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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 謝國煌(Kuo-Huang Hsieh) | |
dc.contributor.author | Wen-Chi Chao | en |
dc.contributor.author | 趙文齊 | zh_TW |
dc.date.accessioned | 2021-06-08T00:22:22Z | - |
dc.date.copyright | 2013-08-23 | |
dc.date.issued | 2013 | |
dc.date.submitted | 2013-07-22 | |
dc.identifier.citation | 1. Langer, R.V.J., Tissue engineering. Science, 1993. 260: p. 920-6.
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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/17573 | - |
dc.description.abstract | 在眾多生物醫學材料中,幾丁聚醣(Chitosan)近年來受到廣泛關注,其為天然的高分子材料,具有良好生物相容性、生物可降解性以及抗菌性等優點。可以運用在不同領域中。
本研究利用兩種分子量的聚乙二醇甲醚與兩種分子量的幾丁聚醣進行接枝改質,並使用了兩種方式來進行鍵結,分別是利用醯胺鍵與尿素官能基鍵結。其中使用醯胺鍵進行接枝反應有效大幅提升幾丁聚醣敷料的吸水性,在避免傷口有過多滲出液方面有好的表現;而使用尿素官能基改質的系列中,選用了具水溶性的低分子量幾丁聚醣,使其水溶液不具有醋酸,使其成為噴劑形式之幾丁聚醣敷料,改善傳統敷料因為身體曲線無法密合的缺點。 在第二部分研究中,與台大臨床牙醫所合作,延伸本研究團隊先前所製作低收縮率複合樹脂與使用二氧化矽膠體溶液,將顆粒表面羥基經由甲基丙烯酸酯基三甲氧基矽(3-(trimethoxy silyl) propyl methacrylate, MSMA)改質具有雙鍵官能基,使其在固化後與有機樹脂基質間可以形成共價鍵結,增進機械性質。應用於牙科填補材具有低收縮率,可有效預防補牙時產生隙縫造成二次龋齒。為了更進一步改善預防二次龋齒,我們將表沒食子兒茶素沒食子酸酯(Epigallocatechin gallate, EGCG)進行改質,使其具有雙鍵官能基,期望能在不失去太多抗菌性的狀況下,改善其穩定性,並使其能與材料鍵結,延長抗菌的時間,以達長期預防龋齒的功效。經傅立葉轉換紅外線光譜儀(FT-IR)確定反應可行及所需時間,以0μg/g~3000μg/g混入材料中,經養菌後用掃瞄式電子顯微鏡(Scanning Electron Microscope, SEM)證實細菌隨EGCG濃度增加而減少,確實具有抗菌效果。 | zh_TW |
dc.description.provenance | Made available in DSpace on 2021-06-08T00:22:22Z (GMT). No. of bitstreams: 1 ntu-102-R00549023-1.pdf: 6801099 bytes, checksum: 581e705a2b9cc0c425029df85b0fbae3 (MD5) Previous issue date: 2013 | en |
dc.description.tableofcontents | 中文摘要 I
Abstract II 目錄 IV 圖目錄 VIII 表目錄 XII 第一部分 幾丁聚醣敷料 1 第一章 簡介 1 第二章 文獻回顧 2 1.2.1 幾丁質及幾丁聚醣簡介 2 1.2.2 幾丁質與幾丁聚醣之物性 5 1.2.3 幾丁質與幾丁聚醣的應用 7 1.2.3.1 幾丁聚醣於創傷敷料之應用 7 1.2.3.2 不同形式幾丁聚醣於創傷敷料之運用 9 1.2.3.3聚乙二醇及聚乙二醇甲醚簡介 17 1.2.4皮膚構造簡介 22 1.2.5傷口癒合機制簡介[57] 26 第三章 實驗方法 30 1.3.1 實驗藥品 30 1.3.2 實驗儀器 33 1.3.3 實驗方法 35 1.3.3.1利用琥珀酸酐改質聚乙二醇甲醚合成方法 35 1.3.3.2 使用二異氰酸異佛爾酮(IPDI)改質聚乙二醇甲醚合成方法 35 1.3.3.3 聚乙二醇甲醚接枝幾丁聚醣製備方法(I) 36 1.3.3.4聚乙二醇甲醚接枝幾丁聚醣製備方法(II) 38 1.3.4 材料性質測試 39 1.3.4.1傅立葉轉換紅外線光譜儀(Fourier-Transformed Infrared Spectra, FT-IR) 39 1.3.4.2熱重分析儀(Thermogravimetric Analysis, TGA) 39 1.3.4.3微差掃描卡計儀(Differential Scanning