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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 鄭謙仁(Chian-Ren Jeng) | |
| dc.contributor.author | Wen-Ta Li | en |
| dc.contributor.author | 李文達 | zh_TW |
| dc.date.accessioned | 2021-05-12T09:34:19Z | - |
| dc.date.available | 2021-03-19 | |
| dc.date.available | 2021-05-12T09:34:19Z | - |
| dc.date.copyright | 2018-07-06 | |
| dc.date.issued | 2018 | |
| dc.date.submitted | 2018-07-02 | |
| dc.identifier.citation | Ajmal, C.M., Menamparambath, M.M., Choi, H.R., Baik, S., 2016. Extraordinarily high conductivity of flexible adhesive films by hybrids of silver nanoparticle-nanowires. Nanotechnology 27, 225603. 10.1088/0957-4484/27/22/225603 Akaighe, N., Maccuspie, R.I., Navarro, D.A., Aga, D.S., Banerjee, S., Sohn, M., Sharma, V.K., 2011. Humic acid-induced silver nanoparticle formation under environmentally relevant conditions. Environ Sci Technol 45, 3895-3901. 10.1021/es103946g Buffet, P.E., Zalouk-Vergnoux, A., Chatel, A., Berthet, B., Metais, I., Perrein-Ettajani, H., Poirier, L., Luna-Acosta, A., Thomas-Guyon, H., Risso-de Faverney, C., Guibbolini, M., Gilliland, D., Valsami-Jones, E., Mouneyrac, C., 2014. A marine mesocosm study on the environmental fate of silver nanoparticles and toxicity effects on two endobenthic species: the ragworm Hediste diversicolor and the bivalve mollusc Scrobicularia plana. Sci Total Environ 470-471, 1151-1159. 10.1016/j.scitotenv.2013.10.114 Danscher, G., 1981. Light and electron microscopic localization of silver in biological tissue. Histochemistry 71, 177-186. Degger, N., Tse, A.C., Wu, R.S., 2015. Silver nanoparticles disrupt regulation of steroidogenesis in fish ovarian cells. Aquat Toxicol 169, 143-151. 10.1016/j.aquatox.2015.10.015 Farkas, J., Christian, P., Urrea, J.A., Roos, N., Hassellov, M., Tollefsen, K.E., Thomas, K.V., 2010. Effects of silver and gold nanoparticles on rainbow trout (Oncorhynchus mykiss) hepatocytes. Aquat Toxicol 96, 44-52. 10.1016/j.aquatox.2009.09.016 Farre, M., Gajda-Schrantz, K., Kantiani, L., Barcelo, D., 2009. Ecotoxicity and analysis of nanomaterials in the aquatic environment. Anal Bioanal Chem 393, 81-95. 10.1007/s00216-008-2458-1 Gagne, F., Auclair, J., Fortier, M., Bruneau, A., Fournier, M., Turcotte, P., Pilote, M., Gagnon, C., 2013. Bioavailability and immunotoxicity of silver nanoparticles to the freshwater mussel Elliptio complanata. J Toxicol Environ Health A 76, 767-777. 10.1080/15287394.2013.818602 Gambardella, C., Costa, E., Piazza, V., Fabbrocini, A., Magi, E., Faimali, M., Garaventa, F., 2015. Effect of silver nanoparticles on marine organisms belonging to different trophic levels. Mar Environ Res 111, 41-49. 10.1016/j.marenvres.2015.06.001 Garcia-Alonso, J., Rodriguez-Sanchez, N., Misra, S.K., Valsami-Jones, E., Croteau, M.N., Luoma, S.N., Rainbow, P.S., 2014. Toxicity and accumulation of silver nanoparticles during development of the marine polychaete Platynereis dumerilii. Sci Total Environ 476-477, 688-695. 10.1016/j.scitotenv.2014.01.039 Ge, L., Li, Q., Wang, M., Ouyang, J., Li, X., Xing, M.M., 2014. Nanosilver particles in medical applications: synthesis, performance, and toxicity. Int J Nanomedicine 9, 2399-2407. 10.2147/IJN.S55015 Glover, R.D., Miller, J.M., Hutchison, J.E., 2011. 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Part Fibre Toxicol 7, 20. 10.1186/1743-8977-7-20 Kwok, K.W., Dong, W., Marinakos, S.M., Liu, J., Chilkoti, A., Wiesner, M.R., Chernick, M., Hinton, D.E., 2016. Silver nanoparticle toxicity is related to coating materials and disruption of sodium concentration regulation. Nanotoxicology 10, 1306-1317. 