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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 林?輝(Feng-Huei Lin) | |
dc.contributor.author | Yu-Hsuan Chang | en |
dc.contributor.author | 張喻旋 | zh_TW |
dc.date.accessioned | 2021-06-07T17:29:15Z | - |
dc.date.copyright | 2020-02-18 | |
dc.date.issued | 2020 | |
dc.date.submitted | 2020-02-10 | |
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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/15277 | - |
dc.description.abstract | Mineral trioxide aggregate (MTA) 作為活髓治療的材料,因具生物相容性、生物活性、封閉性質佳等優點而受到牙醫師的青睞,然而其硬化時間太長以及操作性不佳使其在臨床應用尚未達到理想。介穩水泥是本實驗室以MTA成分作為基礎所開發的材料,研究目的是以摻雜鍶的介穩水泥縮短硬化時間,以及利用鍶具有促進骨生成的特性刺激骨生成的效果,並加上半水硫酸鈣以改善介穩水泥的操作性。
介穩水泥摻雜5 mole% 鍶後初始硬化時間從30分鐘縮短至11分鐘,最終硬化時間從100分鐘縮短為34分鐘,相較於MTA初始硬化時間78分鐘以及最終硬化時間261分鐘縮短許多,搭配抗壓強度和微硬度兩者機械性質結果,顯示摻雜鍶介穩水泥犧牲部分機械性質,而得到較短的硬化時間;從XRD結果發現,水合後產物氫氧化鈣(Portlandite)18.2° 峰值以PSC-5Sr最為明顯,添加5 wt% 石膏會改善PSC-5Sr操作性,在體外實驗之礦化能力分析中,鹼性磷酸酶、鈣沉澱以及基因表現結果顯示摻雜鍶組別優於其他組別。綜合以上結果,本研究所研發摻雜鍶介穩水泥混合半水硫酸鈣具有短的硬化時間以及操作性,且在體外實驗之礦化分析具有促進骨生成相關蛋白質以及基因表現,顯示為相當具有潛力作為活髓治療的材料。 | zh_TW |
dc.description.abstract | Mineral trioxide aggregate (MTA) has been used as a vital pulp material during vital pulp therapy for its good biocompatibility, bioactive and good sealing ability. However, several disadvantages of MTA have been reported such as long setting time, difficulty in handling. Our research group have developed material called Partial Stabilized Cement (PSC) which was based on MTA. The purpose of this study is focused on discussing the influences of strontium-doped PSC to shorten setting time and stimulate hard tissue formation, and adding calcium sulfate hemihydrates to improve handling property of PSC.
5 mole% of strontium were added to PSC. In this study, PSC-5Sr significantly decreased the initial setting time of PSC from 30 to 11 minutes and its final setting time from 100 to 34 minutes. PSC-5Sr had the highest intensity of the peak at the position of 18.2° for portlandite among those groups in XRD patterns of the hydration product for 4 hours, 1 and 7 days among these groups. The compressive strength and microhardness of PSC-5Sr were lower than other groups, which might relate to its shorter setting time. Next, handling properties of PSC-5Sr mixed with 5 weight% of calcium sulfate hemihydrates was improved. The result of ALP assay, Alizarin red S assay and gene expression indicated that PSC-5Sr promote MG63 cells to produce more alkaline phosphatase, calcium deposit and mineralized matrix related gene. In summary, the developed strontium doped partial stabilized cement mixed with calcium sulfate hemihydrates has great potential as a material for vital pulp therapy. | en |
dc.description.provenance | Made available in DSpace on 2021-06-07T17:29:15Z (GMT). No. of bitstreams: 1 ntu-109-R06548077-1.pdf: 4270561 bytes, checksum: 07e5c75e8a825027e52ac8370267e1c3 (MD5) Previous issue date: 2020 | en |
dc.description.tableofcontents | 目錄
