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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
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dc.contributor.advisor | 顏家鈺(Jia-Yush Yen) | |
dc.contributor.author | Yu-Tin Chao | en |
dc.contributor.author | 趙俞婷 | zh_TW |
dc.date.accessioned | 2021-06-08T00:56:26Z | - |
dc.date.copyright | 2015-03-13 | |
dc.date.issued | 2015 | |
dc.date.submitted | 2015-02-12 | |
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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/18247 | - |
dc.description.abstract | 橫穿肋骨高強度聚焦超聲治療最主要的挑戰為避免將能量堆積在肋骨,並且能同時確保有足夠的熱劑量被遞送到目標區域。現今研究方法多仰賴昂貴的多通道相控陣列系統,利用換能器開關系統根據任意幾何形狀安排複雜的波形計算。此類型研究要注意到保護肋骨時,不僅須防止超聲波能量到達肋骨並要注意肋骨前方的能量堆積。本研究提出了一種不同的方法並建立一套治療系統,將聲結構放置於肋骨前使其具有相似於那些發動機的排氣消聲器效果。它的聲音阻擋結構是基於消音器原理,防止超聲波能量到達肋骨且不會導致過多的能量去反饋回探頭。在換能器驅動頻率為0.5 MHz下,有限元素的整體聲場和溫度分佈表示,新穎的聲音阻擋結構有效降低了結構正後方的超聲壓力和能量級別,因此肋骨比腫瘤的溫度還低。如果在沒有結構保護的情況下,肋骨溫度將會達到104.18℃,而有結構的情況只有37.86℃。此外,從豬的肋骨與仿體實驗所提出的驗證,結果顯示出該肋骨在沒有保護下只需一分鐘就達到72.80℃的燒融,而有保護的情況溫度僅36.39℃。而在腫瘤區域分別達到51.39℃,49.33℃。 | zh_TW |
dc.description.abstract | The main challenge in transcostal high-intensity focused ultrasound therapy is minimizing heat deposition on the ribs while ensuring that a sufficient dose is delivered to the target region. Current approaches rely on expensive multichannel phased-array systems to turn individual transducer on and off according to either geometrical arrangements or complicated wave calculations. Notice that to protect the ribs from heating one must prevent the ultrasound energy not only from reaching the ribs but also from accumulating in front of the ribs. This research proposes a different approach to attach a sound-blocking structure with similar effects to those of the exhaust muffler of an engine in front of the rib cage and establish an ablation treatment system. The sound-blocking structure is designed based on the muffler principle to prevent the ultrasound energy from reaching the ribs while not causing too much energy to reflect back to the applicator. Finite-element simulations with 0.5 MHz transducer of the overall sound fields and temperature distribution showed that the ultrasound pressure and energy level decreases behind the novel sound-blocking structures, thereby achieving lower temperature on the ribs than on the tumor. Without the protecting structure the rib temperature reaches 104.19℃ while reaching only 37.86℃ with the structure. An experimental setup using porcine ribs with phantom was also developed to validate the proposed concept. The results showed that the rib temperature reached 72.80℃ without protection within only 1 minute of ablation time while maintained at 36.39℃ with the proposed device. The tumor region in the tests reached 51.39℃ and 49.33℃ respectively. | en |
dc.description.provenance | Made available in DSpace on 2021-06-08T00:56:26Z (GMT). No. of bitstreams: 1 ntu-104-D98522028-1.pdf: 6581963 bytes, checksum: 0ee8e017e201ed386940dd08ea24cadc (MD5) Previous issue date: 2015 | en |
dc.description.tableofcontents | 中文摘要 i
Abstract ii Contents iv List of Figure vi List of Table ix Glossary of Symbols xi Chapter 1 Introduction 1 1.1 Background 1 1.2 Thesis Structure and Contribution 4 Chapter 2 The Theoretical Background 6 2.1 Piezoelectric theory 6 2.2 Expansion-muffler principle 10 2.3 Resonator principle 12 2.4 Bioheat Transfer Theory 14 Chapter 3 THE STRUCTURE DESIGN 16 3.1 The expansion chamber design 16 3.2 The resonance chamber design 25 Chapter 4 Full-Path acoustic model simulation 29 Chapter 5 Simulation results 33 5.1 HIFU ablation without protection 34 5.2 HIFU ablation with baffle protection 37 5.3 HIFU ablation with expansion chamber muffler protection 42 5.4 HIFU ablation with resonator chamber protection 46 Chapter 6 HIFU Experiment Verification 53 6.1 Equipment Specification 53 6.1.1 Phantom 53 6.1.2 Transducer 55 6.1.3 RF Generator 56 6.1.4 Temperature data acquisition system 57 6.2 Experiment Arrangement 59 6.3 Experiment Result 63 6.3.1 HIFU Ablation with Different Protection 63 6.3.2 Temperature Distribution Analysis 65 Chapter 7 The Deviation between Simulation and Experiment 70 Chapter 8 Conclusion 71 References 72 | |
dc.language.iso | en | |
dc.title | 新穎聲阻隔共鳴結構應用於保護肋骨之超音波高能聚焦熱療系統建置 | zh_TW |
dc.title | A novel Rib-sparing transcostal high-intensity focused ultrasound system based on resonant sound-blocking principle | en |
dc.type | Thesis | |
dc.date.schoolyear | 103-1 | |
dc.description.degree | 博士 | |
dc.contributor.oralexamcommittee | 陳永耀(Yung-Yaw Chen),連豐力(Feng-Li Lian),何明志(Ming-Chih Ho),江惠華(Huihua Kenny Chiang) | |
dc.subject.keyword | 消音器,HIFU手術,Pennes方程式,轉移矩陣分析法,赫姆霍茲共鳴器,聲機電類比, | zh_TW |
dc.subject.keyword | Muffler,HIFU therapy,Pennes equation,Transfer matrix method,Helmholtz resonator,Electro-mechanical-acoustical analogy, | en |
dc.relation.page | 80 | |
dc.rights.note | 未授權 | |
dc.date.accepted | 2015-02-12 | |
dc.contributor.author-college | 工學院 | zh_TW |
dc.contributor.author-dept | 機械工程學研究所 | zh_TW |
顯示於系所單位: | 機械工程學系 |
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