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DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 吳岳隆 | |
dc.contributor.author | Yee-Tung Hu | en |
dc.contributor.author | 胡益通 | zh_TW |
dc.date.accessioned | 2021-06-08T02:05:58Z | - |
dc.date.copyright | 2016-03-08 | |
dc.date.issued | 2016 | |
dc.date.submitted | 2016-02-03 | |
dc.identifier.citation | Alaux C, Brunet JL, Dussaubat C, Mondet F, Tchamitchan S, Cousin M, Brillard J, Baldy A, Belzunces LP, Le Conte Y. 2010. Interactions between Nosema microspores and a neonicotinoid weaken honeybees (Apis mellifera). Environmental Microbiology 12:774-782.
Allis D. 2002. Translating the histone code: A tale of tails. Molecular Biology of the Cell 13:278-278. Antunez K, Martin-Hernandez R, Prieto L, Meana A, Zunino P, Higes M. 2009. Immune suppression in the honey bee (Apis mellifera) following infection by Nosema ceranae (Microsporidia). Environ Microbiol 11:2284-2290. Ashman TL, Knight TM, Steets JA, Amarasekare P, Burd M, Campbell DR, Dudash MR, Johnston MO, Mazer SJ, Mitchell RJ, Morgan MT, Wilson WG. 2004. Pollen limitation of plant reproduction: Ecological and evolutionary causes and consequences. Ecology 85:2408-2421. Bailey L. 1971. Honey-Bee Viruses. Sci Prog 59:309-323. Berenbaum MR. 2002. Postgenomic chemical ecology: From genetic code to ecological interactions. J Chem Ecol 28:873-896. Biergans SD, Galizia CG, Reinhard J, Claudianos C. 2015. Dnmts and Tet target memory-associated genes after appetitive olfactory training in honey bees. Sci Rep 5. Blandin S, Levashina EA. 2004. Thioester-containing proteins and insect immunity. Mol Immunol 40:903-908. Bogdanovic O, Veenstra GJC. 2009. DNA methylation and methyl-CpG binding proteins: developmental requirements and function. Chromosoma 118:549-565. Casteels P, Ampe C, Jacobs F, Vaeck M, Tempst P. 1989. Apidaecins - Antibacterial Peptides from Honeybees. EMBO J 8:2387-2391. Claudianos C, Ranson H, Johnson RM, Biswas S, Schuler MA, Berenbaum MR, Feyereisen R, Oakeshott JG. 2006. A deficit of detoxification enzymes: pesticide sensitivity and environmental response in the honeybee. Insect Mol Biol 15:615-636. Collotta M, Bertazzi PA, Bollati V. 2013. Epigenetics and pesticides. Toxicology 307:35-41. Cornman RS, Tarpy DR, Chen YP, Jeffreys L, Lopez D, Pettis JS, vanEngelsdorp D, Evans D. 2012. Pathogen Webs in Collapsing Honey Bee Colonies. Plos One 7. Cox-Foster DL, Conlan S, Holmes EC, Palacios G, Evans JD, Moran NA, Quan PL, Briese T, Hornig M, Geiser DM, Martinson V, vanEngelsdorp D, Kalkstein AL, Drysdale A, Hui J, Zhai JH, Cui LW, Hutchison SK, Simons JF, Egholm M, Pettis JS, Lipkin WI. 2007. A metagenomic survey of microbes in honey bee colony collapse disorder. Science 318:283-287. Cresswell JE, Thompson HM. 2012. Comment on 'A Common Pesticide Decreases Foraging Success and Survival in Honey Bees'. Science 337. Cummins CL, Mangravite LM, Benet LZ. 2001. Characterizing the expression of CYP3A4 and efflux transporters (P-gp, MRP1, and MRP2) in CYP3A4-transfected Caco-2 cells after induction with sodium butyrate