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標題: | 科普重排反應及順反異構物之檢測應用於有機揮發氣體偵測及形狀記憶材料開發 Detection of 2-Aza-Cope Rearrangement and Cis-Trans Isomerization for VOC Sensing and Shape-Memory Materials Study |
作者: | Pei-Hsuan Liao 廖珮璇 |
指導教授: | 江建文(Kien-Voon Kong) |
關鍵字: | 表面增強拉曼散射,科普重排反應,光響應材料,奈米粒子, SERS,2-aza-Cope,responsive material,nanoparticles, |
出版年 : | 2020 |
學位: | 碩士 |
摘要: | 甲醛常存在於建築材料和許多家用產品,人體吸入的甲醛超量,會引發包括氣喘、神經退化性疾病或致癌等; 同時甲醛在臨床上應用於癌症病患呼吸氣體偵測,癌症病患與健康個體的呼出氣體成份不同,其中甲醛是一重要指標,透過實現微量的氣體偵測能幫助在臨床上的應用。我們在晶片上結合甲醛偵測分子來開發基於表面增強拉曼散射 (SERS) 的甲醛測量。SERS 晶片上甲醛偵測分子會與甲醛反應進行科普重排反應,導致觸發小分子和螢光基團鍵結斷裂,在 SERS 光譜中可檢測到此反應的光譜變化,並進行定量。 SERS 也可以用於檢測偶氮化物順/反異構化的變化,我們使用 SERS 來檢測含偶氮化物的形狀記憶液晶材料,使用順反特徵峰來監測形狀記憶材料的轉變。形狀記憶液晶材料被視為是人造肌肉、軟機器人發展上重要的一環,然而調控其形變一直是值得探討的課題,我們觀察到可以透過奈米粒子來調節形狀轉變的速率,而毋需改變偶氮化物的結構或改變光源波長,對於液晶聚合物材料開發提供更多可能性。 Formaldehyde is often found in construction materials and many household products. Excessive formaldehyde inhaled by the human body can cause asthma, neurodegenerative diseases or carcinogenesis. At the same time, formaldehyde is used clinically to detect respiratory gases. In cancer patients and healthy individuals have different exhaled gas components, and formaldehyde is an important indicator. It can help clinical applications by detecting trace amounts of gas. We combined formaldehyde detection molecules on the wafer to develop formaldehyde measurement based on Surface-Enhanced Raman Scattering (SERS). The formaldehyde detection molecules on the SERS chip will react with formaldehyde to undergo 2-aza-Cope rearrangement reaction, leading to triggering the breakage of the bond between the trigger and the fluorescent group. The spectral change of this reaction can be detected and quantified in SERS spectra. SERS can also be used to detect changes in cis/trans isomerization of azo compounds. We use SERS to detect shape memory liquid crystal materials containing azo compounds, and use cis-trans characteristic peaks to monitor the transition of shape memory materials. Shape memory liquid crystal materials are considered to be an important part in the development of artificial muscles and soft robots. However, regulating their deformation has always been a topic that is worth discussing. We have observed that nanoparticles can be used to adjust the rate of shape change without changing the structure of the azo compounds or changing the wavelength of the light source, which provides more possibilities for the development of liquid crystal polymer materials. |
URI: | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/15471 |
DOI: | 10.6342/NTU202001633 |
全文授權: | 未授權 |
顯示於系所單位: | 化學系 |
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