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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 廖秀娟 | |
| dc.contributor.author | I-Ling Tseng | en |
| dc.contributor.author | 曾怡菱 | zh_TW |
| dc.date.accessioned | 2021-06-08T00:08:11Z | - |
| dc.date.copyright | 2013-08-14 | |
| dc.date.issued | 2013 | |
| dc.date.submitted | 2013-08-12 | |
| dc.identifier.citation | Adachi, R., Osada, H., Shingai, R., 2008. Phase-dependent preference of thermosensation and chemosensation during simultaneous presentation assay in Caenorhabditis elegans. BMC Neuroscience 9, 106.
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/17350 | - |
| dc.description.abstract | 鄰苯二甲酸酯類化合物，俗稱塑化劑，係存在於環境中類似於環境賀爾蒙的物質，具有類似生物體內激素作用，可改變生物體內免疫、神經與內分泌系統之正常運作，對人類健康與生物造成危害。然而目前對於生物體暴露鄰苯二甲酸酯類之毒性效應及其機制的研究仍不完整，急需更進一步的探討，因此本研究利用活體模式生物－秀麗隱桿線蟲 (Caenorhabditis elegans) 探討鄰苯二甲酸酯類所誘導之發育毒性、生殖毒性與神經毒性，並探討可能的毒性機制。研究結果顯示，C. elegans暴露於特定濃度之鄰苯二甲酸酯類 (DEHP 、DBP及 DIBP) 會引起生殖缺陷與發育異常，並觀察到C. elegans的行為缺陷，包括身體彎曲、頭部擺動、倒轉頻率、趨化及趨熱行為的改變。在神經發育上，鄰苯二甲酸酯類會影響AFD及ASE感覺神經元螢光標記之轉殖C. elegans其神經元細胞體之fluorescent puncta的大小及強度，同時觀察到，暴露於DEHP會導致AFD神經分化相關之TTX-1、 TAX-2、 TAX-4、 CEH-14及ASE神經分化相關之CHE-1、TAX-2、 TAX-4的mRNA表現量下降。我們也發現，C. elegans暴露於特定之鄰苯二甲酸酯類，細胞內之活性氧Reactive oxygen species (ROS) 含量提高，若先將C. elegans暴露於‐抗氧化劑Ascorbic acid ，則可顯著地修復鄰苯二甲酸酯類所誘導之神經毒性效應，因此，推測鄰苯二甲酸酯類對C. elegans造成之神經毒性，氧化壓力扮演重要的關鍵角色。 | zh_TW |
| dc.description.abstract | Phthalate esters, also called plasticizer, are ubiquitous endocrine disrupting chemicals (EDCs) in the environment. They may have adverse consequences for human and ecosystem. Considering the critical, but limited, researches on human neurobehavioral and other healthy outcomes in association with phthalate exposure, we used the nematode Caenorhabditis elegans as an in vivo model to evaluate phthalates-induced developmental toxicity, reproductive toxicity, neurotoxicity, and the possible associated mechanisms. The results showed that exposure to phthalates (DEHP, DBP, and DIBP) at the examined concentrations induced reproductive defects and developmental abnormality. Moreover, exposure to phthalates (DEHP, DBP, and DIBP) at the examined concentrations induced behavioral defects, including changes in body bending, head thrashing, reversal frequency, chemotaxis, and thermotaxis. Furthermore, phthalate (DEHP, DBP, and DIBP) exposure caused toxicity, affecting the relative sizes of cell body fluorescent puncta, and relative intensities of cell bodies in AFD and ASE neurons. The mRNA levels of the majority of the genes (TTX-1, TAX-2, TAX-4, and CEH-14) that are required for the differentiation and function of AFD neurons and the majority of the genes (CHE-1, TAX-2, TAX-4) that are required for the differentiation and function of ASE neurons were both decreased upon DEHP exposure.Moreover, phthalate (DEHP, DBP, and DIBP) exposure at the examined concentrations produced elevated intracellular reactive oxygen species (ROS) in C. elegans. Finally, pretreatment of worms with the antioxidant ascorbic acid significantly ameliorated phthalates-induced neurotoxicity. Our study suggests that oxidative stress may play a critical role in initiating the phthalate ester-induced neurotoxic effects in C. elegans. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-08T00:08:11Z (GMT). No. of bitstreams: 1 ntu-102-R00622001-1.pdf: 3963226 bytes, checksum: 902e03075c7d923a3256cdcbc55d0a9b (MD5) Previous issue date: 2013 | en |
