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http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/19413完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 葉光勝(Kuang-Sheng Yeh) | |
| dc.contributor.author | Wan-Chen Lee | en |
| dc.contributor.author | 李婉甄 | zh_TW |
| dc.date.accessioned | 2021-06-08T01:57:52Z | - |
| dc.date.copyright | 2016-07-26 | |
| dc.date.issued | 2016 | |
| dc.date.submitted | 2016-06-30 | |
| dc.identifier.citation | 1. Aanensen DM, Spratt BG. 2005. The multilocus sequence typing network: mlst.net. Nucleic Acids Res. 33:W728-733.
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Vet Microbiol. 180:260-267. 122. Zhao WH, Hu ZQ. 2013. Epidemiology and genetics of CTX-M extended-spectrum beta-lactamases in Gram-negative bacteria. Crit Rev Microbiol. 39:79-101. 123. Zheng H, Zeng Z, Chen S, Liu Y, Yao Q, Deng Y, Chen X, Lv L, Zhuo C, Chen Z, Liu JH. 2012. Prevalence and characterisation of CTX-M beta-lactamases amongst Escherichia coli isolates from healthy food animals in China. Int J Antimicrob Agents. 39:305-310. 124. Zurfluh K, Nüesch-Inderbinen M, Morach M, Zihler Berner A, Hächler H, Stephan R. 2015. Extended-spectrum-beta-lactamase-producing Enterobacteriaceae isolated from vegetables imported from the Dominican Republic, India, Thailand, and Vietnam. Appl Environ Microbiol. 81:3115-3120. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/19413 | - |
| dc.description.abstract | 廣效性乙內醯胺酶 (Extended spectrum β-lactamases, ESBLs) 是一種可水解 β-lactams 類抗生素，包括第三代頭孢子素的酵素。雖然 ESBLs 在全球興起和散布成為嚴重的抗藥性問題，但在臺灣，對於家畜 ESBLs 監控的相關研究仍有限。本研究的目的在於研究分析 2015 年間臺灣中南部地區，由下痢仔豬糞便所分離之具有廣效性乙內醯胺酶之大腸桿菌。275 個糞便棉棒拭子來自於台中、南投、彰化、雲林、嘉義、台南和屏東共 16 個豬場的下痢仔豬，其中 54 株大腸桿菌分離株 (19.64%) 經表現型確認試驗確定為 ESBL producer。具 ESBL 的大腸桿菌在不同地區的檢出率如下：嘉義 27.71% (23/83)、台南 20.00% (6/30) 和屏東 21.01% (25/119)，台中、南投、彰化和雲林的豬場沒有從棉棒中分離到任何具 ESBL 的大腸桿菌。抗微生物藥物敏感性方面，所有的 54 株 ESBL 分離株對於 ampicillin、amoxicillin、penicillin-G、cephalexin、cephalothin、ceftiofur、chlortetracycline、oxytetracycline 和 tetracycline 都顯示抗藥性，只有amikacin (20.37%)、amoxicillin-clavulanic acid (42.59%)、gentamicin (62.96%)、doxycycline (48.15%) 和 colistin (0.00%) 部分呈現非抗藥性。ESBL 基因型的結果中，TEM 和 CTX-M group 是兩個主要的 ESBL 基因型，blaSHV 則沒有發現於這 54 株 ESBL 陽性大腸桿菌分離株中。27 株分離株帶有 blaTEM-116、blaCTX-M-55 和 blaCTX-M-15 分別有 34 株 (34/54, 62.96%) 和 16 株 (16/54, 29.63%) 分離株，其中，有 23 株 ESBL 陽性大腸桿菌分離株同時帶有 blaTEM-116 和 blaCTX-M-55 (18/23, 33.33%)/blaCTX-M-15 (5/23, 9.26%)，另外還有唯一一株具有 blaTEM-116、blaCTX-M-55 和 blaCTX-M-65。多重基因座序列分型法 (Multilocus sequence typing, MLST) 分析顯示 ST10 clonal complexes 是最主要的族群，包括 ST10、ST167、ST44 和 ST617。ST4981 和 ST167 是在所有 ESBL 分離株中最常見的序列型。ST4981 和 ST10 分別在嘉義和屏東地區為主要流行序列型，台南地區則沒有特別流行的 ST 序列。