and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate. Pharmaceut Res 18:1102-1109. Davie JR. 2003. Inhibition of histone deacetylase activity by butyrate. J Nutr 133:2485-2493. Decourtye A, Armengaud C, Renou M, Devillers J, Cluzeau S, Gauthier M, Pham-Delegue MH. 2004. Imidacloprid impairs memory and brain metabolism in the honeybee (Apis mellifera). Pestic Biochem Phys 78:83-92. Delpuech JM, Frey F, Carton Y. 1996. Action of insecticides on the cellular immune reaction of Drosophila melanogaster against the parasitoid Leptopilina boulardi. Environmental Toxicology and Chemistry 15:2267-2271. Desneux N, Decourtye A, Delpuech JM. 2007. The sublethal effects of pesticides on beneficial arthropods. Annual Review of Entomology 52:81-106. Dexter F. 2013. Wilcoxon-Mann-Whitney Test Used for Data That Are Not Normally Distributed. Anesth Analg 117:537-538. Di Prisco G, Cavaliere V, Annoscia D, Varricchio P, Caprio E, Nazzi F, Gargiulo G, Pennacchio F. 2013. Neonicotinoid clothianidin adversely affects insect immunity and promotes replication of a viral pathogen in honey bees. P Natl Acad Sci USA 110:18466-18471. Dokmanovic M, Clarke C, Marks PA. 2007. Histone deacetylase inhibitors: Overview and perspectives. Mol Cancer Res 5:981-989. Durmus Y, Buyukguzel K. 2008. Biological and immune response of Galleria mellonella (Lepidoptera : pyralidae) to sodium tetraborate. J Econ Entomol 101:777-783. Dziarski R, Gupta D. 2006. The peptidoglycan recognition proteins (PGRPs). Genome Biol 7. Evans JD, Aronstein K, Chen YP, Hetru C, Imler JL, Jiang H, Kanost M, Thompson GJ, Zou Z, Hultmark D. 2006. Immune pathways and defence mechanisms in honey bees Apis mellifera. Insect Mol Biol 15:645-656. Franssens V, Smagghe G, Simonet G, Claeys I, Breugelmans B, De Loof A, Vanden Broeck J. 2006. 20-hydroxyecdysone and juvenile hormone regulate the laminarin-induced nodulation reaction in larvae of the flesh fly, Neobellieria bullata. Dev Comp Immunol 30:735-740. Ganz T. 2003. Defensins: antimicrobial peptides of innate immunity. Nat Rev Immunol 3:710-720. Gonzalez-Varo JP, Biesmeijer JC, Bommarco R, Potts SG, Schweiger O, Smith HG, Steffan-Dewenter I, Szentgyorgyi H, Woyciechowski M, Vila M. 2013. Combined effects of global change pressures on animal-mediated pollination. Trends in Ecology & Evolution 28:524-530. Gregorc A, Evans JD, Scharf M, Ellis JD. 2012. Gene expression in honey bee (Apis mellifera) larvae exposed to pesticides and Varroa mites (Varroa destructor). J Insect Physiol 58:1042-1049. Gui CY, Ngo L, Xu WS, Richon VM, Marks PA. 2004. Histone deacetylase (HDAC) inhibitor activation of p21(WAF1) involves changes in promoter-associated proteins, including HDAC1. P Natl Acad Sci USA 101:1241-1246. Hassig CA, Tong JK, Fleischer TC, Owa T, Grable PG, Ayer DE, Schreiber SL. 1998. A role for histone deacetylase activity in HDAC1-mediated transcriptional repression. P Natl Acad Sci USA 95:3519-3524. Higes M, Garcia-Palencia P, Martin-Hernandez R, Meana A. 2007. Experimental infection of Apis mellifera honeybees with Nosema ceranae (Microsporidia). Journal