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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 王兆麟 | zh_TW |
| dc.contributor.advisor | Jaw-Lin Wang | en |
| dc.contributor.author | 洪浩瑋 | zh_TW |
| dc.contributor.author | Hao-Wei Hong | en |
| dc.date.accessioned | 2026-08-26T16:12:34Z | - |
| dc.date.available | 2026-08-27 | - |
| dc.date.copyright | 2026-08-26 | - |
| dc.date.issued | 2026 | - |
| dc.date.submitted | 2026-07-23 00:00:00 | - |
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Chinese Herbal Medicine Adjusting Brain Microenvironment via Mediating Central Nervous System Lymphatic Drainage in Alzheimer's Disease. Chin J Integr Med, 28(2), 176–184. https://doi.org/10.1007/s11655-021-3342-5 44. Zinchenko, E., Navolokin, N., Shirokov, A., Khlebtsov, B., Dubrovsky, A., Saranceva, E., Abdurashitov, A., Khorovodov, A., Terskov, A., Mamedova, A., Klimova, M., Agranovich, I., Martinov, D., Tuchin, V., Semyachkina-Glushkovskaya, O., & Kurts, J. (2019). Pilot study of transcranial photobiomodulation of lymphatic clearance of beta-amyloid from the mouse brain: breakthrough strategies for non-pharmacologic therapy of Alzheimer's disease. Biomed Opt Express, 10(8), 4003–4017. https://doi.org/10.1364/boe.10.004003 45. Qi, S., & Chen, J. (2020). Safety Assessment of a Wearable Low-Intensity Pulsed Ultrasound Device for Relieving Mental Illness Symptoms. Annu Int Conf IEEE Eng Med Biol Soc, 2020, 5240–5243. | - |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/104380 | - |
| dc.description.abstract | 隨著全球高齡化社會的到來，罹患神經退化性疾病的人口正逐年增加。這類疾病的主要成因，多與腦內變性蛋白或代謝廢物的異常堆積有關，例如阿茲海默症的 Tau 蛋白與類澱粉蛋白 (Aβ)，或是帕金森氏症的 α-突觸核蛋白 (α-syn)。目前這些疾病的治療大多需仰賴大型醫院的專用設備，對患者、家屬及醫療系統都造成了沉重的負擔。然而，現今已有許多研究證實，透過藥物、侵入性或非侵入性治療，以及自主運動等方式，能有效促進腦部的「膠淋巴系統 (Glymphatic system)」循環，進而加速清除這些有害蛋白與代謝廢物。
本團隊與合作單位在先前的研究中，已證實了非侵入式「低強度超音波刺激」與膠淋巴循環之間的關聯性。實驗結果顯示，當大腦處於受損或衰退狀態時，給予低強度超音波刺激，能顯著提升腦脊髓液 (CSF)擴散至腦區的速率，並大幅改善膠淋巴循環的相關指標。 為了將過去的基礎學理進一步落實於實際臨床治療，本研究設計並開發了一款「頭戴式超音波裝置」。我們建立了一套仿真頭骨模型，藉此進行超音波能量衰減與安全性測試。實驗結果證實，這款專為刺激膠淋巴循環所開發的穿戴式設備，在能量傳遞效率與安全性上皆達到預期的標準。未來本團隊也將持續推進，展開進一步的人體功效試驗。 | zh_TW |
| dc.description.abstract | As the global population ages, the number of individuals suffering from neurodegenerative diseases is increasing annually. These diseases are highly associated with the abnormal accumulation of misfolded proteins—such as Tau and amyloid-beta (Aβ) in Alzheimer's disease, or alpha-synuclein (α-syn) in Parkinson's disease—and other metabolic waste. Currently, treating these conditions predominantly relies on specialized hospital equipment, imposing a heavy burden on the healthcare system. However, recent studies indicate that interventions like pharmacological therapy, non-invasive treatments, and exercise can effectively promote the brain's "glymphatic system" to accelerate the clearance of these harmful substances.
