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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 林亮瑜 | zh_TW |
| dc.contributor.advisor | Liang-Yu Lin | en |
| dc.contributor.author | Nuzhat Sadia | zh_TW |
| dc.contributor.author | Nuzhat Sadia | en |
| dc.date.accessioned | 2026-08-31T16:06:00Z | - |
| dc.date.available | 2026-09-01 | - |
| dc.date.copyright | 2026-08-31 | - |
| dc.date.issued | 2026 | - |
| dc.date.submitted | 2026-06-12 00:00:00 | - |
| dc.identifier.citation | Acierno, C., Nevola, R., Barletta, F., Zielińska, K., Rinaldi, L., Sasso, F. C., … Caturano, A. (2025). The transition from NAFLD to MASLD: Implications for diagnosis, prognosis, and clinical management. Exploration of Medicine, 6. https://doi.org/10.37349/emed.2025.1001365
Arafa, A., Eshak, E. S., Iso, H., Muraki, I., & Tamakoshi, A. (2021). Night work, rotating shift work, and the risk of cancer in Japanese men and women: The JACC study. Journal of Epidemiology, 31(12), 585–592. https://doi.org/10.2188/jea.je20200208 Balakrishnan, M., El-Serag, H. B., Kanwal, F., & Thrift, A. P. (2017). Shiftwork is not associated with increased risk of NAFLD: Findings from the National Health and Nutrition Examination Survey. Digestive Diseases and Sciences, 62(2), 526–533. https://doi.org/10.1007/s10620-016-4401-1 Benchimol, E. I., Smeeth, L., Guttmann, A., Harron, K., Moher, D., Petersen, I., … Langan, S. M. (2015). The REporting of studies Conducted using Observational Routinely-collected health Data (RECORD) Statement. PLOS Medicine, 12(10), e1001885. https://doi.org/10.1371/journal.pmed.1001885 Bertuccio, P., Turati, F., Carioli, G., Rodriguez, T., La Vecchia, C., Malvezzi, M., & Negri, E. (2017). Global trends and predictions in hepatocellular carcinoma mortality. Journal of Hepatology, 67(2), 302–309. https://doi.org/10.1016/j.jhep.2017.03.011 Boivin, D. B., Boudreau, P., & Kosmadopoulos, A. (2022). Disturbance of the circadian system in shift work and its health impact. Journal of Biological Rhythms, 37(1), 3–28. https://doi.org/10.1177/07487304211064218 Calvert, G. (2016, October 5). Shift work and sleep. National Institute for Occupational Safety and Health (NIOSH), Centers for Disease Control and Prevention (CDC). https://www.cdc.gov/niosh/bulletin/2016/shift-work.html Cancer Research UK. (2024). Liver cancer statistics. https://www.cancerresearchuk.org/health-professional/cancer-statistics/statistics-by-cancer-type/liver-cancer Cedernaes, J. R., Moynihan, K., & Bass, J. (2018). Harrison's principles of internal medicine (J. L. Jameson, A. S. Fauci, D. L. Kasper, S. L. Hauser, D. L. Longo, & J. Loscalzo, Eds.; 20th ed.). McGraw-Hill Education. Chidambaranathan-Reghupaty, S., Fisher, P. B., & Sarkar, D. (2021). Hepatocellular carcinoma (HCC): Epidemiology, etiology and molecular classification. Advances in Cancer Research, 149, 1–61. Elsevier. https://doi.org/10.1016/bs.acr.2020.10.001 Clifton, L., Liu, X., Collister, J. A., Littlejohns, T. J., Allen, N., & Hunter, D. J. (2024). Assessing the importance of primary care diagnoses in the UK Biobank. European Journal of Epidemiology, 39(2), 219–229. https://doi.org/10.1007/s10654-023-01095-0 Collins, R. (2012). What makes UK Biobank special? The Lancet, 379(9822), 1173–1174. https://doi.org/10.1016/S0140-6736(12)60404-8 Correa, T. L., & Duong, N. (2025). Redefining fatty liver as metabolic dysfunction-associated