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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 徐善慧 | |
| dc.contributor.author | Yu-Chun Chien | en |
| dc.contributor.author | 簡毓均 | zh_TW |
| dc.date.accessioned | 2021-06-08T01:41:24Z | - |
| dc.date.copyright | 2016-09-08 | |
| dc.date.issued | 2016 | |
| dc.date.submitted | 2016-08-18 | |
| dc.identifier.citation | [1] Zhou, S.; Wang, L.; Yang, X.; Chen H.M.; Yang, G.; Gong, T.; Li, W.B. Polym. Chem. 2013, 4, 4461-4468.
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/18979 | - |
| dc.description.abstract | 在形狀記憶材料中，擁有生物可降解特性的溫感性形狀記憶彈性體在生醫應用上有相當大的潛力。本篇研究中，形狀記憶彈性體是利用poly(-caprolactone) (PCL) oligodiol 和 poly(L-lactic acid) (PLLA) oligodiol兩種軟鏈段以不同比例調整鏈段結晶度，並最佳化形狀記憶性質最好的形狀記憶聚胺酯。一系列的聚胺酯透過差式掃描量熱儀(differential scanning calorimeter,DSC)、X-ray繞射( X-ray diffraction ,XRD)和小角度散射( small angle X-ray scattering,SAXS)分析聚胺酯的結晶。接著，更進一步結合拉力機和原位即時小角/廣角散射(in situ SAXS/WAXS)分析聚胺酯在形狀記憶過程中不同狀態下的結晶行為，並解釋形狀記憶的機制。在2D SAXS圖上的菱形表示順向結晶的生成，有助於固定形狀，並進一步說明恢復是依靠非晶鏈段的彈性。38 wt% PCL 和 25 wt% PLLA組成的聚胺酯能夠在37°C的水中達到恢復率近100%。此外，形狀記憶聚胺酯也有良好的內皮細胞存活率和較低的血小板活化程度。 | zh_TW |
| dc.description.abstract | Thermally induced shape memory is an attractive feature of certain functional materials. Among the shape memory polymers, shape memory elastomers (SMEs) especially those with biodegradability have great potential in the biomedical field. In this study, we prepared waterborne biodegradable polyurethane SME based on poly(-caprolactone) (PCL) oligodiol and poly(L-lactic acid) (PLLA) oligodiol as the mixed soft segments. The ratio of the soft segments in polyurethanes was optimized for shape memory behavior. The thermally induced shape memory mechanism of the series of polyurethanes was clarified using differential scanning calorimeter (DSC), X-ray diffraction (XRD), and small angle X-ray scattering (SAXS). In particular, the in situ SAXS measurements combined with shape deformation processes were employed to examine the stretch-induced (oriented) crystalline structure of the polyurethanes and to elucidate the unique mechanism for shape memory properties. The polyurethane with optimized PLLA crystalline segments showed a diamond-shape two-dimensional SAXS pattern after being stretched, which gave rise to better shape fixing and shape recovery. The shape memory behavior was further tested in 37°C water. The biodegradable polyurethane comprising 38 wt% PCL segments and 25 wt% PLLA segments and synthesized at a relatively lower temperature by the waterborne procedure showed ~100% shape recovery in 37°C water. The biodegradable polyurethane SME also demonstrated good endothelial cell viability as well as low platelet adhesion/activation. We conclude that the waterborne biodegradable polyurethane SME possesses a unique thermally induced shape memory mechanism and may have potential applications in making shape memory biodegradable stents or scaffolds. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-08T01:41:24Z (GMT). No. of bitstreams: 1 ntu-105-R03549022-1.pdf: 3719853 bytes, checksum: 30786b8797b27921e4994164955b5e48 (MD5) Previous issue date: 2016 | en |