此研究為首次於台灣豬源大腸桿菌中檢測出 TEM-116、CTX-M-15 和 CTX-M-55乙內醯胺酶序列，抗藥性程度的增加也可能顯示著治療上的困難。從公共衛生的觀點看，下痢仔豬有可能是傳遞 ESBL 的重要保菌宿主之一，這類相關的議題值得更深入的調查研究。 | zh_TW |
| dc.description.abstract | Extended spectrum β-lactamases (ESBLs) are enzymes capable of hydrolyzing beta-lactam antimicrobials, including the third-generation cephalosporins. Although the global emergence and spread of ESBLs is a serious antimicrobial resistance problem, there are limited surveillance studies regarding the ESBL of livestock in Taiwan. The objective of the present study was to analyze the fecal carriage of ESBL-producing Escherichia coli isolates from the piglets with diarrhea in the Central and Southern Taiwan during 2015. Two hundred and seventy-five fecal swabs were obtained from the piglets with diarrhea in 16 pig farms located in Taichung, Nantou, Chunghua, Yunlin, Chiayi, Tainan and Pingtung. Fifty-four E.coli isolates (19.64%) were confirmed as ESBL producers by the phenotypic confirmatory tests. The ESBL-producing E. coli detection rates in different regions were as follows: Chiayi 27.71% (23/83), Tainan 20.00% (6/30) and Pingtung 21.01% (25/119). No ESBL-producers were detected from the pig farms located in Taichung, Nantou, Chunghua and Yunlin. In respect of the antibiotic susceptibility, all 54 ESBL isolates showed resistance to ampicillin, amoxicillin, penicillin-G, cephalexin, cephalothin, ceftiofur, chlortetracycline, oxytetracycline and tetracycline, while parts of those isolates exhibited non-resistance to amikacin (20.37%), amoxicillin-clavulanic acid (42.59%), gentamicin (62.96%), doxycycline (48.15%) and colistin (0.00%). As for the results of ESBL genotype, TEM and CTX-M groups were the two major ESBL genes and no blaSHV was detected in 54 ESBL-positive E.coli isolates. Twenty-seven isolates harbored the blaTEM-116 gene. The blaCTX-M-55 and blaCTX-M-15 were identified in 34 (34/54, 62.96%) and 16 (16/54, 29.63%) isolates respectively. Among them, 23 ESBL-positive E.coli isolates carried both the blaTEM-116 and blaCTX-M-55 (18/23, 33.33%) /blaCTX-M-15 (5/23, 9.26%), while only one isolate possessed blaTEM-116, blaCTX-M-55 and blaCTX-M-65. Multilocus sequence typing (MLST) revealed that ST10 clonal complexes were the predominant group, including ST10, ST167, ST44 and ST617. ST4981 and ST167 were the most common sequence types in all ESBL isolates. ST4981 and ST10 were the dominant type in Chiayi and Pingtung, respectively, whereas no particular ST type was dominant in Tainan.
