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| ???org.dspace.app.webui.jsptag.ItemTag.dcfield??? | Value | Language |
|---|---|---|
| dc.contributor.advisor | 林啟萬(Chii-Wann Lin) | |
| dc.contributor.author | Chang-Long Li | en |
| dc.contributor.author | 李長瓏 | zh_TW |
| dc.date.accessioned | 2021-06-08T01:57:31Z | - |
| dc.date.copyright | 2016-07-25 | |
| dc.date.issued | 2016 | |
| dc.date.submitted | 2016-06-30 | |
| dc.identifier.citation | [1]Global status report on noncommunicable diseases 2014: attaining the nine global noncommunicable diseases targets; a shared responsibility',WHO, Geneva.(2015)
[2]Global Health Estimates: Deaths by Cause, Age, Sex and Country, 2000-2012',Geneva, WHO.(2014) [3] C.D Mathers, and D.Loncar 'Projections of global mortality and burden of disease from 2002 to 2030',Plos med.3(2006): e442 [4]The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus',N Engl J Med.329(1993): 977-986 [5] J. Brauker, 'Continuous glucose sensing: future technology developments',Diabetes technology & therapeutics.11(2009): S-25-S-36 [6] S.P. Nichols , et al., 'Biocompatible materials for continuous glucose monitoring devices',Chemical reviews.113(2013): 2528-2549 [7] B. Feldman, et al., 'A continuous glucose sensor based on Wired Enzyme™ technology-Results from a 3-day trial in patients with type 1 diabetes',Diabetes technology & therapeutics.5(2003): 769-779 [8]S.K. Garg, et al., 'Comparison of accuracy and safety of the SEVEN and the Navigator continuous glucose monitoring systems',Diabetes technology & therapeutics.11(2009): 65-72 [9] N. Tubiana-Rufi, J.-P. Riveline, and D. Dardari , 'Real-time continuous glucose monitoring using Guardian® RT: from research to clinical practice',Diabetes & metabolism.33(2007): 415-420 [10] M.M. Rahman, et al., 'A comprehensive review of glucose biosensors based on nanostructured metal-oxides',Sensors.10(2010): 4855-4886 [11] S. Park , 'Electrochemical non-enzymatic glucose sensors',Analytica Chimica Acta.556(2006): 46-57 [12] R. Wilson and A. Turner, 'Glucose oxidase: an ideal enzyme',Biosensors and Bioelectronics.7(1992): 165-185 [13] R.F. Taylor, 'Protein immobilization: fundamentals and applications',(1991) [14] L. Clark, et al. 1987, Oxford University Press New York. [15] S. Cosnier, 'Biosensors based on electropolymerized films: new trends',Analytical and Bioanalytical Chemistry.377(2003): 507-520 [16] G. Binyamin , J. Cole, and A. Heller 'Mechanical and electrochemical characteristics of composites of wired glucose oxidase and hydrophilic graphite',Journal of the Electrochemical Society.147(2000): 2780-2783 [17] N. Mano , 'Detection of glucose at 2 fM concentration',Analytical chemistry.77(2005): 729-732 [18] S. Park , T.D. Chung, and H.C. Kim 'Nonenzymatic glucose detection using mesoporous platinum',Analytical chemistry.75(2003): 3046-3049 [19] K. Tian M. Prestgard, and A. Tiwari , 'A review of recent advances in nonenzymatic glucose sensors',Materials Science and Engineering: C.41(2014): 100-118 [20] Z. Zhu, et al., 'A critical review of glucose biosensors based on carbon nanomaterials: carbon nanotubes and graphene',Sensors.12(2012): 5996-6022 [21] J. Wang, 'Amperometric biosensors for clinical and therapeutic drug monitoring: a review',Journal of pharmaceutical and biomedical analysis.19(1999): 47-53 [22] K.E. Toghill, and R.G. Compton, 'Electrochemical non-enzymatic glucose sensors: a perspective and an evaluation',Int J Electrochem Sci.5(2010): 1246-1301 [23] Y. Sun, H. Buck, and T.E. Mallouk, 'Combinatorial discovery of alloy electrocatalysts for amperometric glucose sensors',Analytical chemistry.73(2001): 1599-1604 [24] Y. Zhang , et al., 'Ultrasensitive and selective non-enzymatic glucose detection using copper nanowires',Biosensors and Bioelectronics.31(2012): 426-432 [25] B.J. Sanghavi and A.K. Srivastava , 'Adsorptive stripping differential pulse voltammetric determination of venlafaxine and desvenlafaxine employing Nafion–carbon nanotube composite glassy carbon electrode',Electrochimica Acta.56(2011): 4188-4196 [26] S. Ranganathan, T.-C. Kuo, and R.L. McCreery, 'Facile preparation of active glassy carbon electrodes with activated carbon and organic solvents',Analytical Chemistry.71(1999): 3574-3580 [27] H.-B. Noh , et al., 'Application of a Cu–Co alloy dendrite on glucose and hydrogen peroxide sensors',Electrochimica Acta.61(2012): 36-43 [28] Y. Miao, et al., 'Electrocatalysis and electroanalysis of nickel, its oxides, hydroxides and oxyhydroxides toward small molecules',Biosensors and Bioelectronics.53(2014): 428-439 [29] C. Li, H. Wang, and Y. Yamauchi , 'Electrochemical deposition of mesoporous Pt–Au alloy films in aqueous surfactant solutions: towards a highly sensitive amperometric glucose sensor',Chemistry-A European Journal.19(2013): 2242-2246 [30] X. Cao, et al., 'Detection of glucose based on bimetallic PtCu nanochains modified electrodes',Analytical chemistry.85(2013): 5040-5046 [31] J.H. Shim, et al., 'Nonenzymatic amperometric glucose sensor based on nanoporous gold/ruthenium electrode',Electroanalysis.23(2011): 2057-2062 [32] M. Shao , et al., 'Magnetic-field-assisted assembly of layered double hydroxide/metal porphyrin ultrathin films and their application for glucose sensors',Langmuir.27(2011): 8233-8240 [33] G. Wittstock, et al., 'Glucose oxidation at bismuth-modified platinum electrodes',Journal of Electroanalytical Chemistry.444(1998): 61-73 [34] X. Zhang, et al., 'Partial oxidation of glucose by a Pt| WO 3 electrode',Journal of Electroanalytical Chemistry.430(1997): 147-153 [35] J. Wang, D.F. Thomas, and A. Chen 'Nonenzymatic electrochemical glucose sensor based on nanoporous PtPb networks',Analytical Chemistry.80(2008): 997-1004 [36] E.A. Irhayem, A. Jhas, and V. Birss, 'Glucose detection at sol-derived nanoparticulate Ir oxide films',J Electroanal Chem.538(2002): 153-164 [37] M.Rodriguez and G. Rivas, 'Glucose biosensor prepared by the deposition of iridium and glucose oxidase on glassy carbon transducer',Electroanalysis.11(1999): 558-564 [38] F. Xu, et al., 'Amperometric sensor for glucose and hypoxanthine based on a Pd-IrO 2 modified electrode by a co-crosslinking bienzymic system',Talanta.57(2002): 365-373 [39]J. Wang, G. Rivas, and M. Chicharro, 'Glucose microsensor based on electrochemical deposition of iridium and glucose oxidase onto carbon fiber electrodes',Journal of Electroanalytical Chemistry.439(1997): 55-61 [40] P. Holt-Hindle, et al., 'Amperometric glucose sensor based on platinum–iridium nanomaterials',Electrochemistry Communications.10(2008): 1438-1441 [41] Y.