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標題: | 流體中磁性粒子之虛擬通道 ─ 用於實現動態的通道網路重配 Virtual Channels for Achieving a Dynamically Reconfigurable Network of Flowing Magnetic Beads |
作者: | Hung-Wei Chiang 江宏偉 |
指導教授: | 蔡睿哲 |
關鍵字: | 微流道、非實體通道,磁性粒子,鎳,釹鐵硼磁鐵,磁化現象, microfluidic channel,virtual channel,magnetic bead,nickel,Nd-Fe-B magnet,magnetization, |
出版年 : | 2013 |
學位: | 碩士 |
摘要: | 近年來生物微機電領域中,關於細胞、分子、磁珠或粒子在微流道中引導、捕捉及分類的研究被廣泛且深入地探討。其中含有微流道網路結構的元件,由於具有精準的粒子及細胞操縱能力,被熱門地應用在生醫檢測研究。通常此類的微流道元件,不論使用原理為介電泳動、電磁操控、聲學控制或是其他操控粒子機制,皆具有實體的流道,可以限制進而導引粒子的移動。然而這類的實體微流道系統,常常需要外加幫浦來引入粒子,且由於有時發生阻塞或污染的現象,而降低了元件使用時效。
使用非實體流道來導引粒子可以避免阻塞,若加上適當的元件設計,便可以在不需要幫浦的情況下引入粒子,因此較容易完成微流道網路元件。在本研究中,鎳材在外加磁場下產生磁化現象,我們利用這磁場引導磁珠,完成了磁珠虛擬流道。本研究設計了三種虛擬流道,分別做為收集、引導及捕捉功能使用。研究中的V型流道可以用來收集磁珠,S型、Y型及Z型流道做為引導磁珠使用,最後研究中利用以鎳材製作的雙穩態機械結構,進行磁珠的捕捉。 藉由結合收集型、引導型及捕捉型三種磁珠虛擬流道進行磁珠操控,可以實現動態的通道網路重配。 Recent Bio-MEMS studies have intensively involved microfluidic systems where beads, particles, molecules, and/or cells are guided, trapped, and/or sorted. Thanks to their powerful ability of particle and cell manipulation, biochips containing networks of microfluidic channels are now among the most popular devices. Normally, a microfluidic channel appears in the form of a tunnel which physically confines and guides the flowing liquid and particles, sometimes with some integrated dielectrophoretic, electromagnetic, acoustic, or other trapping/sorting mechanism. However, a channel of this kind usually requires a pumping mechanism - fluidic flow and particle/cell transportation are built by using a pump. Also, it has a limited lifetime due to clogging and contamination. Employing virtual channels can bypass the issue of clogging, and, more importantly, achieve a reconfigurable network easily. In this paper, we demonstrate virtual channels defined by “walls” of magnetic fields, which can be used to construct a dynamically reconfigurable network of flowing magnetic beads. Magnetized by an external magnet, nickel structures generate magnetic fields that can ‘hold’ and, therefore, guide/trap magnetic particles. In this study, we exhibit S- and Y-shaped virtual channels which steer magnetic beads smoothly. We also exhibit several kinds of V-shaped channels which are designed for collecting magnetic beads. A switchable channel implemented with a bistable mechanism is used to demonstrate the passing and blocking of a bead, proving the feasibility of a dynamically reconfigurable network. |
URI: | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/17295 |
全文授權: | 未授權 |
顯示於系所單位: | 光電工程學研究所 |
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