10.1080/17435390.2016.1206150 Lee, H.Y., Choi, Y.J., Jung, E.J., Yin, H.Q., Kwon, J.T., Kim, J.E., Im, H.T., Cho, M.H., Kim, J.H., Kim, H.Y., Lee, B.H., 2010. Genomics-based screening of differentially expressed genes in the brains of mice exposed to silver nanoparticles via inhalation. Journal of Nanoparticle Research 12, 1567-1578. DOI 10.1007/s11051-009-9666-2 Lee, J.H., Kim, Y.S., Song, K.S., Ryu, H.R., Sung, J.H., Park, J.D., Park, H.M., Song, N.W., Shin, B.S., Marshak, D., Ahn, K., Lee, J.E., Yu, I.J., 2013. Biopersistence of silver nanoparticles in tissues from Sprague-Dawley rats. Part Fibre Toxicol 10, 36. 10.1186/1743-8977-10-36 Liz, R., Simard, J.C., Leonardi, L.B., Girard, D., 2015. Silver nanoparticles rapidly induce atypical human neutrophil cell death by a process involving inflammatory caspases and reactive oxygen species and induce neutrophil extracellular traps release upon cell adhesion. Int Immunopharmacol 28, 616-625. 10.1016/j.intimp.2015.06.030 Lubick, N., 2008. Nanosilver toxicity: ions, nanoparticles--or both? Environ Sci Technol 42, 8617. Mao, B.H., Tsai, J.C., Chen, C.W., Yan, S.J., Wang, Y.J., 2016. Mechanisms of silver nanoparticle-induced toxicity and important role of autophagy. Nanotoxicology 10, 1021-1040. 10.1080/17435390.2016.1189614 McGillicuddy, E., Murray, I., Kavanagh, S., Morrison, L., Fogarty, A., Cormican, M., Dockery, P., Prendergast, M., Rowan, N., Morris, D., 2017. Silver nanoparticles in the environment: Sources, detection and ecotoxicology. Sci Total Environ 575, 231-246. 10.1016/j.scitotenv.2016.10.041 Mishra, A.R., Zheng, J., Tang, X., Goering, P.L., 2016. Silver Nanoparticle-Induced Autophagic-Lysosomal Disruption and NLRP3-Inflammasome Activation in HepG2 Cells Is Size-Dependent. Toxicol Sci 150, 473-487. 10.1093/toxsci/kfw011 Moreno-Garrido, I., Perez, S., Blasco, J., 2015. Toxicity of silver and gold nanoparticles on marine microalgae. Mar Environ Res 111, 60-73. 10.1016/j.marenvres.2015.05.008 Mukunthan, K.S., Elumalai, E.K., Patel, T.N., Murty, V.R., 2011. Catharanthus roseus: a natural source for the synthesis of silver nanoparticles. Asian Pac J Trop Biomed 1, 270-274. 10.1016/S2221-1691(11)60041-5 Myrzakhanova, M., Gambardella, C., Falugi, C., Gatti, A.M., Tagliafierro, G., Ramoino, P., Bianchini, P., Diaspro, A., 2013. Effects of nanosilver exposure on cholinesterase activities, CD41, and CDF/LIF-like expression in zebrafish (Danio rerio) larvae. Biomed Res Int 2013, 205183. 10.1155/2013/205183 Oberdorster, G., Sharp, Z., Atudorei, V., Elder, A., Gelein, R., Kreyling, W., Cox, C., 2004. Translocation of inhaled ultrafine particles to the brain. Inhal Toxicol 16, 437-445. 10.1080/08958370490439597 Park, E.J., Bae, E., Yi, J., Kim, Y., Choi, K., Lee, S.H., Yoon, J., Lee, B.C., Park, K., 2010a. Repeated-dose toxicity and inflammatory responses in mice by oral administration of silver nanoparticles. Environ Toxicol Pharmacol 30, 162-168. 10.1016/j.etap.2010.05.004 Park, E.J., Yi, J., Kim, Y., Choi, K., Park, K., 2010b. Silver nanoparticles induce cytotoxicity by a Trojan-horse type mechanism. Toxicol In Vitro 24, 872-878. 10.1016/j.tiv.2009.12.001 Piao, M.J., Kang, K.A., Lee, I.K., Kim, H.S., Kim, S., Choi, J.Y., Choi, J., Hyun, J.W., 2011. Silver nanoparticles induce oxidative cell damage in human liver cells through inhibition of reduced glutathione and induction of mitochondria-involved apoptosis. Toxicol Lett 201, 92-100. DOI 10.1016/j.toxlet.2010.12.010 Poirier, M., Simard, J.C., Antoine, F., Girard, D., 2014. Interaction between silver nanoparticles of 20 nm (AgNP20 ) and human neutrophils: induction of apoptosis and inhibition of de novo protein synthesis by AgNP20 aggregates. J Appl Toxicol 34, 404-412. 