In previous studies, our team demonstrated the correlation between non-invasive "low-intensity ultrasound stimulation" and enhanced glymphatic circulation. Specifically, it significantly increases the diffusion rate of cerebrospinal fluid (CSF) and improves glymphatic indicators in damaged or degenerated brains. To translate these fundamental findings into practical clinical applications, this study designed and developed a head-mounted ultrasound device. By establishing a skull phantom to conduct acoustic attenuation and safety testing , experimental results confirmed that this wearable device meets the expected standards for both energy transmission efficiency and safety. In the future, our team will advance this research by initiating human efficacy trials. | en |
| dc.description.provenance | Submitted by admin ntu (admin@lib.ntu.edu.tw) on 2026-08-26T16:12:34Z No. of bitstreams: 0 | en |
| dc.description.provenance | Made available in DSpace on 2026-08-26T16:12:34Z (GMT). No. of bitstreams: 0 | en |
| dc.description.tableofcontents | 口試委員審定書 i
致謝 ii 中文摘要 iii Abstract iv 目次 v 圖次 ix 表次 xii 第1章 緒論 1 1.1 研究背景 1 1.1.1 神經退化性疾病 1 1.1.2 膠淋巴系統 (Glymphatic System) 2 1.1.3 前期研究 3 1.2 研究目的 4 1.2.1 現今治療與研究 4 1.2.2 研究目標與重要性 5 第2章 材料與方法 6 2.1 超音波 6 2.1.1 超音波相關參數 6 2.1.2 聲功率 (Acoustic Power) 7 2.1.3 聲壓 (Acoustic Pressure) 8 2.1.4 聲強度 (Intensity) 8 2.1.5 衰減計算 10 2.1.5.1 介質中衰減 10 2.1.5.2 介面衰減 11 2.1.6 MI (Mechanical Index, 機械指數) 11 2.1.7 TI (Thermal Index, 熱指數) 12 2.2 設備 13 2.2.1 壓電陶瓷 13 2.2.2 訊號產生器 (Function Generator) 13 2.2.3 放大器 (Amplifier) 14 2.2.4 ONDA AIMS III Hydrophone Scanning System 14 2.2.5 熱電偶Thermocouple 15 2.2.6 超音波脈衝產生器接收器 16 2.2.7 k-Wave 模擬軟體 16 第3章 仿體製作與穿顱衰減試驗 18 3.1 實驗目的 18 3.2 仿體比例試驗 18 3.2.1 皮質骨仿體 18 3.2.1.1 測試結果 19 3.2.2 海綿骨仿體 19 3.2.2.1 測試結果 20 3.2.3 仿骨骼仿體 20 3.3 測量結果與K-WAVE模擬結果比較 21 3.3.1 k-wave環境設定 21 3.3.2 皮質骨仿體模擬與量測結果 22 3.3.3 海綿骨仿體模擬與量測結果 23 3.3.4 三層骨仿體模擬與量測結果 23 第4章 設備開發 25 4.1 設計目標 25 4.2 可攜式輸出裝置開發 25 4.2.1 調控系統設計 26 4.2.2 開發歷程 28 4.2.3 使用者介面與APP 與參數設定 30 4.3 穿戴式裝置 31 4.3.1 超音波探頭封裝 31 4.3.2 穿戴式頭盔開發 32 第5章 安全測試與參數 34 5.1 相關法規 34 5.2 聲強度ISPTA.3 34 5.3 MI 機械指數 34 5.4 TI 熱指數 35 5.5 有效輻射面積 (ERA) 35 5.6 波束非均勻率(BNR) 35 5.7 探頭表面溫度 35 第6章 結論與未來展望 37 6.1 結論與結果討論 37 6.2 未來展望 37 參考文獻 38 | - |
| dc.language.iso | zh_TW | - |
| dc.subject | 膠淋巴系統 | - |
| dc.subject | 低強度超音波 | - |
| dc.subject | 穿戴式設備 | - |
| dc.subject | pzt封裝 | - |
| dc.subject | 能量量測 | - |
| dc.subject | Glymphatic system | - |
| dc.subject | low-intensity ultrasound | - |
| dc.subject | Wearable Stimulation Device | - |
| dc.subject | pzt packaging | - |
| dc.subject | energy measurement | - |
| dc.title | 穿顱低強度超音波能量衰減特性分析與穿戴式刺激裝置之開發與驗證 | zh_TW |
| dc.title | Analysis of Transcranial Low-Intensity Ultrasound Energy Attenuation Characteristics and Development of a Wearable Stimulation Device | en |
| dc.type | Thesis | - |
| dc.date.schoolyear | 114-2 | - |
| dc.description.degree | 碩士 | - |
| dc.contributor.oralexamcommittee | 陳文翔;蕭仲凱;劉浩澧;胡長霖 | zh_TW |
| dc.contributor.oralexamcommittee | Wen-Shiang Chen;Jong-Kai Hsiao;Hao-Li Liu;Chang-Lin Hu | en |
| dc.subject.keyword | 膠淋巴系統; 低強度超音波; 穿戴式設備; pzt封裝; 能量量測 | zh_TW |
| dc.subject.keyword | Glymphatic system; low-intensity ultrasound; Wearable Stimulation Device; pzt packaging; energy measurement | en |
| dc.relation.page | 41 | - |
| dc.identifier.doi | 10.6342/NTU202602256 | - |
| dc.rights.note | 未授權 | - |
| dc.date.accepted | 2026-07-24 | - |
| dc.contributor.author-college | 工學院 | - |
| dc.contributor.author-dept | 醫學工程學系 | - |
| dc.date.embargo-lift | N/A | - |
| 顯示於系所單位： | 醫學工程學研究所 | |
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