of Invertebrate Pathology 94:211-217. Hinnebusch BF, Meng SF, Wu JT, Archer SY, Hodin RA. 2002. The effects of short-chain fatty acids on human colon cancer cell phenotype are associated with histone hyperacetylation. J Nutr 132:1012-1017. Hoffmann JA. 1995. Innate Immunity of Insects. Curr Opin Immunol 7:4-10. Huang CY, Chi LL, Huang WJ, Chen YW, Chen WJ, Kuo YC, Yuan CM, Chen CN. 2012. Growth Stimulating Effect on Queen Bee Larvae of Histone Deacetylase Inhibitors. Journal of Agricultural and Food Chemistry 60:6139-6149. Hultmark D. 1996. Insect lysozymes. EXS 75:87-102. James RR, Xu J. 2012. Mechanisms by which pesticides affect insect immunity. J Invertebr Pathol 109:175-182. Lambin M, Armengaud C, Raymond S, Gauthier M. 2001. Imidacloprid-induced facilitation of the proboscis extension reflex habituation in the honeybee. Archives of Insect Biochemistry and Physiology 48:129-134. Levenson JM, O'Riordan KJ, Brown KD, Trinh MA, Molfese DL, Sweatt JD. 2004. Regulation of histone acetylation during memory formation in the hippocampus. J Biol Chem 279:40545-40559. Licciardi PV, Karagiannis TC. 2012. Regulation of immune responses by histone deacetylase inhibitors. ISRN Hematol 2012:690901. Livak KJ, Schmittgen TD. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2 –△△Ct method. Methods 25:402-408. Mai A, Massa S, Rotili D, Cerbara I, Valente S, Pezzi R, Simeoni S, Ragno R. 2005. Histone deacetylation in epigenetics: An attractive target for anticancer therapy. Medicinal Research Reviews 25:261-309. Manfruelli P, Reichhart JM, Steward R, Hoffmann JA, Lemaitre B. 1999. A mosaic analysis in Drosophila fat body cells of the control of antimicrobial peptide genes by the Rel proteins Dorsal and DIF. EMBO J 18:3380-3391. Mao WF, Schuler MA, Berenbaum MR. 2011. CYP9Q-mediated detoxification of acaricides in the honey bee (Apis mellifera). P Natl Acad Sci USA 108:12657-12662. Marks PA, Miller T, Richon VM. 2003. Histone deacetylases. Current Opinion in Pharmacology 3:344-351. Mitsiades CS, Mitsiades NS, McMullan CJ, Poulaki V, Shringarpure R, Hideshima T, Akiyama M, Chauhan D, Munshi N, Gu XS, Bailey C, Joseph M, Libermann TA, Richon VM, Marks PA, Anderson KC. 2004. Transcriptional signature of histone deacetylase inhibition in multiple myeloma: Biological and clinical implications. P Natl Acad Sci USA 101:540-545. Mukherjee K, Fischer R, Vilcinskas A. 2012. Histone acetylation mediates epigenetic regulation of transcriptional reprogramming in insects during metamorphosis, wounding and infection. Frontiers in Zoology 9. Mullin CA, Frazier M, Frazier JL, Ashcraft S, Simonds R, vanEngelsdorp D, Pettis JS. 2010. High Levels of Miticides and Agrochemicals in North American Apiaries: Implications for Honey Bee Health. Plos One 5. Mustard JA, Beggs KT, Mercer AR. 2005. Molecular biology of the invertebrate dopamine receptors. Arch Insect Biochem 59:103-117. Mustard JA, Blenau W, Hamilton IS, Ward VK, Ebert PR, Mercer AR. 2003. Analysis of two D1-like dopamine receptors from the honey bee Apis mellifera reveals agonist-independent activity. Molecular