-Y. Fang, Y.-C. Hsieh, and C.-W. Lin, 'Electroplating of Nanostructured Pt, Ir and Pt-Ir at Room Temperature',Journal of The Electrochemical Society.159(2012): D518-D520 [42] Y.-Y. Fang, Y.-C. Hsieh, and C.-W. Lin, 'NANOSTRUCTURED Pt–Ir NON-ENZYMATIC GLUCOSE SENSORS',Biomedical Engineering: Applications, Basis and Communications.25(2013): 1350048 [43] L.C. Clark and C. Lyons, 'Electrode systems for continuous monitoring in cardiovascular surgery',Annals of the New York Academy of sciences.102(1962): 29-45 [44] S. Updike and G. Hicks, 'The enzyme electrode',Nature.214(1967): 986-988 [45] G. Nagy, L. Von Storp, and G. Guilbault , 'Enzyme electrode for glucose based on an iodide membrane sensor',Analytica chimica acta.66(1973): 443-445 [46] M.H. Beers, et al. 2003: Pocket Books. [47] A .Mulchandani and S. Pan, 'Ferrocene-Conjugatedm-Phenylenediamine Conducting Polymer-Incorporated Peroxidase Biosensors',Analytical biochemistry.267(1999): 141-147 [48] S. Tsujimura, et al., 'Novel FAD-dependent glucose dehydrogenase for a dioxygen-insensitive glucose biosensor',Bioscience, biotechnology, and biochemistry.70(2006): 654-659 [49] M.G. Loughran, J.M. Hall, and A.P. Turner, 'Development of a pyrroloquinoline quinone (PQQ) mediated glucose oxidase enzyme electrode for detection of glucose in fruit juice',Electroanalysis.8(1996): 870-875 [50] K.T. Lau, et al., 'Disposable Glucose Sensors for Flow Injection Analysis Using Substituted 1, 4‐Benzoquinone Mediators',Electroanalysis.15(2003): 975-981 [51] C. Taylor, et al., '“Wiring” of glucose oxidase within a hydrogel made with polyvinyl imidazole complexed with [(Os-4, 4′-dimethoxy-2, 2′-bipyridine) Cl]+/2+ 1',Journal of Electroanalytical Chemistry.396(1995): 511-515 [52] A. Heller and B. Feldman, 'Electrochemistry in diabetes management',Accounts of chemical research.43(2010): 963-973 [53] F. Mao and A. Heller., Transition metal complexes with (pyridyl) imidazole ligands and sensors using said complexes. 2004. [54] A. Heller, Small volume in vitro analyte sensor. 2003. [55] Y. Wang and F. Caruso, 'Enzyme encapsulation in nanoporous silica spheres',Chemical Communications.(2004): 1528-1529 [56] S. Wu, H. Ju, and Y. Liu, 'Conductive mesocellular silica-carbon nanocomposite foams for immobilization, direct electrochemistry, and biosensing of proteins',Advanced Functional Materials.17(2007): 585-592 [57] S.J. Bao, et al., 'New nanostructured TiO2 for direct electrochemistry and glucose sensor applications',Advanced Functional Materials.18(2008): 591-599 [58] J. Wu and Y. Qu, 'Mediator-free amperometric determination of glucose based on direct electron transfer between glucose oxidase and an oxidized boron-doped diamond electrode',Analytical and bioanalytical chemistry.385(2006): 1330-1335 [59] F. Palmisano, et al., 'A disposable, reagentless, third-generation glucose biosensor based on overoxidized poly (pyrrole)/tetrathiafulvalene-tetracyanoquinodimethane composite',Analytical chemistry.74(2002): 5913-5918 [60] J. Li and X. Lin, 'Glucose biosensor based on immobilization of glucose oxidase in poly (o-aminophenol) film on polypyrrole-Pt nanocomposite modified