論文口試委員審定書 I 誌謝 II 中文摘要 III ABSTRACT IV 目錄 V 圖目錄 X 表目錄 XII 公式目錄 XIII 縮寫目錄 XIV CHAPTER 1 緒論 1 1.1 前言 1 1.2 保存牙髓之重要性 2 1.2.1 牙髓之構造與功能 2 1.2.2 保留牙髓於臨床之意義 3 1.3 活髓治療(Vital Pulp Therapy) 4 1.3.1 活髓治療之介紹 4 1.3.2 活髓材料 4 1.3.2.1 氫氧化鈣(calcium hydroxide) 4 1.3.2.2 Mineral Trioxide Aggregate(MTA) 5 1.4 研究目的 7 CHAPTER 2 文獻回顧 8 2.1 波特蘭水泥 8 2.1.1 波特蘭水泥的水合原理 10 2.2 介穩水泥(Partial-Stabilized Cement, PSC) 11 2.2.1 製程方法 12 2.2.2 成分及比例的調整 12 2.2.3 鍶作為外來原子的摻雜 13 2.2.3.1 鍶摻雜C3S 13 2.2.3.2 鍶摻雜C3A 13 2.2.3.3 鍶在醫學之功用 14 2.3 半水硫酸鈣 15 2.3.1 發展回顧 15 2.3.2 性質與結構 15 CHAPTER 3 材料與方法 16 3.1 實驗儀器 16 3.2 實驗樣品 17 3.3 實驗架構 19 3.4 材料製備 20 3.4.1 PSC-Sr製備 20 3.4.2 PSC-Sr/Calcium sulfate hemihydrate製備 22 3.5 材料分析 23 3.5.1 X光繞射分析儀(X-ray diffraction, XRD) 23 3.5.2 掃瞄式電子顯微鏡(SEM) 23 3.5.3 水合產物分析 23 3.5.4 酸鹼值變化測試(pH Variation) 23 3.5.5 硬化時間測試(Setting time) 23 3.5.6 表面微硬度測試(Microhardness test) 24 3.5.7 抗壓強度測試(Compressive strength) 24 3.5.8 操作性測試(Handling property rating) 24 3.6 In vitro 體外實驗 26 3.6.1 細胞培養 26 3.6.1.1 細胞株培養 26 3.6.1.2 解凍細胞 26 3.6.1.3 繼代培養 26 3.6.1.4 細胞計數 26 3.6.1.5 凍細胞 27 3.6.2 生物相容性分析之材料萃取液製備 27 3.6.3 生物相容性分析 27 3.6.4 生物礦化能力分析 29 3.6.4.1 硬骨分化培養基(osteogenic medium)配製 29 3.6.4.2 礦化分析之材料萃取液製備 29 3.6.4.3 鹼性磷酸酶(Alkaline phosphatase, ALPase)定性染色分析 30 3.6.4.4 鹼性磷酸酶(Alkaline phosphatase, ALPase)定量分析 31 3.6.4.5 鈣沉澱定性染色 32 3.6.4.6 鈣沉澱定量分析 32 3.6.4.7 基因表現 33 3.7 資料分析 34 CHAPTER 4 結果 35 4.1 材料性質分析 35 4.1.1 材料合成前測試 35 4.1.2 材料粉末之 X 光繞射分析 37 4.1.3 水合產物之 X 光繞射分析 40 4.1.4 材料粉末之元素分析 41 4.1.5 材料水合產物之掃描式電子顯微鏡觀察 42 4.1.6 硬化時間測試 43 4.1.7 表面微硬度測試 44 4.1.8 抗壓強度測試 45 4.1.9 操作性測試 46 4.1.10 水合產物之酸鹼值變化 46 4.2 In vitro 體外實驗 47 4.2.1 生物相容性分析 47 4.2.2 生物礦化能力分析 48 4.2.2.1 生物礦化能力分析之前測試 48 4.2.2.2 鹼性磷酸酶(Alkaline phosphatase, ALPase)定性染色分析 49 4.2.2.3 鹼性磷酸酶(Alkaline phosphatase, ALPase)定量分析 51 4.2.2.4 鈣沉澱定性染色與定量 52 4.2.2.5 鈣沉澱定量分析 53 4.2.2.6 基因表現 53 CHAPTER 5 討論 54 5.1 添加半水硫酸鈣對材料操作性的影響 54 5.2 摻雜鍶對材料性質以及生物性質的影響 55 5.2.1 探討摻雜鍶對缺陷、水合產物以及硬化時間的影響 55 5.2.2 探討摻雜鍶對機械強度的影響 57 5.2.3 探討摻雜鍶對礦化能力的影響 58 CHAPTER 6 結論 60 CHAPTER 7 參考資料 61 | |
dc.language.iso | zh-TW | |
dc.title | 摻雜鍶介穩水泥混合半水硫酸鈣用於牙科活髓治療之研究 | zh_TW |
dc.title | The Development of Sr-doped Partial Stabilized Cement Mixed with Calcium Sulfate Hemihydrate for Vital Pulp Therapy | en |
dc.type | Thesis | |
dc.date.schoolyear | 108-1 | |
dc.description.degree | 碩士 | |
dc.contributor.coadvisor | 林俊彬(Chun-Pin Lin) | |
dc.contributor.oralexamcommittee | 郭士民(Shyh-Ming Kuo),黃義侑(Yi-You Huang),方旭偉(Hsu-Wei Fang) | |
dc.subject.keyword | 活髓治療,介穩水泥,鍶,半水硫酸鈣,硬化時間,礦化, | zh_TW |
dc.subject.keyword | vital pulp therapy,partial stabilized cement,strontium,calcium sulfate hemihydrate,setting time,mineralization, | en |
dc.relation.page | 65 | |
dc.identifier.doi | 10.6342/NTU202000387 | |
dc.rights.note | 未授權 | |
dc.date.accepted | 2020-02-10 | |
dc.contributor.author-college | 工學院 | zh_TW |
dc.contributor.author-dept | 醫學工程學研究所 | zh_TW |
顯示於系所單位: | 醫學工程學研究所 |
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