steatotic liver disease: Implications of nomenclature changes for patients with diabetes. World Journal of Hepatology, 17(11). https://doi.org/10.4254/wjh.v17.i11.112573 Craig, C. L., Marshall, A. L., Sjöström, M., Bauman, A. E., Booth, M. L., Ainsworth, B. E.,…Oja, P. (2003). International Physical Activity Questionnaire: 12-country reliability and validity. Medicine & Science in Sports & Exercise, 35(8), 1381–1395. https://doi.org/10.1249/01.mss.0000078924.61453.fb Dutheil, F., Baker, J. S., Mermillod, M., De Cesare, M., Vidal, A., Moustafa, F.,…Navel, V. (2020). Shift work, and particularly permanent night shifts, promote dyslipidaemia: A systematic review and meta-analysis. Atherosclerosis, 313, 156–169. https://doi.org/10.1016/j.atherosclerosis.2020.08.015 Esposito, G., Bravi, F., Santucci, C., Zunarelli, C., Violante, F. S., La Vecchia, C.,…Turati, F. (2025). Night shift work and breast cancer risk in healthcare workers: A systematic review and meta-analysis. Occupational Medicine, 75(9), 596–607. https://doi.org/10.1093/occmed/kqaf040 Filipski, E., Subramanian, P., Carrière, J., Guettier, C., Barbason, H., & Lévi, F. (2009). Circadian disruption accelerates liver carcinogenesis in mice. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 680(1-2), 95-105. https://doi.org/10.1016/j.mrgentox.2009.10.002 Franzese, F., Bergmann, M., & Burzynska, A. (2026). Educational inequalities in well-being in later life in Germany: The role of health behaviours and health literacy. openRxiv. Fry, A., Littlejohns, T. J., Sudlow, C., Doherty, N., Adamska, L., Sprosen, T., … Allen, N. E. (2017). Comparison of sociodemographic and health-related characteristics of UK Biobank participants with those of the general population. American Journal of Epidemiology, 186(9), 1026–1034. https://doi.org/10.1093/aje/kwx246 Gomaa, A. I., Khan, S. A., Toledano, M. B., Waked, I., & Taylor-Robinson, S. D. (2008). Hepatocellular carcinoma: Epidemiology, risk factors and pathogenesis. World Journal of Gastroenterology, 14(27), 4300–4308. https://doi.org/10.3748/wjg.14.4300 Hasanoglu, I., Rivero-Juárez, A., & Özkaya Şahin, G. (2025). When metabolic dysfunction-associated steatotic liver disease meets viral hepatitis. Journal of Clinical Medicine, 14(10), 3422. https://doi.org/10.3390/jcm14103422 Hashim, M. M. A., Khan, M. A. M., Ashraf, M. U., Mohsin, S., Zahoor, K., Niazi, J.,…Khalid, S. (2025). Pathological evolution and internal medicine management of nonalcoholic fatty liver disease (NAFLD) in the era of metabolic dysfunction-associated steatotic liver disease (MASLD). Cureus. https://doi.org/10.7759/cureus.86963 Health and Safety Executive. (2006). Managing shiftwork: Health and safety guidance. HSE Books. Health and Safety Executive. (n.d.). Fatigue: Why is fatigue important? https://www.hse.gov.uk/humanfactors/topics/fatigue.htm Herrett, E., Gallagher, A. M., Bhaskaran, K., Forbes, H., Mathur, R., Van Staa, T., & Smeeth, L. (2015). Data Resource Profile: Clinical Practice Research Datalink (CPRD). International Journal of Epidemiology, 44(3), 827–836. https://doi.org/10.1093/ije/dyv098 Huang, H., Liu, Z., Xie, J., & Xu, C. (2023). Association between night shift work and NAFLD: A prospective analysis of 281,280 UK Biobank participants. BMC Public Health, 23(1). https://doi.org/10.1186/s12889-023-16204-7 International Agency for Research on Cancer. (2024). Liver cancer fact