glassy carbon electrode',Biosensors and Bioelectronics.22(2007): 2898-2905 [61] B. Wu, et al., 'Biosensors for determination of glucose with glucose oxidase immobilized on an eggshell membrane',Talanta.64(2004): 546-553 [62] K. Han , et al., 'Activity of glucose oxidase entrapped in mesoporous gels',Biochemical engineering journal.22(2005): 161-166 [63] S.A. Wring, et al., 'Development of screen-printed carbon electrodes, chemically modified with cobalt phthalocyanine, for electrochemical sensor applications',Analytica chimica acta.231(1990): 203-212 [64] J. Newman, A. Turner, and G. Marrazza , 'Ink-jet printing for the fabrication of amperometric glucose biosensors',Analytica chimica acta.262(1992): 13-17 [65] L. Meng, et al., 'Nonenzymatic electrochemical detection of glucose based on palladium− single-walled carbon nanotube hybrid nanostructures',Analytical chemistry.81(2009): 7271-7280 [66] G. Wang, et al., 'Non-enzymatic electrochemical sensing of glucose',Microchimica Acta.180(2013): 161-186 [67] J. Wang, 'Glucose microsensor based on electrochemical deposition of iridium and glucose oxidase onto carbon fiber electrodes',Journal of Electroanalytical Chemistry.439(1997): 55-61 [68] E. Abu Irhayem, et al., 'Glucose detection based on electrochemically formed Ir oxide films',Journal of Electroanalytical Chemistry.538(2002): 153-164 [69] J.H. Shim and J. Wang, 'Applications of Porous Pt‐Filled Micropore Electrode: Direct Amperometric Glucose Detection and Potentiometric pH Sensing',Electroanalysis.23(2011): 2063-2069 [70] S. Joo,et al., 'Integration of a nanoporous platinum thin film into a microfluidic system for non-enzymatic electrochemical glucose sensing',Analytical Sciences.23(2007): 277-281 [71] J. Yuan, K. Wang, and X. Xia, 'Highly Ordered Platinum‐Nanotubule Arrays for Amperometric Glucose Sensing',Advanced Functional Materials.15(2005): 803-809 [72] M. Guo, et al., 'Ultrasonic electrodeposition of platinum nanoflowers and their application in nonenzymatic glucose sensors',Electrochimica Acta.63(2012): 1-8 [73] J.F. Huang , '3‐D Nanoporous Pt Electrode Prepared by a 2‐D UPD Monolayer Process',Electroanalysis.20(2008): 2229-2234 [74] C.H. Chou, et al., 'A Nonenzymatic Glucose Sensor Using Nanoporous Platinum Electrodes Prepared by Electrochemical Alloying/Dealloying in a Water‐Insensitive Zinc Chloride‐1‐Ethyl‐3‐Methylimidazolium Chloride Ionic Liquid',Electroanalysis.20(2008): 771-775 [75] Y.-J. Lee, et al., 'Fabrication and optimization of a nanoporous platinum electrode and a non-enzymatic glucose micro-sensor on silicon',Sensors.8(2008): 6154-6164 [76] Y.Y. Song, et al., 'Nonenzymatic glucose detection by using a three‐dimensionally ordered, macroporous platinum template',Chemistry–A European Journal.11(2005): 2177-2182 [77] Y.J. Lee, D.J. Park, and J.Y. Park, 'Fully packaged nonenzymatic glucose microsensors with nanoporous platinum electrodes for anti-fouling',Sensors Journal, IEEE.8(2008): 1922-1927 [78] Z. Cao, et al., 'Amperometric glucose biosensor based on ultrafine platinum nanoparticles',Analytical Letters.40(2007): 2116-2127 [79] Q. Shen, et al., 'Three-dimensional dendritic Pt nanostructures: sonoelectrochemical synthesis and electrochemical applications',The Journal of Physical Chemistry C.112(2008): 16385-16392 [80] P. Luo, F. Zhang, and R.P. Baldwin, 'Comparison of metallic electrodes for constant-potential amperometric detection of carbohydrates, amino acids and related compounds in flow systems',Analytica chimica acta.244(1991): 169-178 [81] J.C. Fanguy , 'Pulsed amperometric detection of carbohydrates on an electrophoretic microchip',Analyst.127(2002): 1021-1023 [82] Y.