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標題: | 犬脾臟病理變化之回溯性研究 The Retrospective Studies on Pathological Lesions of Canine Spleen |
作者: | Chung-Chun Sha 沙中群 |
指導教授: | 劉振軒 |
關鍵字: | 犬脾臟,腫瘤,免疫化學染色,血管肉瘤,淋巴瘤, Canine spleen,tumor,immunohistochemistry,hemangiosarcoma,lymphoma, |
出版年 : | 2014 |
學位: | 碩士 |
摘要: | 脾臟是犬體內最大的次級淋巴器官,約含有體內四分之一的淋巴細胞。脾臟腫大(Splenomegaly)在犬有較高發生率。傳統的外科手術認知認為脾臟血管肉瘤是最常見的犬脾臟腫大形式。但近期的文獻提出反對的證據,根據這些研究,在犬脾臟腫大中的惡性腫瘤的病例與非惡性病變的病例皆約佔一半。而犬脾臟本身包含相當多樣複雜的組織:淋巴、血管組織和其它各式各樣不同的組織所構成,因此所以相當多種類腫瘤都曾在犬脾臟都被報告過。而臺灣仍未報告過犬脾臟疾病的回溯性研究,因此我們希望了解臺灣的脾臟疾病是否會有地區性的差別。某些脾臟疾病會因為併發病變而造成區別診斷上的困難,在過去的文獻曾報告特定的關聯性病變能輔助脾臟疾病診斷。
本研究為探討臺灣犬脾臟近五年外科檢體病理診斷的概況;並選定三種脾臟疾病常見之關聯性病變:壞死(Necrosis)、淋巴樣增生(Lymphoid hyperplasia)、含鐵小結(Siderotic nodule)評估在診斷中出現的情況。所收集之165例病例診斷,惡性腫瘤診斷有61例;非惡性病變診斷有104例。惡性腫瘤中以血管肉瘤(Hemangiosarcoma)占最多數有23例。淋巴瘤(Lymphoma)為第二常見之診斷有11例。而本研究中血管肉瘤的比例要比過往的外國研究來的低。非惡性病變病例中占最多數為血腫(Hematoma)有27例,與結節性增生(Nodular hyperplasia)併發血腫有15例。結節性增生和血腫同樣於非惡性疾病中的比例也和以往的研究有所不同。有二項關聯性病變與診斷分類之間出現顯著相關:可見壞死在肉瘤類別較常見;血腫在良性病變與肉瘤較常見;淋巴樣增生在良性病變較常見。總結本研究中的發現,在本次研究中有數種脾臟腫瘤與良性病變呈現出與以往研究不同比例。推測造成的原因是臺灣較多飼養小型犬品種。 Spleen is the largest secondary lymphoid organ containing about one-fourth of the body’s lymphocytes in dog. Conventional surgical wisdom implies that splenic hemangiosarcoma is the most prevalent of dog splenomegaly. However, recent studies provide evidence against this. According to these studies, malignant tumor and non-malignant lesion are population of about half in dog splenomegaly. The dog spleen is composed of complex tissues: lymphoid, vascular, and other compartment, so variable tumors had be reported in dog. The retrospective study for canine splenic diseases had been not reported in Taiwan, so we want to know classification of splenic disease which have or not regional difference. Some splenic diseases present complicated lesion because spleen is the organ with complex tissue, it causes difficult to differentiate from variable spleen disease. In previous studies, some associated lesions can help pathological diagnosis. The present study is to investigate histopathological distribution of canine spleen disease from surgical specimen in recent five years in Taiwan; and selected three common associated lesions in splenic disease: necrosis, lymphoid hyperplasia, and siderotic nodule to study correlation between the associated lesions and histopathological diagnostic type. A total of 165 cases enrolled in this studies, they were diagnosed histologically as 104 of non-malignant disease and 61 of malignant splenic tumor. Hemangiosarcoma was the most common malignant histological diagnosis (n=23). The second common was lymphoma (n=11). The percentage of hemangiosarcoma in malignant tumor are lower than previous foreign studies. The most common of non-malignant disease were splenic hematoma (n =27), and nodular hyperplasia with hematoma (n =15). The percentage of nodular hyperplasia and hematoma in non-malignant disease were also different than previous studies. Two correlation between the histopathological diagnostic type and associated lesions were significant: necrosis is more common in sarcoma type; lymphoid hyperplasia are more common in benign lesions type. In conclusion, several splenic malignant tumors and non-malignant diseases present the different population compare previous studies. It’s considered by more population small breeds in Taiwan. |
URI: | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/16884 |
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顯示於系所單位: | 獸醫學系 |
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