請用此 Handle URI 來引用此文件：
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/15901完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 邱麗珠(Lih-Chu Chiou) | |
| dc.contributor.author | Hsiao-Yun Chiu | en |
| dc.contributor.author | 邱曉筠 | zh_TW |
| dc.date.accessioned | 2021-06-07T17:54:54Z | - |
| dc.date.copyright | 2012-09-18 | |
| dc.date.issued | 2012 | |
| dc.date.submitted | 2012-08-16 | |
| dc.identifier.citation | Abraham I, Juhasz G, Kekesi KA, Kovacs KJ (1998) Corticosterone peak is responsible for stress-induced elevation of glutamate in the hippocampus. Stress 2:171-181.
Airan RD, Meltzer LA, Roy M, Gong Y, Chen H, Deisseroth K (2007) High-speed imaging reveals neurophysiological links to behavior in an animal model of depression. Science 317:819-823. Allard JS, Tizabi Y, Shaffery JP, Manaye K (2007) Effects of rapid eye movement sleep deprivation on hypocretin neurons in the hypothalamus of a rat model of depression. Neuropeptides 41:329-337. Allard JS, Tizabi Y, Shaffery JP, Trouth CO, Manaye K (2004) Stereological analysis of the hypothalamic hypocretin/orexin neurons in an animal model of depression. Neuropeptides 38:311-315. Alonso R, Griebel G, Pavone G, Stemmelin J, Le Fur G, Soubrie P (2004) Blockade of CRF(1) or V(1b) receptors reverses stress-induced suppression of neurogenesis in a mouse model of depression. Mol Psychiatry 9:278-286, 224. Arendt D, Oliver K, Summers C (2012) LOCAL OREXINERGIC ACTIVATION AND THE INFLUENCE ON THE FORCED SWIM TEST. Armario A, Gil M, Marti J, Pol O, Balasch J (1991) Influence of various acute stressors on the activity of adult male rats in a holeboard and in the forced swim test. Pharmacol Biochem Behav 39:373-377. Bain MJ, Dwyer SM, Rusak B (2004) Restraint stress affects hippocampal cell proliferation differently in rats and mice. Neurosci Lett 368:7-10. Balu DT, Lucki I (2009) Adult hippocampal neurogenesis: Regulation, functional implications, and contribution to disease pathology. Neuroscience & Biobehavioral Reviews 33:232-252. Ben Menachem-Zidon O, Goshen I, Kreisel T, Ben Menahem Y, Reinhartz E, Ben Hur T, Yirmiya R (2008) Intrahippocampal transplantation of transgenic neural precursor cells overexpressing interleukin-1 receptor antagonist blocks chronic isolation-induced impairment in memory and neurogenesis. Neuropsychopharmacology 33:2251-2262. Bernal-Morales B, Contreras CM, Cueto-Escobedo J (2009) Acute restraint stress produces behavioral despair in weanling rats in the forced swim test. Behavioural Processes 82:219-222. Berton O, McClung CA, Dileone RJ, Krishnan V, Renthal W, Russo SJ, Graham D, Tsankova NM, Bolanos CA, Rios M, Monteggia LM, Self DW, Nestler EJ (2006) Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress. Science 311:864-868. Brundin L, Bjorkqvist M, Petersen A, Traskman-Bendz L (2007a) Reduced orexin levels in the cerebrospinal fluid of suicidal patients with major depressive disorder. Eur Neuropsychopharmacol 17:573-579. Brundin L, Bjorkqvist M, Traskman-Bendz L, Petersen A (2009) Increased orexin levels in the cerebrospinal fluid the first year after a suicide attempt. J Affect Disord 113:179-182. Brundin L, Petersen A, Bjorkqvist M, Traskman-Bendz L (2007b) Orexin and psychiatric