-J. Lee, 'A coral-like macroporous gold–platinum hybrid 3D electrode for enzyme-free glucose detection',Sensors and Actuators B: Chemical.155(2011): 134-139 [83] M. Guo, 'Electrosynthesis of pinecone-shaped Pt–Pb nanostructures based on the application in glucose detection',Materials Science and Engineering: C.31(2011): 1700-1705 [84] S.S. Mahshid, et al., 'Template-based electrodeposition of Pt/Ni nanowires and its catalytic activity towards glucose oxidation',Electrochimica Acta.58(2011): 551-555 [85] Y. Bai, Y. Sun, and C. Sun, 'Pt–Pb nanowire array electrode for enzyme-free glucose detection',Biosensors and Bioelectronics.24(2008): 579-585 [86]胡啟章. 電化學原理與方法. 2002: 五南圖書出版股份有限公司. [87] Y.B. Vassilyev, O. Khazova, and N. Nikolaeva, 'Kinetics and mechanism of glucose electrooxidation on different electrode-catalysts: Part I. Adsorption and oxidation on platinum', Journal of electroanalytical chemistry and interfacial electrochemistry.196(1985): 105-125 [88] F. L argeaud, et al., 'On the electrochemical reactivity of anomers: electrocatalytic oxidation of α-and β-d-glucose on platinum electrodes in acid and basic media',Journal of Electroanalytical Chemistry.397(1995): 261-269 [89] A.A. RossiNi and J.S. Soeldner, 'Insulin release is glucose anomeric specific in the human',Journal of Clinical Investigation.57(1976): 1083 [90] D. Pletcher, 'Electrocatalysis: present and future',Journal of applied electrochemistry.14(1984): 403-415 [91] F. Xiao, et al., 'Nonenzymatic glucose sensor based on ultrasonic-electrodeposition of bimetallic PtM (M= Ru, Pd and Au) nanoparticles on carbon nanotubes–ionic liquid composite film',Biosensors and Bioelectronics.24(2009): 3481-3486 [92] D. Rathod, et al., 'Platinum nanoparticle decoration of carbon materials with applications in non-enzymatic glucose sensing',Sensors and Actuators B: Chemical.143(2010): 547-554 | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/19406 | - |
| dc.description.abstract | 人體中葡萄糖濃度(Glucose concentration)是糖尿病治療、診斷與監控的黃金指標。傳統上所使用的葡萄糖感測器，是利用葡萄糖與電極上的酵素結合，透過化學反應產生與葡萄糖濃度成正比的電流來感測。然而傳統酵素感測器除了會遇到製程和保存上的困難，酵素在人體內無法長期保存而人體被代謝。
本研究中，嘗試用非酵素式且具有高度生物相容性的材料Pt-Ir 取代傳統酵素型的葡萄糖感測器，希望未來能應用於連續式葡萄糖監控(continuous glucose monitoring, CGM)。本研究分為兩階段，第一階段為Pt-Ir葡萄糖感測器製程及功能測試，內容包含由泰博公司所提供的葡萄糖感測器的電極，透過後製程和穩定性開發測試以及感測器特性測試(sensitivity and selectivity)，並透過高密度恆電流(galvanostatic)電鍍的方式，造成工作電極(working electrode)的奈米結構呈現葉片狀(leaf-like)來增加催化反應面積(catalytic reaction area)。第二階段為動物實驗，以小鼠為實驗標的，測試感測器的穩定性及植入後使用時間的表現。 | zh_TW |
| dc.description.abstract | Glucose concentration in human bodies is gold criteria for Diabetes Mellitus of diagnosis and treatment. The conventional glucose sensors are utilized enzyme electrode to sensing glucose moleculars. However, the conventional enzyme glucose sensors are difficult to synthesis , store and long-term stay in human bodies.
