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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 陳致融 | zh_TW |
| dc.contributor.advisor | Chih-Jung Chen | en |
| dc.contributor.author | 莊秉祐 | zh_TW |
| dc.contributor.author | Ping-Yu Chuang | en |
| dc.date.accessioned | 2026-09-09T16:17:42Z | - |
| dc.date.available | 2026-09-10 | - |
| dc.date.copyright | 2026-09-09 | - |
| dc.date.issued | 2026 | - |
| dc.date.submitted | 2026-08-12 22:52:14 | - |
| dc.identifier.citation | (1) Rao, P.; Rathod, V. Valorization of food and agricultural waste: a step towards greener future. Chem. Rec. 2019, 19 (9), 1858–1871.
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/105110 | - |
| dc.description.abstract | 異位性皮膚炎為常見之慢性發炎性皮膚疾病，其致病原因與皮膚屏障功能異常、免疫失調及環境因子有關，近年全球病例數增加，使相關治療需求受到重視，目前外用皮質類固醇為異位性皮膚炎常見之治療方式，其中莫米松糠酸酯為具代表性之藥物之一，而糠酸可作為其糠酸酯結構之前驅物，顯示糠酸於醫藥分子合成中具有應用價值，然而，傳統糠酸合成途徑常面臨反應條件嚴苛、成本較高、副產物生成以及反應時間較長等問題，限制其高選擇性與高效率製備，因此，電化學催化逐漸成為合成糠酸之替代策略。
目前多數研究於鹼性條件下，藉由施加偏壓將糠醛(furfural; FF)氧化為糠酸(furoic acid; FAD)，但鹼性溶液會使糠醛分子發生歧化反應和自聚合等副反應；同時陰極還原反應亦可能影響糠醛氧化反應表現，為改善上述限制，本研究引入氧化還原儲庫(redox reservoir; RR)概念，藉由氫氧化鎳RR電極之可逆氧化還原特性，將氧化與還原反應解耦，並因應不同目標反應調控操作環境，此外，氫氧化鎳RR電極亦能於無施加偏壓且無電解質的條件下，自發驅動糠醛氧化反應，擺脫鹼性狀況之束縛，解決直接電催化所面臨的副反應問題。 為提高氫氧化鎳RR電極反應活性，本研究引入鈷修飾氫氧化鎳RR電極，以提升其催化效能，並應用於高濃度糠醛氧化反應，除了糠醛以外，氫氧化鎳RR電極亦可作為不同取代基之苯甲醛氧化媒介，以比較不同醛類分子之間反應速率。此外，本研究也探討二氧化碳還原反應(carbon dioxide reduction reaction; CO2RR)，實現90 %以上的糠酸產率與100 % 左右的CO2RR產物總法拉第效率，擴展氫氧化鎳RR電極於解耦催化與成對電解系統中之應用潛力。 | zh_TW |
| dc.description.abstract | Atopic dermatitis is a common chronic inflammatory skin disease associated with barrier dysfunction, immune dysregulation, and environmental factors, and its global prevalence is increasing. Mometasone furoate contains a furoate moiety for which furoic acid (FAD) can serve as a precursor. However, conventional FAD synthesis involves harsh conditions, high costs, byproducts, and long reaction times. Therefore, electrocatalysis offers an alternative.
Most studies oxidize furfural (FF) to FAD under alkaline conditions with an applied bias. However, alkaline media induce FF disproportionation and self-polymerization, while cathodic reactions may also affect oxidation performance. To address these limitations, this study introduces a nickel hydroxide redox reservoir (RR) electrode, whose reversible redox properties decouple oxidation and reduction and allow the environment to be tailored to each reaction. The nickel hydroxide RR electrode spontaneously drives furfural oxidation without applied bias or electrolyte, avoiding alkaline conditions and mitigating side reactions in direct electrocatalysis. To enhance activity, cobalt-modified nickel hydroxide RR electrodes were developed for high-concentration furfural oxidation. The nickel hydroxide RR electrode also mediated oxidation of differently substituted benzaldehydes, enabling comparison of reaction rates. Carbon dioxide reduction reaction (CO2RR) was further investigated, achieving over 90% FAD yield and approximately 100% total faradaic efficiency for CO2RR products. These results highlight the potential of nickel hydroxide RR electrodes in decoupled catalysis and paired electrolysis. | en |
| dc.description.provenance | Submitted by admin ntu (admin@lib.ntu.edu.tw) on 2026-09-09T16:17:42Z No. of bitstreams: 0 | en |
| dc.description.provenance | Made available in DSpace on 2026-09-09T16:17:42Z (GMT). No. of bitstreams: 0 | en |
| dc.description.tableofcontents | 誌謝 I