symptoms in suicide attempters. J Affect Disord 100:259-263. Buynitsky T, Mostofsky DI (2009) Restraint stress in biobehavioral research: Recent developments. Neuroscience & Biobehavioral Reviews 33:1089-1098. Cameron HA, Gould E (1994) Adult neurogenesis is regulated by adrenal steroids in the dentate gyrus. Neuroscience 61:203-209. Cameron HA, Tanapat P, Gould E (1998) Adrenal steroids and N-methyl-D-aspartate receptor activation regulate neurogenesis in the dentate gyrus of adult rats through a common pathway. Neuroscience 82:349-354. Chang H, Saito T, Ohiwa N, Tateoka M, Deocaris CC, Fujikawa T, Soya H (2007) Inhibitory effects of an orexin-2 receptor antagonist on orexin A- and stress-induced ACTH responses in conscious rats. Neurosci Res 57:462-466. Chang L (2010) Endogenous orexins contribute to stress-induced analgesia through endocannabinoid retrograde signaling in the ventrolateral periaqueductal gray. Chiou LC, Lee HJ, Ho YC, Chen SP, Liao YY, Ma CH, Fan PC, Fuh JL, Wang SJ (2010) Orexins/hypocretins: pain regulation and cellular actions. Curr Pharm Des 16:3089-3100. Chou TC, Scammell TE, Gooley JJ, Gaus SE, Saper CB, Lu J (2003) Critical role of dorsomedial hypothalamic nucleus in a wide range of behavioral circadian rhythms. J Neurosci 23:10691-10702. Coskun V, Luskin MB (2002) Intrinsic and extrinsic regulation of the proliferation and differentiation of cells in the rodent rostral migratory stream. J Neurosci Res 69:795-802. Couillard-Despres S, Wuertinger C, Kandasamy M, Caioni M, Stadler K, Aigner R, Bogdahn U, Aigner L (2009) Ageing abolishes the effects of fluoxetine on neurogenesis. Mol Psychiatry 14:856-864. Czeh B, Michaelis T, Watanabe T, Frahm J, de Biurrun G, van Kampen M, Bartolomucci A, Fuchs E (2001) Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine. Proc Natl Acad Sci U S A 98:12796-12801. Czeh B, Muller-Keuker JI, Rygula R, Abumaria N, Hiemke C, Domenici E, Fuchs E (2007) Chronic social stress inhibits cell proliferation in the adult medial prefrontal cortex: hemispheric asymmetry and reversal by fluoxetine treatment. Neuropsychopharmacology 32:1490-1503. Dagyte G, Van der Zee EA, Postema F, Luiten PG, Den Boer JA, Trentani A, Meerlo P (2009) Chronic but not acute foot-shock stress leads to temporary suppression of cell proliferation in rat hippocampus. Neuroscience 162:904-913. David DJ, Samuels BA, Rainer Q, Wang JW, Marsteller D, Mendez I, Drew M, Craig DA, Guiard BP, Guilloux JP, Artymyshyn RP, Gardier AM, Gerald C, Antonijevic IA, Leonardo ED, Hen R (2009) Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression. Neuron 62:479-493. de Lecea L, Kilduff TS, Peyron C, Gao X, Foye PE, Danielson PE, Fukuhara C, Battenberg EL, Gautvik VT, Bartlett FS, 2nd, Frankel WN, van den Pol AN, Bloom FE, Gautvik KM, Sutcliffe JG (1998) The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc Natl Acad Sci U S A 95:322-327. Dong H, Goico B, Martin M, Csernansky CA, Bertchume A, Csernansky JG (2004) Modulation of hippocampal cell proliferation, memory, and amyloid plaque deposition in APPsw (Tg2576) mutant mice by isolation stress. Neuroscience 127:601-609. Dugovic C, Solberg LC, Redei E, Van Reeth O, Turek FW (2000) Sleep in the Wistar-Kyoto rat, a