sheet: Global Cancer Observatory (GLOBOCAN 2022). World Health Organization. https://gco.iarc.who.int/today International Labour Organization. (2004). Shift work (WT-8). Conditions of Work and Employment Programme: Information Sheet. International Labour Office. International Labour Organization. (2022). Working time and work-life balance around the world. International Labour Office. https://www.ilo.org/publns Jih, J., Mukherjea, A., Vittinghoff, E., Nguyen, T. T., Tsoh, J. Y., Fukuoka, Y.,…Kanaya, A. M. (2014). Using appropriate body mass index cut points for overweight and obesity among Asian Americans. Preventive Medicine, 65, 1–6. https://doi.org/10.1016/j.ypmed.2014.04.010 Kettner, N. M., Voicu, H., Finegold, M. J., Coarfa, C., Sreekumar, A., Putluri, N., … Fu, L. (2016). Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis. Cancer Cell, 30(6), 909-924. https://doi.org/10.1016/j.ccell.2016.10.007 Kochan, D. Z., & Kovalchuk, O. (2015). Circadian disruption and breast cancer: An epigenetic link? Oncotarget, 6(19), 16866–16882. https://doi.org/10.18632/oncotarget.4343 Łagowska, K., Kuleta-Koberska, A., Michalak, M., & Bajerska, J. (2024). The effect of shift work on body mass index: A systematic review and meta-analysis of observational studies. American Journal of Human Biology, 36(6). https://doi.org/10.1002/ajhb.24041 Lee, Y., & Lee, W. (2024). Shift work and non-alcoholic fatty liver disease in young, healthy workers. Scientific Reports, 14(1). https://doi.org/10.1038/s41598-024-70538-9 Lin, L.-Y., Mulick, A., Mathur, R., Smeeth, L., Warren-Gash, C., & Langan, S. M. (2022). The association between vitamin D status and COVID-19 in England: A cohort study using UK Biobank. PLOS ONE, 17(6), e0269064. https://doi.org/10.1371/journal.pone.0269064 Lunca, S., Morarasu, S., Zaharia, R., Musina, A. M., Ong, W. L., Dimofte, G. M., & Roata, C. E. (2025). Should we fear the frail? A review on the impact of frailty on liver surgery. Medical Sciences, 13(4), 253. https://doi.org/10.3390/medsci13040253 Ma, B., Fan, Y., & Fan, W. (2025). Shift work and metabolic dysfunction-associated steatotic liver disease: A systematic review of observational studies. International Archives of Occupational and Environmental Health, 98(9-10), 777–786. https://doi.org/10.1007/s00420-025-02171-6 Maidstone, R., Rutter, M. K., Marjot, T., Ray, D. W., & Baxter, M. (2024). Shift work and evening chronotype are associated with hepatic fat fraction and non-alcoholic fatty liver disease in 282,303 UK Biobank participants. Endocrine Connections, 13(2). https://doi.org/10.1530/EC-23-0472 McGlynn, K. A., Petrick, J. L., & London, W. T. (2015). Global epidemiology of hepatocellular carcinoma. Clinics in Liver Disease, 19(2), 223–238. https://doi.org/10.1016/j.cld.2015.01.001 Ministry of Labor. (2024). 112 年勞工生活及就業狀況調查統計結果 [Statistical results of the 2023 labor life and employment status survey]. https://www.mol.gov.tw/1607/1632/1640/66059/ Moon, J., Holzhausen, E. A., & Mun, Y. (2024). Risk of prostate cancer with increasing years of night shift work: A two-stage dose-response meta-analysis with duration of night shift work as exposure dose. Heliyon, 10(8), e29080. https://doi.org/10.1016/j.heliyon.2024.e29080 Moon, J., Ikeda-Araki, A., & Mun, Y. (2024). Night shift work and female breast cancer: A two-stage dose-response meta-analysis for the correct risk definition. BMC Public Health, 