10.1002/jat.2956 Poirier, M., Simard, J.C., Girard, D., 2016. Silver nanoparticles of 70 nm and 20 nm affect differently the biology of human neutrophils. J Immunotoxicol 13, 375-385. 10.3109/1547691X.2015.1106622 Riaz Ahmed, K.B., Nagy, A.M., Brown, R.P., Zhang, Q., Malghan, S.G., Goering, P.L., 2017. Silver nanoparticles: Significance of physicochemical properties and assay interference on the interpretation of in vitro cytotoxicity studies. Toxicol In Vitro 38, 179-192. 10.1016/j.tiv.2016.10.012 Ringwood, A.H., McCarthy, M., Bates, T.C., Carroll, D.L., 2010. The effects of silver nanoparticles on oyster embryos. Mar Environ Res 69 Suppl, S49-51. 10.1016/j.marenvres.2009.10.011 Sahu, S.C., Zheng, J., Graham, L., Chen, L., Ihrie, J., Yourick, J.J., Sprando, R.L., 2014. Comparative cytotoxicity of nanosilver in human liver HepG2 and colon Caco2 cells in culture. J Appl Toxicol 34, 1155-1166. 10.1002/jat.2994 Sal'nikov, D.S., Pogorelova, A.S., Makarov, S.V., Vashurina, I.Y., 2009. Silver ion reduction with peat fulvic acids. Russian Journal of Applied Chemistry 82, 545-548. 10.1134/S107042720904003x Sardari, R.R.R., Zarchi, S.R., Talebi, A., Nasri, S., Imani, S., Khoradmehr, A., Sheshde, S.A.R., 2012. Toxicological effects of silver nanoparticles in rats. African Journal of Microbiology Research 6, 5587-5593. Doi 10.5897/Ajmr11.1070 Shahare, B., Yashpal, M., 2013. Toxic effects of repeated oral exposure of silver nanoparticles on small intestine mucosa of mice. Toxicol Mech Methods 23, 161-167. 10.3109/15376516.2013.764950 Shin, S.H., Ye, M.K., Kim, H.S., Kang, H.S., 2007. 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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/handle/123456789/1211 | - |
| dc.description.abstract | 奈米銀因其光學性質，電子性質，良好的抗微生物活性，催化活性和磁性活性而被廣泛應用於各類商品，也成為環境銀汙染的重要來源。在齧齒類及魚類等實驗動物的研究顯示，奈米銀可由呼吸道及消化道進入血液循環並沉積在各臟器中 (特別是腦組織和睪丸)。奈米銀已經被證實可以在上述這些動物模式引起細胞氧化壓力上升、去氧核苷核酸的損傷和細胞凋亡，並對藻類、海洋無脊椎動物和魚類具有毒性。鯨豚是海洋高階掠食者，也是最可能因奈米銀汙染而受到影響的動物之一。但目前卻沒有任何鯨豚相關的奈米銀毒性研究被發表，因此，評估奈米銀對鯨豚的健康影響是亟需進行。本研究開發輔助方法以定位銀在次器官 (suborgan) 層級的位置 (第二章)，藉由鯨豚組織學銀濃度分析技術 (cetacean histological Ag assay; CHAA)，估算鯨豚組織的銀濃度 (第二章和第三章)，並藉上述方法進行研究，建立鯨豚可能的銀代謝途徑之假說，並證明銀可能對鯨豚健康引起系統性而非器官特定性的負面影響 (第三章)。此外，本研究也揭示奈米銀對鯨豚白血球的細胞毒性和免疫毒性（第四章和第五章）。以上結果皆證實銀/銀化合物和奈米銀對鯨豚健康的負面影響，也顯示其在海洋環境中的潛在生態毒性。 | zh_TW |
| dc.description.abstract | Silver nanoparticles (AgNPs), an important source of silver contamination, have been widely used in many commercial products due to their optical properties, electronic properties, antimicrobial activity, catalytic activity, and magnetic activity. The AgNPs are released into the environment, gradually accumulate in the ocean, and may affect the animals of high trophic level via food-web chain, such as cetaceans and humans. Several rodent and fish studies have demonstrated AgNPs can enter the blood circulation via alimentary/respiratory tracts and deposit in multiple organs especially brain and testis. AgNPs have been reported to induce cellular oxidative stress, DNA damage and apoptosis in these animal models, and cause toxic effects on algae, marine invertebrates, and fishes. Cetaceans, as the top predators of ocean, may have been negatively affected by AgNPs, but no toxicity study of AgNPs in cetaceans has been reported. Therefore, it is urgent to investigate the possible negative effects of AgNPs on the health of