| dc.description.tableofcontents | 目錄
口試委員審定書 I 誌謝 II 摘要 III Abstract IV 目錄 VI 圖目錄 VIII 表目錄 IX 第一章 文獻回顧 1 1.1. 形狀記憶材料 1 1.2. 形狀記憶的生醫應用 3 1.3. 水分驅動形狀記憶 5 1.4. 形狀記憶與聚胺酯 6 1.5. 研究目的 7 第二章 研究方法 9 2.1. 研究架構 9 2.2. L型聚乳酸二元醇合成與鑑定 10 2.2.1. L型聚乳酸二元醇之製備 10 2.2.2. L型聚乳酸二元醇之分子量鑑定 10 2.3. 形狀記憶聚胺酯(Shape memory polyurethane, SMPU)之合成 11 2.3.1 水性聚胺酯合成原料 11 2.3.2. 水性聚胺酯聚合反應 13 2.4. 形狀記憶聚胺酯薄膜之製備 14 2.4.1. 薄膜製備 14 2.5. 長鏈二元醇熱性質分析 15 2.5.1. 熱重分析 15 2.5.2. 差示掃描量熱 15 2.6. 形狀記憶聚胺酯之物化性質分析 16 2.6.1. 傅立葉紅外光譜儀 16 2.6.2. 膠體滲透層析儀 16 2.6.3. 熱重分析 16 2.6.4. 差式掃描量熱儀 17 2.6.5. 廣角X光繞射分析儀 17 2.6.6. 拉力試驗機 18 2.6.7. 小角度X光繞射 18 2.8. 空氣形狀記憶測試 18 2.9. 原位小角度及廣角分析 19 2.10. 水中形狀記憶測試 20 2.11. 衰減式全反射傅立葉紅外光譜分析 20 2.12. 機械性質分析 20 2.13.牛頸動脈內皮細胞(Bovine aortic endothelial cell)相容性測試 21 2.14. 血小板吸附測試 22 2.15. 統計分析 22 第三章 實驗結果 23 3.1. SMPU薄膜物化性質分析 23 3.1.1. 分子量分析 23 3.1.2. 傅立葉紅外線光譜儀(Fourier transform infrared spectroscopy, FTIR)分析 23 3.1.3. 核磁共振儀(Nuclear Magnetic Resonance, NMR) 24 3.1.4. 機械性質分析 25 3.1.5. 熱重性質分析 25 3.1.6. 差式掃描量熱儀分析 26 3.1.7. 廣角x光繞射(wide angle x-ray diffraction, XRD) 27 3.1.8. 小角X光散射(small angle x-ray scattering, SAXS) 27 3.2. SMPU形狀記憶測試 28 3.2.1. 空氣形狀記憶測試 28 3.2.2. 水中形狀記憶測試 29 3.3. 原位小角度/廣角度X光分析 29 3.4. 水對於機械性質及表面氫鍵的影響 30 3.5. 生物相容性測試 31 3.5.1. 牛頸動脈內皮細胞活性測試 31 3.5.2. 血小板貼附測試 32 第四章 討論 33 4.1.聚胺酯分子量分析 33 4.2.機械性質分析 34 4.3.聚胺酯熱性質分析 34 4.4.廣角X光繞射結晶性質分析 35 4.5.小角X光散射分析 36 4.6.空氣形狀記憶性質分析 37 4.7. 原位小角/廣角X光分析 38 4.8. 水中形狀記憶性質分析 39 4.9. 生物相容性測試 40 第五章 結論 42 參考文獻 43 | |
| dc.language.iso | zh-TW | |
| dc.subject | 原位即時小角度散射 | zh_TW |
| dc.subject | 形狀記憶聚胺酯 | zh_TW |
| dc.subject | 生物可降解 | zh_TW |
| dc.subject | 生物相容性 | zh_TW |
| dc.subject | 彈性體 | zh_TW |
| dc.subject | in situ SAXS | en |
| dc.subject | elastomer. | en |
| dc.subject | biocompatible | en |
| dc.subject | biodegradable | en |
| dc.subject | shape memory polyurethane | en |
| dc.title | 生物可降解聚胺酯形狀記憶彈性體之性質分析與機制 | zh_TW |
| dc.title | Preparation, characterization, and mechanism for biodegradable and biocompatible polyurethane shape memory elastomers | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 104-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 孫一明,賴森茂 | |
| dc.subject.keyword | 形狀記憶聚胺酯,原位即時小角度散射,生物可降解,生物相容性,彈性體, | zh_TW |
| dc.subject.keyword | shape memory polyurethane,in situ SAXS,biodegradable,biocompatible,elastomer., | en |
| dc.relation.page | 71 | |
| dc.identifier.doi | 10.6342/NTU201602966 | |
| dc.rights.note | 未授權 | |
| dc.date.accepted | 2016-08-19 | |
| dc.contributor.author-college | 工學院 | zh_TW |
| dc.contributor.author-dept | 高分子科學與工程學研究所 | zh_TW |
| 顯示於系所單位： | 高分子科學與工程學研究所 | |
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