putative genetic animal model for depression. Neuroreport 11:627-631. Dunn AJ, Swiergiel AH (2008) Effects of Acute and Chronic Stressors and CRF in Rat and Mouse Tests for Depression. Annals of the New York Academy of Sciences 1148:118-126. Eisch AJ, Bolanos CA, de Wit J, Simonak RD, Pudiak CM, Barrot M, Verhaagen J, Nestler EJ (2003) Brain-derived neurotrophic factor in the ventral midbrain-nucleus accumbens pathway: a role in depression. Biol Psychiatry 54:994-1005. Encinas JM, Enikolopov G (2008) Identifying and quantitating neural stem and progenitor cells in the adult brain. Methods Cell Biol 85:243-272. Encinas JM, Vaahtokari A, Enikolopov G (2006) Fluoxetine targets early progenitor cells in the adult brain. Proc Natl Acad Sci U S A 103:8233-8238. Fadel J, Burk JA (2010) Orexin/hypocretin modulation of the basal forebrain cholinergic system: Role in attention. Brain Res 1314:112-123. Feng P, Vurbic D, Wu Z, Hu Y, Strohl KP (2008) Changes in brain orexin levels in a rat model of depression induced by neonatal administration of clomipramine. J Psychopharmacol 22:784-791. Ferragud A, Haro A, Sylvain A, Velazquez-Sanchez C, Hernandez-Rabaza V, Canales JJ (2010) Enhanced habit-based learning and decreased neurogenesis in the adult hippocampus in a murine model of chronic social stress. Behav Brain Res 210:134-139. Francis F, Koulakoff A, Boucher D, Chafey P, Schaar B, Vinet MC, Friocourt G, McDonnell N, Reiner O, Kahn A, McConnell SK, Berwald-Netter Y, Denoulet P, Chelly J (1999) Doublecortin is a developmentally regulated, microtubule-associated protein expressed in migrating and differentiating neurons. Neuron 23:247-256. Georgescu D (2005) The Hypothalamic Neuropeptide Melanin-Concentrating Hormone Acts in the Nucleus Accumbens to Modulate Feeding Behavior and Forced-Swim Performance. Journal of Neuroscience 25:2933-2940. Ghanima A, Bennis M, Rampin O (2002) c-Fos expression as endogenous marker of lumbosacral spinal neuron activity in response to vaginocervical-stimulation. Brain Res Brain Res Protoc 9:1-8. Gould E, Tanapat P, McEwen BS, Flugge G, Fuchs E (1998) Proliferation of granule cell precursors in the dentate gyrus of adult monkeys is diminished by stress. Proc Natl Acad Sci U S A 95:3168-3171. Govindarajan A, Rao BS, Nair D, Trinh M, Mawjee N, Tonegawa S, Chattarji S (2006) Transgenic brain-derived neurotrophic factor expression causes both anxiogenic and antidepressant effects. Proc Natl Acad Sci U S A 103:13208-13213. Guo Y, Feng P (2012) OX2R activation induces PKC-mediated ERK and CREB phosphorylation. Exp Cell Res. Hanson ND, Owens MJ, Boss-Williams KA, Weiss JM, Nemeroff CB (2011) Several stressors fail to reduce adult hippocampal neurogenesis. Psychoneuroendocrinology 36:1520-1529. Heine VM, Maslam S, Zareno J, Joels M, Lucassen PJ (2004) Suppressed proliferation and apoptotic changes in the rat dentate gyrus after acute and chronic stress are reversible. Eur J Neurosci 19:131-144. Heydendael W, Sharma K, Iyer V, Luz S, Piel D, Beck S, Bhatnagar S (2011) Orexins/hypocretins act in the posterior paraventricular thalamic nucleus during repeated stress to regulate facilitation to novel stress. Endocrinology 152:4738-4752. Hirani K, Khisti RT, Chopde