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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 張瑞青(Jenny Zwei-Chieng Chang),杜裕康(Yu-Kang Tu) | |
| dc.contributor.author | You-Ning Gao | en |
| dc.contributor.author | 高佑寧 | zh_TW |
| dc.date.accessioned | 2021-06-08T01:48:11Z | - |
| dc.date.copyright | 2016-08-26 | |
| dc.date.issued | 2016 | |
| dc.date.submitted | 2016-08-03 | |
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/19190 | - |
| dc.description.abstract | 睡眠呼吸中止症候群是成人常見的睡眠障礙疾病，病人在睡眠期間會反覆的發生上呼吸道的阻塞，進而產生睡眠品質不良及其他健康相關疾病。最常見的治療為正壓呼吸器，但是有部分病人因為噪音等接受度不好。其他的治療方式包含口內止鼾器，呼吸道相關手術等，多數研究顯示治療效果良好，且病人接受度佳。此篇系統性文獻回顧以網絡統合分析的方式在探討成人睡眠呼吸中止症候群的極微侵入性治療效果。本研究經由 Embase、Medline、Pubmed 以及 Cochrane 資料庫進行系統性文獻回顧，只選用隨機分派對照試驗。研究結果顯示在評估各種治療的效果後，建議以正壓呼吸器治療效果最佳，口內止鼾器可有效地用在治療無法接受正壓呼吸器的病人。 | zh_TW |
| dc.description.abstract | Obstructive sleep apnea-hypopnea syndrome (OSAHS) is a common sleep disorder in adults. The aim of this study was to develop a systematic review and a Bayesian network meta-analysis to compare the objective and subjective outcomes of different minimally-invasive treatments in adult OSAHS patients. An electronic literature search was performed via Ovid within Embase, MEDLINE (via PubMed), and Cochrane databases. Only randomized-controlled trials were included in this study. Interventions for OSAHS including continuous positive airway pressure (CPAP), mandibular advancement device (MAD), surgeries under local anesthesia etc. were compared using Bayesian network meta-analyses. Our results demonstrated the superiority of CPAP over other minimally-invasive treatments in OSAHS patients with moderate to severe OSAHS. MAD may be the clinically effective alternative to CPAP in patients denying CPAP. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-08T01:48:11Z (GMT). No. of bitstreams: 1 ntu-105-R02422018-1.pdf: 14781735 bytes, checksum: e248b9202b1a09aecbf943f2253dd826 (MD5) Previous issue date: 2016 | en |
| dc.description.tableofcontents | CONTENTS
口試委員會審定書 # 誌謝 i 中文摘要 ii ABSTRACT iii CONTENTS iv LIST OF FIGURES vii LIST OF TABLES viii Chapter 1 Introduction 1 1.1 Pathophysiology 1 1.2 Clinical symptoms and signs 2 1.3 Clinical evaluations 2 1.4 Diagnosis 3 1.5 Epidemiology 4 1.6 Medical management 4 1.6.1 Positive airway pressure therapy 4 1.6.2 Oral appliance (OA) 5 1.6.3 Surgery 6 1.6.4 Myofunctional therapy(MT) 8 1.6.5 Cervico-mandibular Support Collar (CMSC) 8 1.6.6 Lifestyle modification (LM) 8 1.6.7 Nasal expiratory positive Airway pressure (EPAP) 9 1.6.8 Positional therapy (PT) 9 1.6.9 Exercise 9 1.6.10 Oxygen therapy 10 1.6.11 Hypoglossal nerve stimulation (HGNS) therapy 10 1.6.12 Nasopharyngeal airway stenting devices 10 Chapter 2 AIM 12 Chapter 3 Materials and methods 13 3.1 Selection criteria 13 3.1.1 Studies 13 3.1.2 Population 13 3.1.3 Interventions 13 3.1.4 Comparisons 14 3.1.5 Outcomes 14 3.2 Identifying research evidence 14 3.3 Study selection 15 3.4 Data extraction 15 3.5 Quality assessment 15 3.6 Pairwise and network meta-analysis 16 Chapter 4 Results 18 4.1 Results of the search 18 4.2 Included studies 18 4.3 Network map 19 4.4 Pairwise comparisons of interventions 20 4.4.1 Reduction of AHI 20 4.4.2 Reduction of ESS 20 4.5 Network comparisons of interventions 20 4.5.1 Effects of treatment on AHI reduction 21 4.5.2 Effects of treatment on ESS reduction 22 4.6 Treatments ranking 22 4.7 Evaluating the inconsistency between direct and indirect evidence 23 4.8 Comparisons between traditional pairwise and Bayesian network meta-analysis 24 4.9 Risk of bias and sensitivity analysis 25 Chapter 5 Discussion 26 5.1 Summary of the main findings 26 5.2 Comparison with other studies or reviews 26 5.3 Methodology 30 Chapter 6 Conclusion 32 Chapter 7 REFERENCE 33 Appendix 42 Appendix-Raw Data 59 | |
| dc.language.iso | en | |
| dc.title | 成人阻塞性睡眠中止症的極微侵入性治療 | zh_TW |
| dc.title | Minimally-invasive treatments of obstructive sleep apnea in adults: A systematic review and Bayesian network meta-analysis | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 104-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 郭彥彬 | |
| dc.subject.keyword | 網絡統合分析,隨機分派對照試驗,睡眠呼吸中止症候群, | zh_TW |
| dc.subject.keyword | Network meta-analysis,randomized-controlled trial,obstructive sleep apnea hypopnea syndrome, | en |
| dc.relation.page | 78 | |
| dc.identifier.doi | 10.6342/NTU201601794 | |
| dc.rights.note | 未授權 | |
| dc.date.accepted | 2016-08-03 | |
| dc.contributor.author-college | 醫學院 | zh_TW |
| dc.contributor.author-dept | 臨床牙醫學研究所 | zh_TW |
| 顯示於系所單位： | 臨床牙醫學研究所 | |
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