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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 劉力瑜(Li-yu Daisy Liu) | |
| dc.contributor.author | Hsi-Min Yang | en |
| dc.contributor.author | 楊西閔 | zh_TW |
| dc.date.accessioned | 2021-05-20T21:45:53Z | - |
| dc.date.available | 2012-08-16 | |
| dc.date.available | 2021-05-20T21:45:53Z | - |
| dc.date.copyright | 2010-08-16 | |
| dc.date.issued | 2010 | |
| dc.date.submitted | 2010-08-05 | |
| dc.identifier.citation | Akutsu T., Miyano S. and Kuhara S. (2000). Algorithms for Identi-fying Boolean Networks and Related Biological Networks Based on Matrix Multiplication and Fingerprint Function. Journal of Computational Biology, 7(3-4): 331-343.
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/10638 | - |
| dc.description.abstract | 近年來，微陣列晶片(Microarray)常用來同時檢驗大量的基因表現值並建立基因調控網路。本篇研究則是利用公開下載的大腸桿菌的微陣列資料庫，對於不同的實驗條件下，探討其目標基因與其下游直接與間接調控基因的相關性。我們利用相關係數(Correlation Coefficient)與本質相關係數(Coefficient of Intrinsic Dependence，CID)來檢驗直接與間接調控關係基因的相關性，配合集群分析(Cluster Analysis)與文氏圖(Venn Diagram)，希望可以從這些統計分析中找到微陣列資料上的數據特性，以應用在預測未知的調控關係。 | zh_TW |
| dc.description.abstract | In recent years, microarray have been widly used to simultaneously monitor expression of a large number of genes and to establish gene regulatory networks.In this study , we use the public-available of E. coli microarray database, to rediscovery the regulation events between the target genes and their downstream targets.We use the coefficient of intrinsic dependence and correlation indentify the genes regulated by modE.We also use the cluster analysis to visualize the possible patterns of expression under different regulatory mechanisms. The results may provide insight into the prediction of gene regulatory mechanisms in the future. | en |
| dc.description.provenance | Made available in DSpace on 2021-05-20T21:45:53Z (GMT). No. of bitstreams: 1 ntu-99-R96621205-1.pdf: 993464 bytes, checksum: e4ee000c80f9a52ff09308bf35c641f0 (MD5) Previous issue date: 2010 | en |
| dc.description.tableofcontents | 1 前言. . . . . . . . . . . . . . . . . . . . . . . . . .1
2 材料與方法. . . . . . . . . . . . . . . . . . . . . . . . . .4 2.1 研究材料. . . . . . . . . . . . . . . . . . . . . . . . . . 4 2.1.1 微陣列基因表現資料庫. . . . . . . . . . . . . . 4 2.1.2 基因調控網路資料庫. . . . . . . . . . . . . . . 5 2.2 統計分析方法. . . . . . . . . . . . . . . . . . . . . . . 7 2.2.1 基因選擇. . . . . . . . . . . . . . . . . . . . . . 7 2.2.2 集群分析. . . . . . . . . . . . . . . . . . . . . . 9 2.3 分析流程整理. . . . . . . . . . . . . . . . . . . . . . . 10 3 結果與討論. . . . . . . . . . . . . . . . . . . . . . . . . .12 3.1 基因選擇能力比較. . . . . . . . . . . . . . . . . . . . . 12 3.1.1 基因排列次序. . . . . . . . . . . . . . . . . . . 12 3.1.2 顯著基因個數. . . . . . . . . . . . . . . . . . . 15 3.2 群集分析. . . . . . . . . . . . . . . . . . . . . . . . . . 20 4 結論. . . . . . . . . . . . . . . . . . . . . . . . . .25 參考文獻. . . . . . . . . . . . . . . . . . . . . . . . . .27 附錄一. . . . . . . . . . . . . . . . . . . . . . . . . .30 | |
| dc.language.iso | zh-TW | |
| dc.title | 利用微陣列資料探索大腸桿菌直接與間接之基因調控關係 | zh_TW |
| dc.title | Using Microarray Data to Explore Primary and Nonprimary
Regulatory Events of Escherichia coli | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 98-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 彭雲明,蘇秀媛 | |
| dc.subject.keyword | 微陣列晶片,相關係數,本質相關係數,集群分析,文氏圖, | zh_TW |
| dc.subject.keyword | Microarray,Correlation Coefficient,Coefficient of In- trinsic Dependence,Cluster Analysis,Venn Diagram, | en |
| dc.relation.page | 34 | |
| dc.rights.note | 同意授權(全球公開) | |
| dc.date.accepted | 2010-08-06 | |
| dc.contributor.author-college | 生物資源暨農學院 | zh_TW |
| dc.contributor.author-dept | 農藝學研究所 | zh_TW |
| 顯示於系所單位： | 農藝學系 | |
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