug and the negatively charged groups. The microspheres could embedded with 188Re-tin-colloid in the pore spaces which on or in the particles. Experimental results show that 50 mg PVSA/PLGA microspheres absorbed 2.5 mg doxorubicin within an hour had the best absorption efficiency. Microspheres were embedded with 188Re-tin-colloid and performed in a rat hepatocellular carcinoma model. NanoSPECT/CT imaging and bio-distribution showed the microspheres were still in the liver after 72 hours. The tumor growth was more profoundly inhibited by treatment with Re/DOX@MS than others by ultrasonography during 4 weeks observation period. The microspheres may offer the advantage of locally injection or embolization. In the future, the drug delivery system for cancer radiotherapy combined with chemotherapy using a biodegradable PLGA microspheres consisting of therapeutic radionuclide and chemotherapeutic drugs could maximize their effects on hepatocellular carcinoma. | en |
dc.description.provenance | Made available in DSpace on 2021-06-08T02:09:10Z (GMT). No. of bitstreams: 1 ntu-105-R01548009-1.pdf: 16487860 bytes, checksum: 06d82f78f13ac6db2a68552d40fceda5 (MD5) Previous issue date: 2016 | en |
dc.description.tableofcontents | 謝辭 I
中文摘要 II ABSTRACT III CONTENT V LIST of SCHEMES VII LIST of FIGURES VIII Chapter 1 Introduction 1 Chapter 2 Materials and methods 5 2.1 Material 5 2.2 Microsphere fabrication 5 2.3 Characterization of PLGA microspheres size and morphology 7 2.4 In vitro drug release from PLGA microspheres 7 2.5 In vitro cytotoxicity assay 8 2.6 TAE technology 9 2.7 Biodistribution of Re/DOX@MS 10 2.8 Antitumor efficacy 11 Chapter 3 Results and discussions 13 3.1 Characterization of PLGA microspheres 13 3.2 Evolution of the kinetics of DOX release 15 3.3 The cytotoxity of drug loaded PLGA microdpheres 15 3.4 Biodistribution of Re/DOX@MS 16 3.5 Antitumor efficacy of drug loaded PLGA microdpheres 17 Chapter 4 Conclusion 19 REFERENCE 20 SCHEME 25 FIGURE 28 | |
dc.language.iso | en | |
dc.title | 生物可分解性多功能微粒體於肝癌栓塞治療之研究 | zh_TW |
dc.title | Biodegradable and multifunctional microspheres for treatment of hepatoma through transarterial embolization | en |
dc.type | Thesis | |
dc.date.schoolyear | 104-1 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 林文澧,張富雄,羅彩月 | |
dc.subject.keyword | 肝癌,肝動脈栓塞,微粒體,艾黴素,錸-188, | zh_TW |
dc.subject.keyword | hepatocellular carcinoma,transcatheter arterial embolization (TAE),microsphere,doxorubicin,188Re, | en |
dc.relation.page | 40 | |
dc.rights.note | 未授權 | |
dc.date.accepted | 2016-01-29 | |
dc.contributor.author-college | 工學院 | zh_TW |
dc.contributor.author-dept | 醫學工程學研究所 | zh_TW |
顯示於系所單位: | 醫學工程學研究所 |
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