摘要 II Abstract III 目次 IV 圖次 VIII 表次 XIII 第一章 緒論 1 1.1 農業廢棄物危害 1 1.2 生物質 (Biomass) 2 1.2.1 糠醛氧化糠酸 4 1.3 傳統製程糠酸途徑 9 1.3.1 分子氧氧化反應 (Aerobic Oxidation) 9 1.3.2 化學-酵素氧化法 (Chemoenzymatic Oxidation) 10 1.3.2.1 全細胞生物催化氧化法 (Whole-cell Biocatalytic Oxidation) 10 1.3.2.2 脂肪酶媒介過酸氧化法 (Lipase-Mediated Peracid Oxidation) 12 1.3.3 雙氧水氧化法（Hydrogen Peroxide Oxidation） 13 1.4 電催化產生糠酸 14 1.4.1 傳統電化學槽反應 16 1.4.2 鹼性條件下糠醛副反應 18 1.4.3 酸性條件下糠醛副反應 19 1.5 解耦電解反應 (Decoupled Electrolysis) 21 1.5.1 氧化還原儲庫 (Redox Reservoir; RR) 23 1.6 研究動機 26 第二章 實驗步驟與儀器原理 29 2.1 實驗藥品來源 29 2.2 氧化還原儲庫活化與漿料合成 31 2.2.1 氫氧化鎳電極 (Redox Reservoir; RR) 31 2.2.2 不同比例鈷修飾之氫氧化鎳電極 32 2.2.3 氫氧化鎳電極漿料 33 2.3 電化學量測裝置 33 2.4 電化學量測方法 34 2.4.1 定電位計時電流法 (Chronoamperometry; CA) 34 2.4.2 循環伏安法(Cyclic Voltammetry; CV) 36 2.4.3 恆定電流充放電(Galvanostatic Charge/Discharge Cycle; GCD) 37 2.5 FOR電化學催化架設 38 2.5.1 工業級FOR電催化反應設計 39 2.6 生物質電催化反應之定量分析 40 2.6.1 高效液相層析儀 (High Performance Liquid Chromatography; HPLC) 40 2.6.1.1 流動相 (Mobile Phase) 41 2.6.1.2 液相層析管柱 (Liquid Chromatographic Column） 42 2.6.1.3 可變波長偵測器 (Variable Wavelength Detector; VWD) 42 2.7 氣相電催化反應之定量分析 44 2.7.1 氣相層析儀 (Gas Chromatography; GC) 44 2.7.1.1 載流氣體 (Carrier Gas) 44 2.7.1.2 氣相層析管柱 (Gas Chromatographic Column) 45 2.7.1.3 偵測器 45 2.8 X光繞射儀 (X-Ray Diffraction; XRD) 46 2.9 場發射掃描式電子顯微鏡 (Field Emission Scanning Electron Microscope; FE-SEM) 48 2.10 國家同步輻射研究中心 (National Synchrotron Radiation Research Center; NSRRC) 50 2.10.1 拉曼光譜 (Raman Spectroscopy) 52 第三章 結果與討論 55 3.1 液相層析檢量線建立方法 55 3.2 氣相層析檢量線建立方法 58 3.3 不同比例鈷修飾之氫氧化鎳電極基本鑑定分析 59 3.3.1 表面形貌與元素組成分析 59 3.3.2 晶體結構及組成分析 61 3.4 電化學特性分析 62 3.4.1 氧化還原行為分析 62 3.4.2 解耦系統中氧化還原儲庫循環響應分析 64 3.5 電化學FOR催化效果評估 67 3.5.1 鹼性條件下FOR副反應分析 67 3.5.2 陰極效應分析 71 3.5.3 施加偏壓之FOR催化行為分析 74 3.6 無外加偏壓下之FOR催化行為探討 76 3.7 不同鈷比例之氫氧化鎳RR電極FOR反應動力學探討 78 3.7.1 FOR反應機制討論 78 3.7.2 FOR反應速率和活化能比較 80 3.8 臨場拉曼光譜分析 84 3.9 FOR反應規模放大潛力評估 87 3.10 CO2RR操作電流密度評估 90 3.11 解耦催化FOR與CO2RR循環穩定性 91 3.12 氫氧化鎳RR電極於不同生物質分子之氧化應用 93 3.12.1 不同取代基之苯甲醛活化能比較 95 3.12.2 不同取代基之苯甲醛臨場拉曼光譜分析 96 第四章 結論 99 參考文獻 100 | - |
| dc.language.iso | zh_TW | - |
| dc.subject | 糠醛氧化反應 | - |
| dc.subject | 苯甲醛氧化反應 | - |
| dc.subject | 二氧化碳還原反應 | - |
| dc.subject | 氧化還原儲庫 | - |
| dc.subject | 解耦催化 | - |
| dc.subject | 無電解質催化 | - |
| dc.subject | furfural oxidation | - |
| dc.subject | benzaldehyde oxidation | - |
| dc.subject | carbon dioxide reduction | - |
| dc.subject | redox reservoir | - |
| dc.subject | decoupled catalysis | - |
| dc.subject | electrolyte-free catalysis | - |
| dc.title | 自發性生物質分子氧化反應之研究 | zh_TW |
| dc.title | Spontaneous Oxidation Reactions of Biomass-derived Molecules | en |
| dc.type | Thesis | - |
| dc.date.schoolyear | 114-2 | - |
| dc.description.degree | 碩士 | - |
| dc.contributor.oralexamcommittee | 姜昌明;周至品;洪崧富 | zh_TW |
| dc.contributor.oralexamcommittee | Chang-Ming Jiang ;Jyh-Pin Chou;Sung-Fu Hung | en |
| dc.subject.keyword | 糠醛氧化反應; 苯甲醛氧化反應; 二氧化碳還原反應; 氧化還原儲庫; 解耦催化; 無電解質催化 | zh_TW |
| dc.subject.keyword | furfural oxidation; benzaldehyde oxidation; carbon dioxide reduction; redox reservoir; decoupled catalysis; electrolyte-free catalysis | en |
| dc.relation.page | 108 | - |
| dc.identifier.doi | 10.6342/NTU202603839 | - |
| dc.rights.note | 同意授權(限校園內公開) | - |
| dc.date.accepted | 2026-08-18 | - |
| dc.contributor.author-college | 重點科技研究學院 | - |
| dc.contributor.author-dept | 奈米工程與科學學位學程 | - |
| dc.date.embargo-lift | 2031-07-29 | - |
| 顯示於系所單位： | 奈米工程與科學學位學程 | |
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