This study reported for the first time that TEM-116, CTX-M-15 and CTX-M-55 β-lactamases sequences were present in the E. coli strains isolated from swine in Taiwan. Increased level of antibiotic resistance may also indicate the difficulty in clinical treatment. From the point of view of public health, the piglets with diarrhea may be one of the reservoirs in transmission ESBLs, and such issue warrants further investigation. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-08T01:57:52Z (GMT). No. of bitstreams: 1 ntu-105-R02629007-1.pdf: 2095005 bytes, checksum: 4ca766d8f7fad8b66d3ded4bfcc03551 (MD5) Previous issue date: 2016 | en |
| dc.description.tableofcontents | 中文摘要………………………………………………………………………………i
英文摘要………………………………………………………………………………iii 目錄………………………………………………………………………………v 第一章 序言…………………………………………………………………………1 第二章 文獻回顧……………………………………………………………………3 第一節 大腸桿菌………………………………………………………………3 2-1-1 型態與背景介紹…………………………………………………3 2-1-2 大腸桿菌型態與生化特性………………………………………3 2-1-3 大腸桿菌的血清型與毒素………………………………………4 第二節 大腸桿菌的抗藥性機制………………………………………………6 2-2-1 通透性的改變……………………………………………………6 2-2-2 藥物排出幫浦系統………………………………………………6 2-2-3 改變藥物與結合標的或流程……………………………………7 2-2-4 產生酶將藥物不活化……………………………………………7 第三節 β-lactam 類抗生素……………………………………………………8 2-3-1 青黴素類…………………………………………………………9 2-3-2 頭孢子素類……………………………………………………..9 2-3-3 碳青黴烯類……………………………………………………..10 2-3-4 單環內醯胺類…………………………………………………..10 第四節 廣效性乙內醯胺酶…………………………………………………..10 2-4-1. β-lactamase 分類…………………………………………….....11 2-4-2. ESBLs 基因型………………………………………………….13 第五節 多重基因座序列分型法 (Multilocus sequence typing, MLST)……18 第六節 ESBLs 流行病學相關研究………………………………………….18 2-5-1. ESBLs 在人醫的流行概況…………………………………….19 2-5-2. ESBLs 在伴侶動物的流行概況……………………………….23 2-5-3. ESBLs 在經濟動物的流行概況……………………………….24 第七節 研究目的……………………………………………………………26 第三章 材料與方法………………………………………………………………27 第一節 菌株來源……………………………………………………………27 第二節 ESBL E. coli 初步篩選與生化鑑定………………………………27 第三節 ESBL 表現型鑑定..…………………………………………………27 第四節 萃取細菌 DNA (加熱煮沸法) ……………………………………28 第五節 抗微生物藥物感受性試驗……………………………………29 第六節 β-lactamase 基因型測定……………………………………29 第七節 MLST 序列定序分析……………………………………30 第四章 研究結果……………………………………32 第一節 ESBL 菌株各區分離率………………32 第二節 ESBL 菌株之抗微生物藥物感受性試驗結果………………………………………………………………………………32 第三節 β-lactamase 基因型檢測結果…………33 第四節 ESBL-producing E.coli 之 MLST 分析結果………………………………………………………………………………33 第五節 ESBL-producing E.coli 之綜合地緣分布………………………………………………………………………………34 第五章 討論……………………………………35 第六章 結論……………………………………41 第七章 參考資料……………………………………43 表次 Table 1. ……………………………………55 Table 2. ……………………………………56 Table 3. ……………………………………57 Table 4. ……………………………………58 Table 5. ……………………………………59 圖次 Figure 1. ……………………………………60 Figure 2. ……………………………………61 Figure 3. ……………………………………62 附錄 Appendix 1. ……………………………………63 Appendix 2. ……………………………………64 Appendix 3. ……………………………………65 Appendix 4. ……………………………………66 Appendix 5. ……………………………………66 Appendix 6. ……………………………………67 Appendix 7. ……………………………………68 Appendix 8. ……………………………………68 Appendix 9. ……………………………………69 Appendix 10. ……………………………………70 Appendix 11. ……………………………………70 Appendix 12. ……………………………………71 | |
| dc.language.iso | zh-TW | |
| dc.title | 由臺灣中南部地區下痢仔豬分離之廣效性乙內醯胺酶大腸桿菌之特性分析 | zh_TW |
| dc.title | Characteristics of Extended Spectrum β-lactamase-producing Escherichia coli from the Piglets with Diarrhea in Central and Southern Taiwan | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 104-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 陳德勛(Ter-Hsin Chen),宣詩玲(Shih-Ling Hsuan) | |
| dc.subject.keyword | 廣效性乙內醯胺?,大腸桿菌,多重基因座序列分析,下痢仔豬, | zh_TW |
| dc.subject.keyword | ESBL,TEM-116,CTX-M-55,E. coli,MLST,piglets with diarrhea, | en |
| dc.relation.page | 71 | |
| dc.identifier.doi | 10.6342/NTU201600230 | |
| dc.rights.note | 未授權 | |
| dc.date.accepted | 2016-06-30 | |
| dc.contributor.author-college | 獸醫專業學院 | zh_TW |
| dc.contributor.author-dept | 獸醫學研究所 | zh_TW |
| 顯示於系所單位： | 獸醫學系 | |
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