24(1). https://doi.org/10.1186/s12889-024-19518-2 Mutambudzi, M., Niedzwiedz, C., Macdonald, E. B., Leyland, A., Mair, F., Anderson, J.,…Demou, E. (2021). Occupation and risk of severe COVID-19: prospective cohort study of 120,075 UK Biobank participants. Occupational and Environmental Medicine, 78(5), 307-314. https://doi.org/10.1136/oemed-2020-106731 National Institute for Occupational Safety and Health (NIOSH). (2020, March 31). Module 1. Introduction – NIOSH training for nurses on shift work and long work hours. Centers for Disease Control and Prevention (CDC). https://www.cdc.gov/niosh/work-hour-training-for-nurses/longhours/mod1/01.html National Toxicology Program. (2018). Draft report on carcinogens monograph on night shift work and light at night: Peer review draft. National Toxicology Program. (2021). NTP cancer hazard assessment report on night shift work and light at night. National Institute of Environmental Health Sciences. https://doi.org/10.22427/NTP-CHR-NSWLAN Occupational Safety and Health Administration, Ministry of Labor. (2021). 職場夜間工作安全衛生指引 (Guidelines for occupational safety and health of night work) (No. 1101060521). Ministry of Labor. Papantoniou, K., Devore, E. E., Massa, J., Strohmaier, S., Vetter, C., Yang, L., … Schernhammer, E. S. (2018). Rotating night shift work and colorectal cancer risk in the nurses’ health studies. International Journal of Cancer, 143(11), 2709–2717. https://doi.org/10.1002/ijc.31655 Reinganum, M., Moynihan, E. A., & Thomas, J. (2024). Shift work hazards. In StatPearls. StatPearls Publishing. Rich, C., Cortina-Borja, M., Dezateux, C., Geraci, M., Sera, F., Calderwood, L.,…Griffiths, L. J. (2013). Predictors of non-response in a UK-wide cohort study of children's accelerometer-determined physical activity using postal methods. BMJ Open, 3(3), e002290. https://doi.org/10.1136/bmjopen-2012-002290 Rivera, A. S., Akanbi, M., O’Dwyer, L. C., & McHugh, M. (2020). Shift work and long work hours and their association with chronic health conditions: A systematic review of systematic reviews with meta-analyses. PLOS ONE, 15(4), e0231037. https://doi.org/10.1371/journal.pone.0231037 Schoeler, T., Pingault, J.-B., & Kutalik, Z. (2024). The impact of self-report inaccuracy in the UK Biobank and its interplay with selective participation. Nature Human Behaviour, 9(3), 584–594. https://doi.org/10.1038/s41562-024-02061-w Singal, A. G., Kanwal, F., & Llovet, J. M. (2023). Global trends in hepatocellular carcinoma epidemiology: Implications for screening, prevention and therapy. Nature Reviews Clinical Oncology, 20(12), 864–884. https://doi.org/10.1038/s41571-023-00825-3 Singh, A., Anjum, B., Naz, Q., Raza, S., Sinha, R. A., Ahmad, M. K.,…Verma, N. (2024). Night shift-induced circadian disruption: Links to initiation of non-alcoholic fatty liver disease/non-alcoholic steatohepatitis and risk of hepatic cancer. Hepatoma Research. https://doi.org/10.20517/2394-5079.2024.88 Sooriyaarachchi, P., Jayawardena, R., Pavey, T., & King, N. A. (2022). Shift work and the risk for metabolic syndrome among healthcare workers: A systematic review and meta-analysis. Obesity Reviews, 23(10). https://doi.org/10.1111/obr.13489 Sterne, J. A. C., White, I. R., Carlin, J. B., Spratt, M., Royston, P., Kenward, M. G.,…Carpenter, J. R. (2009). Multiple imputation for missing data in epidemiological and clinical research: Potential and