Brain Research 113:67-77. Nicolas E, Reichhart JM, Hoffmann JA, Lemaitre B. 1998. In vivo regulation of the IkappaB homologue cactus during the immune response of Drosophila. J Biol Chem 273:10463-10469. Perrine SP, Miller BA, Faller DV, Cohen RA, Vichinsky EP, Hurst D, Lubin BH, Papayannopoulou T. 1989. Sodium-Butyrate Enhances Fetal Globin Gene-Expression in Erythroid Progenitors of Patients with Hb Ss and Beta-Thalassemia. Blood 74:454-459. Pettis JS, vanEngelsdorp D, Johnson J, Dively G. 2012. Pesticide exposure in honey bees results in increased levels of the gut pathogen Nosema. Naturwissenschaften 99:153-158. Pilling ED, Bromleychallenor KAC, Walker CH, Jepson PC. 1995. Mechanism of Synergism between the Pyrethroid Insecticide Lambda-Cyhalothrin and the Imidazole Fungicide Prochloraz, in the Honeybee (Apis mellifera). Pesticide Biochemistry and Physiology 51:1-11. Potts SG, Biesmeijer JC, Kremen C, Neumann P, Schweiger O, Kunin WE. 2010. Global pollinator declines: trends, impacts and drivers. Trends Ecol Evol 25:345-353. Ranson H, Claudianos C, Ortelli F, Abgrall C, Hemingway J, Sharakhova MV, Unger MF, Collins FH, Feyereisen R. 2002. Evolution of supergene families associated with insecticide resistance. Science 298:179-181. Rikhy R, Ramaswami M, Krishnan KS. 2003. A temperature-sensitive allele of Drosophila sesB reveals acute functions for the mitochondrial adenine nucleotide translocase in synaptic transmission and dynamin regulation. Genetics 165:1243-1253. Saber M, Hejazi MJ, Kamali K, Moharramipour S. 2005. Lethal and sublethal effects of fenitrothion and deltamethrin residues on the egg parasitoid Trissolcus grandis (Hymenoptera : Scelionidae). J Econ Entomol 98:35-40. Shao YF, Gao ZH, Marks PA, Jiang XJ. 2004. Apoptotic and autophagic cell death induced by histone deacetylase inhibitors. P Natl Acad Sci USA 101:18030-18035. Spotswood HT, Turner BM. 2002. An increasingly complex code. Journal of Clinical Investigation 110:577-582. Suchail S, Guez D, Belzunces LP. 2001. Discrepancy between acute and chronic toxicity induced by imidacloprid and its metabolites in Apis mellifera. Environmental Toxicology and Chemistry 20:2482-2486. Tabuchi Y, Takasaki I, Doi T, Ishii Y, Sakai H, Kondo T. 2006. Genetic networks responsive to sodium butyrate in colonic epithelial cells. FEBS Letters 580:3035-3041. Turrens JF. 2003. Mitochondrial formation of reactive oxygen species. J Physiol-London 552:335-344. Vo N, Goodman RH. 2001. CREB-binding protein and p300 in transcriptional regulation. J Biol Chem 276:13505-13508. Weirich GF, Collins AM, Williams VP. 2002. Antioxidant enzymes in the honey bee, Apis mellifera. Apidologie 33:3-14. Williamson SM, Wright GA. 2013. Exposure to multiple cholinergic pesticides impairs olfactory learning and memory in honeybees. Journal of Experimental Biology 216:1799-1807. Wu JY, Smart MD, Anelli CM, Sheppard WS. 2012. Honey bees (Apis mellifera) reared in brood combs containing high levels of pesticide residues exhibit increased susceptibility to Nosema (Microsporidia) infection. Journal of