Calorimetry, DSC) 39 1.3.4.4拉伸測試(Tensile Strength Test) 40 1.3.4.5吸水測試(Water Absorption Test) 40 1.3.4.6 水氣透過率(Water Vapor Transmission Rate) 41 1.3.4.7 生物降解性測試 42 1.3.4.8 細胞相容性測試 42 1.3.4.9 抗菌測試 43 第四章 結果與討論 44 1.4.1 傅立葉轉換紅外線光譜分析 44 1.4.2 熱重分析 53 1.4.4 拉伸測試分析 57 1.4.5 吸水性分析 60 1.4.6 水氣透過率分析 62 1.4.7 生物降解性分析 65 1.4.8 細胞相容性分析 67 1.4.9 抗菌性分析 70 第五章 結論 72 第二部分 牙材 73 第一章 簡介 73 2.1.1 前言 73 2.1.2 牙科材料發展之簡要歷史[81] 73 2.1.2 牙科修復材料所需具備條件[84] 76 2.1.3 研究目的 78 第二章 文獻回顧 79 2.2.1 牙科修復材料簡介 79 2.2.2光硬化樹脂聚合機制簡介 91 2.2.2.1自由基連鎖反應 91 2.2.2.2光聚合反應 94 2.2.3溶膠-凝膠法 97 2.2.3.1溶膠-凝膠法簡介 97 2.2.3.2水解反應 99 2.2.3.3縮合反應 102 2.2.3.4粒徑窄分布二氧化矽粒子 104 2.2.4有機/無機混成材料 107 2.2.4.1以溶膠-凝膠法製備有機/無機混成材料之方法 109 2.2.4.2以溶膠-凝膠法製備有機/無機混成材料之優缺點 109 2.2.5兒茶素簡介 112 第三章 實驗方法 116 2.3.1 實驗藥品 116 2.3.2 實驗儀器 119 2.3.3 實驗方法 122 2.3.3.1 EA3-70樹脂合成(HEMA/IPDI/EA) 122 2.3.3.2 無機填充材合成 124 2.3.3.3表沒食子兒茶素沒食子酸酯(EGCG)雙鍵改質 126 2.3.3.4牙科修復材料之製備 128 2.3.4 材料性質測試 129 2.3.4.1 傅立葉轉換紅外線光譜儀(Fourier-Transformed Infrared Spectra, FT-IR) 129 2.3.4.2 動態光散射雷射(Dynamic Light Scattring, DLS)粒徑儀測試 129 2.3.4.3維克氏硬度(Vickers Hardness Test)測試 130 2.3.4.4直徑抗拉強度(Diametral Tensile Strength)測試 131 2.3.4.5抑制生物膜生成抗菌效果測定 131 2.3.4.6掃瞄式電子顯微鏡(Scanning Electron Microscope, SEM)測試 132 第四章 結果與討論 133 2.4.1 傅立葉轉換紅外線光譜分析 133 2.4.2 粒徑大小分析 136 2.4.3 轉化率(Conversion Rate)分析 140 2.4.4維克氏硬度測試分析 147 2.4.5直徑抗拉強度測試分析 149 2.4.6掃瞄式電子顯微鏡測試分析 150 第五章 結論 154 參考文獻 155 | |
dc.language.iso | zh-TW | |
dc.title | 幾丁聚醣與改質環氧樹脂壓克力合成功能性生醫材料之應用 | zh_TW |
dc.title | Synthesis and Characterization of Chitosan and Modified Epoxy Acrylate as Functional Biomaterials | en |
dc.type | Thesis | |
dc.date.schoolyear | 101-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 姜昱至(Yu-Chih Chiang),陳思賢(Szu-Hsien Chen) | |
dc.subject.keyword | 幾丁聚醣,聚乙二醇甲醚,創傷敷料,多官能基,壓克力,光聚合,牙科修復,兒茶素,表沒食子兒茶素沒食子酸酯, | zh_TW |
dc.subject.keyword | chitosan,mPEG,wound dressing,multifunctional,acrylate,photocurable,restorative,dental,Epigallocatechin gallate,EGCG, | en |
dc.relation.page | 168 | |
dc.rights.note | 未授權 | |
dc.date.accepted | 2013-07-22 | |
dc.contributor.author-college | 工學院 | zh_TW |
dc.contributor.author-dept | 高分子科學與工程學研究所 | zh_TW |
顯示於系所單位: | 高分子科學與工程學研究所 |
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