pitfalls. BMJ, 338, b2393. https://doi.org/10.1136/bmj.b2393 Sudlow, C., Gallacher, J., Allen, N., Beral, V., Burton, P., Danesh, J.,…Collins, R. (2015). UK Biobank: An open access resource for identifying the causes of a wide range of complex diseases of middle and old age. PLOS Medicine, 12(3), e1001779. https://doi.org/10.1371/journal.pmed.1001779 Suzuki, H., Fujiwara, N., Singal, A. G., Baumert, T. F., Chung, R. T., Kawaguchi, T., & Hoshida, Y. (2025). Prevention of liver cancer in the era of next-generation antivirals and obesity epidemic. Hepatology. https://doi.org/10.1097/hep.0000000000001227 Tosoratto, J., Tárraga López, P. J., López-González, Á. A., Busquets-Cortes, C., Obrador De Hevia, J., & Ramirez-Manent, J. I. (2025). Associations between shift work, sociodemographic and lifestyle characteristics, body measurements, and MASLD. Life, 15(6), 961. https://doi.org/10.3390/life15060961 Travis, R. C., Balkwill, A., Fensom, G. K., Appleby, P. N., Reeves, G. K., Wang, X.-S.,…Beral, V. (2016). Night shift work and breast cancer incidence: Three prospective studies and meta-analysis of published studies. Journal of the National Cancer Institute, 108(12), djw169. https://doi.org/10.1093/jnci/djw169 U.S. Bureau of Labor Statistics. (2019). Job flexibilities and work schedules — 2017-2018: Data from the American Time Use Survey (USDL-19-1691). U.S. Department of Labor. UK Biobank. (2007). UK Biobank ethics and governance framework (Version 3.0). UK Biobank. (2011). Touch screen questionnaire (Version 1.0). http://www.ukbiobank.ac.uk/ UK Biobank. (2023a). Cancer data: Linkage from national cancer registries (Version 2.0). http://www.ukbiobank.ac.uk/ UK Biobank. (2023b). Hospital inpatient data (Version 4.0). http://www.ukbiobank.ac.uk/ UK Biobank. (2023c). Mortality data: Linkage to death registries (Version 3.0). http://www.ukbiobank.ac.uk/ UK Biobank. (2024). Primary care linked data (Version 2.0). https://www.ukbiobank.ac.uk UK Biobank. (n.d.-a). Data providers and dates of data availability. https://biobank.ndph.ox.ac.uk/ukb/exinfo.cgi?src=Data_providers_and_dates UK Biobank. (n.d.-b). UK Biobank resource 592: Clinical coding classification systems and maps. UK Biobank. (n.d.-c). UK Biobank Showcase: Help - Instances. https://biobank.ndph.ox.ac.uk/ukb/help.cgi?cd=instances World Medical Association. (2024). World Medical Association Declaration of Helsinki: Ethical principles for medical research involving human participants. JAMA. https://doi.org/10.1001/jama.2024.21972 Wu, H., Wang, W., Weng, B., Wei, J., Wang, N., Zhang, J.,…Tan, X. (2026). Diurnal light exposure and rest-activity rhythms in relation to MASLD: Insights from 2 nationwide cohort studies. The Journal of Clinical Endocrinology & Metabolism, 111(5), 1459–1469. https://doi.org/10.1210/clinem/dgaf593 Xu, J., Ni, S., Wang, Y., Yan, M., Yang, X., Ge, H.,…Tang, N.-J. (2023). Shift work and nonalcoholic fatty liver disease incidence among Chinese rail workers: a 4-year longitudinal cohort study. International Archives of Occupational and Environmental Health, 96(1), 179-190. https://doi.org/10.1007/s00420-022-01913-0 Zhang, S., Wang, Y., Wang, Z., Wang, H., Xue, C., Li, Q.,…Yuan, J. (2020). Rotating night shift work and non-alcoholic fatty liver disease among steelworkers in China: a cross-sectional survey. Occupational and Environmental Medicine, 77(5), 333-339. https://doi.org/10.1136/oemed-2019-106220 | - |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/104654 | - |