CT (2002) Behavioral action of ethanol in Porsolt's forced swim test: modulation by 3 alpha-hydroxy-5 alpha-pregnan-20-one. Neuropharmacology 43:1339-1350. Hirose M, Egashira S, Goto Y, Hashihayata T, Ohtake N, Iwaasa H, Hata M, Fukami T, Kanatani A, Yamada K (2003) N-acyl 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline: the first orexin-2 receptor selective non-peptidic antagonist. Bioorg Med Chem Lett 13:4497-4499. Ho YC, Lee HJ, Tung LW, Liao YY, Fu SY, Teng SF, Liao HT, Mackie K, Chiou LC (2011) Activation of orexin 1 receptors in the periaqueductal gray of male rats leads to antinociception via retrograde endocannabinoid (2-arachidonoylglycerol)-induced disinhibition. J Neurosci 31:14600-14610. Ida T, Nakahara K, Murakami T, Hanada R, Nakazato M, Murakami N (2000) Possible Involvement of Orexin in the Stress Reaction in Rats. Biochemical and Biophysical Research Communications 270:318-323. Ito N, Yabe T, Gamo Y, Nagai T, Oikawa T, Yamada H, Hanawa T (2008) I.c.v. administration of orexin-A induces an antidepressive-like effect through hippocampal cell proliferation. Neuroscience 157:720-732. Jang D-P, Lee S-H, Lee S-Y, Park C-W, Cho Z-H, Kim Y-B (2009) Neural responses of rats in the forced swimming test: [F-18]FDG micro PET study. Behavioural Brain Research 203:43-47. Kempermann G, Gage FH (2002) Genetic determinants of adult hippocampal neurogenesis correlate with acquisition, but not probe trial performance, in the water maze task. Eur J Neurosci 16:129-136. Kempermann G, Jessberger S, Steiner B, Kronenberg G (2004) Milestones of neuronal development in the adult hippocampus. Trends Neurosci 27:447-452. Koo JW, Duman RS (2008) IL-1beta is an essential mediator of the antineurogenic and anhedonic effects of stress. Proc Natl Acad Sci U S A 105:751-756. Krishnan V, Nestler EJ (2008) The molecular neurobiology of depression. Nature 455:894-902. Lee J, Duan W, Mattson MP (2002) Evidence that brain-derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice. J Neurochem 82:1367-1375. Lee JH, Bang E, Chae KJ, Kim JY, Lee DW, Lee W (1999) Solution structure of a new hypothalamic neuropeptide, human hypocretin-2/orexin-B. Eur J Biochem 266:831-839. Lee KJ, Kim SJ, Kim SW, Choi SH, Shin YC, Park SH, Moon BH, Cho E, Lee MS, Chun BG, Shin KH (2006) Chronic mild stress decreases survival, but not proliferation, of new-born cells in adult rat hippocampus. Exp Mol Med 38:44-54. Lemaire V, Koehl M, Le Moal M, Abrous DN (2000) Prenatal stress produces learning deficits associated with an inhibition of neurogenesis in the hippocampus. Proc Natl Acad Sci U S A 97:11032-11037. Lucassen PJ, Meerlo P, Naylor AS, van Dam AM, Dayer AG, Fuchs E, Oomen CA, Czeh B (2010) Regulation of adult neurogenesis by stress, sleep disruption, exercise and inflammation: Implications for depression and antidepressant action. Eur Neuropsychopharmacol 20:1-17. Lutter M, Krishnan V, Russo SJ, Jung S, McClung CA, Nestler EJ (2008) Orexin signaling mediates the antidepressant-like effect of calorie restriction. J Neurosci 28:3071-3075. Malberg JE (2004) Implications of adult hippocampal neurogenesis in antidepressant action. J Psychiatry Neurosci 29:196-205. Malberg JE, Duman RS (2003) Cell proliferation