In this research, we attempt using non-enzymatic platinum-Iridium(Pt-Ir) glucose sensor to replace conventional glucose sensors and look forward to applicate in continuous glucose monitoring(CGM). The research were separated into two parts, the first is the fabrication of platinum-Iridium glucose sensor and its feasibility test, including sensitivity, linearity and interference test. The substrate of the electrode is come from TaiDoc Technology and then using galvanostatic method to electroplate the nano-structure of Pt-Ir. The leaf-like of the nano-structure is believed that can increase the catalytic reaction area. The second part is the animal test, the electrodes were implanted into the subcutaneous of mice to test the stability and life cycle. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-08T01:57:31Z (GMT). No. of bitstreams: 1 ntu-105-R03548051-1.pdf: 5727168 bytes, checksum: 1ed0b0fb964f32e5415efebbb7c0183a (MD5) Previous issue date: 2016 | en |
| dc.description.tableofcontents | 謝辭.....................................................................................i
中文摘要.............................................................................ii Abstract.............................................................................iii 目錄................................................................. ..................iv 圖目錄................................................................................vii 表目錄.................................................................................x 第一章:緒論.........................................................................1 1.1背景介紹............................................................................1 1.2葡萄糖感測器之應用..........................................................4 1.2.1 酵素葡萄糖感測器..................................................5 1.2.1.1 第一代葡萄糖感測器.................................7 1.2.1.2 第二代葡萄糖感測器.................................8 1.2.1.3 第三代葡萄糖感測器.................................8 1.2.1.4酵素葡萄糖感測器的優勢與劣勢……….....9 1.2.2 非酵素葡萄糖感測器(第四代葡萄糖感測器)……...9 第二章:理論介紹.................................................................13 2.1 引言..................................................................................13 2.2電化學感測器系統.............................................................13 2.3 電化學分析法....................................................................14 2.3.1循環伏安法..............................................................15 2.3.2電流分析法..............................................................17 2.4 非酵素式葡萄糖感測原理..................................................17 2.4.1 葡萄糖的旋變..........................................................18 2.4.2 非酵素式電化學催化理論........................................19 第三章:實驗材料與研究方法...............................................21 3.1 PET/Ti/Pt-Ir電極晶片穩定性測試與特性分析....................22 3.1.1 材料與配置…………………………………….………22 3.1.2 樣本參數與準備……………………………………….22 3.1.3 電極示意圖…………………………………………….22 3.1.4 電鍍參數………………………………………….…....23 3.2 小鼠晶片植入與量測分析..................................................24 3.2.1 電極表面型態觀察設計……………………….………24 3.2.1 電極基本量測設計…………………………………….24 第四章:實驗結果與討論......................................................25 4.1 PET/Au/Pt-Ir電極晶片穩定性測試與特性分析..................25 4.1.1晶片穩定性測試結果………………………………….25 4.1.2 晶片特性分析結果……………………………………26 4.2 PET/Au/Pt-Ir電極晶片穩定性測試與特性分析..................31 4.2.1晶片穩定性測試結果………………………………….31 4.2.2 晶片特性分析結果……………………………….…...33 4.3 小鼠晶片植入與量測分析.................................................60 4.3.1表面型態觀察...........................................................60 4.3.2電極功能性測試.......................................................62 第五章:結論與未來展望......................................................68 參考文獻.............................................................................72 | |
| dc.language.iso | zh-TW | |
| dc.title | 連續式非酵素葡萄糖感測器可行性研究 | zh_TW |
| dc.title | Feasibility Study on Continuous Nonenzymatic Sensors for Glucose Sensing | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 104-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 陳林祈(Lin-Chi Chen),楊佩芬(Pei-Fen Yang) | |
| dc.subject.keyword | 糖尿病,非酵素感測器,連續式血糖檢測,奈米結構,小鼠植入, | zh_TW |
| dc.subject.keyword | Diabetes Mellitus,non-enzymatic glucose sensor,continuous glucose sensor,nano-structure,mice implant, | en |
| dc.relation.page | 77 | |
| dc.identifier.doi | 10.6342/NTU201600609 | |
| dc.rights.note | 未授權 | |
| dc.date.accepted | 2016-07-01 | |
| dc.contributor.author-college | 工學院 | zh_TW |
| dc.contributor.author-dept | 醫學工程學研究所 | zh_TW |
| Appears in Collections: | 醫學工程學研究所 | |
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