| dc.description.abstract | 背景 : 輪班工作是導致晝夜節律失調、代謝功能異常及多種慢性疾病的重要危險因子。部分研究指出輪班工作可能與代謝功能障礙相關脂肪性肝病（Metabolic Dysfunction-Associated Steatotic Liver Disease, MASLD）的發生有關，但其實際危害程度可能仍被低估。此外，目前輪班工作與致肝癌風險的證據仍然不足。本研究旨在探討輪班工作與新發肝癌及 MASLD 風險之間的關聯。
研究方法 : 本研究利用英國生物銀行（UK Biobank）資料進行回溯性世代研究（retrospective cohort study）。納入於招募時為受僱或自營作業，且具備完整輪班工作資料的參與者。輪班工作暴露狀況來自參與者自行填寫的問卷，將參與者區分為輪班工作者與非輪班工作者。新發肝癌與 MASLD 個案透過連結電子健康紀錄進行確認，包括基層醫療紀錄（primary care records）、住院醫療紀錄及癌症登錄資料。研究採用 Cox 比例風險迴歸模型（Cox proportional hazards regression model）評估風險比（Hazard Ratio, HR）及其 95% 信賴區間（Confidence Interval, CI），並調整人口學、社會經濟、生活型態及代謝相關因素等共變項。 研究結果 : 在納入分析的 285,397 名參與者中，17.3%（n = 49,352）從事輪班工作。在長達 16 年的追蹤期間內，共發現 4,819 例新發 MASLD 個案及 609 例新發肝癌個案，其發生率分別為每 10 萬人年 128.35 例及 16.02 例。在完整校正模型中，輪班工作者罹患 MASLD 的風險較非輪班工作者增加 16%（HR = 1.16，95% CI：1.06–1.28）。相較之下，輪班工作與新發肝癌之間未觀察到具有統計顯著性的關聯（HR = 1.13，95% CI：0.84–1.51)。 結論 : 本研究發現，輪班工作與新發 MASLD 風險顯著增加有關；然而目前並無足夠證據支持輪班工作與肝癌發生風險增加有關。研究結果顯示，非傳統工作時程可能透過干擾晝夜節律而對肝臟健康造成不利影響。未來仍需進行具有更詳細輪班工作暴露評估及更長追蹤期間的研究，以進一步釐清輪班工作與肝癌風險之間的關係。 | zh_TW |
| dc.description.abstract | Background: Shift work has been an emerging risk factor contributing to circadian disruption, metabolic dysfunction, and several chronic diseases. Some research has pointed toward a potential link between shift work and the onset of metabolic dysfunction-associated steatotic liver disease (MASLD), while the real hazards might be underestimated. In addition, the carcinogenic risks of shift work remain poorly understood. This study aimed to investigate the association between shift work and the risk of incident liver cancer and MASLD
Methods: We utilized the UK Biobank to perform a retrospective cohort study. Participants reporting being in paid or self-employment at the time of recruitment and having available information on shift work status were included. Shift work exposure was self-reported and categorized as shift worker and non-shift worker. Incident liver cancer and MASLD cases were ascertained through linked electronic health records, including primary care records, hospital inpatient care records, and cancer registry data. Hazard ratios (HR) along with 95% confidence intervals (CI) were estimated using Cox proportional hazards regression models, and covariates related to demographic, socioeconomic, lifestyle, and metabolic factors were adjusted for. Results: Of the 285,397 employed participants included in the analysis, 17.3% (n = 49,352) were engaged in shift work. Over a 16-year follow-up period, 4,819 incident cases of MASLD and 609 incident cases of liver cancer were identified, corresponding to incidence rates of 128.35 and 16.02 per 100,000 person-years, respectively. In fully adjusted models, we found strong evidence that shift work was associated with a 16% higher risk of MASLD (HR: 1.16, 95% CI: 1.06–1.28). In contrast, no significant association was observed between shift work and incident liver cancer (HR: 1.13, 95% CI: 0.84–1.51). Conclusion: Our study found that shift work was associated with a significantly increased risk of incident MASLD; however, evidence supporting an increased risk of liver cancer was not statistically strong. These results indicate that non-traditional work schedules might negatively impact liver health, potentially through circadian disruption. Further studies with detailed shift work exposure assessments and longer follow-up are needed to clarify the relationship between shift work and liver cancer risk. | en |