in adult hippocampus is decreased by inescapable stress: reversal by fluoxetine treatment. Neuropsychopharmacology 28:1562-1571. Marcus JN, Aschkenasi CJ, Lee CE, Chemelli RM, Saper CB, Yanagisawa M, Elmquist JK (2001) Differential expression of orexin receptors 1 and 2 in the rat brain. J Comp Neurol 435:6-25. Markakis EA, Gage FH (1999) Adult-generated neurons in the dentate gyrus send axonal projections to field CA3 and are surrounded by synaptic vesicles. J Comp Neurol 406:449-460. Mikrouli E, Wortwein G, Soylu R, Mathe AA, Petersen A (2011) Increased numbers of orexin/hypocretin neurons in a genetic rat depression model. Neuropeptides 45:401-406. Mirescu C, Peters JD, Gould E (2004) Early life experience alters response of adult neurogenesis to stress. Nat Neurosci 7:841-846. Murray F, Smith DW, Hutson PH (2008) Chronic low dose corticosterone exposure decreased hippocampal cell proliferation, volume and induced anxiety and depression like behaviours in mice. Eur J Pharmacol 583:115-127. Nacher J, Alonso-Llosa G, Rosell DR, McEwen BS (2003) NMDA receptor antagonist treatment increases the production of new neurons in the aged rat hippocampus. Neurobiol Aging 24:273-284. Nollet M, Gaillard P, Minier F, Tanti A, Belzung C, Leman S (2011) Activation of orexin neurons in dorsomedial/perifornical hypothalamus and antidepressant reversal in a rodent model of depression. Neuropharmacology 61:336-346. Nollet M, Gaillard P, Tanti A, Girault V, Belzung C, Leman S (2012) Neurogenesis-Independent Antidepressant-Like Effects on Behavior and Stress Axis Response of a Dual Orexin Receptor Antagonist in a Rodent Model of Depression. Neuropsychopharmacology. Peyron C, Tighe DK, van den Pol AN, de Lecea L, Heller HC, Sutcliffe JG, Kilduff TS (1998) Neurons containing hypocretin (orexin) project to multiple neuronal systems. J Neurosci 18:9996-10015. Pham K, Nacher J, Hof PR, McEwen BS (2003) Repeated restraint stress suppresses neurogenesis and induces biphasic PSA-NCAM expression in the adult rat dentate gyrus. Eur J Neurosci 17:879-886. Porter RA, Chan WN, Coulton S, Johns A, Hadley MS, Widdowson K, Jerman JC, Brough SJ, Coldwell M, Smart D, Jewitt F, Jeffrey P, Austin N (2001) 1,3-Biarylureas as selective non-peptide antagonists of the orexin-1 receptor. Bioorg Med Chem Lett 11:1907-1910. Rachalski A, Alexandre C, Bernard JF, Saurini F, Lesch KP, Hamon M, Adrien J, Fabre V (2009) Altered sleep homeostasis after restraint stress in 5-HTT knock-out male mice: a role for hypocretins. J Neurosci 29:15575-15585. Rainero I, Ostacoli L, Rubino E, Gallone S, Picci LR, Fenoglio P, Negro E, Rosso C, De Martino P, De Marchi M, Furlan PM, Pinessi L (2011) Association between major mood disorders and the hypocretin receptor 1 gene. J Affect Disord 130:487-491. Rotter A, Asemann R, Decker A, Kornhuber J, Biermann T (2011) Orexin expression and promoter-methylation in peripheral blood of patients suffering from major depressive disorder. J Affect Disord 131:186-192. Sahay A, Hen R (2007) Adult hippocampal neurogenesis in depression. Nat Neurosci 10:1110-1115. Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richarson JA, Kozlowski GP, Wilson S, Arch JR, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu WS, Terrett JA, Elshourbagy NA, Bergsma DJ, Yanagisawa M (1998) Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92:1 page following 696. Sakurai T, Nagata R, Yamanaka A, Kawamura H, Tsujino N, Muraki Y, Kageyama H, Kunita S, Takahashi S, Goto K, Koyama Y, Shioda S, Yanagisawa M (2005) Input of orexin/hypocretin neurons revealed by a genetically encoded tracer in mice. Neuron 46:297-308. Salomon RM, Ripley B, Kennedy JS, Johnson B, Schmidt D, Zeitzer JM, Nishino S, Mignot E (2003) Diurnal variation of cerebrospinal fluid hypocretin-1 (Orexin-A) levels in control and depressed subjects. Biol Psychiatry 54:96-104. Scammell TE, Winrow CJ (2011) Orexin Receptors: Pharmacology and Therapeutic Opportunities. Annual Review of Pharmacology and Toxicology 51:243-266. Scharfman H, Goodman J, Macleod A, Phani S, Antonelli C, Croll S (2005) Increased neurogenesis and the ectopic granule cells after intrahippocampal BDNF infusion in adult rats. Exp Neurol 192:348-356. Schmidt FM, Brugel M, Kratzsch J, Strauss M, Sander C, Baum P, Thiery J, Hegerl U, Schonknecht P (2010) Cerebrospinal fluid hypocretin-1 (orexin A) levels in mania compared to unipolar depression and healthy controls. Neurosci Lett 483:20-22. Scott MM, Marcus JN, Pettersen A, Birnbaum SG, Mochizuki T, Scammell TE, Nestler EJ, Elmquist JK, Lutter M (2011) Hcrtr1 and 2 signaling differentially regulates depression-like behaviors. Behav Brain Res 222:289-294. Seri B, Garcia-Verdugo JM, Collado-Morente L, McEwen BS, Alvarez-Buylla A (2004) Cell types, lineage, and architecture of the germinal zone in the adult dentate gyrus. J Comp Neurol 478:359-378. Seri B, Garcia-Verdugo JM, McEwen BS, Alvarez-Buylla A (2001) Astrocytes give rise to new neurons in the adult mammalian hippocampus. J Neurosci 21:7153-7160. Shi SS, Shao SH, Yuan BP, Pan F, Li ZL (2010) Acute stress and chronic stress change brain-derived neurotrophic factor (BDNF) and tyrosine kinase-coupled receptor (TrkB) expression in both young and aged rat hippocampus. Yonsei Med J 51:661-671. Shirayama Y, Chen AC, Nakagawa S, Russell DS, Duman RS (2002) Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression. J Neurosci 22:3251-3261. Smart D, Sabido-David C, Brough SJ, Jewitt F, Johns A, Porter RA, Jerman JC (2001) SB-334867-A: the first selective orexin-1 receptor antagonist. In: Br J Pharmacol, vol. 132, pp 1179-1182. Snyder JS, Soumier A, Brewer M, Pickel J, Cameron HA (2011) Adult hippocampal neurogenesis buffers stress responses and depressive behaviour. Nature 476:458-461. Surget A, Saxe M, Leman S, Ibarguen-Vargas Y, Chalon S, Griebel G, Hen R, Belzung C (2008) Drug-dependent requirement of hippocampal neurogenesis in a model of depression and of antidepressant reversal. Biol Psychiatry 64:293-301. Takahashi T, Nowakowski RS, Caviness VS, Jr. (1992) BUdR as an S-phase marker for quantitative studies of cytokinetic behaviour in the murine cerebral ventricular zone. J Neurocytol 21:185-197. Taliaz D, Stall N, Dar DE, Zangen A (2010) Knockdown of brain-derived neurotrophic factor in specific brain sites precipitates behaviors associated with depression and reduces neurogenesis. Mol Psychiatry 15:80-92. Tanapat P, Hastings NB, Rydel TA, Galea