cetacean. The current study presented an adjuvant method to localize the Ag distribution at suborgan levels (Chapter II), estimated the Ag concentrations of various tissues by cetacean histological Ag assay (CHAA) (Chapters II and III), provided a presumptive metabolic pathway of Ag in cetaceans, demonstrated the possible systemic rather than organ-targeting negative health effects caused by Ag in cetaceans (Chapter III), and revealed the cytotoxicity and immunotoxicity caused by AgNPs on the leukocytes of cetaceans (Chapters IV and V). All the data have demonstrated the negative effects of Ag/Ag compounds and AgNPs on the health of cetaceans and their potential ecotoxicity in marine environment. | en |
| dc.description.provenance | Made available in DSpace on 2021-05-12T09:34:19Z (GMT). No. of bitstreams: 1 ntu-107-D03629002-1.pdf: 9476316 bytes, checksum: 714c71c75db3b183c38c552469ee10ae (MD5) Previous issue date: 2018 | en |
| dc.description.tableofcontents | 摘要 i Abstract ii Table of Contents iii Chapter I: General Introduction 1 Section 1. Nanotechnology and Silver Nanoparticles (AgNPs) 1 Section 2. An Emerging Contaminant– AgNPs 1 Section 3. The Biodistribution and Bioavailability of AgNPs 3 Section 4. The Toxicity of AgNPs 4 Section 5. The Ecotoxicology of AgNPs 8 Section 6. Summary and Objectives 9 Chapter II: Use of Autometallography to Localize and Semi-quantify Silver in Cetacean Tissues (Manuscript in Submission) 12 Chapter III: Investigation of Silver (Ag) Deposition in Tissues from Stranded Cetaceans by Autometallography (AMG) Environmental Pollution, 2018, 235: 534-545 32 Chapter IV: Immunotoxicity of Silver Nanoparticles (AgNPs) on the Leukocytes of Common Bottlenose Dolphins (Tursiops truncatus) Scientific Reports, 2018, 8:5593 45 Chapter V: Th2 Cytokine Bias Induced by Silver Nanoparticles (AgNPs) in Peripheral Blood Mononuclear Cells (PBMCs) of Common Bottlenose Dolphins (Tursiops truncatus) (Manuscript in Submission) 58 Chapter VI: General Discussion 89 References 93 | |
| dc.language.iso | en | |
| dc.subject | 流式細胞儀 | zh_TW |
| dc.subject | 金屬自顯影技術 | zh_TW |
| dc.subject | 細胞毒性 | zh_TW |
| dc.subject | 鯨豚 | zh_TW |
| dc.subject | 鯨豚組織學銀分析法 | zh_TW |
| dc.subject | 免疫毒性 | zh_TW |
| dc.subject | 奈米銀 | zh_TW |
| dc.subject | Cetacean | en |
| dc.subject | Flow Cytometry | en |
| dc.subject | Silver Nanoparticles (AgNPs) | en |
| dc.subject | Immunotoxicity | en |
| dc.subject | Cetacean Histological Ag Assay (CHAA) | en |
| dc.subject | Autometallography (AMG) | en |
| dc.subject | Cytotoxicity | en |
| dc.title | 台灣擱淺鯨豚組織銀濃度與奈米銀對鯨豚免疫細胞影響的活體外研究 | zh_TW |
| dc.title | Silver Tissue Contamination in Taiwanese Stranded Cetaceans and Effects of Silver Nanoparticles on Cetacean Immune Cells in Vitro | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 106-2 | |
| dc.description.degree | 博士 | |
| dc.contributor.coadvisor | 楊瑋誠(Wei-Cheng Yang) | |
| dc.contributor.oralexamcommittee | 陳孟仙(Meng-Hsien Chen),張惠雯(Hui-Wen Chang),龐飛(Victor Fei Pang) | |
| dc.subject.keyword | 金屬自顯影技術,細胞毒性,鯨豚,鯨豚組織學銀分析法,免疫毒性,奈米銀,流式細胞儀, | zh_TW |
| dc.subject.keyword | Autometallography (AMG),Cytotoxicity,Cetacean,Cetacean Histological Ag Assay (CHAA),Immunotoxicity,Silver Nanoparticles (AgNPs),Flow Cytometry, | en |
| dc.relation.page | 101 | |
| dc.identifier.doi | 10.6342/NTU201801229 | |
| dc.rights.note | 同意授權(全球公開) | |
| dc.date.accepted | 2018-07-02 | |
| dc.contributor.author-college | 獸醫專業學院 | zh_TW |
| dc.contributor.author-dept | 獸醫學研究所 | zh_TW |
| 顯示於系所單位： | 獸醫學系 | |
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