| dc.description.provenance | Submitted by admin ntu (admin@lib.ntu.edu.tw) on 2026-08-31T16:06:00Z No. of bitstreams: 0 | en |
| dc.description.provenance | Made available in DSpace on 2026-08-31T16:06:00Z (GMT). No. of bitstreams: 0 | en |
| dc.description.tableofcontents | Master's Thesis Acceptance Certificate i
Acknowledgements ii Abstract (Chinese) iv Abstract (English) vi 1. Introduction 1 1.1 Shift Work 1 1.1.1 Definition and Burden of Shift Work 1 1.1.2 Shift Work and Circadian Rhythm Disruption 2 1.1.3 Health Impact of Shift Work 3 1.2 Liver Cancer 6 1.2.1 Epidemiology and Risk Factors of Liver Cancer 6 1.2.2 Shift Work and Liver Cancer 7 1.3 MASLD 7 1.3.1 Epidemiology and Risk Factors of MASLD 7 1.3.2 Shift Work and MASLD 8 1.4 Knowledge Gap and Objective 9 2. Methods 11 2.1 Study Population: The UK Biobank 11 2.2 Study Design, Inclusion and Exclusion criteria 12 2.3 Exposure Ascertainment 12 2.4 Outcomes Assessment 13 2.5 Covariates Assessment 14 2.6 Statistical Analyses 15 3. Results 18 3.1 Baseline Characteristics 18 3.2 Missingness Measurement 19 3.3 Kaplan–Meier Survival Analysis 19 3.4 Shift Work and Liver Cancer 20 3.5 Shift Work and MASLD 20 4. Discussion 22 References 32 Supplement file 50 Appendix 69 | - |
| dc.language.iso | en | - |
| dc.subject | 輪班工作 | - |
| dc.subject | 晝夜節律失調 | - |
| dc.subject | 肝癌 | - |
| dc.subject | 肝細胞癌 | - |
| dc.subject | 肝臟惡性腫瘤 | - |
| dc.subject | 肝內膽管癌 | - |
| dc.subject | 英國生物銀行 | - |
| dc.subject | 基層醫療紀錄 | - |
| dc.subject | 代謝功能障礙相關脂肪性肝病（MASLD) | - |
| dc.subject | Shift work | - |
| dc.subject | circadian disruption | - |
| dc.subject | liver cancer | - |
| dc.subject | hepatocellular carcinoma | - |
| dc.subject | hepatic malignancies | - |
| dc.subject | intrahepatic cholangiocarcinoma | - |
| dc.subject | UK Biobank | - |
| dc.subject | primary care record | - |
| dc.subject | metabolic dysfunction-associated steatotic liver disease | - |
| dc.subject | MASLD | - |
| dc.title | 輪班工作與肝癌及代謝功能障礙相關脂肪肝 (MASLD)之關聯: 使用英國生物銀行的回顧性世代研 | zh_TW |
| dc.title | Association of Shift Work with Liver Cancer and Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): A Retrospective Cohort Study of UK Biobank Participants | en |
| dc.type | Thesis | - |
| dc.date.schoolyear | 114-2 | - |
| dc.description.degree | 碩士 | - |
| dc.contributor.oralexamcommittee | 蘇東弘;馮嬿臻;Chen-Long Wu | zh_TW |
| dc.contributor.oralexamcommittee | TUNG-HUNG SU;YEN-CHEN ANNE FENG;Chen-Long Wu | en |
| dc.subject.keyword | 輪班工作; 晝夜節律失調; 肝癌; 肝細胞癌; 肝臟惡性腫瘤; 肝內膽管癌; 英國生物銀行; 基層醫療紀錄; 代謝功能障礙相關脂肪性肝病（MASLD) | zh_TW |
| dc.subject.keyword | Shift work; circadian disruption; liver cancer; hepatocellular carcinoma; hepatic malignancies; intrahepatic cholangiocarcinoma; UK Biobank; primary care record; metabolic dysfunction-associated steatotic liver disease; MASLD | en |
| dc.relation.page | 70 | - |
| dc.identifier.doi | 10.6342/NTU202601263 | - |
| dc.rights.note | 同意授權(全球公開) | - |
| dc.date.accepted | 2026-06-16 | - |
| dc.contributor.author-college | 公共衛生學院 | - |
| dc.contributor.author-dept | 全球衛生學位學程 | - |
| dc.date.embargo-lift | 2026-09-01 | - |
| 顯示於系所單位： | 全球衛生學位學程 | |
文件中的檔案：
| 檔案 | 大小 | 格式 | |
|---|---|---|---|
| ntu-114-2.pdf | 6.19 MB | Adobe PDF | 檢視/開啟 |
系統中的文件，除了特別指名其著作權條款之外，均受到著作權保護，並且保留所有的權利。