LA, Gould E (2001) Exposure to fox odor inhibits cell proliferation in the hippocampus of adult rats via an adrenal hormone-dependent mechanism. J Comp Neurol 437:496-504. Tfilin M, Sudai E, Merenlender A, Gispan I, Yadid G, Turgeman G (2010) Mesenchymal stem cells increase hippocampal neurogenesis and counteract depressive-like behavior. Mol Psychiatry 15:1164-1175. Thomas R, Urban J, Peterson D (2006a) Acute exposure to predator odor elicits a robust increase in corticosterone and a decrease in activity without altering proliferation in the adult rat hippocampus. Experimental Neurology 201:308-315. Thomas RM, Hotsenpiller G, Peterson DA (2007) Acute psychosocial stress reduces cell survival in adult hippocampal neurogenesis without altering proliferation. J Neurosci 27:2734-2743. Thomas RM, Urban JH, Peterson DA (2006b) Acute exposure to predator odor elicits a robust increase in corticosterone and a decrease in activity without altering proliferation in the adult rat hippocampus. Exp Neurol 201:308-315. Trivedi P, Yu H, MacNeil DJ, Van der Ploeg LH, Guan XM (1998) Distribution of orexin receptor mRNA in the rat brain. FEBS Lett 438:71-75. von der Goltz C, Koopmann A, Dinter C, Richter A, Grosshans M, Fink T, Wiedemann K, Kiefer F (2011) Involvement of orexin in the regulation of stress, depression and reward in alcohol dependence. Horm Behav 60:644-650. Wong EY, Herbert J (2005) Roles of mineralocorticoid and glucocorticoid receptors in the regulation of progenitor proliferation in the adult hippocampus. Eur J Neurosci 22:785-792. Wong RW, Guillaud L (2004) The role of epidermal growth factor and its receptors in mammalian CNS. Cytokine Growth Factor Rev 15:147-156. Yap JJ, Takase LF, Kochman LJ, Fornal CA, Miczek KA, Jacobs BL (2006) Repeated brief social defeat episodes in mice: effects on cell proliferation in the dentate gyrus. Behav Brain Res 172:344-350. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/15901 | - |
| dc.description.abstract | 食慾素(orexins)系統，由內生性促效劑orexins A和B組成(或名為hypocretin 1 和2)，及兩種受器OX1R及OX2R所組成，orexin 神經元位於下視丘。許多人類及動物研究指出食慾素與憂鬱症狀相關。先前我們的研究指出，給予小鼠急性關閉警迫壓力(acute restraint stress)會活化下視丘食慾素神經元。在本研究中，利用小鼠強迫游泳試驗(forced swim test; FST)觀察其不動行為(immobility)的表現，及利用免疫螢光染色（immunofluorescence），觀察海馬齒狀回(dentate gyrus)中神經新生(neurogenesis)的情形，計算doublecortin (一種不成熟神經細胞標記) 及BrdU (一種細胞分裂標記)正反應的細胞數目，探討由急性關閉警迫壓力所致的食慾素活化在緩解憂鬱行為中所扮演的角色。由結果得知，小鼠接觸三十分鐘的急性關閉警迫壓力後相較於控制組會減少強迫游泳試驗中不動行為的表現。腦室內給予(i.c.v.) 食慾素(1 nmol/0.5 μl/mouse)重現急性關閉警迫壓力所造成的影響，能夠減少強迫游泳試驗中不動行為的表現。在急性關閉警迫壓力前十五分鐘投予OX2R拮抗劑(Compound 29, 30 mg/kg, i.p.)而非OX1R拮抗劑 (SB-334867, 15 mg/kg, i.p.)，能回復急性關閉警迫壓力及腦室投予食慾素所造成不動行為減少的影響。OX1R拮抗劑及OX2R拮抗劑單獨作用在未施與壓力的小鼠皆不會影響其不動行為的表現。此外,腦室內投藥所造成的壓力能減少不動行為的表現，且此表現不會對OX1R拮抗劑及OX2R拮抗劑影響。急性關閉警迫壓力會增加海馬齒狀回齒狀迴顆粒細胞下區(subgranular zone of the dentate gyrus)中同時有BrdU及doublecortin正反應的細胞數目。這些結果暗示急性關閉警迫壓力活化下視丘食慾素神經系統活化OX2R造成抗憂鬱作用，此外，由腦室內投藥引起的壓力所造成的抗憂鬱作用則與食慾素無關。 | zh_TW |