Invertebrate Pathology 109:326-329. Yang EC, Chuang YC, Chen YL, Chang LH. 2008. Abnormal Foraging Behavior Induced by Sublethal Dosage of Imidacloprid in the Honey Bee (Hymenoptera: Apidae). J Econ Entomol 101:1743-1748. Yin JCP, Tully T. 1996. CREB and the formation of long-term memory. Curr Opin Neurobiol 6:264-268. Yoshihara M, Montana ES. 2004. The synaptotagmins: Calcium sensors for vesicular trafficking. Neuroscientist 10:566-574. Zhao YM, Sun H, Lu J, Li XX, Chen X, Tao D, Huang WF, Huang BQ. 2005. Lifespan extension and elevated hsp gene expression in Drosophila caused by histone deacetylase inhibitors. Journal of Experimental Biology 208:697-705. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/19568 | - |
dc.description.abstract | 西方蜜蜂 (Apis mellifera) 是全球重要的經濟益蟲,也是生態系中重要的授粉者;蜜蜂負責植物授粉工作,對糧食生產的重要性極高;近幾十年來,自從農業藥劑問世後,對於生態系的衝擊受到高度重視,對蜜蜂的衝擊尤甚。近來全球各地皆有蜜蜂大量消失的報告,背後的成因尚未明朗,雖然蜂群消失非單一成因,農藥和病原菌極可能是元兇,許多研究指出受農藥影響的蜜蜂除了免疫功能表現受影響,對病原菌的抵抗變差,具神經毒性的農藥如益達安對蜜蜂的行為與記憶也具負面影影響。本研究使用組蛋白去乙醯化酶抑制劑來探討對蜜蜂基因調控與對抗逆境的影響;去乙醯化酶抑制劑主要參與組蛋白修飾,會抑制去乙醯化酶導致染色體結構較開放,而影響基因表現;研究中使用去乙醯化酶抑制劑,丁酸鈉作為蜜蜂飲食添加劑,利用即時聚合酶鏈鎖反應偵測基因表現,結果顯示丁酸鈉對蜜蜂免疫與解毒基因的表現量有提升效果;生物活性測試結果顯示蜜蜂對益達安的耐受度獲得提升,並較能抵禦微粒子蟲 (Nosema ceranae) 的入侵與降低蜜蜂病毒的感染。本實驗也初步分析丁酸鈉對蜜蜂記憶基因的調控,發現丁酸納對免疫、記憶與解讀相關基因具有提昇表現量的作用,提供初步的資訊給往後的研究,並了解蜜蜂如何抵抗逆境,以及去乙醯化酶抑制劑在養蜂資材的潛力應用 | zh_TW |
dc.description.provenance | Made available in DSpace on 2021-06-08T02:05:58Z (GMT). No. of bitstreams: 1 ntu-105-R01632006-1.pdf: 1067023 bytes, checksum: a429e3187414f5d02b9fbbc6110ed17a (MD5) Previous issue date: 2016 | en |
dc.description.tableofcontents | 1. Introduction 1
2. Materials and methods 5 2.1 Bee rearing 5 2.2 Total RNA preparation 5 2.3 cDNA synthesis 6 2.4 Relative quantitative RT-PCR expression 6 2.5 PCR array image and data analysis 7 2.6 Contact toxicity of imidacloprid 7 2.7 Microsporidian spore infection and purification 7 2.8 Statistical analysis 8 3. Results 9 3.1 The effects of NaB on immunity gene signaling factors and anti-microbial peptides 9 3.2 The effects of NaB on detoxification gene expression 10 3.3 Bioassay of topical treatment of imidacloprid on forager and nursing bees 11 3.4 Spore counting of Nosema ceranae and honey bee virus infection 12 3.5 The effects of NaB on memory genes 14 4. Discussion 16 References 24 | |
dc.language.iso | en | |
dc.title | 丁酸納對西方蜜蜂 (Apis mellifera) 免疫、記憶與解毒相關基因調控之研究 | zh_TW |
dc.title | Expression profiling of sodium butyrate-treated Apis mellifera: Identification of regulation of genes related to immune, memory and detoxification by sodium butyrate | en |
dc.type | Thesis | |
dc.date.schoolyear | 104-1 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 蔡志偉,吳佩穎,乃育昕 | |
dc.subject.keyword | 西洋蜜蜂,去乙醯化?抑制劑,免疫基因,解毒基因,記憶基因, | zh_TW |
dc.subject.keyword | Western honeybee,Sodium butyrate,immunity gene,detoxification gene,memory gene, | en |
dc.relation.page | 52 | |
dc.rights.note | 未授權 | |
dc.date.accepted | 2016-02-04 | |
dc.contributor.author-college | 生物資源暨農學院 | zh_TW |
dc.contributor.author-dept | 昆蟲學研究所 | zh_TW |
顯示於系所單位: | 昆蟲學系 |
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