| dc.description.tableofcontents | 目錄
致謝 I 中文摘要 II ABSTRACT IV 目錄 VI 表次 IX 圖次 X 縮寫表 XII 壹、研究動機 1 貳、文獻探討與研究目的 2 2.1環境賀爾蒙 (Endocrine-disrupting chemicals, EDCs) 2 2.2塑化劑‐鄰苯二甲酸酯類化合物 (Phthalate esters, PAEs) 3 2.3鄰苯二甲酸酯類相關化合物之毒性效應 5 2.3.1生殖和發育 5 2.3.2神經發育與行為模式 5 2.3.3活性氧物質 (Reactive oxygen species, ROS) 和神經毒性 6 2.4以秀麗隱桿線蟲 (Caenorhabditis elegans) 為模式生物探討毒理學 7 2.5 C. elegans 的分子神經遺傳學 9 2.6研究目的 11 参、材料與方法 13 3.1實驗藥品 13 3.2實驗動物與生長條件 13 3.3繁殖分析試驗 14 3.4體長量測試驗 14 3.5 C. elegans運動行為分析試驗 14 3.5.1身體彎曲試驗 (Body bending assay) 15 3.5.2頭部擺動試驗 (Head thrashing assay) 15 3.5.3倒轉頻率試驗 (Reversal frequency assay) 16 3.6趨性分析試驗. 16 3.6.1趨化分析試驗 (Chemotaxis assay) 16 3.6.2趨熱分析試驗 (Thermotaxis assay) 17 3.7基因轉殖C. elegans螢光分析試驗 18 3.8反轉錄聚合酶鏈鎖反應 (Quantitative real-time RT-PCR) 19 3.9生物體內ROS分析試驗 19 3.10統計分析 20 肆、結果 21 4.1鄰苯二甲酸酯類DEHP、DBP及DIBP對C. elegans具有繁殖毒性 21 4.2鄰苯二甲酸酯類DEHP、DBP及DIBP造成C. elegans體長縮短 21 4.3鄰苯二甲酸酯類DEHP、DBP及DIBP對C. elegans行為模式之影響 22 4.3.1鄰苯二甲酸酯類DEHP、DBP及DIBP造成C. elegans身體彎曲頻率下降 22 4.3.2鄰苯二甲酸酯類DEHP、DBP及DIBP造成C. elegans頭部擺動下降 22 4.3.3鄰苯二甲酸酯類DEHP、DBP及DIBP造成C. elegans倒轉頻率下降 23 4.4鄰苯二甲酸酯類DEHP、DBP及DIBP對C. elegans趨性分析之影響 23 4.4.1鄰苯二甲酸酯類DEHP、DBP及DIBP造成C. elegans趨化行為下降 23 4.4.2鄰苯二甲酸酯類DEHP、DBP及DIBP造成線蟲趨熱行為下降 24 4.5鄰苯二甲酸酯DEHP、DBP及DIBP對感覺神經元之影響 25 4.5.1鄰苯二甲酸酯類DEHP、DBP及DIBP改變ASER感覺神經元 25 4.5.2鄰苯二甲酸酯類DEHP、DBP及DIBP改變AFD感覺神經元 26 4.6鄰苯二甲酸酯類DEHP、DBP及DIBP對AFD、ASE神經相關基因表現之影響 27 4.6.1鄰苯二甲酸酯類DEHP、DBP及DIBP抑制 ASE神經相關基因之表現 27 4.6.2鄰苯二甲酸酯類DEHP、DBP及DIBP抑制 AFD神經相關基因之表現 28 4.7 鄰苯二甲酸酯類和氧化壓力關係 29 4.7.1鄰苯二甲酸酯類DEHP、DBP及DIBP增加C. elegans體內ROS 29 4.7.2抗氧化劑降低鄰苯二甲酸酯類DEHP、DBP、DIBP對C. elegans造成的毒性效應 29 伍、討論 31 5.1鄰苯二甲酸酯類DEHP、DBP及DIBP對C. elegans繁殖與發育探討 31 5.2鄰苯二甲酸酯類DEHP、DBP及DIBP對C. elegans運動行為與趨性分析之探討 32 5.3鄰苯二甲酸酯類DEHP、DBP及DIBP對C. elegans ASE、AFD感覺神經之探討 33 5.4鄰苯二甲酸酯類DEHP、DBP及DIBP對C. elegans產生神經毒性機制之探討 35 陸、結論 37 柒、建議 38 捌、參考資料 39 玖、附錄 74 | |
| dc.language.iso | zh-TW | |
| dc.title | 塑化劑‐鄰苯二甲酸酯類化合物對秀麗隱桿線蟲之
毒性效應評估 | zh_TW |
| dc.title | Toxicity Evaluation of Plasticizer‐Phthalates in Caenorhabditis elegans | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 101-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 陳佩貞,沈偉強 | |
| dc.subject.keyword | 秀麗隱桿線蟲,鄰苯二甲酸酯類,神經毒性,氧化壓力, | zh_TW |
| dc.subject.keyword | phthalates,Caenorhabditis elegans,neurotoxicity,oxidative stress, | en |
| dc.relation.page | 78 | |
| dc.rights.note | 未授權 | |
| dc.date.accepted | 2013-08-12 | |
| dc.contributor.author-college | 生物資源暨農學院 | zh_TW |
| dc.contributor.author-dept | 生物環境系統工程學研究所 | zh_TW |
| 顯示於系所單位： | 生物環境系統工程學系 | |
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