| dc.description.abstract | The orexin system, consisting of orexin A and B and OX1R and OX2R, has been reported to be associated with depression in both human and animal studies. Orexin-containing neurons are limitedly localized in the hypothalamus. Previously, we found that acute restraint stress can activate hypothalamic orexin neurons. Here, we examined if the orexin system activated by restraint stress plays a role in relieving the depressive behavior in mice, immobility in the forced swimming test (FST), and hippocampal neurogenesis, which was measured by the number of cells double-immunoreactive to doublecortin (a neuronal marker) and BrdU (a cell proliferation marker) in the subgranular zone of the dente gyrus. Mice subjecting to restraint stress for 30 min showed significantly shorter immobility time in the FST than un-restrained mice. Orexin A (1 nmol/0.5 μl/mouse, i.c.v.) reproduced the effect of restraint stress, i.e. significantly shorter immobility time in un-restrained mice. Pretreatment with the antagonist of OX2 receptors (Compound 29, 30 mg/kg, i.p.), but not that of OX1 receptors (SB-334867, 15 mg/kg, i.p.), for 15 min significantly restored the immobility time in restrained mice and that in i.c.v. orexin-treated un-restrained mice. Both antagonists alone had no effect on the immobility time in un-restrained mice. The FST immobility time in the vehicle group by i.c.v. injection was shorter than by i.p. injection and this difference was not affected by either OX1R or OX2R antagonist. Restraint stress increased the number of BrdU/doublecortin double-immunorective cells in the subgranular zone of the dente gyrus. These results suggest that acute restraint stress results in activation of hypothalamic orexin neurons, releasing orexins which induce an antidepressant-like effect mediated through OX2 receptors. The stress induced by i.cv. procedure also decreased the FST depressive behavior, but this antidepressant effect is orexin-independent. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-07T17:54:54Z (GMT). No. of bitstreams: 1 ntu-101-R98443006-1.pdf: 937593 bytes, checksum: 4b9b7ac103ec252f3edf80a07e4ad8af (MD5) Previous issue date: 2012 | en |
| dc.description.tableofcontents | 口試委員審定書…………………………………………………I
致謝……………………………………………………………………….II 中文摘要(Abstract in Chinese)…………………………………………III 英文摘要(Abstract in English)…………………………………………..V List of Abbreviations……………………………………………………..1 Introduction………………………………………………………………3 Material and Methods…………………………………………………...20 Results………………………………………………………………….....27 Discussion………………………………………………………………...35 Tables……………………………………………………………………..49 Figures……………………………………………………………………58 References……………………………………………………………......77 | |
| dc.language.iso | en | |
| dc.title | 急性壓力活化食慾素系統造成抗憂鬱效果 | zh_TW |
| dc.title | Acute restraint stress leads to antidepression by activating orexin neurons | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 100-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 黃玲玲(Ling-Ling Hwang),李立仁(Li-Jen Lee),簡伯武(Po-Wu Gean) | |
| dc.subject.keyword | 食慾素,憂鬱,神經新生,強迫游泳試驗, | zh_TW |
| dc.subject.keyword | Stress,Orexin,OX1 receptors,OX2 receptors,depression,neurogenesis,forced swimming test, | en |
| dc.relation.page | 94 | |
| dc.rights.note | 未授權 | |
| dc.date.accepted | 2012-08-16 | |
| dc.contributor.author-college | 醫學院 | zh_TW |
| dc.contributor.author-dept | 藥理學研究所 | zh_TW |
| 顯示於系所單位： | 藥理學科所 | |
文件中的檔案：
| 檔案 | 大小 | 格式 | |
|---|---|---|---|
| ntu-101-1.pdf 目前未授權公開取用 | 915.62 kB | Adobe PDF |
系統中的文件，除了特別指名其著作權條款之外，均受到著作權保護，並且保留所有的權利。